{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:19:44Z","timestamp":1792153184903,"version":"4.4.0"},"reference-count":296,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T00:00:00Z","timestamp":1616284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FONDECYT de Iniciaci\u00f3n : 1119042","award":["\u2019ANID (ex-CONICYT), PAI, convocatoria nacional subvenci\u00f3n a instalaci\u00f3n en la academia, convocatoria a\u00f1o 2018 : PAI77180086"],"award-info":[{"award-number":["\u2019ANID (ex-CONICYT), PAI, convocatoria nacional subvenci\u00f3n a instalaci\u00f3n en la academia, convocatoria a\u00f1o 2018 : PAI77180086"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>During the last years, accumulating evidence has suggested that the gut microbiota plays a key role in the pathogenesis of neurodevelopmental and neurodegenerative diseases via the gut\u2013brain axis. Moreover, current research has helped to elucidate different communication pathways between the gut microbiota and neural tissues (e.g., the vagus nerve, tryptophan production, extrinsic enteric-associated neurons, and short chain fatty acids). On the other hand, altering the composition of gut microbiota promotes a state known as dysbiosis, where the balance between helpful and pathogenic bacteria is disrupted, usually stimulating the last ones. Herein, we summarize selected findings of the recent literature concerning the gut microbiome on the onset and progression of neurodevelopmental and degenerative disorders, and the strategies to modulate its composition in the search for therapeutical approaches, focusing mainly on animal models studies. Readers are advised that this is a young field, based on early studies, that is rapidly growing and being updated as the field advances.<\/jats:p>","DOI":"10.3390\/jcm10061299","type":"journal-article","created":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T22:00:37Z","timestamp":1616364037000},"page":"1299","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["Gut Microbiota Interaction with the Central Nervous System throughout Life"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6677-6536","authenticated-orcid":false,"given":"Jorge","family":"Ojeda","sequence":"first","affiliation":[{"name":"Neuroimmunology and Regeneration of the Central Nervous System Unit, Biomedical Science Research Laboratory, Basic Sciences Department, Faculty of Medicine, Universidad Cat\u00f3lica de la Sant\u00edsima Concepci\u00f3n, Concepci\u00f3n 4090541, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"\u00c1vila","sequence":"additional","affiliation":[{"name":"Developmental Neurobiology Unit, Biomedical Science Research Laboratory, Basic Sciences Department, Faculty of Medicine, Universidad Cat\u00f3lica de la Sant\u00edsima Concepci\u00f3n, Concepci\u00f3n 4090541, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00eda M.","family":"Vidal","sequence":"additional","affiliation":[{"name":"Neuroimmunology and Regeneration of the Central Nervous System Unit, Biomedical Science Research Laboratory, Basic Sciences Department, Faculty of Medicine, Universidad Cat\u00f3lica de la Sant\u00edsima Concepci\u00f3n, Concepci\u00f3n 4090541, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,21]]},"reference":[{"key":"ref_1","first-page":"8","article-title":"Ome SweetOmics\u2014A genealogical treasury of words","volume":"15","author":"Lederberg","year":"2001","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.cell.2012.01.035","article-title":"The Impact of the Gut Microbiota on Human Health: An Integrative View","volume":"148","author":"Clemente","year":"2012","journal-title":"Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40168-018-0485-5","article-title":"The contribution of culturomics to the repertoire of isolated human bacterial and archaeal species","volume":"6","author":"Bilen","year":"2018","journal-title":"Microbiome"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1172\/JCI58109","article-title":"Gut microbiome, obesity, and metabolic dysfunction","volume":"121","author":"Tilg","year":"2011","journal-title":"J. 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