{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:20:51Z","timestamp":1762341651535,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T00:00:00Z","timestamp":1617062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Ministry of Science and Technology of Taiwan","award":["MOST 108-2314-B-182 -037 -MY3"],"award-info":[{"award-number":["MOST 108-2314-B-182 -037 -MY3"]}]},{"name":"Chang Gung Memorial Hospital in Taiwan","award":["BMRPA32"],"award-info":[{"award-number":["BMRPA32"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Kawasaki disease (KD) is a systemic vasculitis that primarily affects children under the age of 5 years old. The most significant complication is coronary artery lesions, but several ocular manifestations have also been reported. Recently, one study revealed an increasing incidence of myopia among KD patients. Therefore, the aim of this study was to assess the difference in myopic incidence between Kawasaki disease (KD) patients treated with aspirin and intravenous immunoglobulin (IVIG). Materials and methods: We carried out a nationwide retrospective cohort study by analyzing the data of KD patients (ICD-9-CM code 4461) from Taiwan\u2019s National Health Insurance Research Database (NHIRD) during the period of 1996\u20132013. Results: A total of 14,102 diagnosed KD were found in Taiwan during the study period. After excluded missing data, treatment strategy and age distribution, a total of 1446 KD patients were enrolled for analysis including 53 of which received aspirin (without IVIG) and 1393 of which were treated with IVIG. Patients who had myopia, astigmatism, glaucoma, cataract, etc. prior to their KD diagnosis were excluded. The age range was 0 to 6 years old. According to the cumulative curves, our results demonstrated that the myopic incidence in the IVIG group was significantly lower than the aspirin group (hazard ratio: 0.59, 95% confidence intervals: 0.36~0.96, p = 0.02). Treatment with IVIG for KD patients may have benefit for myopia control. Conclusion: Compared to aspirin, IVIG may decrease the myopic risk in KD patients. However, it needs further investigation including clinical vision survey of myopia due to the limitations of this population-based study.<\/jats:p>","DOI":"10.3390\/jcm10071381","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T03:29:45Z","timestamp":1617074985000},"page":"1381","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Intravenous Immunoglobulin Treatment in Kawasaki Disease Decreases the Incidence of Myopia"],"prefix":"10.3390","volume":"10","author":[{"given":"Hun-Ju","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Ni","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiao-Lun","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 83301, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Lin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 83301, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Chen","family":"Ho","sequence":"additional","affiliation":[{"name":"Kawasaki Disease Center and Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3295-2984","authenticated-orcid":false,"given":"Ho-Chang","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 83301, Taiwan"},{"name":"Kawasaki Disease Center and Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","article-title":"Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050","volume":"123","author":"Holden","year":"2016","journal-title":"Ophthalmology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.survophthal.2017.03.006","article-title":"Myopia among schoolchildren in East Asia and Singapore","volume":"62","author":"Ding","year":"2017","journal-title":"Surv. Ophthalmol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/S0140-6736(12)60272-4","article-title":"Myopia","volume":"379","author":"Morgan","year":"2012","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/bs.pmbts.2015.05.005","article-title":"Scleral Mechanisms Underlying Ocular Growth and Myopia","volume":"134","author":"Metlapally","year":"2015","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ebiom.2016.07.021","article-title":"Role of Chronic Inflammation in Myopia Progression: Clinical Evidence and Experimental Validation","volume":"10","author":"Lin","year":"2016","journal-title":"EBioMedicine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1542\/peds.54.3.271","article-title":"A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan","volume":"54","author":"Kawasaki","year":"1974","journal-title":"Pediatrics"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e927","DOI":"10.1161\/CIR.0000000000000484","article-title":"Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association","volume":"135","author":"McCrindle","year":"2017","journal-title":"Circulation"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bj.2017.04.002","article-title":"Preventing coronary artery lesions in Kawasaki disease","volume":"40","author":"Kuo","year":"2017","journal-title":"Biomed. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2188\/jea.JE20130048","article-title":"Mortality among Japanese with a history of Kawasaki disease: Results at the end of 2009","volume":"23","author":"Nakamura","year":"2013","journal-title":"J. Epidemiol."