{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T19:53:01Z","timestamp":1785613981364,"version":"3.56.0"},"reference-count":35,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Vertebral lumbar surgery can be performed under both general anesthesia (GA) and spinal anesthesia. A clear benefit from spinal anesthesia (SA) remains unproven. The aim of our meta-analysis was to compare the early analgesic efficacy and recovery after SA and GA in adult patients undergoing vertebral lumbar surgery. A systematic investigation with the following criteria was performed: adult patients undergoing vertebral lumbar surgery (P); single-shot SA (I); GA care with or without wound infiltration (C); analgesic efficacy measured as postoperative pain, intraoperative hypotension, bradycardia, length of surgery, blood loss, postoperative side effects (such as postoperative nausea\/vomiting and urinary retention), overall patient and surgeon satisfaction, and length of hospital stay (O); and randomized controlled trials (S). The search was performed in Pubmed, the Cochrane Central Register of Controlled Trials, and Google Scholar up to 1 November 2020. Eleven studies were found upon this search. SA in vertebral lumbar surgery decreases postoperative pain and the analgesic requirement in the post anesthesia care unit. It is associated with a reduced incidence of postoperative nausea and vomiting and a higher patient satisfaction. It has no effect on urinary retention, intraoperative bradycardia, or hypotension. SA should be considered as a viable and efficient anesthetic technique in vertebral lumbar surgery.<\/jats:p>","DOI":"10.3390\/jcm10010102","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T09:35:23Z","timestamp":1609320923000},"page":"102","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["General Anesthesia Compared to Spinal Anesthesia for Patients Undergoing Lumbar Vertebral Surgery: A Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.3390","volume":"10","author":[{"given":"Alessandro","family":"De Cassai","sequence":"first","affiliation":[{"name":"UOC Anaesthesia and Intensive Care Unit, University Hospital of Padua, 35121 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Geraldini","sequence":"additional","affiliation":[{"name":"UOC Anaesthesia and Intensive Care Unit, University Hospital of Padua, 35121 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Boscolo","sequence":"additional","affiliation":[{"name":"UOC Anaesthesia and Intensive Care Unit, University Hospital of Padua, 35121 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pasin","sequence":"additional","affiliation":[{"name":"UOC Anaesthesia and Intensive Care Unit, University Hospital of Padua, 35121 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Pettenuzzo","sequence":"additional","affiliation":[{"name":"UOC Anaesthesia and Intensive Care Unit, University Hospital of Padua, 35121 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1584-5148","authenticated-orcid":false,"given":"Paolo","family":"Persona","sequence":"additional","affiliation":[{"name":"UOC Anaesthesia and Intensive Care Unit, University Hospital of Padua, 35121 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Munari","sequence":"additional","affiliation":[{"name":"UOC Anaesthesia and Intensive Care Unit, University Hospital of Padua, 35121 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Navalesi","sequence":"additional","affiliation":[{"name":"UOC Anaesthesia and Intensive Care Unit, University Hospital of Padua, 35121 Padua, Italy"},{"name":"UOC Anaesthesia and Intensive Care Unit, Department of Medicine-DIMED, University of Padua, 35121 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,30]]},"reference":[{"key":"ref_1","first-page":"CD000521","article-title":"General versus spinal\/epidural anaesthesia for surgery for hip fractures in adults","volume":"4","author":"Parker","year":"2000","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_2","first-page":"1","article-title":"Regional versus general anesthesia for spine surgery. A comprehensive review","volume":"66","author":"Mergeay","year":"2015","journal-title":"Acta Anaesthesiol. Belg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/ANA.0000000000000362","article-title":"A Comparison of Regional versus General Anesthesia for Lumbar Spine Surgery: A Meta-Analysis of Randomized Studies","volume":"29","author":"Healy","year":"2017","journal-title":"J. Neurosurg. Anesthesiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/anae.13702","article-title":"Impact of spinal anaesthesia vs. general anaesthesia on peri-operative outcome in lumbar spine surgery: A systematic review and meta-analysis of randomised, controlled trials","volume":"72","author":"Meng","year":"2017","journal-title":"Anaesthesia"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"b2700","DOI":"10.1136\/bmj.b2700","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: Explanation and elaboration","volume":"339","author":"Liberati","year":"2009","journal-title":"BMJ"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"De Cassai, A. (2020). Comparison of Spinal Anesthesia and General Anesthesia for Spine Surgery: A Meta-analysis of Randomized Controlled Trials. OSF.","DOI":"10.3390\/jcm10010102"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: A revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Higgins, J., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M., and Welch, V. (2020). Interpreting results and drawing conclusions. Cochrane Handbook for Systematic Reviews of Interventions, Cochrane. Available online: https:\/\/training.cochrane.org\/cochrane-handbook-systematic-reviews-interventions.","DOI":"10.1002\/9781119536604"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Wetterslev, J., Jakobsen, J.C., and Gluud, C. (2017). Trial Sequential Analysis in systematic reviews with meta-analysis. BMC Med. Res. Methodol., 17.","DOI":"10.1186\/s12874-017-0315-7"},{"key":"ref_11","first-page":"206","article-title":"Regional anesthesia for lumbar microdiscectomy","volume":"50","author":"Dagher","year":"2002","journal-title":"J. Med. Liban."},{"key":"ref_12","first-page":"61","article-title":"A prospective randomized trial comparing the spinal and general anesthesia in lumbar disc surgery: A study of 44 cases","volume":"23","author":"Khan","year":"2012","journal-title":"Med. Forum. Mon."