{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:00:13Z","timestamp":1790406013265,"version":"4.1.0"},"reference-count":130,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T00:00:00Z","timestamp":1612569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Thrombocytopenia and impaired platelet function are known as intrinsic drawbacks of cardiac surgery and extracorporeal life supports (ECLS). A number of different factors influence platelet count and function including the inflammatory response to a cardiopulmonary bypass (CPB) or to ECLS, hemodilution, hypothermia, mechanical damage and preoperative treatment with platelet-inhibiting agents. Moreover, although underestimated, heparin-induced thrombocytopenia is still a hiccup in the perioperative management of cardiac surgical and, above all, ECLS patients. Moreover, recent investigations have highlighted how platelet disorders also affect patients undergoing biological prosthesis implantation. Though many hypotheses have been suggested, the mechanism underlying thrombocytopenia and platelet disorders is still to be cleared. This narrative review aims to offer clinicians a summary of their major causes in the cardiac surgery setting.<\/jats:p>","DOI":"10.3390\/jcm10040615","type":"journal-article","created":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T14:07:40Z","timestamp":1612706860000},"page":"615","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Quantitative and Qualitative Platelet Derangements in Cardiac Surgery and Extracorporeal Life Support"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6887-747X","authenticated-orcid":false,"given":"Enrico","family":"Squiccimarro","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Mater Dei Hospital, 70125 Bari, Italy"},{"name":"Department of Emergency and Organ Transplant (DETO), University of Bari, 70125 Bari, Italy"},{"name":"Cardio-Thoracic Surgery Department, Heart &amp; Vascular Centre, Maastricht University Medical Centre (MUMC), 6229HX Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6889-5686","authenticated-orcid":false,"given":"Federica","family":"Jiritano","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic Surgery Department, Heart &amp; Vascular Centre, Maastricht University Medical Centre (MUMC), 6229HX Maastricht, The Netherlands"},{"name":"Cardiac Surgery Unit, Department of Experimental and Clinical Medicine, University \u201cMagna Graecia\u201d of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe Filiberto","family":"Serraino","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, Department of Experimental and Clinical Medicine, University \u201cMagna Graecia\u201d of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7796-4463","authenticated-orcid":false,"given":"Hugo","family":"ten Cate","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, D-55131 Mainz, Germany"},{"name":"Thrombosis Center Maastricht, Maastricht University Medical Center (MUMC), 6229HX Maastricht, The Netherlands"},{"name":"Cardiovascular Research Institute Maastricht (CARIM), 6229HX Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2261-7098","authenticated-orcid":false,"given":"Domenico","family":"Paparella","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Santa Maria Hospital, GVM Care &amp; Research, 70125 Bari, Italy"},{"name":"Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Lorusso","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic Surgery Department, Heart &amp; Vascular Centre, Maastricht University Medical Centre (MUMC), 6229HX Maastricht, The Netherlands"},{"name":"Cardiovascular Research Institute Maastricht (CARIM), 6229HX Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41569-018-0110-0","article-title":"Platelet biology and functions: New concepts and clinical perspectives","volume":"16","author":"Heemskerk","year":"2019","journal-title":"Nat. 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