},{"key":"ref_10","first-page":"287","article-title":"Increasing incidence of Kawasaki disease in Japan: Nationwide survey","volume":"50","author":"Nakamura","year":"2008","journal-title":"Pediatrics Int. Off. J. Jpn. Pediatric Soc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.pedneo.2013.05.011","article-title":"Estimation of the incidence of Kawasaki disease in Taiwan. A comparison of two data sources: Nationwide hospital survey and national health insurance claims","volume":"55","author":"Lue","year":"2014","journal-title":"Pediatrics Neonatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3389\/fped.2019.00121","article-title":"Increased Incidence of Kawasaki Disease in Taiwan in Recent Years: A 15 Years Nationwide Population-Based Cohort Study","volume":"7","author":"Huang","year":"2019","journal-title":"Front. Pediatr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/INF.0b013e3181cf8705","article-title":"Hospitalizations for Kawasaki syndrome among children in the United States, 1997\u20132007","volume":"29","author":"Holman","year":"2010","journal-title":"Pediatric Infect. Dis. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e689","DOI":"10.1542\/peds.2004-1037","article-title":"Treatment of acute Kawasaki disease: Aspirin\u2019s role in the febrile stage revisited","volume":"114","author":"Hsieh","year":"2004","journal-title":"Pediatrics"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/0002-9394(82)90465-2","article-title":"Ocular manifestations of Kawasaki\u2019s disease (mucocutaneous lymph node syndrome)","volume":"93","author":"Ohno","year":"1982","journal-title":"Am. J. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3345\/kjp.2016.59.4.174","article-title":"Usefulness of anterior uveitis as an additional tool for diagnosing incomplete Kawasaki disease","volume":"59","author":"Lee","year":"2016","journal-title":"Korean J. Pediatrics"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2657913","DOI":"10.1155\/2017\/2657913","article-title":"Kawasaki Disease Increases the Incidence of Myopia","volume":"2017","author":"Kung","year":"2017","journal-title":"BioMed Res. Int."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1008\u20131013.e8","DOI":"10.1016\/j.jaci.2008.09.011","article-title":"Elevated granulocyte colony-stimulating factor levels predict treatment failure in patients with Kawasaki disease","volume":"122","author":"Abe","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1017\/S2045796015000840","article-title":"Association of Attention deficit hyperactivity disorder and Kawasaki disease: A nationwide population-based cohort study","volume":"25","author":"Kuo","year":"2016","journal-title":"Epidemiol. Psychiatr. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1755-3768.1983.tb04344.x","article-title":"Is myopia getting more frequent? A cross-sectional study of 1416 Danes aged 16 years+","volume":"61","author":"Fledelius","year":"1983","journal-title":"Acta Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1167\/iovs.05-1153","article-title":"Myopic refractive error in adult Latinos: The Los Angeles Latino Eye Study","volume":"47","author":"Varma","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ebiom.2018.01.024","article-title":"Allergic Conjunctivitis-induced Retinal Inflammation Promotes Myopia Progression","volume":"28","author":"Wei","year":"2018","journal-title":"EBioMedicine"},{"key":"ref_23","first-page":"270","article-title":"Myopia and inflammation","volume":"6","author":"Herbort","year":"2011","journal-title":"J. Ophthalmic Vis. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4103\/0974-9233.58422","article-title":"Inflammatory choroidal neovascularization","volume":"16","author":"Neri","year":"2009","journal-title":"Middle East Afr. J. Ophthalmol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1056\/NEJM198608073150601","article-title":"The treatment of Kawasaki syndrome with intravenous gamma globulin","volume":"315","author":"Newburger","year":"1986","journal-title":"N. Engl. J. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1038\/s41598-019-39652-x","article-title":"Inflammatory cytokines in highly myopic eyes","volume":"9","author":"Yuan","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1203\/PDR.0b013e31819ed68d","article-title":"Infliximab reduces the cytokine-mediated inflammation but does not suppress cellular infiltration of the vessel wall in refractory Kawasaki disease","volume":"65","author":"Hirono","year":"2009","journal-title":"Pediatr. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1001\/archopht.123.7.977","article-title":"Relationship of age, sex, and ethnicity with myopia progression and axial elongation in the correction of myopia evaluation trial","volume":"123","author":"Hyman","year":"2005","journal-title":"Arch. Ophthalmol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.ophtha.2012.11.009","article-title":"Outdoor activity during class recess reduces myopia onset and progression in school children","volume":"120","author":"Wu","year":"2013","journal-title":"Ophthalmology"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/7\/1381\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:55:36Z","timestamp":1760363736000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/7\/1381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,30]]},"references-count":29,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,4]]}},"alternative-id":["jcm10071381"],"URL":"https:\/\/doi.org\/10.3390\/jcm10071381","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2021,3,30]]}}}