{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:28:25Z","timestamp":1760239705860,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T00:00:00Z","timestamp":1609372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: In Crohn\u2019s disease (CD), intra-abdominal abscess (IA) and intestinal free-wall perforation (IP) have a common mechanism of transmural inflammation; however, their manifestation is different. Objective: This study aimed to investigate differences in the clinical features between IA and IP in Korean patients with Crohn\u2019s disease. Design: A retrospective cohort study. Setting: Thirty university hospitals and two local hospitals in Korea. Patients: Patients who were diagnosed with CD between July 1982 and December 2008 were enrolled. Main Outcome Measures: Clinical characteristics of IA and IP. Results: Among 1286 patients with CD, 147 (11.4%) had IA and 83 (6.5%) had IP. IA patients were younger than those of IP (24.2 \u00b1 8.6 vs. 30.4 \u00b1 11.1 years, p = 0.001). Location and behavior were significantly different between IA and IP (p = 0.035 and 0.021). In multivariate analyses, perianal fistula was not associated with increased risk of IA and IP, while intestinal stricture was associated with increased risk of IA (OR: 2.72, p &lt; 0.0001) and IP (OR: 2.76, p &lt; 0.0001). In subgroup analyses, 55 (36.5%) IA patients were diagnosed at the diagnosis of CD, and 92 (63.5%) during follow-up of CD, while 47 (56.6%) IP patients were diagnosed at the diagnosis of CD, and 36 (43.3%) during follow-up of CD. Conclusions: There are several differences in the clinical features of IA and IP in Korean patients with CD. The development mechanism is considered as identical, but further investigation should be needed for clinical implication.<\/jats:p>","DOI":"10.3390\/jcm10010116","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T10:10:37Z","timestamp":1609409437000},"page":"116","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Features of Intra-Abdominal Abscess and Intestinal Free-Wall Perforation in Korean Patients with Crohn\u2019s Disease: Results from the CONNECT Study"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9197-1184","authenticated-orcid":false,"given":"Seok-Hoo","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Catholic Kwandong University International St. Mary\u2019s Hospital, Incheon 22711, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ja Sung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Catholic Kwandong University International St. Mary\u2019s Hospital, Incheon 22711, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju 26526, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7983-1928","authenticated-orcid":false,"given":"Hee Man","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju 26526, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7190-0362","authenticated-orcid":false,"given":"Hyun-Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju 26526, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1584-0160","authenticated-orcid":false,"given":"Jong Pil","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 03080, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 03080, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5156-3458","authenticated-orcid":false,"given":"You Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul Paik Hospital, Inje University College of Medicine, Seoul 04551, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Hee","family":"Cheon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 03722, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5682-9972","authenticated-orcid":false,"given":"Won Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 03722, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byong Duk","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 03181, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7103-3318","authenticated-orcid":false,"given":"Dong Soo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hanyang University College of Medicine, Guri 11923, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.suc.2007.03.011","article-title":"Operative management of small bowel Crohn\u2019s disease","volume":"87","author":"Gardiner","year":"2007","journal-title":"Surg Clin. North. Am."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1046\/j.1365-2168.2000.01589.x","article-title":"Risk factors for surgery and recurrence in 907 patients with primary ileocaecal Crohn\u2019s disease","volume":"87","author":"Bernell","year":"2000","journal-title":"Br. J. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1111\/j.1572-0241.2008.02158.x","article-title":"An update on the epidemiology of inflammatory bowel disease in Asia","volume":"103","author":"Thia","year":"2008","journal-title":"Am. J. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/ibd.20310","article-title":"Epidemiology of inflammatory bowel disease in the Songpa-Kangdong district, Seoul, Korea, 1986\u20132005: A KASID study","volume":"14","author":"Yang","year":"2008","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3109\/00365529509096316","article-title":"Disease activity courses in a regional cohort of Crohn\u2019s disease patients","volume":"30","author":"Munkholm","year":"1995","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s11605-006-0030-x","article-title":"Percutaneous drainage and ileocolectomy for spontaneous intraabdominal abscess in Crohn\u2019s disease","volume":"11","author":"Poritz","year":"2007","journal-title":"J. Gastrointest Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1136\/gut.49.6.777","article-title":"Behaviour of Crohn\u2019s disease according to the Vienna classification: Changing pattern over the course of the disease","volume":"49","author":"Louis","year":"2001","journal-title":"Gut"},{"key":"ref_8","first-page":"249","article-title":"Human diseases caused by free-living amoebae. II. Primary amebic ++ meningoencephalitis","volume":"64","year":"1990","journal-title":"Rev. Sanid. Hig. Publica"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1002\/ibd.21865","article-title":"Efficacy of different therapeutic options for spontaneous abdominal abscesses in Crohn\u2019s disease: Are antibiotics enough?","volume":"18","author":"Bermejo","year":"2012","journal-title":"Inflamm. Bowel. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/00004836-200105000-00010","article-title":"Abscesses in Crohn\u2019s disease: Outcome of medical versus surgical treatment","volume":"32","author":"Garcia","year":"2001","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_11","first-page":"175","article-title":"Free perforation in Crohn\u2019s disease","volume":"5","author":"Werbin","year":"2003","journal-title":"Isr Med. Assoc. J."