{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:45:26Z","timestamp":1760233526840,"version":"build-2065373602"},"reference-count":34,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Endometrial cancer (EC) has been associated with an increased risk of cardiovascular disease, including atrial fibrillation (AF). We performed a prospective, case-controlled analysis among 310 Bulgarian women with new-onset, histologically confirmed EC, free of AF at the baseline survey, and women with normal (senile) endometrium\/endometrial hyperplasia as a control group (n = 205). The risk of AF as well as relationship of adiponectin (APN) and high sensitivity C-reactive protein (hs-CRP) levels with AF in women with EC were calculated by Cox proportional hazards models. During the mean follow-up of 2.5 \u00b1 0.5 years, new-onset AF had occurred in 11.7% of women with EC vs. 5.8% in the control group (p &lt; 0.01). The risk of AF was highest in the first 6 months after new-onset EC, with an incidence rate ratio (IRR) of 1.19 (95% CI 1.10\u20131.29; p = 0.01). Women with EC, who were obese (body mass index (BMI) &gt; 30 kg\/m2) and younger (age &lt; 60) were found to be more likely to develop AF (HR 1.95; 95% CI 1.18\u20133.32; p = 0.05). APN levels were not significantly associated with new-onset AF (95% CI 0.87\u20131.21; p = 0.063). However, the secondary analysis showed evidence of APN\u2013AF association when adjusted for BMI (2.05; 95% CI 1.04\u20134.04; p = 0.037). We conclude that EC was significantly associated with the incidence of AF.<\/jats:p>","DOI":"10.3390\/jcm10020266","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T11:52:32Z","timestamp":1610538752000},"page":"266","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Incidence of Atrial Fibrillation in Postmenopausal Women with Endometrial Cancer"],"prefix":"10.3390","volume":"10","author":[{"given":"Mariana S.","family":"Parahuleva","sequence":"first","affiliation":[{"name":"Internal Medicine\/Cardiology and Angiology, University Hospital of Giessen and Marburg, 35043 Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9498-9558","authenticated-orcid":false,"given":"Julian","family":"Kreutz","sequence":"additional","affiliation":[{"name":"Internal Medicine\/Cardiology and Angiology, University Hospital of Giessen and Marburg, 35043 Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9094-773X","authenticated-orcid":false,"given":"Gerhild","family":"Euler","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Justus Liebig University Giessen, 35390 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dora","family":"Terzieva","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amar","family":"Mardini","sequence":"additional","affiliation":[{"name":"Internal Medicine\/Cardiology and Angiology, University Hospital of Giessen and Marburg, 35043 Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina","family":"Uchikova","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikoleta","family":"Parahuleva","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1093\/eurheartj\/eht280","article-title":"Projections on the number of individuals with atrial fibrillation in the European Union, from 2000 to 2060","volume":"34","author":"Krijthe","year":"2013","journal-title":"Eur. Heart J."},{"key":"ref_2","unstructured":"Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J.J., Blomstr\u00f6m-Lundqvist, C., Boriani, G., Castella, M., Dan, G.-A., and Dilaveris, P.E. (2020). 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTs). Eur. Heart J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/j.jacc.2014.01.023","article-title":"Lone Atrial Fibrillation","volume":"63","author":"Wyse","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/14779072.2019.1581064","article-title":"Interaction of obesity and atrial fibrillation: An overview of pathophysiology and clinical management","volume":"17","author":"Pouwels","year":"2019","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1016\/j.jacc.2012.04.063","article-title":"Inflammation in Atrial Fibrillation","volume":"60","author":"Guo","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1161\/01.STR.0000260090.90508.3e","article-title":"High-Sensitivity C-Reactive Protein and Soluble CD40 Ligand as Indices of Inflammation and Platelet Activation in 880 Patients with Nonvalvular Atrial Fibrillation","volume":"38","author":"Lip","year":"2007","journal-title":"Stroke"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1016\/j.jacc.2017.09.002","article-title":"Obesity and Atrial Fibrillation Prevalence, Pathogenesis, and Prognosis","volume":"70","author":"Lavie","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.amjcard.2004.06.023","article-title":"Comparison of the impact of atrial fibrillation on the risk of stroke and cardiovascular death in women versus men (The Copenhagen City Heart Study)","volume":"94","author":"Friberg","year":"2004","journal-title":"Am. J. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Veneruso, A., Slocum, M.R., Kircher, S.M., Akhter, N., Murtagh, G., and Strauss, J.B. (2017). Developing a cardiac monitoring plan in at-risk cancer survivors. J. Clin. Oncol., 35.","DOI":"10.1200\/JCO.2017.35.5_suppl.133"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Jakobsen, C.B., Lamberts, M., Carlson, N., Lock-Hansen, M., Torp-Pedersen, C., Gislason, G.H., and Schou, M. (2019). Incidence of atrial fibrillation in different major cancer subtypes: A Nationwide population-based 12 year follow up study. BMC Cancer, 19.","DOI":"10.1186\/s12885-019-6314-9"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ijcard.2017.03.132","article-title":"Atrial fibrillation in cancer patients: Hindsight, insight and foresight","volume":"240","author":"Mery","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.blre.2019.03.005","article-title":"Atrial fibrillation and cancer\u2014An unexplored field in cardiovascular oncology","volume":"35","author":"Chu","year":"2019","journal-title":"Blood Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1001\/jamacardio.2016.0280","article-title":"Risk of Malignant Cancer Among Women With New-Onset Atrial Fibrillation","volume":"1","author":"Conen","year":"2016","journal-title":"JAMA Cardiol."