{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:16Z","timestamp":1787028616521,"version":"build-2736575974"},"reference-count":50,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:00:00Z","timestamp":1616371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG1G0121"],"award-info":[{"award-number":["CMRPG1G0121"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The temporal relationships between inflammatory bowel disease (IBD)-associated cutaneous manifestations and IBD remain uncertain, with existing evidence mostly from separate cross-sectional studies. We sought to determine the risks of IBD-related dermatologic diseases before and after the diagnosis of IBD. We identified 2847 cases of IBD and 14,235 matched controls from the Taiwan National Health Insurance Research Database between 2003 and 2014. The risks of cutaneous manifestations before and after the diagnosis of IBD were estimated with multivariable-adjusted analyses. At diagnosis, IBD was associated with atopic dermatitis (odds ratio (OR) = 1.61; 95% confidence interval (CI), 1.14\u20132.28), erythema nodosum (OR = 7.44; 95%CI, 3.75\u201314.77), aphthous stomatitis (OR = 2.01; 95%CI, 1.72\u20132.35), polyarteritis nodosa (OR = 5.67; 95%CI, 2.69\u201311.98), rosacea (OR = 1.67, 95%CI = 1.19\u20132.35), and cutaneous T cell lymphoma (OR = 21.27; 95%CI, 2.37\u2013191.00). IBD was associated with the subsequent development of pyoderma gangrenosum (hazard ratio (HR) = 17.79; 95%CI, 6.35\u201349.86), erythema nodosum (HR = 6.54; 95%CI, 2.83\u201315.13), polyarteritis nodosa (HR = 2.69; 95%CI, 1.05\u20136.90), hidradenitis suppurativa (HR = 2.48; 95%CI, 1.03\u20135.97), psoriasis (HR = 2.19; 95%CI, 1.27\u20133.79), rosacea (HR = 1.92; 95%CI, 1.39\u20132.65), and aphthous stomatitis (HR = 1.45; 95%CI, 1.22\u20131.72). This study clarified the associations and temporal relationships between cutaneous manifestations and IBD, highlighting the need for interdisciplinary care in the patient with specific dermatologic diseases presenting with abdominal symptoms, or the IBD patients with cutaneous lesions.<\/jats:p>","DOI":"10.3390\/jcm10061311","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T21:17:52Z","timestamp":1616447872000},"page":"1311","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The Temporal Relationships and Associations between Cutaneous Manifestations and Inflammatory Bowel Disease: A Nationwide Population-Based Cohort Study"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1759-7790","authenticated-orcid":false,"given":"Yi-Teng","family":"Hung","sequence":"first","affiliation":[{"name":"Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fuxing St., Guishan Dist., Taoyuan City 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1100-5371","authenticated-orcid":false,"given":"Puo-Hsien","family":"Le","sequence":"additional","affiliation":[{"name":"School of Medicine, Chang Gung University, No. 259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 333, Taiwan"},{"name":"Department of Gastroenterology, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fuxing St., Guishan Dist., Taoyuan City 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Jung","family":"Kuo","sequence":"additional","affiliation":[{"name":"School of Medicine, Chang Gung University, No. 259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 333, Taiwan"},{"name":"Department of Gastroenterology, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fuxing St., Guishan Dist., Taoyuan City 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chuan","family":"Tang","sequence":"additional","affiliation":[{"name":"Center for Artificial Intelligence in Medicine, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fuxing St., Guishan Dist., Taoyuan City 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Jiun","family":"Chiou","sequence":"additional","affiliation":[{"name":"Center for Artificial Intelligence in Medicine, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fuxing St., Guishan Dist., Taoyuan City 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Tang","family":"Chiu","sequence":"additional","affiliation":[{"name":"School of Medicine, Chang Gung University, No. 259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 333, Taiwan"},{"name":"Department of Gastroenterology, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fuxing St., Guishan Dist., Taoyuan City 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Fu","family":"Kuo","sequence":"additional","affiliation":[{"name":"School of Medicine, Chang Gung University, No. 259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 333, Taiwan"},{"name":"Center for Artificial Intelligence in Medicine, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fuxing St., Guishan Dist., Taoyuan City 333, Taiwan"},{"name":"Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fuxing St., Guishan Dist., Taoyuan City 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0574-1839","authenticated-orcid":false,"given":"Yu-Huei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fuxing St., Guishan Dist., Taoyuan City 333, Taiwan"},{"name":"School of Medicine, Chang Gung University, No. 259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.5217\/ir.2018.00096","article-title":"Epidemiological trend in inflammatory bowel disease in Taiwan from 2001 to 2015: A nationwide populationbased study","volume":"17","author":"Yen","year":"2019","journal-title":"Intest. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s12016-017-8617-4","article-title":"Skin Manifestations of Inflammatory Bowel Disease","volume":"53","author":"Greuter","year":"2017","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1097\/MIB.0000000000000429","article-title":"Chronological order of appearance of extraintestinal manifestations relative to the time of IBD diagnosis in the Swiss inflammatory bowel disease cohort","volume":"21","author":"Vavricka","year":"2015","journal-title":"Inflamm. Bowel. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jcma.2016.08.009","article-title":"Gastrointestinal complications and extraintestinal manifestations of inflammatory bowel disease in Taiwan: A population-based study","volume":"80","author":"Hsu","year":"2017","journal-title":"J. Chin. Med. Assoc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1097\/MIB.0000000000000392","article-title":"Extraintestinal manifestations of inflammatory bowel disease","volume":"21","author":"Vavricka","year":"2015","journal-title":"Inflamm. Bowel. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Roth, N., Biedermann, L., Fournier, N., Butter, M., Vavricka, S.R., Navarini, A.A., Rogler, G., Scharl, M., and on behalf of the Swiss IBD Cohort Study Group (2019). Occurrence of skin manifestations in patients of the Swiss Inflammatory Bowel Disease Cohort Study. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0210436"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1365-2133.2010.09894.x","article-title":"The impact of rosacea on quality of life: Effects of demographic and clinical characteristics and various treatment modalities","volume":"163","author":"Aksoy","year":"2010","journal-title":"Br. J. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/ecco-jcc\/jjz152","article-title":"Global prevalence and bidirectional association between psoriasis and inflammatory bowel disease: A systematic review and meta-analysis","volume":"14","author":"Alinaghi","year":"2020","journal-title":"J. Crohns. Colitis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1001\/jamadermatol.2019.0891","article-title":"Association of hidradenitis suppurativa with inflammatory bowel disease: A systematic review and me-ta-analysis","volume":"155","author":"Chen","year":"2019","journal-title":"JAMA Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jaad.2016.08.022","article-title":"Inflammatory bowel disease is associated with an increased risk of inflammatory skin diseases: A population-based cross-sectional study","volume":"76","author":"Kim","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e16448","DOI":"10.1097\/MD.0000000000016448","article-title":"Association of rosacea with inflammatory bowel disease: A MOOSE-compliant meta-analysis","volume":"98","author":"Wang","year":"2019","journal-title":"Medicine"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.jaad.2016.11.065","article-title":"Risk of inflammatory bowel disease in patients with rosacea: Results from a nationwide cohort study in Taiwan","volume":"76","author":"Wu","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_13","first-page":"31","article-title":"Cutaneous manifestations in inflammatory bowel disease (Review)","volume":"20","author":"Ungureanu","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_14","first-page":"235","article-title":"Extraintestinal Manifestations of Inflammatory Bowel Disease","volume":"7","author":"Levine","year":"2011","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4103\/sjmms.sjmms_81_18","article-title":"A review of extraintestinal manifestations and complications of inflammatory bowel disease","volume":"7","author":"Annese","year":"2019","journal-title":"Saudi J. Med. Med. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"500","DOI":"10.2188\/jea.JE20140076","article-title":"Validation of Acute Myocardial Infarction Cases in the National Health Insurance Research Database in Taiwan","volume":"24","author":"Cheng","year":"2014","journal-title":"J. Epidemiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1080\/17474124.2019.1574569","article-title":"Extraintestinal manifestations in inflammatory bowel disease\u2013epidemiology, genetics, and patho-genesis","volume":"13","author":"Greuter","year":"2019","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/ecco-jcc\/jjx158","article-title":"Expression patterns of TNF\u03b1, MAdCAM1, and STAT3 in intestinal and skin manifestations of inflammatory bowel disease","volume":"12","author":"Vavricka","year":"2018","journal-title":"J. Crohns. Colitis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fphys.2012.00013","article-title":"Skin Manifestations of Inflammatory Bowel Disease","volume":"3","author":"Huang","year":"2012","journal-title":"Front. Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.clindermatol.2007.10.018","article-title":"Skin manifestations of inflammatory bowel disease","volume":"26","author":"Timani","year":"2008","journal-title":"Clin. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/MD.0b013e318187cc9c","article-title":"Significance of erythema nodosum and pyoderma gan-grenosum in inflammatory bowel diseases: A cohort study of 2402 patients","volume":"87","author":"Farhi","year":"2008","journal-title":"Medicine"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1093\/ibd\/izy174","article-title":"Pyoderma Gangrenosum: A Review for the Gastroenterologist","volume":"24","author":"Plumptre","year":"2018","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s12328-019-00958-y","article-title":"Current clinical issue of skin lesions in patients with inflammatory bowel disease","volume":"12","author":"Iida","year":"2019","journal-title":"Clin. J. Gastroenterol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Lauritano, D., Boccalari, E., Di Stasio, D., Della Vella, F., Carinci, F., Lucchese, A., and Petruzzi, M. (2019). Prevalence of Oral Lesions and Correlation with Intestinal Symptoms of Inflammatory Bowel Disease: A Systematic Review. Diagnostics, 9.","DOI":"10.3390\/diagnostics9030077"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2147\/PTT.S85194","article-title":"Psoriasis and inflammatory bowel disease: Links and risks","volume":"6","author":"Bassukas","year":"2016","journal-title":"Psoriasis Targets Ther."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1136\/annrheumdis-2018-214273","article-title":"Incidence rates of inflammatory bowel disease in patients with psoriasis, psoriatic arthritis and ankylosing spondylitis treated with secukinumab: A retrospective analysis of pooled data from 21 clinical trials","volume":"78","author":"Schreiber","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00403-017-1775-7","article-title":"Digestive system in psoriasis: An update","volume":"309","author":"Pietrzak","year":"2017","journal-title":"Arch. Dermatol. