{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T09:05:38Z","timestamp":1769591138438,"version":"3.49.0"},"reference-count":61,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:00:00Z","timestamp":1612828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005297","name":"Uniwersytet Medyczny w Bialymstoku","doi-asserted-by":"publisher","award":["No R-I-002\/315\/2018"],"award-info":[{"award-number":["No R-I-002\/315\/2018"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Psoriasis is a chronic, inflammatory skin disease affecting 2\u20134% of the general population. Accompanying subjective symptoms (pruritus or pain) may cause decreased life quality including sleep disorders (SD). Sixty psoriatic patients fulfilled the following questionnaires: Pittsburgh Sleep Quality Index (PSQI), STOP BANG for the obstructive sleep apnea syndrome (OSAS) assessment, and Restless Legs Syndrome (RLS) Severity Scale. Patients\u2019 laboratory and clinical data were also investigated. All data obtained were compared to 40 participants without dermatoses. Mean PSQI, risk of OSAS, and RLS severity of psoriatics were significantly higher than in controls (p &lt; 0.0001, p &lt; 0.05, p &lt; 0.05 respectively). There was a positive correlation between the time of suffering from psoriasis and the risk of OSAS (R = 0.286, p &lt; 0.05). We did not observe any significant relationship between PSQI, risk of OSAS, or RLS and psoriasis severity assessed with PASI (Psoriasis Area and Severity Index). We identified four possible predictors of RLS: glucose, CRP and total cholesterol concentrations, and PSQI. SD are significantly more frequent in psoriatics than in people without chronic dermatological diseases but surprisingly they are not correlated with psoriasis severity. SD decrease patients\u2019 life quality and may result in serious consequences. Therefore, establishing recommendations concerning screening for SD and their predictors should be considered.<\/jats:p>","DOI":"10.3390\/jcm10040664","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:49:26Z","timestamp":1613090966000},"page":"664","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The Assessment of Risk and Predictors of Sleep Disorders in Patients with Psoriasis\u2014A Questionnaire-Based Cross-Sectional Analysis"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6870-1167","authenticated-orcid":false,"given":"Julia","family":"Nowowiejska","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, Medical University of Bialystok, Zurawia 14 St, 15-540 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Baran","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Medical University of Bialystok, Zurawia 14 St, 15-540 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Lewoc","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Medical University of Bialystok, Zurawia 14 St, 15-540 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina","family":"Grabowska","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Medical University of Bialystok, Zurawia 14 St, 15-540 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8688-4171","authenticated-orcid":false,"given":"Tomasz W.","family":"Kaminski","sequence":"additional","affiliation":[{"name":"Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15260, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwona","family":"Flisiak","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Medical University of Bialystok, Zurawia 14 St, 15-540 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.5114\/ada.2019.84007","article-title":"Sleep quality among adult patients with chronic dermatoses","volume":"36","author":"Kaaz","year":"2019","journal-title":"Adv. Dermatol. Allergol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.smrv.2015.09.003","article-title":"Psoriasis and sleep disorders: A systematic review","volume":"29","author":"Gupta","year":"2016","journal-title":"Sleep Med. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.det.2014.09.004","article-title":"Psoriasis Is a Systemic Disease with Multiple Cardiovascular and Metabolic Comorbidities","volume":"33","author":"Ryan","year":"2015","journal-title":"Dermatol. Clin."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Li, X., Kong, L., Li, F., Chen, C., Xu, R., Wang, H., and Li, B. (2015). Association between psoriasis and chronic obstructive pulmonary disease: A system-atic review and meta-analysis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0145221"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1590\/abd1806-4841.20186981","article-title":"Impact of psoriasis in the quality of life of children, adolescents and their families: A cross-sectional study","volume":"93","author":"Salman","year":"2018","journal-title":"An. Bras. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Kim, H.-N., Han, K., Song, S.-W., and Lee, J.H. (2018). Hypertension and risk of psoriasis incidence: An 11-year nationwide population-based cohort study. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0202854"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Baran, A., Nowowiejska, J., Krahel, J.A., Kami\u0144ski, T.W., Maciaszek, M., and Flisiak, I. (2020). Higher Serum Selenoprotein P Level as a Novel Inductor of Metabolic Complications in Psoriasis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21134594"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Baran, A., Krahel, J., Kaminski, T.W., Krawiel, M., Maciaszek, M., and Flisiak, I. (2020). Elevated circulating Kr\u00fcppel-like fac-tor 4 level as a novel independent marker of the proatherogenic risk in patients with psoriasis: A preliminary study. Adv. Dermatol. Allergol., 10, in press.","DOI":"10.5114\/ada.2020.98560"},{"key":"ref_9","first-page":"e6369","article-title":"Psoriasis and Metabolic Syndrome: Comorbidities and Environmental and Therapeutic Implications","volume":"11","author":"Peralta","year":"2019","journal-title":"Cureus"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"273","DOI":"10.5114\/dr.2020.97780","article-title":"Sleep disturbances in psoriasis","volume":"107","author":"Nowowiejska","year":"2020","journal-title":"Dermatol. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"301","DOI":"10.5114\/reum.2018.79501","article-title":"Sleep disorders in patients with psoriatic ar-thritis and psoriasis","volume":"56","author":"Placek","year":"2018","journal-title":"Reumatologia"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/ejhf.113","article-title":"Psoriasis and risk of heart failure: A nationwide cohort study","volume":"16","author":"Khalid","year":"2014","journal-title":"Eur. J. Heart Fail."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1080\/13548506.2018.1442011","article-title":"Systemic lupus erythematosus is associated with negatively variable impacts on domains of sleep disturbances: A systematic review and meta-analysis","volume":"23","author":"Zhao","year":"2018","journal-title":"Psychol. Health Med."},{"key":"ref_14","first-page":"137","article-title":"Risk of Obstructive Sleep Apnea Syndrome in Psoriasis Patients","volume":"22","author":"Tas","year":"2019","journal-title":"Arch. Iran. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/jhh.2015.15","article-title":"Obstructive sleep apnea, hypertension and cardiovascular diseases","volume":"29","author":"Gonzaga","year":"2015","journal-title":"J. Hum. Hypertens."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"E1481","DOI":"10.1503\/cmaj.170296","article-title":"Diagnosis and treatment of obstructive sleep apnea in adults","volume":"189","author":"Laratta","year":"2017","journal-title":"Can. Med. Assoc. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.5664\/jcsm.27497","article-title":"Clinical Guideline for the Evaluation, Management and Long-term Care of Obstructive Sleep Apnea in Adults","volume":"5","author":"Epstein","year":"2009","journal-title":"J. Clin. Sleep Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e015313","DOI":"10.1161\/JAHA.119.015313","article-title":"Association between risk of obstructive sleep ap-nea and cerebrovascular reactivity in stroke patients","volume":"9","author":"Andrade","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.mehy.2017.12.004","article-title":"The complex associations between obstructive sleep apnea and auto-immune dis-orders: A review","volume":"110","author":"Vakil","year":"2018","journal-title":"Med. Hypotheses"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1684\/ejd.2015.2525","article-title":"Restless legs syndrome in psoriasis: An unexpected comorbidity","volume":"25","author":"Schell","year":"2015","journal-title":"Eur. J. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.bbi.2012.06.003","article-title":"Elevated C-reactive protein is associated with severe periodic leg movements of sleep in patients with restless legs syndrome","volume":"26","author":"Trotti","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/S1474-4422(18)30311-9","article-title":"Comorbidities, treatment, and pathophysiology in restless legs syn-drome","volume":"17","author":"Trenkwalder","year":"2018","journal-title":"Lancet Neurol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/jcsm.12061","article-title":"Deranged iron status in pso-riasis: The impact of low body mass","volume":"6","author":"Ponikowska","year":"2015","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jsmc.2015.05.022","article-title":"Restless Leg Syndrome\/Willis-Ekbom Disease Pathophysiology","volume":"10","author":"Allen","year":"2015","journal-title":"Sleep Med. Clin."},{"key":"ref_25","first-page":"331","article-title":"Restless legs syndrome and insomnia frequency in patients with psoriasis","volume":"68","author":"Tekatas","year":"2015","journal-title":"Ideggy\u00f3gy\u00e1szati Szle."