{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:26:45Z","timestamp":1784032005952,"version":"3.55.0"},"reference-count":30,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: There has been various reports on the potential impact of anesthetic agents used during oocyte retrieval (OR) on the impairment of the capacity of the oocyte for fertilization and subsequent embryo quality; results have been conflicting; (2) Methods: The effects of two different sedation protocols during OR in two groups of patients undergoing In Vitro Fertilization\/Intra-Cytoplasmic Sperm Injection IVF\/ICSI, were compared on propofol consumption and on in vitro fertilization (IVF)\/ICSI success. The study group received dexmedetomidine and fentanyl, while the control remifentanil and midazolam. In a prospective cohort study, we encompassed 72 cycles\/patients. The administered dose of propofol per patient and fertilization rates were the primary outcomes, while anesthesiological parameters and IVF\/ICSI outcomes were the secondary endpoints; (3) Results: We found a significant increase in propofol consumption in the study compared to the control group (77.0 \u00b1 10.6 mg vs. 12.1 \u00b1 6.1; p &lt; 0.001), but fertilization rates were similar (p = 0.469). From the secondary anesthesiological outcomes, the post anesthesia discharge scores were better in the control group (15.0 (13.5 min) vs. 5.0 (10.0 min), p = 0.028). From the IVF\/ICSI secondary outcome parameters, we found a higher quality of embryos on day three in the study compared to the control group (p = 0.040). The comparison of the other secondary outcomes yielded non-significant differences; (4) Conclusions: The use of dexmedetomidine, as an alternative agent during OR, was associated with higher propofol consumption as a rescue dose compared to remifentanil but was linked with similar fertilization rates and higher quality of embryos produced.<\/jats:p>","DOI":"10.3390\/jcm10050963","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T22:02:20Z","timestamp":1614636140000},"page":"963","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of Two Different Sedation Protocols during Transvaginal Oocyte Retrieval: Effects on Propofol Consumption and IVF Outcome: A Prospective Cohort Study"],"prefix":"10.3390","volume":"10","author":[{"given":"Paraskevi","family":"Matsota","sequence":"first","affiliation":[{"name":"Second Department of Anesthesiology, \u201cAttikon Hospital\u201d, Medical School, National and Kapodistrian University of Athens, Rimini 1, Chaidari, 12642 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2937-639X","authenticated-orcid":false,"given":"Tatiana","family":"Sidiropoulou","sequence":"additional","affiliation":[{"name":"Second Department of Anesthesiology, \u201cAttikon Hospital\u201d, Medical School, National and Kapodistrian University of Athens, Rimini 1, Chaidari, 12642 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tereza","family":"Vrantza","sequence":"additional","affiliation":[{"name":"Assisted Reproduction Unit, Third Department of Obstetrics and Gynecology, \u201cAttikon Hospital\u201d, Medical School, National and Kapodistrian University of Athens, Rimini 1, Chaidari, 12642 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Boutsikou","sequence":"additional","affiliation":[{"name":"Cardiology Department, Mediterraneo Hospital, 16675 Athens, Greece"},{"name":"Adult Congenital Heart Disease Unit\/MRI Unit, Royal Brompton Hospital, London SW3 6NP, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Midvighi","sequence":"additional","affiliation":[{"name":"Second Department of Anesthesiology, \u201cAttikon Hospital\u201d, Medical School, National and Kapodistrian University of Athens, Rimini 1, Chaidari, 12642 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0850-6623","authenticated-orcid":false,"given":"Charalampos","family":"Siristatidis","sequence":"additional","affiliation":[{"name":"Assisted Reproduction Unit, Third Department of Obstetrics and Gynecology, \u201cAttikon Hospital\u201d, Medical School, National and Kapodistrian University of Athens, Rimini 1, Chaidari, 12642 Athens, Greece"},{"name":"Assisted Reproduction Unit, Second Department of Obstetrics and Gynecology, \u201cAretaieion Hospital\u201d, Medical School, National and Kapodistrian University of Athens, Vas. Sofias 76, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1046\/j.1365-2346.1999.00461.x","article-title":"Anaesthesia for assisted conception: A survey of UK practice","volume":"16","author":"Bokhari","year":"1999","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0952-8180(01)00331-2","article-title":"General anesthesia versus monitored anesthesia care with remifentanil for assisted reproductive technologies: Effect on pregnancy rate","volume":"14","author":"Wilhelm","year":"2002","journal-title":"J. Clin. Anesth."},{"key":"ref_3","first-page":"CD004829","article-title":"Pain relief for women undergoing oocyte retrieval for assisted reproduction","volume":"2018","author":"Kwan","year":"2018","journal-title":"Cochrane Database Syst. 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