{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T19:47:54Z","timestamp":1767901674161,"version":"3.49.0"},"reference-count":20,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Serious complications in both mother and newborn arising as a result of fetal macrosomia indicate the need for early diagnosis and prevention. Unfortunately, current predictors, such as fetal biometry, fundal height, and amniotic fluid index, appear to be insufficient. Therefore, we decided to assess the predictive potential of interventricular septal thickness (IVST), as measured at \u226533 weeks of gestation. Two hundred and ninety-nine patients met the inclusion criteria: complete medical history including all necessary measurements\u2014namely, IVST obtained by M-mode echocardiography, fetal biometry, and birth weight. The Statistica 13.1 PL software was used to generate the receiver operating curve. The optimal cut-off point (IVST of 4.7 mm) was selected using the Youden index method. The analysis of fetal biometry abnormalities resulted in 46.6% of macrosomia cases being correctly predicted; however, IVST analysis detected 71.4% of cases. IVST at \u22654.7 mm appears to have a higher sensitivity and negative predictive value (NPV) than routine ultrasound.<\/jats:p>","DOI":"10.3390\/jcm10050949","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T10:25:18Z","timestamp":1614594318000},"page":"949","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Interventricular Septal Thickness as a Diagnostic Marker of Fetal Macrosomia"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4051-0887","authenticated-orcid":false,"given":"Bartosz","family":"Szmyd","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Oncology, and Hematology, Medical University of Lodz, 91-738 \u0141\u00f3d\u017a, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Biedrzycka","sequence":"additional","affiliation":[{"name":"Student\u2019s Scientific Association Prenatal Cardiology, Medical University of Lodz, 93-338 \u0141\u00f3d\u017a, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6551-6804","authenticated-orcid":false,"given":"Filip Franciszek","family":"Karuga","sequence":"additional","affiliation":[{"name":"Student\u2019s Scientific Association Prenatal Cardiology, Medical University of Lodz, 93-338 \u0141\u00f3d\u017a, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Rogut","sequence":"additional","affiliation":[{"name":"Student\u2019s Scientific Association Prenatal Cardiology, Medical University of Lodz, 93-338 \u0141\u00f3d\u017a, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwona","family":"Strzelecka","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Prevention Fetal Malformations, Medical University of Lodz, 93-338 \u0141\u00f3d\u017a, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Respondek-Liberska","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Prevention Fetal Malformations, Medical University of Lodz, 93-338 \u0141\u00f3d\u017a, Poland"},{"name":"Department of Prenatal Cardiology, Polish Mother\u2019s Memorial Hospital, 93-338 \u0141\u00f3d\u017a, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"(2020). ACOG Macrosomia. Obstet. Gynecol., 135, e18\u2013e35.","DOI":"10.1097\/AOG.0000000000003606"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Capobianco, G., Gulotta, A., Tupponi, G., Dessole, F., Pola, M., Virdis, G., Petrillo, M., Mais, V., Olzai, G., and Antonucci, R. (2020). Materno-Fetal and Neonatal Complications of Diabetes in Pregnancy: A Retrospective Study. J. Clin. Med., 9.","DOI":"10.3390\/jcm9092707"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Gujski, M., Szukiewicz, D., Cho\u0142uj, M., Sawicki, W., and Bojar, I. (2020). Fetal and Placental Weight in Pre-Gestational Maternal Obesity (PGMO) vs. Excessive Gestational Weight Gain (EGWG)\u2014A Preliminary Approach to the Perinatal Outcomes in Diet-Controlled Gestational Diabetes Mellitus. J. Clin. Med., 9.","DOI":"10.3390\/jcm9113530"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.anai.2013.12.007","article-title":"Temporal trends and racial\/ethnic disparity in self-reported pediatric food allergy in the United States","volume":"112","author":"Keet","year":"2014","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1007\/s00125-013-2881-5","article-title":"Gestational diabetes, pre-pregnancy obesity and pregnancy weight gain in relation to excess fetal growth: Variations by race\/ethnicity","volume":"56","author":"Bowers","year":"2013","journal-title":"Diabetologia"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1515\/pcard-2017-0011","article-title":"Fetal macrosomia, polyhydramnios and cardiac anomalies may be helpful to predict poor outcome in neonate\u2013Case report of a possible fetal RASopathy with sonographic and neonatal findings and genetic evaluation","volume":"7","author":"Oszukowski","year":"2017","journal-title":"Prenat. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s13224-014-0586-4","article-title":"Risk Factors for Macrosomia","volume":"65","author":"Nkwabong","year":"2015","journal-title":"J. Obstet. Gynecol. India"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.7863\/jum.2008.27.1.39","article-title":"Predicting Macrosomia","volume":"27","author":"Pates","year":"2008","journal-title":"J. Ultrasound Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/uog.6378","article-title":"Comparison of fundal height measurement and sonographically measured fetal abdominal circumference in the prediction of high and low birth weight at term","volume":"34","author":"Kayem","year":"2009","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_10","first-page":"37","article-title":"Prognostic values of biophysical methods in the intrauetrine monitoring of fetal well-being in pregnant women with insulin-dependent diabetes","volume":"1","author":"Krekora","year":"1996","journal-title":"Arch. Perinat. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3126\/njr.v2i2.7683","article-title":"Fetal Cardiac Interventricular Septal Thickness at 28\u201337 Weeks of Gestation in Nepalese Population","volume":"2","author":"Kafle","year":"2013","journal-title":"Nepal. J. Radiol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Gabryelska, A., Szmyd, B., Panek, M., Szemraj, J., Kuna, P., and Bia\u0142asiewicz, P. (2020). Serum hypoxia\u2013inducible factor\u20131\u03b1 protein level as a diagnostic marker of obstructive sleep apnea. Polish Arch. Intern. Med., 130.","DOI":"10.20452\/pamw.15104"},{"key":"ref_13","first-page":"1","article-title":"Births: Final Data for 2018","volume":"68","author":"Martin","year":"2019","journal-title":"Natl. Vital. Stat. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1177\/1933719114561557","article-title":"Serum MicroRNAs as Diagnostic Biomarkers for Macrosomia","volume":"22","author":"Jiang","year":"2015","journal-title":"Reprod. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3389\/fendo.2018.00407","article-title":"Biomarkers for macrosomia prediction in pregnancies affected by diabetes","volume":"9","author":"Nahavandi","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Sibiak, R., Jankowski, M., Gutaj, P., Mozdziak, P., Kempisty, B., and Wender-O\u017cegowska, E. (2020). Placental Lactogen as a Marker of Maternal Obesity, Diabetes, and Fetal Growth Abnormalities: Current Knowledge and Clinical Perspectives. J. Clin. Med., 9.","DOI":"10.3390\/jcm9041142"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Ye, S., Zhang, H., Shi, F., Guo, J., Wang, S., and Zhang, B. (2020). Ensemble Learning to Improve the Prediction of Fetal Macrosomia and Large-for-Gestational Age. J. Clin. Med., 9.","DOI":"10.3390\/jcm9020380"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/1471-0528.13517","article-title":"Antenatal magnetic resonance imaging versus ultrasound for predicting neonatal macrosomia: A systematic review and meta-analysis","volume":"123","author":"Malin","year":"2016","journal-title":"BJOG An Int. J. Obstet. Gynaecol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Karuga, F.F., Szmyd, B., and Respondek-Liberska, M. (2020). Fetal congenital heart disease and fetal position-are they related?. Prenat. Cardiol.","DOI":"10.5114\/pcard.2019.92544"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Szmyd, B., Karuga, F., Gach, A., Moszura, T., Kopala, M., and Respondek-Liberska, M. (2021). Complex cardiovascular defects in a male infant with Williams syndrome juxtaposed with results of a preliminary survey illustrating other patients\u2019 ouctomes. Kardiol. Pol.","DOI":"10.33963\/KP.15740"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/5\/949\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:30:52Z","timestamp":1760160652000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/5\/949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,1]]},"references-count":20,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["jcm10050949"],"URL":"https:\/\/doi.org\/10.3390\/jcm10050949","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,1]]}}}