{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:37:07Z","timestamp":1792103827119,"version":"4.4.0"},"reference-count":65,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T00:00:00Z","timestamp":1613174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Transanal irrigation (TAI) has received increasing attention as a treatment option in patients with bowel dysfunction. This systematic review was conducted according to the PRISMA guidelines and evaluates the effect of TAI in neurogenic bowel dysfunction (NBD), low anterior resection syndrome (LARS), faecal incontinence (FI) and chronic constipation (CC). The primary outcome was the effect of TAI on bowel function. Secondary outcomes included details on TAI, quality of life (QoL), the discontinuation rate, adverse events, predictive factors for a successful outcome, and health economics. A systematic search for articles reporting original data on the effect of TAI on bowel function was performed, and 27 eligible studies including 1435 individuals were included. Three randomised controlled trials, one non-randomised trial, and 23 observational studies were included; 70% of the studies were assessed to be of excellent or good methodological quality. Results showed an improvement in bowel function among patients with NBD, LARS, FI, and CC with some studies showing improvement in QoL. However, discontinuation rates were high. Side effects were common, but equally prevalent among comparative treatments. No consistent predictive factors for a successful outcome were identified. Results from this review show that TAI improves bowel function and potentially QoL; however, evidence remains limited.<\/jats:p>","DOI":"10.3390\/jcm10040753","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T02:08:12Z","timestamp":1613268492000},"page":"753","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Transanal Irrigation for Neurogenic Bowel Disease, Low Anterior Resection Syndrome, Faecal Incontinence and Chronic Constipation: A Systematic Review"],"prefix":"10.3390","volume":"10","author":[{"given":"Mira","family":"Mekhael","sequence":"first","affiliation":[{"name":"Department of Surgery, Aarhus University Hospital, DK8200 Aarhus, Denmark"},{"name":"Danish Cancer Society Centre for Research on Survivorship and Late Adverse Effects after Cancer in the Pelvic Organs, DK8200 Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, DK8200 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle \u00d8","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Aarhus University Hospital, DK8200 Aarhus, Denmark"},{"name":"Danish Cancer Society Centre for Research on Survivorship and Late Adverse Effects after Cancer in the Pelvic Organs, DK8200 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1802-6474","authenticated-orcid":false,"given":"Helene Mathilde","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Aarhus University Hospital, DK8200 Aarhus, Denmark"},{"name":"Danish Cancer Society Centre for Research on Survivorship and Late Adverse Effects after Cancer in the Pelvic Organs, DK8200 Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, DK8200 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5411-4826","authenticated-orcid":false,"given":"Therese","family":"Juul","sequence":"additional","affiliation":[{"name":"Department of Surgery, Aarhus University Hospital, DK8200 Aarhus, Denmark"},{"name":"Danish Cancer Society Centre for Research on Survivorship and Late Adverse Effects after Cancer in the Pelvic Organs, DK8200 Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, DK8200 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Emmanuel","sequence":"additional","affiliation":[{"name":"GI Physiology Unit, University College London Hospital, London NW1 2BU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Krogh","sequence":"additional","affiliation":[{"name":"Danish Cancer Society Centre for Research on Survivorship and Late Adverse Effects after Cancer in the Pelvic Organs, DK8200 Aarhus, Denmark"},{"name":"Department of Hepatology and Gastroenterology, Aarhus University Hospital, DK8200 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Aarhus University Hospital, DK8200 Aarhus, Denmark"},{"name":"Danish Cancer Society Centre for Research on Survivorship and Late Adverse Effects after Cancer in the Pelvic Organs, DK8200 Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, DK8200 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,13]]},"reference":[{"key":"ref_1","first-page":"CD002115","article-title":"Management of faecal incontinence and constipation in adults with central neurological diseases","volume":"13","author":"Coggrave","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s40258-018-0447-x","article-title":"Peristeen Transanal Irrigation System to Manage Bowel Dysfunction: A NICE Medical Technology Guidance","volume":"17","author":"Dale","year":"2019","journal-title":"Appl. Health Econ. Health Policy"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s10350-004-6498-0","article-title":"Scintigraphic assessment of retrograde colonic washout in fecal incontinence and constipation","volume":"46","author":"Christensen","year":"2003","journal-title":"Dis. Colon