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.5664\/jcsm.7194","article-title":"Psoriasis Is Associated With a Higher Prevalence of Obstructive Sleep Apnea and Restless Legs Syndrome: A Possible Indication of Autonomic Activation in Psoriasis","volume":"14","author":"Gupta","year":"2018","journal-title":"J. Clin. Sleep Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1365-2230.2012.04356.x","article-title":"Increased frequency of restless legs syndrome in atopic dermatitis","volume":"37","author":"Cicek","year":"2012","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"109780","DOI":"10.1016\/j.jpsychores.2019.109780","article-title":"Quality of life, anxiety and depressive symptoms in patients with psoriasis: A case-control study","volume":"124","author":"Nogueras","year":"2019","journal-title":"J. Psychosom. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00403-019-01998-7","article-title":"Pruritus and sleep disturbances in patients with psoriasis","volume":"312","author":"Hawro","year":"2020","journal-title":"Arch. Dermatol. Res."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Chiu, H.Y., Hsieh, C.F., Chiang, Y.T., Tsai, Y.W., Huang, W.F., Li, C.Y., Wang, T.S., and Tsai, T.F. (2016). Concomitant sleep disorders significantly increase the risk of cardio-vascular disease in patients with Psoriasis. PLoS ONE., 11.","DOI":"10.1371\/journal.pone.0146462"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/10401334.2018.1456928","article-title":"Adapting Maslow\u2019s Hierarchy of Needs as a frame-work for resident wellness","volume":"31","author":"Hale","year":"2019","journal-title":"Teach. Learn Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s11325-019-01820-8","article-title":"Sleep disorders in patients with psoriasis: A cross-sectional study using non-polysomnographical methods","volume":"23","author":"Sacmaci","year":"2019","journal-title":"Sleep Breath."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"124","DOI":"10.5152\/eurasianjmed.2017.17132","article-title":"Sleep Quality and its Association with Disease Severity in Psoriasis","volume":"49","author":"Melikoglu","year":"2017","journal-title":"Eurasian J. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.jaad.2018.11.058","article-title":"Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with awareness and attention to comorbidities","volume":"80","author":"Elmets","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"92","DOI":"10.5114\/dr.2020.95258","article-title":"Psoriasis. Diagnostic and therapeutic recommendations of the Polish Dermatological Society. Part 1","volume":"107","author":"Reich","year":"2020","journal-title":"Dermatol. Rev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.3389\/fpsyg.2016.01126","article-title":"Structural validity of the Pittsburgh Sleep Quality Index in Chinese undergradu-ate students","volume":"7","author":"Guo","year":"2016","journal-title":"Front Psychol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"563","DOI":"10.5664\/jcsm.27351","article-title":"Relationships between the Pittsburgh Sleep Quality Index (PSQI), Ep-worth Sleepiness Scale (ESS), and clinical\/polysomnographic measures in a community sample","volume":"4","author":"Buysse","year":"2008","journal-title":"J. Clin. Sleep Med."},{"key":"ref_38","first-page":"655","article-title":"Psoriasis vulgaris does not adversely influence the quality of sleep","volume":"148","author":"Stinco","year":"2013","journal-title":"G. Ital. Dermatol. Venereol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"284","DOI":"10.5021\/ad.2018.30.3.284","article-title":"Both educational lectures and reference photographs are necessary to improve the accuracy and reliability of Psoriasis Area and Severity Index (PASI) assessment: Results from Kore-an nation-wide PASI educational workshop","volume":"30","author":"Choi","year":"2018","journal-title":"Ann. Dermatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"851","DOI":"10.17219\/acem\/69804","article-title":"The reliability of three psoriasis assessment tools: Psoriasis area and severity index, body surface area and physician global assessment","volume":"26","author":"Reich","year":"2017","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_41","first-page":"181","article-title":"Sleep quality in psoriasis patients and its relations with possible af-fecting factors","volume":"54","author":"Tas","year":"2020","journal-title":"Med Bull. Sisli Etfal Hosp."},{"key":"ref_42","first-page":"1234","article-title":"Relationships between sleep quality, physical fitness and body mass index in college freshmen","volume":"55","author":"Chang","year":"2014","journal-title":"J. Sports Med. Phys. Fit."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1590\/1806-9282.65.6.845","article-title":"Sleep quality is inversely related to body mass index among university students","volume":"65","author":"Wang","year":"2019","journal-title":"Rev. Assoc. M\u00e9dica Bras."