{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:18:29Z","timestamp":1778599109685,"version":"3.51.4"},"reference-count":24,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T00:00:00Z","timestamp":1613260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Mechanical circulatory support (MCS) devices are effective tools in managing refractory cardiogenic shock (CS). Data comparing veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and IMPELLA\u00ae are however scarce. We aimed to assess outcomes of patients implanted with these two devices and eligible to both systems. From 2004 to 2020, we retrospectively analyzed 128 patients who underwent VA-ECMO or IMPELLA\u00ae in our institution for refractory left ventricle (LV) dominant CS. All patients were eligible to both systems: 97 patients were first implanted with VA-ECMO and 31 with IMPELLA\u00ae. The primary endpoint was 30-day all-cause death. VA-ECMO patients were younger (52 vs. 59.4, p = 0.006) and had a higher lactate level at baseline than those in the IMPELLA\u00ae group (6.84 vs. 3.03 mmol\/L, p &lt; 0.001). Duration of MCS was similar between groups (9.4 days vs. 6 days in the VA-ECMO and IMPELLA\u00ae groups respectively, p = 0.077). In unadjusted analysis, no significant difference was observed between groups in 30-day mortality: 43.3% vs. 58.1% in the VA-ECMO and IMPELLA\u00ae groups, respectively (p = 0.152). After adjustment, VA-ECMO was associated with a significant reduction in 30-day mortality (HR = 0.25, p = 0.004). A higher rate of MCS escalation was observed in the IMPELLA\u00ae group: 32.3% vs. 10.3% (p = 0.003). In patients eligible to either VA-ECMO or IMPELLA\u00ae for LV dominant refractory CS, VA-ECMO was associated with improved survival rate and a lower need for escalation.<\/jats:p>","DOI":"10.3390\/jcm10040759","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T05:54:49Z","timestamp":1613282089000},"page":"759","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["IMPELLA\u00ae or Extracorporeal Membrane Oxygenation for Left Ventricular Dominant Refractory Cardiogenic Shock"],"prefix":"10.3390","volume":"10","author":[{"given":"Guillaume","family":"Schurtz","sequence":"first","affiliation":[{"name":"Cardiac Intensive Care Unit, Heart and Lung Institute, CHU Lille, 59000 Lille, France"},{"name":"Department of Interventional Cardiology for Coronary, Valves and Structural Heart Diseases, CHU Lille, Institut Coeur Poumon, Cardiology, 59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natacha","family":"Rousse","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Institut C\u0153ur Poumon, CHU Lille, INSERM U1011, Institut Pasteur de Lille, Universit\u00e9 de Lille, 59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3565-3509","authenticated-orcid":false,"given":"Ouriel","family":"Saura","sequence":"additional","affiliation":[{"name":"Cardiac Intensive Care Unit, Heart and Lung Institute, CHU Lille, 59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Balmette","sequence":"additional","affiliation":[{"name":"Cardiac Intensive Care Unit, Heart and Lung Institute, CHU Lille, 59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavien","family":"Vincent","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology for Coronary, Valves and Structural Heart Diseases, CHU Lille, Institut Coeur Poumon, Cardiology, 59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Lamblin","sequence":"additional","affiliation":[{"name":"Cardiac Intensive Care Unit, Heart and Lung Institute, CHU Lille, 59000 Lille, France"},{"name":"Heart and Lung Institute, University Hospital of Lille, Institut Pasteur of Lille, Inserm U1011 and FACT (French Alliance for Cardiovascular Trials), F-75000 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sina","family":"Porouchani","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology for Coronary, Valves and Structural Heart Diseases, CHU Lille, Institut Coeur Poumon, Cardiology, 59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basile","family":"Verdier","sequence":"additional","affiliation":[{"name":"Cardiac Intensive Care Unit, Heart and Lung Institute, CHU Lille, 59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etienne","family":"Puymirat","sequence":"additional","affiliation":[{"name":"Department of Cardiology, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Robin","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Institut C\u0153ur Poumon, CHU Lille, INSERM U1011, Institut Pasteur de Lille, Universit\u00e9 de Lille, 59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Van Belle","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology for Coronary, Valves and Structural Heart Diseases, CHU Lille, Institut Coeur Poumon, Cardiology, 59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Vincentelli","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Institut C\u0153ur Poumon, CHU Lille, INSERM U1011, Institut Pasteur de Lille, Universit\u00e9 de Lille, 59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Aissaoui","sequence":"additional","affiliation":[{"name":"Department of Critical Care Unit, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Europ\u00e9en Georges Pompidou (HEGP), Universit\u00e9 Paris-Descartes, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9dric","family":"Delhaye","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology for Coronary, Valves and Structural Heart Diseases, CHU Lille, Institut Coeur Poumon, Cardiology, 59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9180-9128","authenticated-orcid":false,"given":"Cl\u00e9ment","family":"Delmas","sequence":"additional","affiliation":[{"name":"INSERM UMR-1048, Intensive Cardiac Care Unit, Rangueil University Hospital, 31400 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Cosenza","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology for Coronary, Valves and Structural Heart Diseases, CHU Lille, Institut Coeur Poumon, Cardiology, 59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Bonello","sequence":"additional","affiliation":[{"name":"Cardiology Department, Mediterranean Association for Research and Studies in Cardiology (MARS Cardio), 13015 Marseille, France"},{"name":"Centre for CardioVascular and Nutrition Research (C2VN), Aix-Marseille Univ, INSERM 1263, INRA 1260, Hopital Nord, 13015 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Juthier","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Institut C\u0153ur Poumon, CHU Lille, INSERM U1011, Institut Pasteur de Lille, Universit\u00e9 de Lille, 59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mouhamed Djahoum","family":"Moussa","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Institut C\u0153ur Poumon, CHU Lille, INSERM U1011, Institut Pasteur de Lille, Universit\u00e9 de Lille, 59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Lemesle","sequence":"additional","affiliation":[{"name":"Cardiac Intensive Care Unit, Heart and Lung Institute, CHU Lille, 59000 Lille, France"},{"name":"Heart and Lung Institute, University Hospital of Lille, Institut Pasteur of Lille, Inserm U1011 and FACT (French Alliance for Cardiovascular Trials), F-75000 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/ejhf.1750","article-title":"Trends in cardiogenic shock complicating acute myocardial infarction","volume":"22","author":"Aissaoui","year":"2020","journal-title":"Eur. 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Dis."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/4\/759\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:23:57Z","timestamp":1760160237000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/4\/759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,14]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["jcm10040759"],"URL":"https:\/\/doi.org\/10.3390\/jcm10040759","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,14]]}}}