{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T02:46:29Z","timestamp":1789267589782,"version":"build-2803163510"},"reference-count":60,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT &amp; Future Planning","award":["NRF-2017M3C7A1029610"],"award-info":[{"award-number":["NRF-2017M3C7A1029610"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Exploring the disruptions to intrinsic resting-state networks (RSNs) in schizophrenia-spectrum disorders yields a better understanding of the disease-specific pathophysiology. However, our knowledge of the neurobiological underpinnings of schizotypal personality disorders mostly relies on research on schizotypy or schizophrenia. This study aimed to investigate the RSN abnormalities of schizotypal personality disorder (SPD) and their clinical implications. Using resting-state data, the intra- and inter-network of the higher-order functional networks (default mode network, DMN; frontoparietal network, FPN; dorsal attention network, DAN; salience network, SN) were explored in 22 medication-free, community-dwelling, non-help seeking individuals diagnosed with SPD and 30 control individuals. Consequently, while there were no group differences in intra-network functional connectivity across DMN, FPN, DAN, and SN, the SPD participants exhibited attenuated anticorrelation between the right frontal eye field region of the DAN and the right posterior parietal cortex region of the FPN. The decreases in anticorrelation were correlated with increased cognitive\u2013perceptual deficits and disorganization factors of the schizotypal personality questionnaire, as well as reduced independence\u2013performance of the social functioning scale for all participants together. This study, which links SPD pathology and social functioning deficits, is the first evidence of impaired large-scale intrinsic brain networks in SPD.<\/jats:p>","DOI":"10.3390\/jcm10020312","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T12:44:05Z","timestamp":1610714645000},"page":"312","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Attenuated Resting-State Functional Anticorrelation between Attention and Executive Control Networks in Schizotypal Personality Disorder"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1939-7365","authenticated-orcid":false,"given":"Ji-Won","family":"Hur","sequence":"first","affiliation":[{"name":"Department of Psychology, Korea University, Seoul 02841, Korea"},{"name":"Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1901-8636","authenticated-orcid":false,"given":"Taekwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang Ik K.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02215, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1060-1462","authenticated-orcid":false,"given":"Jun Soo","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul 08826, Korea"},{"name":"Department of Psychiatry, Seoul National University College of Medicine, Seoul 03080, Korea"},{"name":"Institute of Human Behavioral Medicine, SNU-MRC, Seoul 03080, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Li, S., Hu, N., Zhang, W., Tao, B., Dai, J., Gong, Y., Tan, Y., Cai, D., and Lui, S. (2019). Dysconnectivity of multiple brain networks in schizophrenia: A meta-analysis of resting-state functional connectivity. Front. Psychiatry, 10.","DOI":"10.3389\/fpsyt.2019.00482"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.pneurobio.2016.08.003","article-title":"How do abnormalities in the brain\u2019s spontaneous activity translate into symptoms in schizophrenia? From an overview of resting state activity findings to a proposed spatiotemporal psychopathology","volume":"145\u2013146","author":"Northoff","year":"2016","journal-title":"Prog. Neurobiol."},{"key":"ref_3","first-page":"408","article-title":"The treatment of adolescents with schizotypal personality disorder and related conditions: A practice-oriented review of the literature","volume":"20","author":"Ryan","year":"2013","journal-title":"Clin. Psychol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1521\/pedi_2012_26_053","article-title":"Schizotypal personality disorder","volume":"27","author":"Chemerinski","year":"2013","journal-title":"J. Personal. Disord."},{"key":"ref_5","unstructured":"APA (2013). Diagnostic and Statistical Manual of Mental Disorders (DSM-5\u00ae), American Psychiatric Pub."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1017\/S0033291719001430","article-title":"Multivariate patterns of gray matter volume in thalamic nuclei are associated with positive schizotypy in healthy individuals","volume":"50","author":"Pergola","year":"2020","journal-title":"Psychol. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S417","DOI":"10.1093\/schbul\/sbu190","article-title":"Cognition and brain function in schizotypy: A selective review","volume":"41","author":"Ettinger","year":"2015","journal-title":"Schizophr. Bull."