Rectum"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Emmanuel, A. (2019). Neurogenic bowel dysfunction. F1000Research, 8.","DOI":"10.12688\/f1000research.20529.1"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/sc.2013.86","article-title":"Consensus review of best practice of transanal irrigation in adults","volume":"51","author":"Emmanuel","year":"2013","journal-title":"Spinal Cord"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/S0140-6736(96)91487-7","article-title":"Bowel dysfunction in spinal-cord-injury patients","volume":"347","author":"Glickman","year":"1996","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1053\/j.gastro.2006.06.004","article-title":"A randomized, controlled trial of transanal irrigation versus conservative bowel management in spinal cord-injured patients","volume":"131","author":"Christensen","year":"2006","journal-title":"Gastroenterology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1007\/s10151-020-02348-w","article-title":"Transanal irrigation: Another hope for patients with LARS","volume":"24","author":"Christensen","year":"2020","journal-title":"Tech. Coloproctol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00384-017-2954-x","article-title":"Treatment possibilities for low anterior resection syndrome: A review of the literature","volume":"33","author":"Dulskas","year":"2018","journal-title":"Int. J. Colorectal Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/DCR.0000000000001228","article-title":"Low Anterior Resection Syndrome and Quality of Life After Sphincter-Sparing Rectal Cancer Surgery: A Long-term Longitudinal Follow-up","volume":"62","author":"Pieniowski","year":"2019","journal-title":"Dis. Colon Rectum"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.clcc.2014.12.007","article-title":"Bowel function 14 years after preoperative short-course radiotherapy and total mesorectal excision for rectal cancer: Report of a multicenter randomized trial","volume":"14","author":"Chen","year":"2015","journal-title":"Clin. Colorectal Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3109\/00365520903583855","article-title":"Transanal irrigation for disordered defecation: A systematic review","volume":"45","author":"Christensen","year":"2010","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/DCR.0b013e3181979341","article-title":"Long-term outcome and safety of transanal irrigation for constipation and fecal incontinence","volume":"52","author":"Christensen","year":"2009","journal-title":"Dis. Colon Rectum"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1177\/0269215509353253","article-title":"Managing neurogenic bowel dysfunction","volume":"24","author":"Emmanuel","year":"2010","journal-title":"Clin. Rehabil."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"BMJ"},{"key":"ref_16","unstructured":"(2020, December 01). Covidence Systematic Review Software, Veritas Health Innovation, Melbourne, Australia. Available online: www.covidence.org."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1136\/jech.52.6.377","article-title":"The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions","volume":"52","author":"Downs","year":"1998","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3129\/i08-001","article-title":"Age-related macular degeneration and low-vision rehabilitation: A systematic review","volume":"43","author":"Hooper","year":"2008","journal-title":"Can. J. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.7748\/ns.19.9.39.s58","article-title":"Rectal irrigation for relief of functional bowel disorders","volume":"19","author":"Gardiner","year":"2004","journal-title":"Nurs. Stand."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1080\/10790268.2008.11754571","article-title":"Outcome of transanal irrigation for bowel dysfunction in patients with spinal cord injury","volume":"31","author":"Christensen","year":"2008","journal-title":"J. Spinal Cord Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/sj.sc.3102167","article-title":"Treatment of neurogenic bowel dysfunction using transanal irrigation: A multicenter Italian study","volume":"46","author":"Mosiello","year":"2008","journal-title":"Spinal Cord"},{"key":"ref_22","first-page":"241","article-title":"Transanal irrigation in the management of neurogenic bowel dysfunction","volume":"105","author":"Loftus","year":"2012","journal-title":"Ir. Med. J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/sc.2012.171","article-title":"Application of transanal irrigation for patients with spinal cord injury in South Korea: A 6-month follow-up study","volume":"51","author":"Kim","year":"2013","journal-title":"Spinal Cord"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.rehab.2013.01.005","article-title":"Long-term transanal irrigation\u2019s continuation at home. Preliminary study","volume":"56","author":"Bordes","year":"2013","journal-title":"Ann. Phys. Rehabil. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.apmr.2015.01.011","article-title":"Outcomes of neurogenic bowel management in individuals living with a spinal cord injury for at least 10 years","volume":"96","author":"Adriaansen","year":"2015","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1097\/DCR.0b013e3182653bd1","article-title":"Transanal irrigation for bowel symptoms in patients with multiple sclerosis","volume":"55","author":"Preziosi","year":"2012","journal-title":"Dis. Colon Rectum"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1111\/nmo.12833","article-title":"Long-term efficacy and safety of transanal irrigation in multiple sclerosis","volume":"28","author":"Passananti","year":"2016","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/nau.23904","article-title":"Defecation disorders in Spina Bifida: Realistic goals and best therapeutic approaches","volume":"38","author":"Brochard","year":"2019","journal-title":"Neurourol. Urodyn."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/BF02056950","article-title":"A constipation scoring system to simplify evaluation and management of constipated patients","volume":"39","author":"Agachan","year":"1996","journal-title":"Dis. Colon Rectum"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1136\/gut.44.1.77","article-title":"Prospective comparison of faecal incontinence grading systems","volume":"44","author":"Vaizey","year":"1999","journal-title":"Gut"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/sj.sc.3101887","article-title":"Neurogenic bowel dysfunction score","volume":"44","author":"Krogh","year":"2006","journal-title":"Spinal Cord"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF02237236","article-title":"Fecal Incontinence Quality of Life Scale: Quality of life instrument for patients with fecal incontinence","volume":"43","author":"Rockwood","year":"2000","journal-title":"Dis. Colon Rectum"},{"key":"ref_33","unstructured":"(2001). International Classification of Functioning, Disability, and Health, ICF World Health Organization."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF02050307","article-title":"Etiology and management of fecal incontinence","volume":"36","author":"Jorge","year":"1993","journal-title":"Dis. Colon Rectum"},{"key":"ref_35","first-page":"225","article-title":"A systematic review of psychometric evidence and expert opinion regarding the assessment of faecal incontinence in older community-dwelling adults","volume":"6","author":"Fallon","year":"2008","journal-title":"Int. J. Evid. Based Healthc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection","volume":"30","author":"Ware","year":"1992","journal-title":"Med. Care"},{"key":"ref_37","unstructured":"EQ-5D-5L User Guide (2020, December 01). EuroQol Research Foundation. Available online: https:\/\/euroqol.org\/publications\/user-guides."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/BF02471596","article-title":"Self washout method for defecational complaints following low anterior rectal resection","volume":"19","author":"Iwama","year":"1989","journal-title":"Jpn. J. Surg."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s00384-009-0719-x","article-title":"Retrograde colonic irrigation for faecal incontinence after low anterior resection","volume":"24","author":"Koch","year":"2009","journal-title":"Int. J. Colorectal Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e335","DOI":"10.1111\/j.1463-1318.2011.02692.x","article-title":"Transanal irrigation improves quality of life in patients with low anterior resection syndrome","volume":"13","author":"Rosen","year":"2011","journal-title":"Colorectal Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s10151-018-1829-7","article-title":"Role of transanal irrigation in the treatment of anterior resection syndrome","volume":"22","author":"Martellucci","year":"2018","journal-title":"Tech. Coloproctol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/codi.14870","article-title":"A randomized trial comparing transanal irrigation and percutaneous tibial nerve stimulation in the management of low anterior resection syndrome","volume":"22","year":"2020","journal-title":"Colorectal Dis."},{"key":"ref_43","first-page":"461","article-title":"Randomized clinical trial of prophylactic transanal irrigation versus supportive therapy to prevent symptoms of low anterior resection syndrome after rectal resection","volume":"3","author":"Rosen","year":"2019","journal-title":"BJS Open"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1007\/s10151-020-02261-2","article-title":"\u201cProphylactic\u201d transanal irrigation (TAI) to prevent symptoms of low anterior resection syndrome (LARS) after rectal resection: Results at 12-month follow-up of a controlled randomized multicenter trial","volume":"24","author":"Rosen","year":"2020","journal-title":"Tech. Coloproctol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/0140-6736(91)92031-V","article-title":"Development of an electrically stimulated neoanal sphincter","volume":"338","author":"Williams","year":"1991","journal-title":"Lancet"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1097\/SLA.0b013e31824f1c21","article-title":"Low anterior resection syndrome score: Development and validation of a symptom-based scoring system for bowel dysfunction after low anterior resection for rectal cancer","volume":"255","author":"Emmertsen","year":"2012","journal-title":"Ann. Surg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1111\/codi.12952","article-title":"Validation of the English translation of the low anterior resection syndrome score","volume":"17","author":"Juul","year":"2015","journal-title":"Colorectal Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1097\/SLA.0b013e31828fac0b","article-title":"International validation of the low anterior resection syndrome score","volume":"259","author":"Juul","year":"2014","journal-title":"Ann. Surg."