{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T19:04:15Z","timestamp":1779217455608,"version":"3.51.4"},"reference-count":36,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Health and Welfare","award":["MOHW105-TDU-B-211-134002"],"award-info":[{"award-number":["MOHW105-TDU-B-211-134002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Transoral robotic surgery (TORS) has been used for treating pharyngeal and laryngeal cancers for many years. However, the application of neoadjuvant chemotherapy (NACT) before TORS, the sparing rate of adjuvant irradiation after TORS, and the long-term oncologic\/functional outcomes of TORS are seldom reported. From September 2014 to May 2018, 30 patients with clinical T1 to T3 cancers of oropharynx (7), larynx (3), and hypopharynx (20) were prospectively recruited for TORS in a tertiary referral medical center. Twelve (40%) patients had clinical early stage (I or II) disease, and 18 (60%) patients had late-stage (III or IV) disease. All 30 patients were suggested to receive TORS with neck dissection. Cisplatin-based NACT was given to 11 patients before the surgery, and it led to a 100% reduction in tumor size. Only 40% of patients needed adjuvant irradiation with a mean dosage of 5933 cGY after TORS. After a mean follow up of 38.9\u00b1 14.7 months, the Kaplan\u2013Meier method estimated 5-year disease-specific survival, and organ preservation was 86.3% and 96.2%, respectively. Twenty-five patients were alive without tracheostomy and tube feeding. We found that NACT is a potential method for facilitating tumor resection and TORS effectively de-escalated adjuvant irradiation with a satisfactory 5-year survival and functional outcomes.<\/jats:p>","DOI":"10.3390\/jcm10050967","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T01:49:44Z","timestamp":1614649784000},"page":"967","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Transoral Robotic Surgery for Pharyngeal and Laryngeal Cancers\u2014A Prospective Medium-Term Study"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5934-724X","authenticated-orcid":false,"given":"Chen-Chi","family":"Wang","sequence":"first","affiliation":[{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"School of Speech Language Pathology &amp; Audiology, Chung Shan Medical University, Taichung 40121, Taiwan"},{"name":"Department of Audiology and Speech-Language Pathology, Asia University, Taichung 41354, Taiwan"},{"name":"Department of Otolaryngology-Head &amp; Neck Surgery, Taichung Veterans General Hospital, Taichung 40705, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Jiun","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head &amp; Neck Surgery, Taichung Veterans General Hospital, Taichung 40705, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Chun","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Department of Radiation Oncology, Taichung Veterans General Hospital, Taichung 40705, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Chih","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Taichung Veterans General Hospital, Taichung 40705, Taiwan"},{"name":"Ph. D. Program in Translational Medicine, National Chung-Hsing University, Taichung 40227, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang-Heng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head &amp; Neck Surgery, Taichung Veterans General Hospital, Taichung 40705, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-An","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Department of Otolaryngology-Head &amp; Neck Surgery, Taichung Veterans General Hospital, Taichung 40705, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai-Li","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Department of Otolaryngology-Head &amp; Neck Surgery, Taichung Veterans General Hospital, Taichung 40705, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1200\/JCO.1994.12.8.1592","article-title":"Tumor response, toxicity, and survival after neoadjuvant organ-preserving chemotherapy for advanced laryngeal carcinoma. The Department of Veterans Affairs Cooperative Laryngeal Cancer Study Group","volume":"12","author":"Spaulding","year":"1994","journal-title":"J. Clin. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"253e62","DOI":"10.1016\/S0167-8140(02)00404-8","article-title":"Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: A systematic literature review","volume":"66","author":"Trotti","year":"2003","journal-title":"Radiother. Oncol. J. Eur. Soc. Ther. Radiol. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"613e24","DOI":"10.1016\/S1470-2045(07)70144-4","article-title":"TAME: Development of a new method for summarizing adverse events of cancer treatment by the Radiation Therapy Oncology Group","volume":"8","author":"Trotti","year":"2007","journal-title":"Lancet Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s00066-012-0288-8","article-title":"Dysphagia after definitive radiotherapy for head and neck cancer. Correlation of dose volume parameters of the pharyngeal constrictor muscles","volume":"189","author":"Deantonio","year":"2013","journal-title":"Strahlenther. Onkol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.3109\/0284186X.2013.824609","article-title":"Factors associated with acute and late dysphagia in the DAHANCA 6 & 7 randomized trial with accelerated radiotherapy for head and neck cancer","volume":"52","author":"Mortensen","year":"2013","journal-title":"Acta Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.radonc.2013.06.001","article-title":"Late dysphagia after IMRT for head and neck cancer and correlation withdose-volumeparameters","volume":"107","author":"Mortensen","year":"2013","journal-title":"Radiother. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.oraloncology.2011.05.012","article-title":"The impact of late treatment toxicity on generic health-related quality of life in head and neck cancer patients after radiotherapy","volume":"47","author":"Ramaekers","year":"2011","journal-title":"Oral Oncol."},{"key":"ref_8","first-page":"108","article-title":"Combination treatment of hypopharyngeal cancer using endoscopic laser surgery and radiation follow-up [in German]","volume":"81","author":"Steiner","year":"1987","journal-title":"Sonderb. Strahlenther. Onkol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/hed.20993","article-title":"Endoscopic laser surgery of early glottic cancer: Involvement of the anterior commissure","volume":"31","author":"Steiner","year":"2009","journal-title":"Head Neck"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1002\/hed.25806","article-title":"Transoral laser microsurgery for treatment of orpharyngeal cancer in 368 patients","volume":"41","author":"Weiss","year":"2019","journal-title":"Head Neck"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1097\/01.mlg.0000227184.90514.1a","article-title":"Transoral Robotic Surgery (TORS) for Base of Tongue Neoplasms","volume":"116","author":"Weinstein","year":"2006","journal-title":"Laryngoscope"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/000348940711600104","article-title":"Transoral robotic surgery: Supraglottic partial laryngectomy","volume":"116","author":"Weinstein","year":"2007","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1001\/archotol.133.12.1220","article-title":"Transoral robotic surgery: Radical tonsillectomy","volume":"133","author":"Weinstein","year":"2007","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1089\/lap.2008.0320","article-title":"Transoral robotic surgery (TORS) in laryngeal and hypopharyngeal cancer","volume":"19","author":"Park","year":"2009","journal-title":"J. Laparoendosc. Adv. Surg. Tech. A"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1177\/000348941212100801","article-title":"Transoral robotic cordectomy for early glottiscarcinoma","volume":"121","author":"Kayhan","year":"2012","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Howard, J., Masterson, L., Dwivedi, R.C., Riffat, F., Benson, R., Jefferies, S., Jani, P., Tysome, J.R., and Nutting, C. (2016). Minimally invasives urgery versus radiotherapy\/chemoradiotherapy for small-volume primary oropharyngeal carcinoma. Cochrane Database Syst. Rev., 12.","DOI":"10.1002\/14651858.CD010963.pub2"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Howard, J., Dwivedi, R.C., Masterson, L., Kothari, P., Quon, H., and Holsinger, F.C. (2018). De-intensified Adjuvant (Chemo)radiotherapy Versus Standard Adjuvant Chemoradiotherapy Post Transoral Minimally Invasive Surgery for Resectable HPV-positive Oropharyngeal Carcinoma. Cochrane Database Syst. Rev., 12.","DOI":"10.1002\/14651858.CD012939.pub2"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/hed.24160","article-title":"Trans-oral robotic surgery for early T-classification hypopharyngeal cancer","volume":"38","author":"Wang","year":"2016","journal-title":"Head Neck"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/hed.24354","article-title":"Transoral robotic surgery for early glottic carcinoma involving anterior commissure preliminary reports","volume":"38","author":"Wang","year":"2016","journal-title":"Head Neck"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1097\/00005537-200409000-00009","article-title":"Development and validation of the voice handicap index-10","volume":"114","author":"Rosen","year":"2004","journal-title":"Laryngoscope"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000016941","article-title":"A functional outcome swallowing scale for staging oropharyngeal dysphagia","volume":"17","author":"Salassa","year":"1999","journal-title":"Dig. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1177\/0194599819844755","article-title":"Systematic Review of Validated Quality of Life and Swallow Outcomes After Transoral Robotic Surgery","volume":"161","author":"Castellano","year":"2019","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1001\/jamaoto.2015.1508","article-title":"Oncologic Outcomes After Transoral Robotic Surgery: A Multi-institutional Study","volume":"141","author":"Li","year":"2015","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.oraloncology.2013.10.002","article-title":"Radiation dose to the floor of mouth musclespredicts swallowing complications following chemoradiation in oropharyngealsquamous cell carcinoma","volume":"50","author":"Kumar","year":"2014","journal-title":"Oral Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.clon.2015.12.026","article-title":"Prognostic value of 2-[(18)F] Fluoro-2-deoxy-D-glucosepositron emission tomography-computed tomography scan carried out duringand after radiation therapy for head and neck cancer using visual therapy response interpretation criteria","volume":"28","author":"Min","year":"2016","journal-title":"Clin. Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/PPO.0000000000000253","article-title":"Role of Induction Chemotherapy Prior to Chemoradiation in Head and Neck Squamous Cell Cancer-Systematic Review and Meta-analysis","volume":"23","author":"Vidal","year":"2017","journal-title":"Cancer J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1200\/JCO.2005.01.2047","article-title":"Single-cycle induction chemotherapy select patients with advanced laryngeal cancer for combined chemoradiation: A new treatment paradigm","volume":"24","author":"Urba","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1200\/JCO.2007.12.7597","article-title":"Chemoselection as a strategy for organ preservation in advanced oropharynx cancer: Response and survival positively associated with HPV16 copy number","volume":"26","author":"Worden","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1002\/lary.27011","article-title":"Meta-analysis of Induction Chemotherapy as a Selection Marker for Chemoradiation in the Head and Neck","volume":"128","author":"Kiong","year":"2018","journal-title":"Laryngoscope"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3904\/kjim.2015.020","article-title":"Induction chemotherapy in head and neck squamous cell carcinoma of the paranasal sinus and nasal cavity: A role in organ preservation","volume":"31","author":"Ock","year":"2016","journal-title":"Korean J. Intern. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.oraloncology.2014.07.015","article-title":"Neoadjuvant chemotherapy followedby surgery in very locally advanced technically unresectable oralcavity cancers","volume":"50","author":"Patil","year":"2014","journal-title":"Oral Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1080\/00016489.2019.1631480","article-title":"Transoral Robotic Surgery in Patients with Stage III\/IV Hypopharyngeal Squamous Cell Carcinoma: Treatment Outcome and Prognostic Factor","volume":"139","author":"Park","year":"2019","journal-title":"Acta Otolaryngol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s11912-012-0286-0","article-title":"Transoral Microsurgery for Treatment of Laryngealand Pharyngeal Cancers","volume":"15","author":"Rodrigo","year":"2013","journal-title":"Curr. Oncol. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s00405-002-0520-8","article-title":"Transoral carbon-dioxide laser resection of hypopharyngeal carcinoma","volume":"260","author":"Rudert","year":"2003","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1001\/archotol.133.2.139","article-title":"Transoral laser surgery for pharyngeal and pharyngolaryngeal carcinomas","volume":"133","author":"Kutter","year":"2007","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/jso.21550","article-title":"T1 and T2 hypopharyngeal cancer treatment with laser microsurgery","volume":"102","author":"Karatzanis","year":"2010","journal-title":"J. Surg. Oncol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/5\/967\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:31:09Z","timestamp":1760160669000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/5\/967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,2]]},"references-count":36,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["jcm10050967"],"URL":"https:\/\/doi.org\/10.3390\/jcm10050967","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,2]]}}}