{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:32:59Z","timestamp":1777926779997,"version":"3.51.4"},"reference-count":67,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Although pulmonary events are considered to be frequently associated with malignant haemopathies, they have been sparsely studied in the specific context of myelodysplastic syndromes (MDS). We aimed to describe their different types, their relative proportions and their relative effects on overall survival (OS). We conducted a multicentre retrospective cohort study. Patients with MDS (diagnosed according to the 2016 WHO classification) and pulmonary events were included. The inclusion period was 1 January 2007 to 31 December 2017 and patients were monitored until August 2019. Fifty-five hospitalized patients were included in the analysis. They had 113 separate pulmonary events. Thirteen patients (23.6%) had a systemic autoimmune disease associated with MDS. Median age at diagnosis of MDS was 77 years. Median time to onset of pulmonary events was 13 months. Pulmonary events comprised: 70 infectious diseases (62%); 27 interstitial lung diseases (23.9%), including 13 non-specific interstitial pneumonias and seven secondary organizing pneumonias or respiratory bronchiolitis\u2013interstitial lung diseases; 10 pleural effusions (8.8%), including four cases of chronic organizing pleuritis with exudative effusion; and six pulmonary hypertensions (5.3%). The median OS of the cohort was 29 months after MDS diagnosis but OS was only 10 months after a pulmonary event. The OS was similar to that of the general myelodysplastic population. However, the occurrence of a pulmonary event appeared to be either an accelerating factor of death or an indicator for the worsening of the underlying MDS in our study. More than a third of pulmonary events were non-infectious and could be systemic manifestations of MDS.<\/jats:p>","DOI":"10.3390\/jcm10061162","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T13:27:20Z","timestamp":1615382840000},"page":"1162","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Systemic Pulmonary Events Associated with Myelodysplastic Syndromes: A Retrospective Multicentre Study"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5865-1525","authenticated-orcid":false,"given":"Quentin","family":"Scanvion","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology, National Reference Centre for Rare Systemic Autoimmune Disease North and North-West of France, University of Lille, CHU Lille, F-59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Pascal","sequence":"additional","affiliation":[{"name":"Department of Haematology, H\u00f4pital Saint-Vincent de Lille, Catholic University of Lille, F-59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierno","family":"Sy","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Armenti\u00e8res Hospital, F-59280 Armenti\u00e8res, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidwine","family":"Stervinou-W\u00e9meau","sequence":"additional","affiliation":[{"name":"Service de Pneumologie et ImmunoAllergologie, Centre de R\u00e9f\u00e9rence Constitutif des Maladies Pulmonaires Rares, CHU Lille, F-59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Laure","family":"Lejeune","sequence":"additional","affiliation":[{"name":"Department of Thoracic Imagining, University of Lille, CHU Lille, F-59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Deken","sequence":"additional","affiliation":[{"name":"ULR 2694\u2014METRICS: \u00c9valuation des Technologies de Sant\u00e9 et des Pratiques M\u00e9dicales, University of Lille, CHU Lille, F-59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9ric","family":"Hachulla","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology, National Reference Centre for Rare Systemic Autoimmune Disease North and North-West of France, University of Lille, CHU Lille, F-59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6563-2709","authenticated-orcid":false,"given":"Bruno","family":"Quesnel","sequence":"additional","affiliation":[{"name":"Department of Haematology, H\u00f4pital Saint-Vincent de Lille, Catholic University of Lille, F-59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ars\u00e8ne","family":"M\u00e9kinian","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, AP-HP, Saint-Antoine Hospital, F-75012 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Launay","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology, National Reference Centre for Rare Systemic Autoimmune Disease North and North-West of France, University of Lille, CHU Lille, F-59000 Lille, France"},{"name":"INFINITE\u2014Institute for Translational Research in Inflammation, University of Lille, F-59000 Lille, France"},{"name":"Inserm, U1286, F-59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Terriou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology, National Reference Centre for Rare Systemic Autoimmune Disease North and North-West of France, University of Lille, CHU Lille, F-59000 Lille, France"},{"name":"Department of Haematology, H\u00f4pital Saint-Vincent de Lille, Catholic University of Lille, F-59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.critrevonc.2019.07.018","article-title":"The Yin and Yang of Myelodysplastic Syndromes and Autoimmunity: The Paradox of Autoimmune Disorders Responding to Therapies Specific for MDS","volume":"142","author":"Fozza","year":"2019","journal-title":"Crit. 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