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1007\/s10350-004-0942-z","article-title":"The development of a validated instrument to evaluate bowel function after sphincter-preserving surgery for rectal cancer","volume":"48","author":"Temple","year":"2005","journal-title":"Dis. Colon Rectum"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1463-1318.2007.01262.x","article-title":"Set-up and statistical validation of a new scoring system for obstructed defaecation syndrome","volume":"10","author":"Altomare","year":"2008","journal-title":"Colorectal Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","article-title":"The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology","volume":"85","author":"Aaronson","year":"1993","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1007\/BF02055436","article-title":"Clinical value of colonic irrigation in patients with continence disturbances","volume":"40","author":"Briel","year":"1997","journal-title":"Dis. Colon Rectum"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1463-1318.2004.00584.x","article-title":"A retrospective evaluation of rectal irrigation in the treatment of disorders of faecal continence","volume":"6","author":"Crawshaw","year":"2004","journal-title":"Colorectal Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.3748\/wjg.v13.i22.3101","article-title":"Anal plugs and retrograde colonic irrigation are helpful in fecal incontinence or constipation","volume":"13","author":"Cazemier","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/bjs.6232","article-title":"Prospective study of colonic irrigation for the treatment of defaecation disorders","volume":"95","author":"Koch","year":"2008","journal-title":"Br. J. Surg."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s10151-016-1502-y","article-title":"Results of long-term retrograde rectal cleansing in patients with constipation or fecal incontinence","volume":"20","author":"Vollebregt","year":"2016","journal-title":"Tech. Coloproctol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s10151-017-1635-7","article-title":"Prospective evaluation of transanal irrigation for fecal incontinence and constipation","volume":"21","author":"Juul","year":"2017","journal-title":"Tech. Coloproctol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.3748\/wjg.v23.i11.2029","article-title":"Predictive factors for compliance with transanal irrigation for the treatment of defecation disorders","volume":"23","author":"Bildstein","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s00384-012-1468-9","article-title":"A prospective non-randomized two-centre study of patients with passive faecal incontinence after birth trauma and patients with soiling after anal surgery, treated by elastomer implants versus rectal irrigation","volume":"27","author":"Soeters","year":"2012","journal-title":"Int. J. Colorectal Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3826087","DOI":"10.1155\/2017\/3826087","article-title":"Transanal Irrigation for Refractory Chronic Idiopathic Constipation: Patients Perceive a Safe and Effective Therapy","volume":"2017","author":"Etherson","year":"2017","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_61","first-page":"681","article-title":"Royal Society of Medicine, Section of Proctology; Meeting 27 November 1974. President\u2019s Address. Anorectal incontinence","volume":"68","author":"Parks","year":"1975","journal-title":"Proc. R. Soc. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s11934-019-0888-2","article-title":"Patient-Reported Outcome Measures (PROMs) in Pelvic Floor Disorders","volume":"20","author":"Habashy","year":"2019","journal-title":"Curr. Urol. Rep."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1586\/egh.09.31","article-title":"Neurogenic bowel dysfunction: Pathophysiology, clinical manifestations and treatment","volume":"3","author":"Preziosi","year":"2009","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/sc.2014.45","article-title":"Autonomic dysreflexia during bowel evacuation procedures and bladder filling in subjects with spinal cord injury","volume":"52","author":"Faaborg","year":"2014","journal-title":"Spinal Cord"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/sc.2008.159","article-title":"Long-term outcome and safety of transanal colonic irrigation for neurogenic bowel dysfunction","volume":"47","author":"Faaborg","year":"2009","journal-title":"Spinal Cord"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/4\/753\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:23:55Z","timestamp":1760160235000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/4\/753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,13]]},"references-count":65,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["jcm10040753"],"URL":"https:\/\/doi.org\/10.3390\/jcm10040753","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,13]]}}}