{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T08:38:55Z","timestamp":1769503135031,"version":"3.49.0"},"reference-count":48,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Huntington\u2019s disease is a progressive neurodegenerative disorder that usually manifests in adulthood and is inherited in an autosomal dominant manner. The main aim of the study was to assess the psychometric properties of the 12-item WHO Disability Assessment Schedule (WHODAS) 2.0 in studying the level of disability in people with Huntington\u2019s disease. Method: This is a cross-sectional study that covered 128 people with Huntington\u2019s disease living in Poland. We examined scale score reliability, internal consistency, convergent validity, and known-group validity. The disability and quality of life of people with Huntington\u2019s disease were also assessed. Results: The scale score reliability of the entire tool for the research group was high. The Cronbach\u2019s \u03b1 test result for the whole scale was 0.97. Cronbach\u2019s \u03b1 for individual domains ranged from 0.95 to 0.79. Time consistency for the overall result was 0.99 and for particular domains ranged from 0.91 to 0.99, which confirmed that the scale was consistent over time. All of the 12-item WHODAS 2.0 domains negatively correlated with all of the Huntington Quality of Life Instrument (H-QoL-I) domains. All correlation coefficients were statistically significant at the level of p &lt; 0.001. The results obtained in the linear regression model showed that with each subsequent point of decrease in BMI the level of disability increases by an average of 0.83 points on the 12-item WHODAS 2.0 scale. With each subsequent year of the disease, the level of disability increases by an average of 1.39 points. Conclusions: This is the first study assessing disability by means of the WHODAS 2.0 in the HD patient population in Poland, and it is also one of the few studies evaluating the validity of the WHODAS 2.0 scale in assessing the disability of people with HD in accordance with the recommendations of DSM-5 (R). We have confirmed that the 12-item WHODAS 2.0 is an effective tool for assessing disability and changes in functioning among people with Huntington\u2019s disease.<\/jats:p>","DOI":"10.3390\/jcm10051053","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T21:58:07Z","timestamp":1614895087000},"page":"1053","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Psychometric Properties and Validation of the Polish Version of the 12-Item World Health Organization Disability Assessment Schedule 2.0 in Patients with Huntington\u2019s Disease"],"prefix":"10.3390","volume":"10","author":[{"given":"Agnieszka","family":"\u0106wirlej-Soza\u0144ska","sequence":"first","affiliation":[{"name":"Institute of Health Sciences, Medical College of Rzeszow University, 35-310 Rzeszow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Soza\u0144ski","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Medical College of Rzeszow University, 35-310 Rzeszow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateusz","family":"Kupczyk","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences, Medical College of Rzeszow University, 35-310 Rzeszow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8769-0048","authenticated-orcid":false,"given":"Justyna","family":"Leszczak","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences, Medical College of Rzeszow University, 35-310 Rzeszow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Kwolek","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences, Medical College of Rzeszow University, 35-310 Rzeszow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7733-4189","authenticated-orcid":false,"given":"Anna","family":"Wilmowska-Pietruszy\u0144ska","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lazarski University, 02-662 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6651-0861","authenticated-orcid":false,"given":"Agnieszka","family":"Wi\u015bniowska-Szurlej","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences, Medical College of Rzeszow University, 35-310 Rzeszow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s12041-018-0957-1","article-title":"Huntington\u2019s disease: The coming of age","volume":"97","author":"Pandey","year":"2018","journal-title":"J. Genet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1002\/mds.26012","article-title":"Determinants of functional disability in Huntington\u2019s disease: Role of cognitive and motor dysfunction","volume":"29","author":"Ross","year":"2014","journal-title":"Mov. Disord."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/mds.23716","article-title":"Factors contributing to institutionalization in patients with Huntington\u2019s disease","volume":"26","author":"Rosenblatt","year":"2011","journal-title":"Mov. Disord."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S1474-4422(13)70088-7","article-title":"Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington\u2019s disease in the TRACK-HD study: Analysis of 36-month observational data","volume":"12","author":"Tabrizi","year":"2013","journal-title":"Lancet Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.parkreldis.2016.02.008","article-title":"Neuropsychiatric symptoms are very common in preman-ifest and early stage Huntington\u2019s disease","volume":"25","author":"Carceller","year":"2016","journal-title":"Parkinsonism Relat Disord."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/ene.13889","article-title":"Longitudinal assessment of the Unified Huntington\u2019s Disease Rating Scale (UHDRS) and UHDRS\u2013For Advanced Patients (UHDRS-FAP) in patients with late stage Huntington\u2019s disease","volume":"26","author":"Winder","year":"2019","journal-title":"Eur. J. Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1750-1172-5-40","article-title":"Huntington\u2019s disease: A clinical review","volume":"5","author":"Roos","year":"2010","journal-title":"Orphanet. J. Rare Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.parkreldis.2018.01.006","article-title":"The contribution of gender differences in motor, behavioral and cognitive features to functional capacity, independence and quality of life in patients with Huntington\u2019s disease","volume":"49","author":"Zielonka","year":"2018","journal-title":"Park. Relat. Disord."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jcomdis.2010.12.004","article-title":"Applying the WHO ICF framework to communication assessment and goal setting in Huntington\u2019s Disease: A case discussion","volume":"44","author":"Power","year":"2011","journal-title":"J. Commun. Disord."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Kostanjsek, N. (2011). Use of The International Classification of Functioning, Disability and Health (ICF) as a conceptual framework and common language for disability statistics and health information systems. BMC Public Health, 11.","DOI":"10.1186\/1471-2458-11-S4-S3"},{"key":"ref_11","unstructured":"\u00dcst\u00fcn, T.B., Kostanjsek, N., Chatterji, S., and Rehm, J. (2001). Measuring Health and Disability: Manual for WHO Disability Assessment Schedule (WHODAS 2.0), WHO."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/ejhg.2013.275","article-title":"WHODAS 2.0 in prodromal Huntington disease: Measures of functioning in neuropsychiatric disease","volume":"22","author":"Downing","year":"2014","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_13","unstructured":"WHO (2001). International Classification of Functioning, Disability and Health (ICF), WHO."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"815","DOI":"10.2471\/BLT.09.067231","article-title":"Developing the World Health Organization Disability Assessment Schedule 2.0","volume":"88","author":"Chatterji","year":"2010","journal-title":"Bull. World Health Organ."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Andrews, G., Kemp, A., Sunderland, M., Von Korff, M., and Ustun, T.B. (2009). Normative Data for the 12 Item WHO Disability Assessment Schedule 2.0. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0008343"},{"key":"ref_16","unstructured":"(2020, April 14). Quality-of-Life Scales for Neurologic Diseases. Available online: https:\/\/www.medlink.com\/scripts\/mpdf\/print_friendly.php?title=quality-of-life_scales_for_neurologic_diseases&action=print&channel=public_content&entryid=16970."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"A567","DOI":"10.1016\/j.jval.2014.08.1887","article-title":"Assessment Of The Huntington Quality Of Life Instrument (H-QOL-I) Cross-Cultural Validity","volume":"17","author":"Clay","year":"2014","journal-title":"Value Health"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3233\/JHD-140115","article-title":"Understanding the Outcomes Measures used in Huntington Disease Pharmacological Trials: A Systematic Review","volume":"3","author":"Carlozzi","year":"2014","journal-title":"J. Huntingt. Dis."},{"key":"ref_19","unstructured":"(2020, April 14). Huntington\u2019s Disease and Palliative Care. Available online: https:\/\/www.promotingexcellence.org\/huntingtons\/monograph\/pe5670.html."},{"key":"ref_20","unstructured":"Nunnlly, J., and Bernestein, I. (1994). Psychometric Theory, Mackgrow Hill."},{"key":"ref_21","unstructured":"Kline, P. (1986). A Handbook of Test Construction. Introduction to Psychometric Design, Methuen."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jclinepi.2006.03.012","article-title":"Quality criteria were proposed for measurement properties of health status questionnaires","volume":"60","author":"Terwee","year":"2007","journal-title":"J. Clin. Epidemiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/mds.27908","article-title":"HDQLIFE and neuro-QoL physical function measures: Responsiveness in persons with huntington\u2019s disease","volume":"35","author":"Carlozzi","year":"2020","journal-title":"Mov. Disord."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1037\/h0046016","article-title":"Convergent and discriminant validation by the multitrait-multimethod matrix","volume":"56","author":"Campbell","year":"1959","journal-title":"Psychol. Bull."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Dorey, J., Clay, E., Khemiri, A., Belhadj, A., Cubillo, P.T., and Toumi, M. (2016). The quality of life of Spanish patients with Huntington\u2019s disease measured with H-QoL-I and EQ-5D. J. Mark Access Health Policy, 4.","DOI":"10.3402\/jmahp.v4.27356"},{"key":"ref_26","first-page":"A60","article-title":"F58 Assessment scales for patients with advanced huntington\u2019s disease: Comparison of the UHDRS and UHDRS-FAP","volume":"89","author":"Winder","year":"2018","journal-title":"Clin. Stud."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1007\/s11136-015-0930-x","article-title":"Validity of the 12-item World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) in individuals with Huntington disease (HD)","volume":"24","author":"Carlozzi","year":"2015","journal-title":"Qual. Life Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1007\/s00296-017-3723-4","article-title":"Reliability and validity of the 12-item WHODAS 2.0 in patients with Kashin\u2013Beck disease","volume":"37","author":"Younus","year":"2017","journal-title":"Rheumatol. Int."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.2196\/mental.7497","article-title":"The 12-item Self-Report World Health Organization Disability Assessment Schedule (WHODAS) 2.0 Administered Via the Internet to Individuals With Anxiety and Stress Disorders: A Psychometric Investigation Based on Data From Two Clinical Trials","volume":"4","author":"Axelsson","year":"2017","journal-title":"JMIR Ment. Health"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/MRR.0000000000000064","article-title":"Disability in Italian neurosurgical patients: Validity of the 12-item World Health Organization Disability Assessment Schedule","volume":"37","author":"Schiavolin","year":"2014","journal-title":"Int. J. Rehabil. Res."