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There is mounting evidence to suggest that XBP1s performs a critical function in a range of different cardiovascular diseases (CVDs), indicating that it is necessary to gain a comprehensive knowledge of the processes involved in XBP1s in various disorders to make progress in research and clinical therapy. In this research, we provide a summary of the functions that XBP1s performs in the onset and advancement of CVDs such as atherosclerosis, hypertension, cardiac hypertrophy, and heart failure. Furthermore, we discuss XBP1s as a novel therapeutic target for CVDs.<\/jats:p>","DOI":"10.3390\/jcdd9120459","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T03:01:51Z","timestamp":1671073311000},"page":"459","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Molecular Mechanism Underlying Role of the XBP1s in Cardiovascular Diseases"],"prefix":"10.3390","volume":"9","author":[{"given":"Shu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Lanzhou University Second Hospital, Lanzhou University, Lanzhou 730030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Lanzhou University Second Hospital, Lanzhou University, Lanzhou 730030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongnan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Lanzhou University Second Hospital, Lanzhou University, Lanzhou 730030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Lanzhou University Second Hospital, Lanzhou University, Lanzhou 730030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10654-018-0473-x","article-title":"Cardiovascular mortality attributable to dietary risk factors in 51 countries in the WHO European Region from 1990 to 2016: A systematic analysis of the Global Burden of Disease Study","volume":"34","author":"Meier","year":"2019","journal-title":"Eur. 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