{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:23:40Z","timestamp":1761719020319,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/011704"],"award-info":[{"award-number":["PI17\/011704"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI17\/011704"],"award-info":[{"award-number":["PI17\/011704"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The objective of this study is to describe the profile of primary preventive treatment for cardiovascular disease in adult males and to analyze the association between treatment profile and subclinical atherosclerosis. We selected male workers who had undergone ultrasound imaging and had no previous history of cardiovascular disease (n = 2138). Data on the consumption of primary cardiovascular drugs from the previous year were obtained. We performed bivariate analyses to compare patient characteristics according to cardiovascular treatment and the presence of subclinical atherosclerosis, and logistic regression models to explore the association between these two variables. Among participants with no personal history of cardiovascular disease, subclinical atherosclerosis was present in 77.7% and 31.2% had received some form of preventive treatment. Of those who received no preventive treatment, 73.6% had subclinical atherosclerosis. Cardiovascular preventive treatment was associated only with CACS &gt; 0 (odds ratio (OR), 1.37; 95% confidence interval (95% CI), 1.06\u20131.78). Statin treatment was associated with a greater risk of any type of subclinical atherosclerosis (OR, 1.73) and with CACS &gt; 0 (OR, 1.72). Subclinical atherosclerosis existed in almost 75% of men who had no personal history of cardiovascular disease and had not received preventive treatment for cardiovascular disease.<\/jats:p>","DOI":"10.3390\/jcm10050945","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T10:25:18Z","timestamp":1614594318000},"page":"945","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacological Primary Cardiovascular Prevention and Subclinical Atherosclerosis in Men: Evidence from the Aragon Workers\u2019 Health Study"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7293-701X","authenticated-orcid":false,"given":"Isabel","family":"Aguilar-Palacio","sequence":"first","affiliation":[{"name":"Preventive Medicine and Public Health Department, University of Zaragoza, 50009 Zaragoza, Spain"},{"name":"Instituto Aragon\u00e9s de Ciencias de Salud, IIS Arag\u00f3n, 50009 Zaragoza, Spain"},{"name":"Grupo de Investigaci\u00f3n en Servicios Sanitarios de Arag\u00f3n (GRISSA) IIS Arag\u00f3n, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7194-8275","authenticated-orcid":false,"given":"Sara","family":"Malo","sequence":"additional","affiliation":[{"name":"Preventive Medicine and Public Health Department, University of Zaragoza, 50009 Zaragoza, Spain"},{"name":"Instituto Aragon\u00e9s de Ciencias de Salud, IIS Arag\u00f3n, 50009 Zaragoza, Spain"},{"name":"Grupo de Investigaci\u00f3n en Servicios Sanitarios de Arag\u00f3n (GRISSA) IIS Arag\u00f3n, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estibaliz","family":"Jarauta","sequence":"additional","affiliation":[{"name":"Instituto Aragon\u00e9s de Ciencias de Salud, IIS Arag\u00f3n, 50009 Zaragoza, Spain"},{"name":"Hospital Universitario Miguel Servet, IIS Arag\u00f3n, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0604-5042","authenticated-orcid":false,"given":"Bel\u00e9n","family":"Moreno-Franco","sequence":"additional","affiliation":[{"name":"Preventive Medicine and Public Health Department, University of Zaragoza, 50009 Zaragoza, Spain"},{"name":"Instituto Aragon\u00e9s de Ciencias de Salud, IIS Arag\u00f3n, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1647-3462","authenticated-orcid":false,"given":"Lina","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Department of Economic Structure, Economic History and Public Economics, University of Zaragoza, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Comp\u00e9s","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Servicios Sanitarios de Arag\u00f3n (GRISSA) IIS Arag\u00f3n, 50009 Zaragoza, Spain"},{"name":"Direcci\u00f3n General de Salud P\u00fablica, Gobierno de Arag\u00f3n, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6671-5661","authenticated-orcid":false,"given":"M\u00aa Jos\u00e9","family":"Rabanaque","sequence":"additional","affiliation":[{"name":"Preventive Medicine and Public Health Department, University of Zaragoza, 50009 Zaragoza, Spain"},{"name":"Instituto Aragon\u00e9s de Ciencias de Salud, IIS Arag\u00f3n, 50009 Zaragoza, Spain"},{"name":"Grupo de Investigaci\u00f3n en Servicios Sanitarios de Arag\u00f3n (GRISSA) IIS Arag\u00f3n, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9887-2629","authenticated-orcid":false,"given":"Jos\u00e9 Antonio","family":"Casasnovas","sequence":"additional","affiliation":[{"name":"Instituto Aragon\u00e9s de Ciencias de Salud, IIS Arag\u00f3n, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Moreno-Lostao, A., Guerras, J.M., Lostao, L., de la Fuente, L., Martinez, D., Rodriguez-Artalejo, F., and Regidor, E. 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