},{"key":"ref_31","first-page":"179","article-title":"Validation of a Portuguese version of WHODAS 2.0 \u201412 items in people aged 55 or more","volume":"33","author":"Moreira","year":"2015","journal-title":"Rev. Sa\u00fade P\u00fabl."},{"key":"ref_32","first-page":"1","article-title":"Cross-cultural adaptation of the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) for Hebrew-speaking subjects with and without hand injury","volume":"39","author":"Marom","year":"2016","journal-title":"Disabil. Rehabil."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/MRR.0000000000000032","article-title":"Measuring functional health among the elderly: Development of the Japanese version of the World Health Organization Disability Assessment Schedule II","volume":"37","author":"Tazaki","year":"2014","journal-title":"Int. J. Rehabil. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jad.2009.05.008","article-title":"Psychometric properties of the twelve item World Health Organization Disability Assessment Schedule II (WHO-DAS II) in Spanish primary care patients with a first major depressive episode","volume":"121","author":"Luciano","year":"2010","journal-title":"J. Affect. Disord."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/ejhg.2015.11","article-title":"Performance of the 12-item WHODAS 2.0 in prodromal Huntington disease","volume":"23","author":"Kim","year":"2015","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/mds.870080212","article-title":"Assessment of adaptive functioning in huntington\u2019s disease","volume":"8","author":"Bylsma","year":"1993","journal-title":"Mov. Disord."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.nut.2003.10.007","article-title":"Assessment of the nutrition status of patients with Huntington\u2019s disease","volume":"20","author":"Trejo","year":"2004","journal-title":"Nutrition"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/ana.25007","article-title":"Body weight is a robust predictor of clinical progression in Huntington disease","volume":"82","author":"Gardiner","year":"2017","journal-title":"Ann. Neurol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1001\/archneur.1991.00530200036015","article-title":"Factors Associated with Slow Progression in Huntington\u2019s Disease","volume":"48","author":"Myers","year":"1991","journal-title":"Arch. Neurol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2217\/nmt.11.69","article-title":"Nutritional management of individuals with Huntington\u2019s disease: Nutritional guidelines","volume":"2","author":"Brotherton","year":"2012","journal-title":"Neurodegener. Dis. Manag."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Wallace, M., Downing, N., Lourens, S., Mills, J., Kim, J.-I., Long, J., Paulsen, J., and PREDICT-HD Investigators and Coordinators of the Huntington Study Group (2016). Is There an Association of Physical Activity with Brain Volume, Behavior, and Day-to-day Functioning? A Cross Sectional Design in Prodromal and Early Huntington Disease. PLoS Curr., 8.","DOI":"10.1371\/currents.hd.cba6ea74972cf8412a73ce52eb018c1e"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1002\/mds.23108","article-title":"A retrospective study of the impact of lifestyle on age at onset of Huntington disease","volume":"25","author":"Trembath","year":"2010","journal-title":"Mov. Disord."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.psychres.2010.04.030","article-title":"Earliest functional declines in Huntington disease","volume":"178","author":"Beglinger","year":"2010","journal-title":"Psychiatry Res."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Vaccarino, A.L., Sills, T., Anderson, K.E., Endicott, J., Giuliano, J., Guttman, M., Ho, A.K., Kupchak, P., Paulsen, J.S., and Warner, J.H. (2011). Assessment of Day-to-Day Functioning in Prodromal and Early Huntington Disease. PLoS Curr., 3.","DOI":"10.1371\/currents.RRN1262"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1176\/appi.neuropsych.17040086","article-title":"Predictors of Workplace Disability in a Premanifest Huntington\u2019s Disease Cohort","volume":"30","author":"Goh","year":"2018","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s10198-019-01092-9","article-title":"Health state utility values (QALY weights) for Huntington\u2019s disease: An analysis of data from the European Huntington\u2019s Disease Network (EHDN)","volume":"20","author":"Hawton","year":"2019","journal-title":"Eur. J. Health Econ."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s40271-018-0312-x","article-title":"Understanding How Chorea Affects Health-Related Quality of Life in Huntington Disease: An Online Survey of Patients and Caregivers in the United States","volume":"11","author":"Thorley","year":"2018","journal-title":"Patient Patient Cent. Outcomes Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/mds.22412","article-title":"Healthrelated quality of life in Huntington\u2019s disease: Which factors matter most?","volume":"24","author":"Ho","year":"2009","journal-title":"Mov. Disord."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/5\/1053\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:32:27Z","timestamp":1760160747000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/5\/1053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,4]]},"references-count":48,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["jcm10051053"],"URL":"https:\/\/doi.org\/10.3390\/jcm10051053","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,4]]}}}