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Program","award":["CYFY2021YB04"],"award-info":[{"award-number":["CYFY2021YB04"]}]},{"name":"Sichuan Science and Technology Program","award":["2021LHJYZD-01"],"award-info":[{"award-number":["2021LHJYZD-01"]}]},{"name":"Sichuan Science and Technology Program","award":["2021YFS0376"],"award-info":[{"award-number":["2021YFS0376"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Background: Excessive supraventricular ectopic activity (ESVEA) is correlated with the development of atrial fibrillation (AF) and is frequently observed in ischemic stroke patients. This meta-analysis aims to summarize the evidence on the association between ESVEA and the risk of AF and stroke. Methods: PubMed and Embase databases were systematically searched to identify all publications providing relevant data from inception to 23 August 2022. Hazard ratio (HR) and 95% confidence interval (CI) were pooled using fixed-effect or random-effect models. Results: We included 23,272 participants from 20 studies. Pooled results showed that ESVEA was associated with an increased risk of AF in the general population (HR: 2.57; 95% CI 2.16\u20133.05), increased risk of AF in ischemic stroke patients (HR: 2.91; 95% CI 1.80\u20134.69), new-onset ischemic stroke (HR: 1.91; 95% CI 1.30\u20132.79), and all-cause mortality (HR: 1.41; 95% CI 1.24\u20131.59). Pooled analysis indicated that ESVEA was not associated with recurrent ischemic stroke\/transient ischemic attack (TIA) (HR: 1.24; 95% CI 0.91\u20131.67). Conclusions: ESVEA is associated with AF, new-onset ischemic stroke, and all-cause mortality.<\/jats:p>","DOI":"10.3390\/jcdd9120461","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T03:01:51Z","timestamp":1671073311000},"page":"461","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Excessive Supraventricular Ectopic Activity and the Risk of Atrial Fibrillation and Stroke: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"9","author":[{"given":"Min","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yapeng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, China"},{"name":"International Clinical Research Center, Chengdu Medical College, Chengdu 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danni","family":"Zheng","sequence":"additional","affiliation":[{"name":"Biomedical Informatics and Digital Health, School of Medical Sciences, University of Sydney, Sydney, NSW 2050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Zhu","sequence":"additional","affiliation":[{"name":"International Clinical Research Center, Chengdu Medical College, Chengdu 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zimeng","family":"Li","sequence":"additional","affiliation":[{"name":"International Clinical Research Center, Chengdu Medical College, Chengdu 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S1474-4422(13)70310-7","article-title":"Embolic strokes of undetermined source: The case for a new clinical construct","volume":"13","author":"Hart","year":"2014","journal-title":"Lancet Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/01.STR.22.8.983","article-title":"Atrial fibrillation as an independent risk factor for stroke: The Framingham Study","volume":"22","author":"Wolf","year":"1991","journal-title":"Stroke"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1001\/archinte.164.16.1761","article-title":"Predictors of in-hospital mortality and attributable risks of death after ischemic stroke: The German Stroke Registers Study Group","volume":"164","author":"Heuschmann","year":"2004","journal-title":"Arch. 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