},{"key":"ref_14","first-page":"1342","article-title":"Long-term Cardiovascular Outcomes Among Endometrial Cancer Survivors in a Large, Population-Based Cohort Study","volume":"110","author":"Soisson","year":"2018","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1515\/hmbci-2014-0049","article-title":"Molecular cues on obesity signals, tumor markers and endometrial cancer","volume":"21","author":"Lee","year":"2015","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/ijc.26046","article-title":"Long-term overweight and weight gain in early adulthood in association with risk of endometrial cancer","volume":"129","author":"Lu","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1515\/hmbci-2016-0005","article-title":"Hormones and endometrial carcinogenesis","volume":"25","author":"Kamal","year":"2016","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1002\/ijc.25267","article-title":"Endometrial cancer incidence trends in Norway during 1953-2007 and predictions for 2008-2027","volume":"127","author":"Lindemann","year":"2010","journal-title":"Int. J. Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1136\/heartjnl-2015-308927","article-title":"The associations of leptin, adiponectin and resistin with incident atrial fibrillation in women","volume":"102","author":"Ermakov","year":"2016","journal-title":"Heart"},{"key":"ref_20","unstructured":"Potpara, T.S., Dan, G.-A., Trendafilova, E., Goda, A., Kusljugic, Z., Manola, S., Music, L., Musetescu, R., Badila, E., and The BALKAN-AF Investigators (2016). Stroke prevention in atrial fibrillation and \u2018real world\u2019 adherence to guidelines in the Balkan Region: The BALKAN-AF Survey. Sci. Rep., 6."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/europace\/eut373","article-title":"A prospective survey in European Society of Cardiology member countries of atrial fibrillation management: Baseline results of EURObservational Research Programme Atrial Fibrillation (EORP-AF) Pilot General Registry","volume":"16","author":"Lip","year":"2014","journal-title":"Europace"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","article-title":"Recommendations for Chamber Quantification: A Report from the American Society of Echocardiography\u2019s Guidelines and Standards Committee and the Chamber Quantification Writing Group, Developed in Conjunction with the European Association of Echocardiography, a Branch of the European Society of Cardiology","volume":"18","author":"Lang","year":"2005","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"vi35","DOI":"10.1093\/annonc\/mdr374","article-title":"Endometrial cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"22","author":"Colombo","year":"2011","journal-title":"Ann. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ygyno.2012.06.001","article-title":"Cardiovascular disease and endometrial cancer","volume":"126","author":"Mehta","year":"2012","journal-title":"Gynecol. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.ijcard.2016.07.133","article-title":"Incidence of atrial fibrillation is associated with age and gender in subjects practicing physical exercise: A meta-analysis and meta-regression analysis","volume":"221","author":"Brunetti","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s12020-017-1434-y","article-title":"Adiponectin circulating levels and 10-year (2002\u20132012) cardiovascular disease incidence: The ATTICA Study","volume":"58","author":"Kyrou","year":"2017","journal-title":"Endocrine"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1093\/europace\/eux173","article-title":"High circulating adiponectin level is associated with poor clinical outcome after catheter ablation for paroxysmal atrial fibrillation","volume":"20","author":"Kim","year":"2017","journal-title":"Europace"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ahj.2011.09.029","article-title":"Plasma resistin, adiponectin, and risk of incident atrial fibrillation: The Framingham Offspring Study","volume":"163","author":"Rienstra","year":"2012","journal-title":"Am. Heart J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10654-013-9875-y","article-title":"A cohort study examination of established and emerging risk factors for atrial fibrillation: The Busselton Health Study","volume":"29","author":"Knuiman","year":"2014","journal-title":"Eur. J. Epidemiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nm724","article-title":"Diet-induced insulin resistance in mice lacking adiponectin\/ACRP30","volume":"8","author":"Maeda","year":"2002","journal-title":"Nat. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1161\/01.CIR.102.11.1296","article-title":"Adiponectin, an Adipocyte-Derived Plasma Protein, Inhibits Endothelial NF-\u03baB Signaling Through a cAMP-Dependent Pathway","volume":"102","author":"Ouchi","year":"2000","journal-title":"Circulation"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/658913","article-title":"New Insight into Adiponectin Role in Obesity and Obesity-Related Diseases","volume":"2014","author":"Nigro","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Karam, B., Chavez-Moreno, A., Koh, W., Akar, J.G., and Akar, F.G. (2017). Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes. Cardiovasc. Diabetol., 16.","DOI":"10.1186\/s12933-017-0604-9"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1093\/europace\/eux177","article-title":"Screening for atrial fibrillation: A European Heart Rhythm Association (EHRA) consensus document endorsed by the Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulaci\u00f3n Card\u00edaca y Electrofisiolog\u00eda (SOLAECE)","volume":"19","author":"Mairesse","year":"2017","journal-title":"Europace"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/2\/266\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:10:35Z","timestamp":1760159435000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/2\/266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,13]]},"references-count":34,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,1]]}},"alternative-id":["jcm10020266"],"URL":"https:\/\/doi.org\/10.3390\/jcm10020266","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2021,1,13]]}}}