{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:24:26Z","timestamp":1761578666092,"version":"build-2065373602"},"reference-count":113,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Coronary artery disease (CAD) is highly prevalent in patients with severe aortic stenosis (AS). The management of CAD is a central aspect of the work-up of patients undergoing transcatheter aortic valve implantation (TAVI), but few data are available on this field and the best percutaneous coronary intervention (PCI) practice is yet to be determined. A major challenge is the ability to elucidate the severity of bystander coronary stenosis independently of the severity of aortic valve stenosis and subsequent impact on blood flow. The prognostic role of CAD in patients undergoing TAVI is being still debated and the benefits and the best timing of PCI in this context are currently under evaluation. Additionally, PCI in the setting of advanced AS poses some technical challenges, due to the complex anatomy, risk of hemodynamic instability, and the increased risk of bleeding complications. This review aims to provide a comprehensive synthesis of the available literature on myocardial revascularization in patients with severe AS undergoing TAVI. This work can assist the Heart Team in individualizing decisions about myocardial revascularization, taking into account available diagnostic tools as well as the risks and benefits.<\/jats:p>","DOI":"10.3390\/jcm10050946","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T10:25:18Z","timestamp":1614594318000},"page":"946","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Aortic Valve Disease and Associated Complex CAD: The Interventional Approach"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8776-6647","authenticated-orcid":false,"given":"Federico","family":"Marin","sequence":"first","affiliation":[{"name":"Oxford Heart Centre, Oxford University Hospitals, NHS Trust, Oxford OX3 9DU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Scarsini","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Verona, 37129 Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8132-6130","authenticated-orcid":false,"given":"Rafail","family":"Kotronias","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre, Oxford University Hospitals, NHS Trust, Oxford OX3 9DU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Terentes-Printzios","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre, Oxford University Hospitals, NHS Trust, Oxford OX3 9DU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3837-8140","authenticated-orcid":false,"given":"Matthew","family":"Burrage","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre, Oxford University Hospitals, NHS Trust, Oxford OX3 9DU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Bray","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences 2, Swansea Bay University Health Board and Swansea University Medical School, SA2 8QA Swansea, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4476-6051","authenticated-orcid":false,"given":"Jonathan","family":"Ciofani","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal North Shore Hospital, 2065 Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Venturi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Verona, 37129 Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Pighi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Verona, 37129 Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"De Maria","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre, Oxford University Hospitals, NHS Trust, Oxford OX3 9DU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2842-7861","authenticated-orcid":false,"given":"Adrian","family":"Banning","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre, Oxford University Hospitals, NHS Trust, Oxford OX3 9DU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1056\/NEJMoa1514616","article-title":"Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients","volume":"374","author":"Leon","year":"2016","journal-title":"N. 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