{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T14:38:25Z","timestamp":1768919905511,"version":"3.49.0"},"reference-count":16,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: Spontaneous pneumomediastinum (PM), pneumothorax (PT), and pneumopericardium (PP) were recently reported as rare complications in patients with severe COVID-19 pneumonia, and our study aims to follow the evolution of these involvements in 11 cases. The presumed pathophysiological mechanism is air leak due to extensive diffuse alveolar damage followed by alveolar rupture. (2) Methods: We followed the occurrence of PM, PN, PP, and subcutaneous emphysema (SE) in 1648 patients hospitalized during the second outbreak of COVID-19 (October 2020\u2013January 2021) in the main hospital of infectious diseases of our county and recorded their demographic data, laboratory investigations and clinical evolution. (3) Results: Eleven patients (0.66%) developed PM, with eight of them having associated PT, one PP, and seven SE, in the absence of mechanical ventilation. Eight patients (72.72%) died and only three (27.27%) survived. All subjects were nonsmokers, without known pulmonary pathology or risk factors for such complications. (4) Conclusions: pneumomediastinum, pneumothorax, and pneumopericardium are not so uncommon complications of SARS-CoV2 pneumonia, being observed mostly in male patients with severe forms and associated with prolonged hospitalization and poor prognosis. In some cases, with mild forms and reduced pulmonary injury, the outcome is favorable, not requiring surgical procedures, mechanical ventilation, or intensive care stay.<\/jats:p>","DOI":"10.3390\/jcm10071346","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T15:42:19Z","timestamp":1616600539000},"page":"1346","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Spontaneous Pneumomediastinum, Pneumothorax, Pneumopericardium and Subcutaneous Emphysema\u2014Not So Uncommon Complications in Patients with COVID-19 Pulmonary Infection\u2014A Series of Cases"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6567-4407","authenticated-orcid":false,"given":"Talida Georgiana","family":"Cut","sequence":"first","affiliation":[{"name":"Department XIII, Discipline of Infectious Diseases, University of Medicine and Pharmacy \u201cVictor Babes\u201d Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7351-741X","authenticated-orcid":false,"given":"Cristina","family":"Tudoran","sequence":"additional","affiliation":[{"name":"Department VII, Internal Medicine II, Discipline of Cardiology, University of Medicine and Pharmacy \u201cVictor Babes\u201d Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania"},{"name":"County Emergency Hospital \u201c Pius Brinzeu\u201d, L. Rebreanu Str., Nr. 156, 300041 Timisoara, Romania"},{"name":"Center of Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine, University of Medicine and Pharmacy \u201cVictor Babes\u201d Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Voichita Elena","family":"Lazureanu","sequence":"additional","affiliation":[{"name":"Department XIII, Discipline of Infectious Diseases, University of Medicine and Pharmacy \u201cVictor Babes\u201d Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelina Raluca","family":"Marinescu","sequence":"additional","affiliation":[{"name":"Department XIII, Discipline of Infectious Diseases, University of Medicine and Pharmacy \u201cVictor Babes\u201d Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1790-8130","authenticated-orcid":false,"given":"Raluca","family":"Dumache","sequence":"additional","affiliation":[{"name":"Department VIII, Discipline of Forensic Medicine, University of Medicine and Pharmacy \u201cVictor Babes\u201d Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Tudoran","sequence":"additional","affiliation":[{"name":"Department VII, Internal Medicine II, Discipline of Cardiology, University of Medicine and Pharmacy \u201cVictor Babes\u201d Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania"},{"name":"County Emergency Hospital \u201c Pius Brinzeu\u201d, L. Rebreanu Str., Nr. 156, 300041 Timisoara, Romania"},{"name":"Center of Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine, University of Medicine and Pharmacy \u201cVictor Babes\u201d Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.hrtlng.2020.09.006","article-title":"Alveolar Air Leakage in COVID-19 Patients: Pneumomediastinum and\/or Pneumopericardium","volume":"49","author":"Hamad","year":"2020","journal-title":"Heart Lung"},{"key":"ref_2","unstructured":"Brito, D.A.M. (2020). COVID-19 Pneumonia Associated With Spontaneous Pneumomediastinum and Pneumopericardium. CTSNET."