{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:25:40Z","timestamp":1791390340637,"version":"4.3.3"},"reference-count":27,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016275","name":"Seoul National University Bundang Hospital","doi-asserted-by":"publisher","award":["02-2019-026"],"award-info":[{"award-number":["02-2019-026"]}],"id":[{"id":"10.13039\/100016275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The risk of neuromuscular blockade is certainly minimized by sugammadex in combination with monitoring. However, the effect of sugammadex-aided recovery on patients\u2019 satisfaction is unclear. This study compared the Quality of Recovery (QoR)-15 score, which is a patient-reported outcome, in patients undergoing laparoscopic cholecystectomy. Eighty patients were randomly assigned to the neostigmine or sugammadex groups. At the end of surgery, neostigmine or sugammadex was administered, and tracheal extubation was performed after confirmation of a train of four ratio \u2265 0.9. The QoR-15 questionnaire was administered at 1 day before surgery and on post-operative days (POD) 1 and 2. The primary outcome was the QoR-15 score on POD 1. The secondary outcomes were the QoR-15 score on POD 2, modified Aldrete score, length of post-anesthetic care unit stay, post-operative pain, administration of anti-emetics, urinary retention, and length of hospital stay. No significant differences were found in QoR-15 scores on POD 1 (94.4 vs. 95.5, p = 0.87) or 2 (116.3 vs. 122, p = 0.33). Secondary outcomes were also comparable, with the exception of urinary retention (15.8% neostigmine vs. 2.6% sugammadex, p = 0.04). This study demonstrated that the quality of recovery was comparable between the neostigmine and sugammadex groups when reversal and tracheal extubation were performed in accordance with the current guidelines.<\/jats:p>","DOI":"10.3390\/jcm10050938","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T03:35:40Z","timestamp":1614569740000},"page":"938","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Quality of Recovery after Laparoscopic Cholecystectomy Following Neuromuscular Blockade Reversal with Neostigmine or Sugammadex: A Prospective, Randomized, Controlled Trial"],"prefix":"10.3390","volume":"10","author":[{"given":"Jiwon","family":"Han","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Gumi-ro, Bundang-gu, Seongnam-si 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3659-6171","authenticated-orcid":false,"given":"Ah-Young","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Gumi-ro, Bundang-gu, Seongnam-si 13620, Korea"},{"name":"Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Daehak-ro, Jongno-gu, Seoul 03080, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Tae","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Gumi-ro, Bundang-gu, Seongnam-si 13620, Korea"},{"name":"Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Daehak-ro, Jongno-gu, Seoul 03080, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bon-Wook","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Gumi-ro, Bundang-gu, Seongnam-si 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Gumi-ro, Bundang-gu, Seongnam-si 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Gumi-ro, Bundang-gu, Seongnam-si 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Insung","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Gumi-ro, Bundang-gu, Seongnam-si 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/oxfordjournals.bja.a013366","article-title":"Validity and reliability of a postoperative quality of recovery score: The QoR-40","volume":"84","author":"Myles","year":"2000","journal-title":"Br. J. Anaesth."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/bja\/aet014","article-title":"Measurement of quality of recovery using the QoR-40: A quantitative systematic review","volume":"111","author":"Gornall","year":"2013","journal-title":"Br. J. Anaesth."},{"key":"ref_3","first-page":"92","article-title":"Pain Management after Laparoscopic Cholecystectomy-A Randomized Prospective Trial of Low Pressure and Standard Pressure Pneumoperitoneum","volume":"8","author":"Mittal","year":"2014","journal-title":"J. Clin. Diagn.Res."},{"key":"ref_4","first-page":"455","article-title":"Randomized trial of different insufflation pressures for laparoscopic cholecystectomy","volume":"84","author":"Wallace","year":"1997","journal-title":"Br. J. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.curtheres.2011.02.002","article-title":"Preventing Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy: A Prospective, Randomized, Double-Blind Study","volume":"72","author":"Arslan","year":"2011","journal-title":"Curr Ther Res. Clin. Exp."},{"key":"ref_6","first-page":"CD012763","article-title":"Efficacy and safety of Sugammadex versus Neostigmine in reversing neuromuscular blockade in adults","volume":"8","author":"Hristovska","year":"2017","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S2213-2600(18)30294-7","article-title":"Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): A multicentre, prospective observational study","volume":"7","author":"Kirmeier","year":"2019","journal-title":"Lancet Respir. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1097\/ALN.0000000000003256","article-title":"Sugammadex versus Neostigmine for Reversal of Neuromuscular Blockade and Postoperative Pulmonary Complications (STRONGER)","volume":"132","author":"Kheterpal","year":"2020","journal-title":"Anesthesiology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.bja.2018.11.028","article-title":"Retrospective analysis of 30-day unplanned readmission after major abdominal surgery with reversal by sugammadex or neostigmine","volume":"122","author":"Oh","year":"2019","journal-title":"Br. J. Anaesth."