{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:48:15Z","timestamp":1760233695173,"version":"build-2065373602"},"reference-count":16,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background and aim: Recent randomized data comparing percutaneous mitral valve repair (PMVR) versus optimal medical treatment in patients with functional MR (FMR) seemed to highlight the importance of the learning curve not only for procedural outcomes but also for patient selection. The aim of the study was to compare a contemporary series of patients undergoing PMVR using a second-generation Mitraclip device (Mitraclip NT) with previous cohorts treated with a first-generation system. Methods: This multicenter study collected individual data from 18 centers between 2012 and 2017. The cohort was divided into three groups according to the use of the first-generation Mitraclip during the first (control-1) or second half (control-2) or the Mitraclip NT system. Results: A total of 545 consecutive patients were included in the study. Among all, 182 (33.3%), 183 (33.3%), and 180 (33.3%) patients underwent mitral repair in the control-1, control-2, and NT cohorts, respectively. Procedural success was achieved in 93.3% of patients without differences between groups. Major adverse events did not statistically differ among groups, but there was a higher rate of pericardial effusion in the control-1 group (4.3%, 0.6%, and 2.6%, respectively; p = 0.025). The composite endpoint of death, surgery, and admission for congestive heart failure (CHF) at 12 months was lower in the NT group (23.5% in control-1, 22.5% in control-2, and 8.3% in the NT group; p = 0.032). Conclusions: The present paper shows that contemporary clinical outcomes of patients undergoing PMVR with the Mitraclip system have improved over time.<\/jats:p>","DOI":"10.3390\/jcm10040734","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T18:45:00Z","timestamp":1613155500000},"page":"734","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Percutaneous Mitral Valve Repair: Outcome Improvement with Operator Experience and a Second-Generation Device"],"prefix":"10.3390","volume":"10","author":[{"given":"Xavier","family":"Freixa","sequence":"first","affiliation":[{"name":"Hospital Clinic de Barcelona, Institut Cl\u00ednic Cardiovascular, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Est\u00e9vez-Loureiro","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Le\u00f3n, 24071 Le\u00f3n, 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Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Nombela-Franco","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico de San Carlos, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5433-1364","authenticated-orcid":false,"given":"Isaac","family":"Pascual","sequence":"additional","affiliation":[{"name":"Hospital Central de Asturias, 33011 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belen","family":"Cid","sequence":"additional","affiliation":[{"name":"Complejo Hospitalario Universitario de Santiago, 15706 Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Ram\u00f3n","family":"L\u00f3pez-M\u00ednguez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Infanta Cristina, 06080 Badajoz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa 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Am. Coll. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMoa1009355","article-title":"Percutaneous repair or surgery for mitral regurgitation","volume":"364","author":"Feldman","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.amjcard.2013.01.300","article-title":"One- and Twelve-Month Safety and Efficacy Outcomes of Patients Undergoing Edge-to-Edge Percutaneous Mitral Valve Repair (from the GRASP Registry)","volume":"111","author":"Grasso","year":"2013","journal-title":"Am. J. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1093\/eurjhf\/hfs079","article-title":"MitraClip therapy in daily clinical practice: Initial results from the German transcatheter mitral valve interventions (TRAMI) registry","volume":"14","author":"Baldus","year":"2012","journal-title":"Eur. J. Hear. Fail."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.jacc.2013.02.094","article-title":"Percutaneous mitral valve interventions in the real world: Early and 1-year results from the ACCESS-EU, a prospective, multicenter, nonrandomized post-approval study of the MitraClip therapy in Europe","volume":"62","author":"Maisano","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.jacc.2014.06.1166","article-title":"Percutaneous mitral valve edge-to-edge repair: In-hospital results and 1-year follow-up of 628 patients of the 2011-2012 Pilot European Sentinel Registry","volume":"64","author":"Nickenig","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_7","first-page":"1007","article-title":"Initial experience of percutaneous treatment of mitral regurgitation with MitraClip(R) therapy in Spain","volume":"67","author":"Arzamendi","year":"2014","journal-title":"Rev. Esp. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1056\/NEJMoa1805374","article-title":"Percutaneous Repair or Medical Treatment for Secondary Mitral Regurgitation","volume":"379","author":"Obadia","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1056\/NEJMoa1806640","article-title":"Transcatheter Mitral-Valve Repair in Patients with Heart Failure","volume":"379","author":"Stone","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ijcard.2018.08.023","article-title":"Long-term outcome, survival and predictors of mortality after MitraClip therapy: Results from the German Transcatheter Mitral Valve Interventions (TRAMI) registry","volume":"277","author":"Kalbacher","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Grasso, C., and Ince, H. (2016). The MitraClip system: Strategies for optimal patient selection and optimised results. EuroIntervention, 12.","DOI":"10.4244\/EIJV12SYA14"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Kebler, M.J., Wh\u00f6rle, J., Rpttbauer, W., and Markovic, S. (2018). Procedural and Clinical Results of the New Mitraclip NT after Percutaneous Edge to Edge Repair of Mitral Valve Regurgitation. Int. J. Cardiovac. Res., 7.","DOI":"10.4172\/2324-8602.1000340"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ijcard.2018.06.041","article-title":"Two-year cardiac mortality after MitraClip treatment of functional mitral regurgitation in ischemic and non-ischemic dilated cardiomyopathy","volume":"269","author":"Godino","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/ejhf.1289","article-title":"Predictors of rehospitalization after percutaneous edge-to-edge mitral valve repair by MitraClip implantation","volume":"21","author":"Seeger","year":"2019","journal-title":"Eur. J. Heart Fail."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/ccd.26806","article-title":"Influence of experience on procedure steps, safety, and functional results in edge to edge mitral valve repair-a single center study","volume":"90","author":"Hamm","year":"2016","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1007\/s00392-014-0734-y","article-title":"Impact of the learning curve on outcome after transcatheter mitral valve repair: Results from the German Mitral Valve Registry","volume":"103","author":"Ledwoch","year":"2014","journal-title":"Clin. Res. Cardiol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/4\/734\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:23:26Z","timestamp":1760160206000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/4\/734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,12]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["jcm10040734"],"URL":"https:\/\/doi.org\/10.3390\/jcm10040734","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2021,2,12]]}}}