{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:49:32Z","timestamp":1791535772501,"version":"4.3.4"},"reference-count":35,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012952","name":"Universit\u00e9 Grenoble Alpes","doi-asserted-by":"publisher","award":["ANR-19-P3IA-0003"],"award-info":[{"award-number":["ANR-19-P3IA-0003"]}],"id":[{"id":"10.13039\/100012952","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ResMed","award":["unrestricted grant"],"award-info":[{"award-number":["unrestricted grant"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The nationwide claims data lake for sleep apnoea (ALASKA)\u2014real-life data for understanding and increasing obstructive sleep apnea (OSA) quality of care study\u2014investigated long-term continuous positive airway pressure (CPAP) termination rates, focusing on the contribution of comorbidities. The French national health insurance reimbursement system data for new CPAP users aged \u226518 years were analyzed. Innovative algorithms were used to determine the presence of specific comorbidities (hypertension, diabetes and chronic obstructive pulmonary disease (COPD)). Therapy termination was defined as cessation of CPAP reimbursements. A total of 480,000 patients were included (mean age 59.3 \u00b1 13.6 years, 65.4% male). An amount of 50.7, 24.4 and 4.3% of patients, respectively, had hypertension, diabetes and COPD. Overall CPAP termination rates after 1, 2 and 3 years were 23.1, 37.1 and 47.7%, respectively. On multivariable analysis, age categories, female sex (1.09 (1.08\u20131.10) and COPD (1.12 (1.10\u20131.13)) and diabetes (1.18 (1.16\u20131.19)) were significantly associated with higher CPAP termination risk; patients with hypertension were more likely to continue using CPAP (hazard ratio 0.96 (95% confidence interval 0.95\u20130.97)). Therapy termination rates were highest in younger or older patients with \u22651 comorbidity. Comorbidities have an important influence on long-term CPAP continuation in patients with OSA.<\/jats:p>","DOI":"10.3390\/jcm10050936","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T01:26:33Z","timestamp":1614561993000},"page":"936","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":168,"title":["CPAP Therapy Termination Rates by OSA Phenotype: A French Nationwide Database Analysis"],"prefix":"10.3390","volume":"10","author":[{"given":"Jean-Louis","family":"P\u00e9pin","sequence":"first","affiliation":[{"name":"HP2 Laboratory, University Grenoble Alpes, Inserm, CHU Grenoble Alpes, 38043 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2179-4650","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Bailly","sequence":"additional","affiliation":[{"name":"HP2 Laboratory, University Grenoble Alpes, Inserm, CHU Grenoble Alpes, 38043 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Rinder","sequence":"additional","affiliation":[{"name":"SEMEIA, 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9915-862X","authenticated-orcid":false,"given":"Dan","family":"Adler","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Szeftel","sequence":"additional","affiliation":[{"name":"SEMEIA, 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7920-4924","authenticated-orcid":false,"given":"Peter","family":"Cistulli","sequence":"additional","affiliation":[{"name":"Charles Perkins Centre, Faculty of Medicine and Health, University Sydney, Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Benjafield","sequence":"additional","affiliation":[{"name":"ResMed Science Center, Sydney, NSW 2153, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8624-5900","authenticated-orcid":false,"given":"Florent","family":"Lavergne","sequence":"additional","affiliation":[{"name":"ResMed Science Center, 69791 Saint Priest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Josseran","sequence":"additional","affiliation":[{"name":"ResMed Science Center, 69791 Saint Priest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Tamisier","sequence":"additional","affiliation":[{"name":"HP2 Laboratory, University Grenoble Alpes, Inserm, CHU Grenoble Alpes, 38043 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Hornus","sequence":"additional","affiliation":[{"name":"SEMEIA, 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the medXcloud Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S2213-2600(19)30198-5","article-title":"Estimation of the global prevalence and burden of obstructive sleep apnoea: A literature-based analysis","volume":"7","author":"Benjafield","year":"2019","journal-title":"Lancet Respir. 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