{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:16Z","timestamp":1787028616971,"version":"build-2736575974"},"reference-count":33,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: To prove the benefits of pelvic floor muscle training with biofeedback (BFB) as a complementary treatment in women with bladder pain syndrome\/interstitial cystitis (BPS\/IC). Methods: Prospective, randomized study in 123 women with BPS\/IC. Groups: BFB+ (n = 48): women with oral drug treatment (perphenazine and amitriptyline) plus intravesical instillations (sodium hyaluronate) plus pelvic floor muscle training with BFB; BFB\u2212: (n = 75): women with oral drug treatment plus intravesical instillations. Variables: age, body mass index (BMI), time of follow-up, length of disease, time free of disease, diseases and health conditions concomitant, and responses to the SF-36 health-related quality of life questionnaire at the first consultation (SF-36 pre-treatment), and at the end of the study (SF-36 post-treatment). The treatment was considered successful when the SF-36 score reached values equal to or greater than 80 points or when the initial value increased by 30 or more points. Results: Mean age was 51.62 years old (23\u201382). BMI was higher in BFB\u2212. The mean length of BPS\/IC condition was 4.92 years (1\u201320), shorter in BFB+ than in BFB\u2212. Mean SF-36 score pre-treatment was 45.92 points (40\u201358), lower in BFB+ than in BFB\u2212. Post-treatment SF-36 score was higher than pre-treatment SF-36 score both in BFB+ and BFB\u2212. SF-36 values were higher in BFB+ compared to BFB\u2212 over the follow-up. Conclusions: BFB improves quality of life in women with BPS\/IC as adjunct therapy to combined oral and intravesical treatment.<\/jats:p>","DOI":"10.3390\/jcm10040862","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T20:54:08Z","timestamp":1613768048000},"page":"862","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Improvement in Quality of Life with Pelvic Floor Muscle Training and Biofeedback in Patients with Painful Bladder Syndrome\/Interstitial Cystitis"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8492-4451","authenticated-orcid":false,"given":"Pedro-Santiago","family":"Borrego-Jimenez","sequence":"first","affiliation":[{"name":"Physiotherapy Department of Institute of Applied Technology, Abu Dhabi 3798, United Arab Emirates"},{"name":"Department of Health Sciences and Education, University UDIMA, 28400 Madrid, Spain"},{"name":"Department of Surgery, University of Salamanca, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1338-0551","authenticated-orcid":false,"given":"Javier","family":"Flores-Fraile","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Salamanca, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8566-6033","authenticated-orcid":false,"given":"B\u00e1rbara-Yolanda","family":"Padilla-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Cirug\u00eda, Universidad de La Laguna, 38200 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2797-3262","authenticated-orcid":false,"given":"Sebasti\u00e1n","family":"Valverde-Martinez","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Salamanca, 37007 Salamanca, Spain"},{"name":"Renal Urological Multidisciplinary Research Group (GRUMUR), Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"},{"name":"Department of Urology, University Hospital of \u00c1vila, 05004 \u00c1vila, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn","family":"G\u00f3mez-Prieto","sequence":"additional","affiliation":[{"name":"Department of Emergency, University Hospital of Salamanca, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1046-0118","authenticated-orcid":false,"given":"Magaly Teresa","family":"M\u00e1rquez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Renal Urological Multidisciplinary Research Group (GRUMUR), Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7483-2761","authenticated-orcid":false,"given":"Jos\u00e9-Antonio","family":"Mir\u00f3n-Canelo","sequence":"additional","affiliation":[{"name":"Renal Urological Multidisciplinary Research Group (GRUMUR), Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"},{"name":"Department of Biomedical and Diagnostic Sciences, University of Salamanca, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1208-3408","authenticated-orcid":false,"given":"Mar\u00eda-Fernanda","family":"Lorenzo-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Salamanca, 37007 Salamanca, Spain"},{"name":"Renal Urological Multidisciplinary Research Group (GRUMUR), Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"},{"name":"Department of Urology, University Hospital of Salamanca, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,19]]},"reference":[{"key":"ref_1","first-page":"25","article-title":"Physiopathologic relationship between interstitial cystitis and rheumatic, autoimmune, and chronic inflammatory diseases","volume":"57","year":"2004","journal-title":"Arch. 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