{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:45:53Z","timestamp":1760402753423,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T00:00:00Z","timestamp":1617062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: To compare adult patients\u2019 characteristics suffering from idiopathic retroperitoneal fibrosis between \u201crelapse-free\u201d and relapsing patients at the diagnosis and identify factors associated with relapse at initial presentation. Methods: We conducted a retrospective multicentric study in four hospitals in Eastern France, from 1993 to 2020, of adult patients suffering from idiopathic retroperitoneal fibrosis. We analyzed clinical, biological, and radiological features at diagnosis and during a forty-month follow-up. Results: Of 47 patients suffering from retroperitoneal fibrosis, 21 patients had idiopathic retroperitoneal fibrosis. Among them, 13 experienced one or more relapses during follow-up. At diagnosis, clinical characteristics, relevant comorbidities, biological and radiological features were similar between groups. Smoking cessation seems associated with decreased relapse risk (p: 0.0624). A total of 8 patients developed chronic renal failure during follow-up. Ureteral infiltration at diagnosis was associated with evolution to chronic renal failure (p: 0.0091). Conclusion: No clinical, biological, or radiological features could predict relapse at retroperitoneal fibrosis diagnosis, but smoking cessation may prevent relapse.<\/jats:p>","DOI":"10.3390\/jcm10071380","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T03:29:45Z","timestamp":1617074985000},"page":"1380","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Characteristics of Adult Patients with Idiopathic Retroperitoneal Fibrosis and Assessment of Risk of Relapse at Diagnosis"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8453-7224","authenticated-orcid":false,"given":"Jerome","family":"Razanamahery","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology, Dijon University Hospital, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7439-1700","authenticated-orcid":false,"given":"Bastien","family":"Bouldoires","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hopital Pasteur, 68000 Colmar, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0454-0840","authenticated-orcid":false,"given":"Sebastien","family":"Humbert","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Besancon University Hospital, 25000 Besancon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Bielefeld","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 2, Dijon University Hospital, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronique","family":"Fournier","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Trevenans Hospital, 90000 Belfort, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7229-3808","authenticated-orcid":false,"given":"Bernard","family":"Bonnotte","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology, Dijon University Hospital, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Blaison","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hopital Pasteur, 68000 Colmar, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1117-5079","authenticated-orcid":false,"given":"Nadine","family":"Magy-Bertrand","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Besancon University Hospital, 25000 Besancon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0140-6736(06)68035-5","article-title":"Retroperitoneal Fibrosis","volume":"367","author":"Vaglio","year":"2006","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1007\/s10157-019-01759-w","article-title":"Risk Factors for Relapse and Long-Term Outcome of Idiopathic Retroperitoneal Fibrosis","volume":"23","author":"Moriconi","year":"2019","journal-title":"Clin. Exp. Nephrol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/MD.0b013e3181afc439","article-title":"Retroperitoneal Fibrosis: The Clinical, Laboratory, and Radiographic Presentation","volume":"88","author":"Scheel","year":"2009","journal-title":"Medicine (Baltimore)"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s10067-013-2225-3","article-title":"Idiopathic Retroperitoneal Fibrosis: A Clinicopathological Study in 24 Spanish Cases","volume":"32","author":"Detorres","year":"2013","journal-title":"Clin. Rheumatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/MD.0b013e3181afc420","article-title":"Idiopathic Retroperitoneal Fibrosis: Prospective Evaluation of Incidence and Clinicoradiologic Presentation","volume":"88","author":"Jansen","year":"2009","journal-title":"Medicine (Baltimore)"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.amjmed.2003.08.033","article-title":"Immunosuppressive Therapy for Idiopathic Retroperitoneal Fibrosis: A Retrospective Analysis of 26 Cases","volume":"116","author":"Marcolongo","year":"2004","journal-title":"Am. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.eururo.2017.09.024","article-title":"[18F]-Fluorodeoxyglucose Positron Emission Tomography and Response to Therapy in Idiopathic Retroperitoneal Fibrosis","volume":"73","author":"Maritati","year":"2018","journal-title":"Eur. Urol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ejim.2019.01.019","article-title":"Persistent FDG\/PET CT Uptake in Idiopathic Retroperitoneal Fibrosis Helps Identifying Patients at a Higher Risk for Relapse","volume":"62","author":"Morin","year":"2019","journal-title":"Eur. J. Intern. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1148\/radiol.14131565","article-title":"Role of Diffusion-Weighted MR Imaging in the Differentiation of Benign Retroperitoneal Fibrosis from Malignant Neoplasm: Preliminary Study","volume":"272","author":"Bakir","year":"2014","journal-title":"Radiology"},{"key":"ref_10","first-page":"570","article-title":"Idiopathic retroperitoneal fibrosis: A multicentric retrospective study of 30 French cases and follow-up of the renal function","volume":"35","author":"Belenfant","year":"2014","journal-title":"Rev. Med. Internet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S0140-6736(11)60934-3","article-title":"Prednisone versus Tamoxifen in Patients with Idiopathic Retroperitoneal Fibrosis: An Open-Label Randomised Controlled Trial","volume":"378","author":"Vaglio","year":"2011","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/path.1711450205","article-title":"The Distribution of Ceroid in Human Atherosclerosis","volume":"145","author":"Mitchinson","year":"1985","journal-title":"J. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1136\/jcp.47.8.721","article-title":"Cytokine Gene Expression in Aortic Adventitial Inflammation Associated with Advanced Atherosclerosis (Chronic Periaortitis)","volume":"47","author":"Ramshaw","year":"1994","journal-title":"J. Clin. Pathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1002\/art.41024","article-title":"Fibrocytes in Chronic Periaortitis: A Novel Mechanism Linking Inflammation and Fibrosis","volume":"71","author":"Nicastro","year":"2019","journal-title":"Arthritis Rheumatol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Yuan, F., Fu, X., Shi, H., Chen, G., Dong, P., and Zhang, W. (2014). Induction of Murine Macrophage M2 Polarization by Cigarette Smoke Extract via the JAK2\/STAT3 Pathway. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0107063"},{"key":"ref_16","first-page":"e539","article-title":"Cigarette Smoking-Mediated Macrophage Reprogramming: Mechanistic Insights and Therapeutic Implications","volume":"4","author":"Yang","year":"2018","journal-title":"J. Nat. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/ni.1937","article-title":"Macrophage Plasticity and Interaction with Lymphocyte Subsets: Cancer as a Paradigm","volume":"11","author":"Biswas","year":"2010","journal-title":"Nat. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0022-5347(17)43353-2","article-title":"The Occurrence of Vasculitis in Perianeurysmal Fibrosis","volume":"138","author":"Lindell","year":"1987","journal-title":"J. Urol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1136\/annrheumdis-2019-216561","article-title":"The 2019 American College of Rheumatology\/European League Against Rheumatism Classification Criteria for IgG4-Related Disease","volume":"79","author":"Wallace","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e12631","DOI":"10.1097\/MD.0000000000012631","article-title":"Rituximab for Idiopathic and IgG4-Related Retroperitoneal Fibrosis","volume":"97","author":"Wallwork","year":"2018","journal-title":"Medicine (Baltimore)"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/7\/1380\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:55:36Z","timestamp":1760363736000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/7\/1380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,30]]},"references-count":20,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,4]]}},"alternative-id":["jcm10071380"],"URL":"https:\/\/doi.org\/10.3390\/jcm10071380","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2021,3,30]]}}}