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Martinelli, A.W., Ingle, T., Newman, J., Nadeem, I., Jackson, K., Lane, N.D., Melhorn, J., Davies, H.E., Rostron, A.J., and Adeni, A. (2020). COVID-19 and Pneumothorax: A Multicentre Retrospective Case Series. Eur. Respir. J., 56.","DOI":"10.1183\/13993003.02697-2020"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e239489","DOI":"10.1136\/bcr-2020-239489","article-title":"Spontaneous Pneumomediastinum, Pneumothorax and Subcutaneous Emphysema in COVID-19 Pneumonia: A Rare Case and Literature Review","volume":"13","author":"Elhakim","year":"2020","journal-title":"BMJ Case Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.arbres.2020.09.013","article-title":"Spontaneous Pneumopericardium and Pneumomediastinum in Twelve COVID-19 Patients","volume":"57","year":"2021","journal-title":"Arch. Bronconeumol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"L\u00f3pez Vega, J.M., Parra Gordo, M.L., Diez Tasc\u00f3n, A., and Ossaba V\u00e9lez, S. (2020). Pneumomediastinum and Spontaneous Pneumothorax as an Extrapulmonary Complication of COVID-19 Disease. Emerg. Radiol., 1\u20134.","DOI":"10.1007\/s10140-020-01806-0"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3348\/kjr.2020.0281","article-title":"Spontaneous Pneumomediastinum: A Probable Unusual Complication of Coronavirus Disease 2019 (COVID-19) Pneumonia","volume":"21","author":"Wang","year":"2020","journal-title":"Korean J. Radiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S1473-3099(20)30156-0","article-title":"COVID-19 with Spontaneous Pneumomediastinum","volume":"20","author":"Zhou","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3348\/kjr.2020.0180","article-title":"Mediastinal Emphysema, Giant Bulla, and Pneumothorax Developed during the Course of COVID-19 Pneumonia","volume":"21","author":"Sun","year":"2020","journal-title":"Korean J. Radiol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Singh, A., Bass, J., and Lindner, D.H. (2021, January 28). Rare Complication of Pneumomediastinum and Pneumopericardium in a Patient with COVID-19 Pneumonia. Available online: https:\/\/www.hindawi.com\/journals\/cripu\/2020\/8845256\/.","DOI":"10.1155\/2020\/8845256"},{"key":"ref_11","first-page":"101265","article-title":"Pneumothorax In Covid-19 Pneumonia: A Case Series","volume":"31","author":"Hameed","year":"2020","journal-title":"Respir. Med. Case Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e236519","DOI":"10.1136\/bcr-2020-236519","article-title":"Spontaneous Pneumomediastinum in COVID-19","volume":"13","author":"Mohan","year":"2020","journal-title":"BMJ Case Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s12931-020-01504-y","article-title":"Pneumothorax in COVID-19 Disease- Incidence and Clinical Characteristics","volume":"21","author":"Zantah","year":"2020","journal-title":"Respir. Res."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Alharthy, A., Bakirova, G.H., Bakheet, H., Balhamar, A., Brindley, P.G., Alqahtani, S.A., Memish, Z.A., and Karakitsos, D. (2020). COVID-19 with Spontaneous Pneumothorax, Pneumomediastinum, and Subcutaneous Emphysema in the Intensive Care Unit: Two Case Reports. J. Infect. Public Health.","DOI":"10.1016\/j.jiph.2020.12.019"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.arbres.2020.06.008","article-title":"Spontaneous Pneumomediastinum in Patients With COVID-19: A Case Series of Four Patients","volume":"56","author":"Gorospe","year":"2020","journal-title":"Arch. Bronconeumol."},{"key":"ref_16","first-page":"101187","article-title":"Pneumothorax in Patients with Prior or Current COVID-19 Pneumonia","volume":"31","author":"Janssen","year":"2020","journal-title":"Respir. Med. Case Rep."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/7\/1346\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:40:30Z","timestamp":1760161230000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/7\/1346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,24]]},"references-count":16,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,4]]}},"alternative-id":["jcm10071346"],"URL":"https:\/\/doi.org\/10.3390\/jcm10071346","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,24]]}}}