{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T03:48:27Z","timestamp":1780372107135,"version":"3.54.1"},"reference-count":26,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T00:00:00Z","timestamp":1611446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Permanent hypoparathyroidism, a feared thyroidectomy complication, leads to significant patient morbidity, medical treatment, and monitoring. This study explores whether preoperative high-dose vitamin D loading decreases the incidence of permanent hypoparathyroidism. In a subgroup analysis, the study examines the predictive utility of day 1 parathyroid hormone (PTH) in permanent hypoparathyroidism. Patients (n = 150) were previously recruited in the VItamin D In Thyroidectomy (VIDIT) trial, a multicentre, randomised, double blind, placebo-controlled trial evaluating the role of 300,000 IU cholecalciferol administered orally a week before total thyroidectomy. Patients were contacted postoperatively beyond six months through a telephonic questionnaire. The primary outcome was permanent hypoparathyroidism, strictly defined as the need for activated vitamin D six months postoperatively. Out of 150 patients, 130 (86.7%) were contactable. Permanent hypoparathyroidism occurred in 11\/130 (8.5%) patients, with a lower incidence of 5.3% (3\/57) in the cholecalciferol group compared to 11% (8\/73) in the placebo group; however, this was non-significant (p = 0.34). In a subgroup analysis, no relationship between day 1 PTH level and the incidence of permanent hypoparathyroidism was found (p \u2265 0.99). There was a lower rate of permanent hypoparathyroidism in the cholecalciferol group, which was not significant. The predictive utility of day 1 postoperative PTH levels may be limited to transient hypoparathyroidism.<\/jats:p>","DOI":"10.3390\/jcm10030442","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T02:07:00Z","timestamp":1611540420000},"page":"442","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Post-Operative Permanent Hypoparathyroidism and Preoperative Vitamin D Prophylaxis"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1952-4296","authenticated-orcid":false,"given":"Tara","family":"Kannan","sequence":"first","affiliation":[{"name":"School of Medicine and Public Health, University of Newcastle, Newcastle, NSW 2308, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1963-8410","authenticated-orcid":false,"given":"Yasmin","family":"Foster","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health, University of Newcastle, Newcastle, NSW 2308, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9576-4227","authenticated-orcid":false,"given":"David J.","family":"Ho","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health, University of Newcastle, Newcastle, NSW 2308, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Gelzinnis","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health, University of Newcastle, Newcastle, NSW 2308, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Merakis","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health, University of Newcastle, Newcastle, NSW 2308, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7980-3337","authenticated-orcid":false,"given":"Katie","family":"Wynne","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health, University of Newcastle, Newcastle, NSW 2308, Australia"},{"name":"Department of Endocrinology, John Hunter Hospital, Newcastle, NSW 2305, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt J.","family":"Balogh","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health, University of Newcastle, Newcastle, NSW 2308, Australia"},{"name":"Department of Surgery, John Hunter Hospital, Newcastle, NSW 2305, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cino","family":"Bendinelli","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health, University of Newcastle, Newcastle, NSW 2308, Australia"},{"name":"Department of Surgery, John Hunter Hospital, Newcastle, NSW 2305, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1001\/jamaoto.2017.1746","article-title":"Nationwide variation in rates of thyroidectomy among US medicare beneficiaries","volume":"143","author":"Francis","year":"2017","journal-title":"JAMA Otolaryngol. 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