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.sleep.2018.12.028","article-title":"Poor sleep quality and lipid profile in a rural cohort (The Baependi Heart Study)","volume":"57","author":"Geovanini","year":"2019","journal-title":"Sleep Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/1759720X11416862","article-title":"Improved sleep efficiency after anti-tumor necrosis factor \u03b1 therapy in rheumatoid arthritis patients","volume":"3","author":"Gjevre","year":"2011","journal-title":"Ther. Adv. Musculoskelet. Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1111\/ijd.13026","article-title":"The bidirectional interactions between psoriasis and obstructive sleep apnea","volume":"54","author":"Hirotsu","year":"2015","journal-title":"Int. J. Dermatol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s11325-017-1507-4","article-title":"Psoriasis is associated with risk of obstructive sleep apnea independently from metabolic parameters and other comorbidities: A large hospital-based case-control study","volume":"21","author":"Papadavid","year":"2017","journal-title":"Sleep Breath."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/1440-1681.12024","article-title":"Obstructive sleep apnoea and cardiovascular complications: Perception versus knowledge","volume":"39","author":"Thomas","year":"2012","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_49","first-page":"294","article-title":"Rheumatoid arthritis and sleep quality","volume":"57","author":"Goes","year":"2017","journal-title":"Rev. Bras. Reum. English Ed."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1080\/000155599750011075","article-title":"Cardiovascular complications of psoriasis: Does obstructive sleep apnea play a role?","volume":"79","author":"Buslau","year":"1999","journal-title":"Acta Derm Venereol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1007\/s12070-015-0914-8","article-title":"Evaluation of Liver Functions Based on Serum Aminotransferase Enzyme Levels in Patients with Obstructive Sleep Apnea Syndrome","volume":"71","author":"Atan","year":"2019","journal-title":"Indian J. Otolaryngol. Head Neck Surg."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Hirotsu, C., Tufik, S., Guindalini, C., Mazzotti, D.R., Bittencourt, L.R.A., and Andersen, M.L. (2013). Association Between Uric Acid Levels and Obstructive Sleep Apnea Syndrome in a Large Epidemiological Sample. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0066891"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.2169\/internalmedicine.3005-19","article-title":"Severity Indices for Obstructive Sleep Apnea Syndrome Reflecting Glycemic Control or Insulin Resistance","volume":"58","author":"Isobe","year":"2019","journal-title":"Intern. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.metabol.2018.01.022","article-title":"Effects of obesity therapies on sleep disorders","volume":"84","author":"Xanthopoulos","year":"2018","journal-title":"Metabolism"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jaad.2014.02.012","article-title":"Diet and psoriasis, part I: Impact of weight loss inter-ventions","volume":"71","author":"Debbaneh","year":"2014","journal-title":"J. Am. Acad Dermatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e12875","DOI":"10.1111\/jsr.12875","article-title":"Gender differences in clinical, laboratory and polysomnographic features of restless legs syndrome","volume":"29","author":"Holzknecht","year":"2020","journal-title":"J. Sleep Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.sleep.2019.02.022","article-title":"Serum C-reactive protein\/albumin ratio and restless legs syn-drome","volume":"58","author":"Yazar","year":"2019","journal-title":"Sleep Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"445","DOI":"10.5664\/jcsm.6996","article-title":"Evaluation of Cardiovascular Risk Factors and Restless Legs Syndrome in Women and Men: A Preliminary Population-Based Study in China","volume":"14","author":"Liu","year":"2018","journal-title":"J. Clin. Sleep Med."},{"key":"ref_59","first-page":"54","article-title":"Insomnia, excessive daytime sleepiness, anxiety, depression and socioeconomic status among customer service employees in Canada","volume":"13","year":"2020","journal-title":"Sleep Sci."},{"key":"ref_60","first-page":"e6183","article-title":"Socioeconomic Status in Pregnant Women and Sleep Quality During Pregnancy","volume":"11","author":"Surani","year":"2019","journal-title":"Cureus"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Papadopoulos, D., Sosso, F.E., Khoury, T., and Surani, S.R. (2020). Sleep Disturbances Are Mediators between Socioeconomic Status and Health: A Scoping Review. Int. J. Ment. Health Addict., 1\u201325.","DOI":"10.1007\/s11469-020-00378-x"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/4\/664\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:21:59Z","timestamp":1760160119000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/4\/664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,9]]},"references-count":61,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["jcm10040664"],"URL":"https:\/\/doi.org\/10.3390\/jcm10040664","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,9]]}}}