},{"key":"ref_10","unstructured":"Glopper, M.A., Cohen, N.H., Eriksson, L.I., Fleisher, L.A., Leslie, K., and Wiener-Kronish, J.P. (2015). Miller\u2019s Anesthesia, Elsevier. [9th ed.]."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"467","DOI":"10.4097\/kja.d.18.27188","article-title":"Validity and reliability of the Korean version of the Quality of Recovery-40 questionnaire","volume":"71","author":"Lee","year":"2018","journal-title":"Korean J. Anesthesiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.bja.2020.06.040","article-title":"Validation and clinical utility of the Korean version of the Quality of Recovery-15 with enhanced recovery after surgery: A prospective observational cohort study","volume":"125","author":"Yoon","year":"2020","journal-title":"Br. J. Anaesth."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/ALN.0000000000001158","article-title":"Minimal Clinically Important Difference for Three Quality of Recovery Scales","volume":"125","author":"Myles","year":"2016","journal-title":"Anesthesiology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1213\/01.ane.0000265534.73169.95","article-title":"A Systematic Review of Postoperative Recovery Outcomes Measurements After Ambulatory Surgery","volume":"105","author":"Herrera","year":"2007","journal-title":"Anesth. Analg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1097\/ALN.0b013e318289b84b","article-title":"Development and psychometric evaluation of a postoperative quality of recovery score: The QoR-15","volume":"118","author":"Stark","year":"2013","journal-title":"Anesthesiology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bja.2017.11.013","article-title":"Systematic review of the QoR-15 score, a patient- reported outcome measure measuring quality of recovery after surgery and anaesthesia","volume":"120","author":"Kleif","year":"2018","journal-title":"Brit. J. Anaesth."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jclinane.2019.02.014","article-title":"Influence of reversal of neuromuscular blockade with sugammadex or neostigmine on postoperative quality of recovery following a single bolus dose of rocuronium: A prospective, randomized, double-blinded, controlled study","volume":"57","author":"Kim","year":"2019","journal-title":"J. Clin. Anesthesia"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1111\/aas.12389","article-title":"Neostigmine vs. sugammadex: Observational cohort study comparing the quality of recovery using the Postoperative Quality Recovery Scale","volume":"58","author":"Amorim","year":"2014","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1213\/ane.0b013e31816d1268","article-title":"Residual neuromuscular blockade and critical respiratory events in the postanesthesia care unit","volume":"107","author":"Murphy","year":"2008","journal-title":"Anesthesia Analg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1097\/EJA.0b013e328345cd11","article-title":"The influence of residual neuromuscular block on the incidence of critical respiratory events. A randomised, prospective, placebo-controlled trial","volume":"28","author":"Sauer","year":"2011","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/EJA.0000000000001157","article-title":"Postoperative residual neuromuscular blockade after reversal based on a qualitative peripheral nerve stimulator response","volume":"37","author":"Lee","year":"2020","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/EJA.0000000000000140","article-title":"Electromyographic activity of the diaphragm during neostigmine or sugammadex-enhanced recovery after neuromuscular blockade with rocuronium: A randomised controlled study in healthy volunteers","volume":"32","author":"Schepens","year":"2015","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/EJA.0000000000000543","article-title":"Diaphragmatic and intercostal electromyographic activity during neostigmine, sugammadex and neostigmine-sugammadex-enhanced recovery after neuromuscular blockade: A randomised controlled volunteer study","volume":"34","author":"Cammu","year":"2017","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/bja\/aer094","article-title":"Effect of patient sex on general anaesthesia and recovery","volume":"106","author":"Buchanan","year":"2011","journal-title":"Br. J. Anaesth."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.1007\/s00268-018-4697-4","article-title":"Prospective Risk Factor Analysis for the Development of Post-operative Urinary Retention Following Ambulatory General Surgery","volume":"42","author":"Scott","year":"2018","journal-title":"World J. Surg."},{"key":"ref_26","first-page":"643","article-title":"Urinary retention in adults: Diagnosis and initial management","volume":"77","author":"Selius","year":"2008","journal-title":"Am. Fam Physician"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"40","DOI":"10.17085\/apm.2018.13.1.40","article-title":"Sugammadex use can decrease the incidence of post-operative urinary retention by avoiding anticholinergics: A retrospective study","volume":"13","author":"Cha","year":"2018","journal-title":"Anesth. Pain Med."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/5\/938\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:30:44Z","timestamp":1760160644000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/5\/938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,1]]},"references-count":27,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["jcm10050938"],"URL":"https:\/\/doi.org\/10.3390\/jcm10050938","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,1]]}}}