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1001\/jamapsychiatry.2013.665","article-title":"Globally and locally reduced MRI gray matter volumes in neuroleptic-naive men with schizotypal personality disorder: Association with negative symptoms","volume":"70","author":"Asami","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1176\/appi.ajp.2010.10020165","article-title":"Correlation of individual differences in schizotypal personality traits with amphetamine-induced dopamine release in striatal and extrastriatal brain regions","volume":"168","author":"Woodward","year":"2011","journal-title":"Am. J. Psychiatry"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jpsychires.2019.04.018","article-title":"Schizotypal personality disorder in individuals with the Attenuated Psychosis Syndrome: Frequent co-occurrence without an increased risk for conversion to threshold psychosis","volume":"114","author":"Zoghbi","year":"2019","journal-title":"J. Psychiatr. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1038\/nn.4135","article-title":"Functional connectome fingerprinting: Identifying individuals using patterns of brain connectivity","volume":"18","author":"Finn","year":"2015","journal-title":"Nat. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.biopsych.2018.03.013","article-title":"Resting-state connectivity biomarkers of cognitive performance and social function in individuals with schizophrenia spectrum disorder and healthy control subjects","volume":"84","author":"Viviano","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"ref_13","first-page":"436","article-title":"Brain-wide analysis of functional connectivity in first-episode and chronic stages of schizophrenia","volume":"43","author":"Li","year":"2017","journal-title":"Schizophr. Bull."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.brainres.2011.03.072","article-title":"Cooperation between the default mode network and the frontal\u2013parietal network in the production of an internal train of thought","volume":"1428","author":"Smallwood","year":"2012","journal-title":"Brain Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1017\/S0033291715002755","article-title":"Failed cooperative, but not competitive, interaction between large-scale brain networks impairs working memory in schizophrenia","volume":"46","author":"Pu","year":"2016","journal-title":"Psychol. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.tics.2011.08.003","article-title":"Large-scale brain networks and psychopathology: A unifying triple network model","volume":"15","author":"Menon","year":"2011","journal-title":"Trends Cogn. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1093\/schbul\/sbv123","article-title":"Neurobiological models of self-disorders in early schizophrenia","volume":"42","author":"Mishara","year":"2016","journal-title":"Schizophr. Bull."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.schres.2011.03.010","article-title":"Functional resting-state networks are differentially affected in schizophrenia","volume":"130","author":"Woodward","year":"2011","journal-title":"Schizophr. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1093\/brain\/awq010","article-title":"The default-mode, ego-functions and free-energy: A neurobiological account of Freudian ideas","volume":"133","author":"Friston","year":"2010","journal-title":"Brain"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"8112","DOI":"10.1073\/pnas.1415439112","article-title":"Dynamic reorganization of human resting-state networks during visuospatial attention","volume":"112","author":"Spadone","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.neuroimage.2016.12.073","article-title":"Interactions between the default network and dorsal attention network vary across default subsystems, time, and cognitive states","volume":"147","author":"Dixon","year":"2017","journal-title":"NeuroImage"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1503\/jpn.180245","article-title":"Abnormalities of intrinsic regional brain activity in first-episode and chronic schizophrenia: A meta-analysis of resting-state functional MRI","volume":"45","author":"Gong","year":"2020","journal-title":"J. Psychiatry Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.pscychresns.2015.09.013","article-title":"Schizophrenia symptoms and brain network efficiency: A resting-state fMRI study","volume":"234","author":"Su","year":"2015","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Lagioia, A., van de Ville, D., Debbane, M., Lazeyras, F., and Eliez, S. (2010). Adolescent resting state networks and their associations with schizotypal trait expression. Front. Syst. Neurosci., 4.","DOI":"10.3389\/fnsys.2010.00035"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"101603","DOI":"10.1016\/j.nicl.2018.11.013","article-title":"Multi-echo fMRI, resting-state connectivity, and high psychometric schizotypy","volume":"21","author":"Waltmann","year":"2019","journal-title":"Neuroimage Clin."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.schres.2014.10.013","article-title":"Altered default mode network functional connectivity in schizotypal personality disorder","volume":"160","author":"Zhang","year":"2014","journal-title":"Schizophr. Res."