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/bjd.14930","article-title":"Rosacea and gastrointestinal disorders: A population-based cohort study","volume":"176","author":"Egeberg","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1001\/jamadermatol.2018.0878","article-title":"Overall and subgroup prevalence of Crohn disease among patients with hidradenitis suppu-rativa: A population-based analysis in the United States","volume":"154","author":"Garg","year":"2018","journal-title":"JAMA Dermatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/MIB.0000000000000579","article-title":"Identification of Clinical and Genetic Parameters Associated with Hidradenitis Suppurativa in Inflammatory Bowel Disease","volume":"22","author":"Janse","year":"2016","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4103\/ds.ds_3_20","article-title":"Is there a relationship between rosacea with gut dysbiosis?","volume":"38","author":"Yilmaz","year":"2020","journal-title":"Dermatol. Sin."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jaad.2016.08.031","article-title":"Inflammatory bowel disease is associated with hidradenitis suppurativa: Results from a multicenter cross-sectional study","volume":"76","author":"Deckers","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.jid.2016.11.040","article-title":"Prevalence and Risk of Inflammatory Bowel Disease in Patients with Hidradenitis Suppurativa","volume":"137","author":"Egeberg","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.clinre.2018.09.009","article-title":"The relationship between inflammatory bowel disease and rosacea over the lifespan: A meta-analysis","volume":"43","author":"Han","year":"2019","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/ijd.13932","article-title":"The in-hospital burden of hidradenitis suppurativa in patients with inflammatory bowel disease: A decade nationwide analysis from 2004 to 2014","volume":"57","author":"Timerman","year":"2018","journal-title":"Int. J. Dermatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ijwd.2018.08.009","article-title":"An assessment of the relative impact of hidradenitis suppurativa, psoriasis, and obesity on quality of life","volume":"4","author":"Storer","year":"2018","journal-title":"Int. J. Women\u2019s Dermatol."},{"key":"ref_37","first-page":"784","article-title":"Risk of Lymphoma in Inflammatory Bowel Disease","volume":"5","author":"Siegel","year":"2009","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/jgh.12015","article-title":"Lymphoma and other lymphoproliferative disorders in inflammatory bowel disease: A review","volume":"28","author":"Subramaniam","year":"2013","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_39","first-page":"2050313","article-title":"Cutaneous T-cell lymphoma in the setting of anti-tumor necrosis factor and immunomodulator therapy: A case report and literature review","volume":"8","author":"Dotimas","year":"2020","journal-title":"SAGE Open Med. Case Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/MOG.0000000000000538","article-title":"Diagnosis and treatment of dermatologic diseases in inflammatory bowel disease","volume":"35","author":"Brenner","year":"2019","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/ibd\/izx046","article-title":"Incidence of Colorectal Cancer and Extracolonic Cancers in Veteran Patients with Inflammatory Bowel Disease","volume":"24","author":"Mosher","year":"2018","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/jgh.14041","article-title":"The risk of non-melanoma skin cancer in New Zealand in inflammatory bowel disease patients treated with thiopurines","volume":"33","author":"Bahi","year":"2017","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1111\/jdv.14105","article-title":"Increased non-melanoma skin cancer risk in young patients with inflammatory bowel disease on immunomodulatory therapy: A retrospective single-centre cohort study","volume":"31","author":"Clowry","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_44","first-page":"203","article-title":"Disease-related and drug-induced skin manifestations in inflammatory bowel disease","volume":"11","author":"Hindryckx","year":"2017","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/jgh.14533","article-title":"Risk of skin cancers in thiopurines-treated and thiopu-rines-untreated patients with inflammatory bowel disease: A systematic review and meta-analysis","volume":"34","author":"Huang","year":"2019","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1097\/MIB.0000000000001240","article-title":"Cancer risk in 2621 Chinese patients with inflammatory bowel disease: A population-based cohort study","volume":"23","author":"So","year":"2017","journal-title":"Inflamm. Bowel. Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.jaad.2018.09.025","article-title":"Association between atopic dermatitis and autoimmune disorders in US adults and children: A cross-sectional study","volume":"80","author":"Narla","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jaci.2015.06.029","article-title":"Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes","volume":"137","author":"Schmitt","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1159\/000505290","article-title":"The bidirectional association between inflammatory bowel disease and atopic dermatitis: A systematic review and meta-analysis","volume":"236","author":"Shi","year":"2020","journal-title":"Dermatology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/ecco-jcc\/jjv238","article-title":"Smoking is associated with extra-intestinal manifestations in inflammatory bowel disease","volume":"10","author":"Severs","year":"2015","journal-title":"J. Crohn\u2019s Coliti"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/6\/1311\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:39:27Z","timestamp":1760161167000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/6\/1311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,22]]},"references-count":50,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["jcm10061311"],"URL":"https:\/\/doi.org\/10.3390\/jcm10061311","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,22]]}}}