{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:00:29Z","timestamp":1774260029832,"version":"3.50.1"},"reference-count":44,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T00:00:00Z","timestamp":1616284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"&quot;Increasing the research capacity in 420 the field of vulnerable plaque imaging, based on advanced nanoparticles, fusion imaging and 421 computational simulation \u2013 PlaqueImage&quot; financed by the National Authority of Scientific Research 422 and Innovation a","award":["contract number 26\/01.09.2016, SMIS code:103544"],"award-info":[{"award-number":["contract number 26\/01.09.2016, SMIS code:103544"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The present study aimed to investigate the link between the severity of periodontal disease (PD), coronary calcifications and unstable plaque features in patients who underwent coronary computed tomography for unstable angina (UA). Fifty-two patients with UA, included in the ATHERODENT trial (NCT03395041), underwent computed tomographic coronary angiography (CCTA) and dental examination. Based on the median value of the periodontal index (PI), patients were assigned to the low periodontal index (LPI) group (PI &lt; 22) and a high periodontal index (HPI) group (PI &gt; 22). Patients with HPI had higher plaque volume (p = 0.013) and noncalcified plaque volume (p = 0.0003) at CCTA. In addition, the presence of vulnerability features in the atheromatous plaques was significantly correlated with PI (p = 0.001). Among periodontal indices, loss of gingival attachment (p = 0.009) and papillary bleeding index (p = 0.002) were strongly associated with high-risk plaques. PI significantly correlated with coronary calcium score (r = 0.45, p = 0.0008), but not with traditional markers of subclinical atherosclerosis. Overall, this subgroup analysis of the ATHERODENT study indicates that patients with advanced PD and UA present a higher amount of calcium in the coronary tree and have a more vulnerable phenotype of their culprit plaques.<\/jats:p>","DOI":"10.3390\/jcm10061290","type":"journal-article","created":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T22:00:37Z","timestamp":1616364037000},"page":"1290","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Periodontal Disease Is Associated with Increased Vulnerability of Coronary Atheromatous Plaques in Patients Undergoing Coronary Computed Tomography Angiography\u2014Results from the Atherodent Study"],"prefix":"10.3390","volume":"10","author":[{"given":"Ioana-Patricia","family":"Rodean","sequence":"first","affiliation":[{"name":"Clinic of Cardiology, Emergency Clinical County Hospital, 540136 T\u00e2rgu Mure\u0219, Romania"},{"name":"Center of Advanced Research in Multimodality Cardiac Imaging, CardioMed Medical Center, 540124 T\u00e2rgu Mure\u0219, Romania"},{"name":"Department of Cardiology, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science and Technology, 540139 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lumini\u021ba","family":"Laz\u0103r","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science and Technology, 540139 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6793-9248","authenticated-orcid":false,"given":"Vasile-Bogdan","family":"Hala\u021biu","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology, Emergency Clinical County Hospital, 540136 T\u00e2rgu Mure\u0219, Romania"},{"name":"Department of Cardiology, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science and Technology, 540139 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Biri\u0219","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science and Technology, 540139 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imre","family":"Benedek","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology, Emergency Clinical County Hospital, 540136 T\u00e2rgu Mure\u0219, Romania"},{"name":"Center of Advanced Research in Multimodality Cardiac Imaging, CardioMed Medical Center, 540124 T\u00e2rgu Mure\u0219, Romania"},{"name":"Department of Cardiology, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science and Technology, 540139 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodora","family":"Benedek","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology, Emergency Clinical County Hospital, 540136 T\u00e2rgu Mure\u0219, Romania"},{"name":"Center of Advanced Research in Multimodality Cardiac Imaging, CardioMed Medical Center, 540124 T\u00e2rgu Mure\u0219, Romania"},{"name":"Department of Cardiology, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science and Technology, 540139 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1002\/JPER.19-0723","article-title":"Periodontal Disease Classifications and Incident Coronary Heart Disease in the Atherosclerosis Risk in Communities Study","volume":"91","author":"Beck","year":"2020","journal-title":"J. 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