{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:35:02Z","timestamp":1792794902198,"version":"4.5.0"},"reference-count":39,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hungarian Thoracic Society","award":["Grants to AB and MM"],"award-info":[{"award-number":["Grants to AB and MM"]}]},{"DOI":"10.13039\/501100002332","name":"Semmelweis University","doi-asserted-by":"publisher","award":["Grant to LK"],"award-info":[{"award-number":["Grant to LK"]}],"id":[{"id":"10.13039\/501100002332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Dyslipidaemia is well recognised in obstructive sleep apnoea (OSA) and could contribute to the development of cardiovascular disease (CVD). Atherogenic index of plasma (AIP) predicts cardiovascular morbidity and mortality better than the individual lipid levels. The aim of this study was to investigate the AIP in patients with OSA in relation with disease severity. Methods: Four hundred sixty-one patients with OSA and 99 controls participated in this study. AIP was assessed in the morning following a diagnostic sleep study. The association between lipid values and OSA were adjusted for age, gender, and body mass index. Results: Patients with OSA had higher AIP and triglyceride, and lower high-density lipoprotein cholesterol (HDL-C) levels (all p &lt; 0.05). AIP significantly correlated with the Epworth Sleepiness Scale score (\u03c1 = 0.19), the apnoea-hypopnoea index (\u03c1 = 0.40) and oxygen desaturation index (\u03c1 = 0.43, all p &lt; 0.05). However, there was no relationship between the AIP and markers of sleep quality such as total sleep time, sleep period time, sleep efficiency, arousal index or percentage of REM sleep (all p &gt; 0.05). AIP was not a better predictor for self-reported cardiovascular disease or diabetes than HDL-C. Conclusions: AIP is elevated in OSA and is related to disease severity. However, it does not seem to have an additional clinical value compared to HDL-C.<\/jats:p>","DOI":"10.3390\/jcm10030417","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T11:13:53Z","timestamp":1611314033000},"page":"417","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Atherogenic Index of Plasma in Obstructive Sleep Apnoea"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8983-740X","authenticated-orcid":false,"given":"Andras","family":"Bikov","sequence":"first","affiliation":[{"name":"Department of Pulmonology, Semmelweis University, 1085 Budapest, Hungary"},{"name":"North West Lung Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UK"},{"name":"Division of Infection, Immunity &amp; Respiratory Medicine, University of Manchester, Manchester M23 9LT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Meszaros","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laszlo","family":"Kunos","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-744X","authenticated-orcid":false,"given":"Alina Gabriela","family":"Negru","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"},{"name":"Cardiology Department, Institute of Cardiovascular Diseases Timisoara, 300310 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7469-6755","authenticated-orcid":false,"given":"Stefan Marian","family":"Frent","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"},{"name":"Pulmonology Department, \u2018Victor Babes\u2019 Infectious Diseases and Pulmonology Hospital Timisoara, 300310 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8897-8342","authenticated-orcid":false,"given":"Stefan","family":"Mihaicuta","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"},{"name":"Pulmonology Department, \u2018Victor Babes\u2019 Infectious Diseases and Pulmonology Hospital Timisoara, 300310 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0140-6736(05)71141-7","article-title":"Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: An observational study","volume":"365","author":"Marin","year":"2005","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1056\/NEJMoa1606599","article-title":"CPAP for Prevention of Cardiovascular Events in Obstructive Sleep Apnea","volume":"375","author":"McEvoy","year":"2016","journal-title":"N. 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