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Tang, Y., Zhang, T., Li, H., Tang, Y., Li, C., Luo, X., He, Y., Lu, Z., and Wang, J. (2017). Reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder. BMC Psychiatry, 17.","DOI":"10.1186\/s12888-016-1146-5"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3389\/fpsyt.2019.00476","article-title":"Psychosis and schizophrenia-spectrum personality disorders require early detection on different symptom dimensions","volume":"10","author":"Nenadic","year":"2019","journal-title":"Front. Psychiatry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1001\/jamapsychiatry.2015.2985","article-title":"Biological motion perception, brain responses, and schizotypal personality disorder","volume":"73","author":"Hur","year":"2016","journal-title":"JAMA Psychiatry"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"413","DOI":"10.15842\/kjcp.2014.33.2.011","article-title":"Validity of the K-WAIS-IV short forms","volume":"33","author":"Choe","year":"2014","journal-title":"Korean J. Clin. Psychol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/schbul\/17.4.555","article-title":"The SPQ: A scale for the assessment of schizotypal personality based on DSM-III-R criteria","volume":"17","author":"Raine","year":"1991","journal-title":"Schizophr. Bull."},{"key":"ref_32","first-page":"329","article-title":"The preliminary study on the validation of schizotypal personality questionnaire-Korean version","volume":"36","author":"Moon","year":"1997","journal-title":"J. Korean Neuropsychiatr. Assoc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1093\/oxfordjournals.schbul.a033481","article-title":"Three-factor model of schizotypal personality: Invariance across culture, gender, religious affiliation, family adversity, and psychopathology","volume":"26","author":"Reynolds","year":"2000","journal-title":"Schizophr. Bull."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1192\/bjp.166.5.654","article-title":"A brief mental health outcome scale: Reliability and validity of the Global Assessment of Functioning (GAF)","volume":"166","author":"Jones","year":"1995","journal-title":"Br. J. Psychiatry"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Lee, H.-R., Nam, G., and Hur, J.-W. (2020). Development and validation of the Korean version of the reading the mind in the eyes test. PLoS ONE, 15.","DOI":"10.1037\/t82159-000"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/1469-7610.00715","article-title":"The \u201cReading the Mind in the Eyes\u201d Test revised version: A study with normal adults, and adults with Asperger syndrome or high-functioning autism","volume":"42","author":"Wheelwright","year":"2001","journal-title":"J. Child Psychol. Psychiatry Allied Discip."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1192\/bjp.157.6.853","article-title":"The social functioning scale. The development and validation of a new scale of social adjustment for use in family intervention programmes with schizophrenic patients","volume":"157","author":"Birchwood","year":"1990","journal-title":"Br. J. Psychiatry"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/(SICI)1097-0193(1999)7:4<254::AID-HBM4>3.0.CO;2-G","article-title":"Nonlinear spatial normalization using basis functions","volume":"7","author":"Ashburner","year":"1999","journal-title":"Hum. Brain Mapp."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neuroimage.2013.05.116","article-title":"The nuisance of nuisance regression: Spectral misspecification in a common approach to resting-state fMRI preprocessing reintroduces noise and obscures functional connectivity","volume":"82","author":"Hallquist","year":"2013","journal-title":"NeuroImage"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/brain.2012.0073","article-title":"Conn: A functional connectivity toolbox for correlated and anticorrelated brain networks","volume":"2","year":"2012","journal-title":"Brain Connect."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"101775","DOI":"10.1016\/j.nicl.2019.101775","article-title":"Visual network alterations in brain functional connectivity in chronic low back pain: A resting state functional connectivity and machine learning study","volume":"22","author":"Shen","year":"2019","journal-title":"Neuroimage Clin."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Wolak, T., Cie\u015bla, K., Pluta, A., W\u0142odarczyk, E., Biswal, B., and Skar\u017cy\u0144ski, H. (2019). Altered functional connectivity in patients with sloping sensorineural hearing loss. Front. Hum. Neurosci., 13.","DOI":"10.3389\/fnhum.2019.00284"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/nn.3470","article-title":"Multi-task connectivity reveals flexible hubs for adaptive task control","volume":"16","author":"Cole","year":"2013","journal-title":"Nat. Neurosci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1177\/1073858413494269","article-title":"Dorsal and ventral attention systems: Distinct neural circuits but collaborative roles","volume":"20","author":"Vossel","year":"2014","journal-title":"Neuroscientist"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Posner, M.I., and Fan, J. (2008). Attention as an organ system. Topics in Integrative Neuroscience, Cambridge University Press.","DOI":"10.1017\/CBO9780511541681.005"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Ozaki, T.J. (2011). Frontal-to-parietal top-down causal streams along the dorsal attention network exclusively mediate voluntary orienting of attention. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0020079"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e01365","DOI":"10.1002\/brb3.1365","article-title":"Parcellation-based tractographic modeling of the dorsal attention network","volume":"9","author":"Allan","year":"2019","journal-title":"Brain Behav."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.neuron.2006.04.031","article-title":"A core system for the implementation of task sets","volume":"50","author":"Dosenbach","year":"2006","journal-title":"Neuron"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Qureshi, A., Nielsen, J., and Sepulcre, J. (2020). Topographic shifts in functional connectivity and reduced lateralization in 16p11.2 deletion carriers: A genetics-first approach to understanding autism. Res. Sq.","DOI":"10.21203\/rs.3.rs-28618\/v1"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"E1598","DOI":"10.1073\/pnas.1715766115","article-title":"Heterogeneity within the frontoparietal control network and its relationship to the default and dorsal attention networks","volume":"115","author":"Dixon","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1162\/jocn_a_00517","article-title":"Selective development of anticorrelated networks in the intrinsic functional organization of the human brain","volume":"26","author":"Chai","year":"2014","journal-title":"J. Cogn. Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Karcher, N.R., Michelini, G., Kotov, R., and Barch, D.M. (2020). Associations between resting state functional connectivity and a hierarchical dimensional structure of psychopathology in middle childhood. bioRxiv.","DOI":"10.1101\/2020.04.28.065086"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1093\/schbul\/sbt037","article-title":"Aberrant dependence of default mode\/central executive network interactions on anterior insular salience network activity in schizophrenia","volume":"40","author":"Manoliu","year":"2013","journal-title":"Schizophr. Bull."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1093\/schbul\/sby112","article-title":"Salience-default mode functional network connectivity linked to positive and negative symptoms of schizophrenia","volume":"45","author":"Hare","year":"2019","journal-title":"Schizophr. Bull."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41398-018-0118-6","article-title":"Aberrant salience network functional connectivity in auditory verbal hallucinations: A first episode psychosis sample","volume":"8","author":"Mallikarjun","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.psychres.2007.06.004","article-title":"Awareness of everyday executive difficulties precede overt executive dysfunction in schizotypal subjects","volume":"160","author":"Laws","year":"2008","journal-title":"Psychiatry Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.schres.2006.12.005","article-title":"Psychometric properties of the Brief Version of the Schizotypal Personality Questionnaire in relatives of patients with schizophrenia-spectrum disorders and non-psychiatric controls","volume":"91","author":"Compton","year":"2007","journal-title":"Schizophr. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1037\/bul0000101","article-title":"Interpersonal dysfunction in personality disorders: A meta-analytic review","volume":"143","author":"Wilson","year":"2017","journal-title":"Psychol. Bull."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1126\/science.1138071","article-title":"Top-down versus bottom-up control of attention in the prefrontal and posterior parietal cortices","volume":"315","author":"Buschman","year":"2007","journal-title":"Science"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.schres.2013.06.019","article-title":"General intellectual functioning as a buffer against theory-of-mind deficits in individuals at ultra-high risk for psychosis","volume":"149","author":"Hur","year":"2013","journal-title":"Schizophr. Res."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/2\/312\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:11:43Z","timestamp":1760159503000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/2\/312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,15]]},"references-count":60,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,1]]}},"alternative-id":["jcm10020312"],"URL":"https:\/\/doi.org\/10.3390\/jcm10020312","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,15]]}}}