{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:55:19Z","timestamp":1787583319678,"version":"build-2736575974"},"reference-count":27,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: Sudden sensorineural hearing loss (SSNHL) is defined as sensorineural hearing loss of 30 dB or more over at least three adjacent audiometric frequencies occurring within a 72-h period of time. One of the causes of SSNHL could be the progressive inflammatory state caused by an infection. The aim of this study was to assess the prevalence of SSNHL caused by various factors, most importantly those potentially related to Lyme disease. Material and Methods: The study includes a group of 86 patients between the ages of 20 and 70 who were hospitalized due to SSNHL between 2017 and 2018. All of these patients underwent a detailed medical interview and an otolaryngological examination, including audiological and diagnostic tests. Additionally, ELISA and Western blot tests were performed to confirm the diagnosis of Lyme disease. Results: In this group of 86 patients, nine patients presented with positive antibodies toward Borrelia burgdorferi sensu lato. This group was treated with antibiotics and experienced partial or complete regression of their deafness. This may suggest a relationship between SSNHL and Lyme disease. Conclusion: Infections caused by Borrelia burgdorferi may contribute to the development of inflammatory and angiopathic lesions, which are a possible cause of SSNHL. The longer the duration of the infection, the greater the likelihood of permanent and irreversible changes in the vessels of the cochlea or auditory nerve. Therefore, serological tests for Borrelia burgdorferi should be performed during the diagnosis of SSNHL as a possible cause of this illness.<\/jats:p>","DOI":"10.3390\/jcm10051130","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T12:12:18Z","timestamp":1615205538000},"page":"1130","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Association between Sudden Sensorineural Hearing Loss and Lyme Disease"],"prefix":"10.3390","volume":"10","author":[{"given":"Klaudia","family":"Sowula","sequence":"first","affiliation":[{"name":"ENT Department, Faculty of Medicine, Jagiellonian University Medical College, Jakubowskiego 2, 30-688 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7980-0497","authenticated-orcid":false,"given":"Joanna","family":"Szaleniec","sequence":"additional","affiliation":[{"name":"ENT Department, Faculty of Medicine, Jagiellonian University Medical College, Jakubowskiego 2, 30-688 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Stolcman","sequence":"additional","affiliation":[{"name":"ENT Department, Faculty of Medicine, Jagiellonian University Medical College, Jakubowskiego 2, 30-688 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3478-0108","authenticated-orcid":false,"given":"Piotr","family":"Ceranowicz","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, Grzeg\u00f3rzecka 16, 31-531 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Koco\u0144","sequence":"additional","affiliation":[{"name":"ENT Department, Faculty of Medicine, Jagiellonian University Medical College, Jakubowskiego 2, 30-688 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Tomik","sequence":"additional","affiliation":[{"name":"ENT Department, Faculty of Medicine, Jagiellonian University Medical College, Jakubowskiego 2, 30-688 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"key":"ref_1","unstructured":"WHO (2021, January 15). World Health Organisation. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/deafness-and-hearing-loss."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1001\/jamapediatrics.2013.3974","article-title":"Psychopathology and its risk and protective factors in hearing-impaired children and adolescents: A systematic review","volume":"168","author":"Theunissen","year":"2014","journal-title":"JAMA Pediatr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/lary.20873","article-title":"Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss","volume":"120","author":"Chau","year":"2010","journal-title":"Laryngoscope"},{"key":"ref_4","first-page":"3103","article-title":"Sudden sensorineural hearing loss: Cummings C.W. (red.)","volume":"Volume 4","author":"Wilson","year":"1993","journal-title":"Otolaryngology\u2014Head and Neck Surgery"},{"key":"ref_5","unstructured":"Bernstein, T.M. (1987). The immunobiology of autoimmune diseases of the inner ear, W: Bernstein J., Orge P. (red.). Immunology of Ear, Raven Press."},{"key":"ref_6","first-page":"65","article-title":"Sudden sensorineural hearing loss\u2014position paper of the Polish Society of Audiology and Phoniatrics on the diagnostic and therapeutic recommendations","volume":"14","author":"Sekula","year":"2015","journal-title":"Otorynolaryngologia"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4045\/tidsskr.15.1115","article-title":"Lyme neuroborreliosis in cases of non-specific neurological symptoms","volume":"137","author":"Roaldsnes","year":"2017","journal-title":"Tidsskrift for den Norske Laegeforening Tidsskrift for Praktisk Medicin ny Raekke"},{"key":"ref_8","first-page":"5","article-title":"Analysis of cases of Lyme arthritis in patients hospitalized in Infectious Diseases Department, University Hospital in Cracow","volume":"59","author":"Czepiel","year":"2019","journal-title":"Folia Med. Cracov."