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jclinane.2018.01.026","article-title":"The effect of spinal versus general anesthesia on intraocular pressure in lumbar disc surgery in the prone position: A randomized, controlled clinical trial","volume":"46","author":"Karaca","year":"2018","journal-title":"J. Clin. Anesth."},{"key":"ref_14","first-page":"524","article-title":"Spinal anesthesia versus general anesthesia for elective lumbar spine surgery: A randomized clinical trial","volume":"16","author":"Attari","year":"2011","journal-title":"J. Res. Med. Sci."},{"key":"ref_15","first-page":"47","article-title":"Comparative study in prolapse lumbar intervertebral disc (PLID) surgery by spinal vs general anaesthesia","volume":"23","author":"Chowdhury","year":"2010","journal-title":"J. Bangladesh. S. Anesth."},{"key":"ref_16","first-page":"397","article-title":"Can spinal anaesthesia be a routine for single level lumbar discectomy?","volume":"65","author":"Hussain","year":"2015","journal-title":"Pak. Armed Forces Med. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1213\/00000539-199609000-00021","article-title":"A prospective randomized study comparing short-and intermediate-term perioperative outcome variables after spinal or general anesthesia for lumbar disk and laminectomy surgery","volume":"83","author":"Jellish","year":"1996","journal-title":"Anesth. Analg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.pjnns.2014.05.005","article-title":"Perioperative outcome and cost-effectiveness of spinal versus general anesthesia for lumbar spine surgery","volume":"48","author":"Kahveci","year":"2014","journal-title":"Neurol. Neurochir. Pol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.surneu.2008.08.003","article-title":"A prospective randomized trial comparing the technique of spinal and general anesthesia for lumbar disk surgery: A study of 100 cases","volume":"71","author":"Sadrolsadat","year":"2009","journal-title":"Surg. Neurol."},{"key":"ref_20","first-page":"380","article-title":"Comparison of patient satisfaction and cost in spinal and general anesthesia for lumbar disc surgery","volume":"24","author":"Vural","year":"2014","journal-title":"Turk. Neurosurg."},{"key":"ref_21","first-page":"487","article-title":"Comparison of spinal and general anesthesia in lum-bar disc surgery","volume":"28","author":"Kara","year":"2011","journal-title":"J. Neurol. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/ANA.0000000000000555","article-title":"Regional Versus General Anesthesia: Effect of Anesthetic Techniques on Clinical Outcome in Lumbar Spine Surgery: A Prospective Randomized Controlled Trial","volume":"32","author":"Baenziger","year":"2020","journal-title":"J. Neurosurg. Anesthesiol."},{"key":"ref_23","first-page":"843","article-title":"Effects of Anesthesia Protocol on Perioperative Outcomes and Costs of Lumbar Microdiscectomies","volume":"29","author":"Kilic","year":"2019","journal-title":"Turk. Neurosurg."},{"key":"ref_24","first-page":"586","article-title":"Neuroendocrine and Hemodynamic Effects of General Anesthesia and Spinal Anesthesia for Minimally Invasive Lumbar Disc Surgery: A Randomized Trial","volume":"3","author":"Attar","year":"2014","journal-title":"Neurol. Sci."},{"key":"ref_25","unstructured":"Institute of Medicine (US) Committee on Quality of Health Care in America (2001). Crossing the Quality Chasm: A New Health System for the 21st Century, National Academies Press."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1097\/SLA.0000000000000932","article-title":"Is there a relationship between patient satisfaction and favorable outcomes?","volume":"260","author":"Kennedy","year":"2014","journal-title":"Ann. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Higgins, J., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M., and Welch, V. (2020). Chapter IV: Updating a review. Cochrane Handbook for Systematic Reviews of Interventions, Cochrane. Available online: https:\/\/training.cochrane.org\/cochrane-handbook-systematic-reviews-interventions.","DOI":"10.1002\/9781119536604"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"224","DOI":"10.7326\/0003-4819-147-4-200708210-00179","article-title":"How quickly do systematic reviews go out of date? A survival analysis","volume":"147","author":"Shojania","year":"2007","journal-title":"Ann. Intern. Med."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"De Cassai, A., Pasin, L., Boscolo, A., Salvagno, M., and Navalesi, P. (2020). Trial Sequential Analysis: Plain and Simple. Korean J. Anesthesiol.","DOI":"10.4097\/kja.20637"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1213\/01.ANE.0000093310.47375.44","article-title":"The pharmacokinetics and efficacy of ropivacaine continuous wound instillation after spine fusion surgery","volume":"98","author":"Bianconi","year":"2004","journal-title":"Anesth. Analg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4103\/0974-8237.161589","article-title":"Pain management following spinal surgeries: An appraisal of the available options","volume":"6","author":"Bajwa","year":"2015","journal-title":"J. Craniovertebr. Junction Spine"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"109669","DOI":"10.1016\/j.jclinane.2019.109669","article-title":"Injectate spread in ESP block: A review of anatomical investigations","volume":"61","author":"Andreatta","year":"2020","journal-title":"J. Clin. Anesth."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1136\/rapm-2020-101718","article-title":"Pharmacokinetics of lidocaine after bilateral ESP block","volume":"46","author":"Bonanno","year":"2021","journal-title":"Reg. Anesth. Pain Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"388","DOI":"10.4103\/0259-1162.179310","article-title":"Postoperative nausea and vomiting: A simple yet complex problem","volume":"10","author":"Shaikh","year":"2016","journal-title":"Anesth. Essays Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/00000542-199907000-00018","article-title":"Can postoperative nausea and vomiting be predicted?","volume":"91","author":"Sinclair","year":"1999","journal-title":"Anesthesiology"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/1\/102\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:47:54Z","timestamp":1760179674000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/1\/102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,30]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1]]}},"alternative-id":["jcm10010102"],"URL":"https:\/\/doi.org\/10.3390\/jcm10010102","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,30]]}}}