},{"key":"ref_12","first-page":"37","article-title":"Large retroperitoneal abscess extended to the inferior right limb secondary to a perforated ileal Crohn\u2019s disease: The importance of the multidisciplinary approach","volume":"37","author":"Mascolino","year":"2016","journal-title":"G Chir."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/bjs.1800700904","article-title":"The influence of disease at the margin of resection on the outcome of Crohn\u2019s disease","volume":"70","author":"Heuman","year":"1983","journal-title":"Br. J. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/00000658-199101000-00006","article-title":"Intra-abdominal abscess in regional enteritis","volume":"213","author":"Ribeiro","year":"1991","journal-title":"Ann. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.5217\/ir.2014.12.3.173","article-title":"Crohn\u2019s Disease Clinical Network and Cohort (CONNECT) study: The first step toward nationwide multicenter research of Crohn\u2019s disease in Korea","volume":"12","author":"Cheon","year":"2014","journal-title":"Intest. Res."},{"key":"ref_16","first-page":"2","article-title":"Classification of inflammatory bowel disease","volume":"170","year":"1989","journal-title":"Scand. J. Gastroenterol Suppl."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"5A","DOI":"10.1155\/2005\/269076","article-title":"Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology","volume":"19","author":"Silverberg","year":"2005","journal-title":"Can. J. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Doh, Y.S., Kim, Y.S., Bae, S.I., Im, J.P., Cheon, J.H., Ye, B.D., Kim, J.W., Park, Y.S., Lee, J.H., and Kim, Y. (2015). The clinical characteristics of patients with free perforation in Korean Crohn\u2019s disease: Results from the CONNECT study. BMC Gastroenterol., 15.","DOI":"10.1186\/s12876-015-0262-x"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1046\/j.1365-2168.1998.00575.x","article-title":"Intra-abdominal and pelvic abscess in Crohn\u2019s disease: Results of noninvasive and surgical management","volume":"85","author":"Jawhari","year":"1998","journal-title":"Br. J. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.2214\/ajr.150.5.1043","article-title":"Percutaneous drainage of abscesses in patients with Crohn disease","volume":"150","author":"Lambiase","year":"1988","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/S0016-5085(82)80139-X","article-title":"Incidence and microbiology of abdominal and pelvic abscess in Crohn\u2019s disease","volume":"83","author":"Keighley","year":"1982","journal-title":"Gastroenterology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00535-003-1317-2","article-title":"The clinical characteristics and outcome of intraabdominal abscess in Crohn\u2019s disease","volume":"39","author":"Yamaguchi","year":"2004","journal-title":"J. Gastroenterol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000360618","article-title":"Risk and management of intra-abdominal abscess in Crohn\u2019s disease treated with infliximab","volume":"89","author":"Yoneno","year":"2014","journal-title":"Digestion"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/00000658-198701000-00013","article-title":"Spontaneous free perforation and perforated abscess in 30 patients with Crohn\u2019s disease","volume":"205","author":"Greenstein","year":"1987","journal-title":"Ann. Surg."},{"key":"ref_25","first-page":"38","article-title":"Free perforation in Crohn\u2019s disease: A report of 33 cases and review of literature","volume":"81","author":"Katz","year":"1986","journal-title":"Am. J. Gastroenterol."},{"key":"ref_26","first-page":"682","article-title":"Free perforation in Crohn\u2019s disease: I. A survey of 99 cases","volume":"80","author":"Greenstein","year":"1985","journal-title":"Am. J. Gastroenterol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/BF01654694","article-title":"Free perforation of the small bowel in Crohn\u2019s disease","volume":"6","author":"Abascal","year":"1982","journal-title":"World J. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/BF02236603","article-title":"Free perforation in regional enteritis","volume":"13","author":"Kyle","year":"1968","journal-title":"Am. J. Dig. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"544","DOI":"10.5009\/gnl18157","article-title":"Association of perianal fistulas with clinical features and prognosis of Crohn\u2019s disease in Korea: Results from the CONNECT Study","volume":"12","author":"Chun","year":"2018","journal-title":"Gut Liver."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000342608","article-title":"Clinical risk factors for complicated disease: How reliable are they?","volume":"30","author":"Zallot","year":"2012","journal-title":"Dig. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.crohns.2014.01.023","article-title":"Diagnostic delay in a French cohort of Crohn\u2019s disease patients","volume":"8","author":"Nahon","year":"2014","journal-title":"J. Crohns Colitis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1038\/ajg.2013.248","article-title":"Diagnostic delay in Crohn\u2019s disease is associated with a complicated disease course and increased operation rate","volume":"108","author":"Schoepfer","year":"2013","journal-title":"Am. J. Gastroenterol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/ibd.21719","article-title":"Systematic evaluation of risk factors for diagnostic delay in inflammatory bowel disease","volume":"18","author":"Vavricka","year":"2012","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1097\/MIB.0000000000001257","article-title":"Impact of diagnostic delay and associated factors on clinical outcomes in a US inflammatory bowel disease cohort","volume":"23","author":"Nguyen","year":"2017","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1053\/j.gastro.2011.01.055","article-title":"Epidemiology and natural history of inflammatory bowel diseases","volume":"140","author":"Cosnes","year":"2011","journal-title":"Gastroenterology."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Kim, H.M., Kim, J.W., Kim, H.-S., Kim, J.S., Kim, Y.S., Cheon, J.H., Kim, W.H., Ye, B.D., Moon, W., and Jung, S.H. (2021). Effect of Thiopurine on Potential Surgical Intervention in Crohn\u2019s Disease in Korea: Results from the CONNECT Study. J. Clin. Med., 10.","DOI":"10.3390\/jcm10010025"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/1\/116\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:48:19Z","timestamp":1760179699000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/1\/116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,31]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1]]}},"alternative-id":["jcm10010116"],"URL":"https:\/\/doi.org\/10.3390\/jcm10010116","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2020,12,31]]}}}