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/00005537-200302000-00021","article-title":"Sudden deafness and Lyme disease","volume":"113","author":"Lorenzi","year":"2003","journal-title":"Laryngoscope"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s004059900206","article-title":"Lyme borreliosis, an etiological factor in sensorineural hearing loss?","volume":"257","author":"Peltomaa","year":"2000","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1177\/014556139407301106","article-title":"Lyme disease: A review for the otolaryngologist","volume":"73","author":"Goldfarb","year":"1994","journal-title":"Ear. Nose Throat J."},{"key":"ref_12","first-page":"320","article-title":"Borreliosis as a cause of sudden deafness and vestibular neuritis in Sweden","volume":"520","author":"Roberg","year":"1995","journal-title":"Acta Otolaryngol. Suppl."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1017\/S0022215114003417","article-title":"Lyme disease: Sudden hearingloss as the sole presentation","volume":"129","author":"Amaro","year":"2015","journal-title":"J. Laryngol. Otol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4236\/ijohns.2014.31010","article-title":"Cochlear and vestibular functional study in patients with sudden deafness a Lyme disease","volume":"3","author":"Selmani","year":"2014","journal-title":"Int. J. Otolaryngol. Head Neck Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/j.anorl.2017.12.011","article-title":"International consensus (ICON) on treatment of sudden sensorineural hearing loss","volume":"135","author":"Marx","year":"2018","journal-title":"Eur. Ann. Otorhinolaryngol. Head Neck Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/00129492-200203000-00010","article-title":"Infection screening in sudden and progressive idiopathic sensorineural hearing loss: A retrospective study of 182 cases","volume":"23","author":"Gagnebin","year":"2002","journal-title":"Otol. Neurotol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1179\/016164105X49508","article-title":"Role of immunologic cross-reactivity in neurological diseases","volume":"27","author":"Ercolini","year":"2005","journal-title":"Neurol. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.5604\/01.3001.0013.0899","article-title":"A case of lyme borreliosis complicated by the development of sensorineural hearing loss: (Case study)","volume":"8","author":"Zinchuk","year":"2019","journal-title":"Pol. Otorhinolaryngol. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1177\/1084713811408349","article-title":"Sudden sensorineural hearingloss: A review of diagnosis, treatment, and prognosis","volume":"15","author":"Kuhn","year":"2011","journal-title":"Trends Amplif."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.medmal.2018.12.004","article-title":"Limitations of diagnostic tests for bacterial infections","volume":"49","author":"Eldin","year":"2019","journal-title":"Med. Mal. Infect."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3389\/fcimb.2020.00241","article-title":"Immunoserological Diagnosis of Human Borrelioses: Current Knowledge and Perspectives","volume":"10","author":"Raffetin","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1055\/s-2003-38938","article-title":"Lyme disease\u2014a reason for sudden sensorineural hearing loss and vestibular neuronitis?","volume":"82","author":"Walther","year":"2003","journal-title":"Laryngorhinootologie"},{"key":"ref_23","first-page":"486","article-title":"Asymmetric sudden sensorineural hearing loss: Is all this testing necessary?","volume":"39","author":"Jabbour","year":"2010","journal-title":"J. Otolaryngol. Head Neck Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0140-6736(11)60103-7","article-title":"Lyme borreliosis","volume":"379","author":"Stanek","year":"2012","journal-title":"Lancet"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1067\/mhn.2000.98758","article-title":"Bilateral sensorineural hearing loss and spasticparaparesis in Lyme disease","volume":"122","author":"Bertholon","year":"2000","journal-title":"J. Otolaryngol. Head Neck Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1097\/MAO.0b013e31827c9f93","article-title":"Lyme disease associated withsudden sensorineural hearing loss: Case report and literature review","volume":"34","author":"Peeters","year":"2013","journal-title":"Otol. Neurotol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/ar2853","article-title":"Treatment of Lyme borreliosis","volume":"11","author":"Girschick","year":"2009","journal-title":"Arthritis Res. Ther."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/5\/1130\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:34:56Z","timestamp":1760160896000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/5\/1130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,8]]},"references-count":27,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["jcm10051130"],"URL":"https:\/\/doi.org\/10.3390\/jcm10051130","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,8]]}}}