{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:03:37Z","timestamp":1779375817212,"version":"3.53.1"},"reference-count":13,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>In this retrospective single-center trial, we analyze 109 consecutive patients (female: 27.5%, median age: 69 years, median left ventricular ejection fraction: 20%) who survived sudden cardiac death (SCD) and needed hemodynamic support from an Impella assist device between 2008 and 2018. Rhythm monitoring is investigated in this population and associations with hospital survival are analyzed. Hospital mortality is high, at 83.5%. Diverse cardiac arrhythmias are frequently registered during Impella treatment. These include atrial fibrillation (AF, 21.1%) and ventricular tachycardia (VT, 18.3%), as well as AV block II\u00b0\/III\u00b0 (AVB, 7.3%), while intermittent asystole (ASY) is the most frequently observed arrhythmia (42.2%). Nevertheless, neither ventricular nor supraventricular tachycardias are associated with patients\u2019 survival. In patients who experience intermittent asystole, a trend towards a fatal outcome is noted (p = 0.06). Conclusions: Mortality is high in these severely sick patients. While cardiac arrhythmias were frequent, they did not predict hospital mortality in this population. The hemodynamic support of the pump seems to counterbalance the adverse effects of these events.<\/jats:p>","DOI":"10.3390\/jcm10071393","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T05:57:18Z","timestamp":1617170238000},"page":"1393","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cardiac Arrhythmias in Survivors of Sudden Cardiac Death Requiring Impella Assist Device Therapy"],"prefix":"10.3390","volume":"10","author":[{"given":"Khaled Q. A.","family":"Abdullah","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hospital Maria Hilf Moenchengladbach, 41063 Moenchengladbach, Germany"},{"name":"Department of Cardiology, University Hospital Aachen, RWTH University Aachen, 52062 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana V.","family":"Roedler","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Maria Hilf Moenchengladbach, 41063 Moenchengladbach, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen","family":"vom Dahl","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Maria Hilf Moenchengladbach, 41063 Moenchengladbach, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istvan","family":"Szendey","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Maria Hilf Moenchengladbach, 41063 Moenchengladbach, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Dimitroulis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Maria Hilf Moenchengladbach, 41063 Moenchengladbach, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Eckardt","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Division of Electrophysiology, University of Muenster, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Topf","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinic II for Internal Medicine, University Hospital Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Ohnewein","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinic II for Internal Medicine, University Hospital Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Fritsch","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinic II for Internal Medicine, University Hospital Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"F\u00f6ttinger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinic II for Internal Medicine, University Hospital Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias C.","family":"Brandt","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinic II for Internal Medicine, University Hospital Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4024-0220","authenticated-orcid":false,"given":"Bernhard","family":"Wernly","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinic II for Internal Medicine, University Hospital Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria"},{"name":"Department of Anesthesiology, Perioperative Medicine and Intensive Care Medicine, Paracelsus Medical University of Salzburg, 5026 Salzburg, Austria"},{"name":"Center for Public Health and Healthcare Research, Paracelsus Medical University of Salzburg, 5026 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas J.","family":"Motloch","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinic II for Internal Medicine, University Hospital Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Larbig","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Aachen, RWTH University Aachen, 52062 Aachen, Germany"},{"name":"Department of Cardiovascular Medicine, Division of Electrophysiology, University of Muenster, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1161\/01.CIR.98.21.2334","article-title":"Sudden cardiac death","volume":"98","author":"Zipes","year":"1998","journal-title":"Circulation"},{"key":"ref_2","unstructured":"European Heart Rhythm Association, Heart Rhythm Society, and Zipes, D.P. (2006). ACC\/AHA\/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: A report of the american college of cardiology\/american heart association task force and the European society of cardiology committee for practice guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death). J. Am. Coll. Cardiol., 48, e247\u2013e346."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ijcard.2016.06.023","article-title":"Retrospective analysis of circulatory support with the Impella CP(R) device in patients with therapy refractory cardiogenic shock","volume":"219","author":"Lackermair","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.athoracsur.2013.07.053","article-title":"The Impella device for acute mechanical circulatory support in patients in cardiogenic shock","volume":"97","author":"Lemaire","year":"2014","journal-title":"Ann. Thorac. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1001\/jama.2020.0254","article-title":"Association of use of an intravascular microaxial left ventricular assist device vs intra-aortic balloon pump with in-hospital mortality and major bleeding among patients with acute myocardial infarction complicated by cardiogenic shock","volume":"323","author":"Dhruva","year":"2020","journal-title":"JAMA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.jvs.2015.03.040","article-title":"Incidence and prognosis of vascular complications after percutaneous placement of left ventricular assist device","volume":"62","author":"Abaunza","year":"2015","journal-title":"J. Vasc. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/europace\/euy110","article-title":"European Heart Rhythm Association (EHRA) consensus document on management of arrhythmias and cardiac electronic devices in the critically ill and post-surgery patient, endorsed by Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS), Cardiac Arrhythmia Society of Southern Africa (CASSA), and Latin American Heart Rhythm Society (LAHRS)","volume":"21","author":"Boriani","year":"2019","journal-title":"Europace"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1093\/europace\/euz163","article-title":"Cardiac arrhythmias in the emergency settings of acute coronary syndrome and revascularization: An European Heart Rhythm Association (EHRA) consensus document, endorsed by the European Association of Percutaneous Cardiovascular Interventions (EAPCI), and European Acute Cardiovascular Care Association (ACCA)","volume":"21","author":"Kalarus","year":"2019","journal-title":"Europace"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e281","DOI":"10.1097\/CCM.0000000000002089","article-title":"Effectiveness of extracorporeal life support for patients with cardiogenic shock due to intractable arrhythmic storm","volume":"45","author":"Flecher","year":"2017","journal-title":"Crit. Care. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"248","DOI":"10.31486\/toj.18.0018","article-title":"Impella-Induced incessant ventricular tachycardia","volume":"19","author":"Kaki","year":"2019","journal-title":"Ochsner J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1097\/CCM.0000000000001166","article-title":"Atrial Fibrillation is an independent predictor of mortality in critically ill patients","volume":"43","author":"Shaver","year":"2015","journal-title":"Crit. Care. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.4022\/jafib.2179","article-title":"The impact of atrial fibrillation on in-hospital outcomes in patients with acute myocardial infarction complicated by cardiogenic shock undergoing coronary revascularization with percutaneous ventricular assist device support","volume":"12","author":"Sonu","year":"2020","journal-title":"J. Atr. Fibrillation"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13054-017-1677-2","article-title":"Early predictors of poor outcome after out-of-hospital cardiac arrest","volume":"21","author":"Martinell","year":"2017","journal-title":"Crit. Care."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/7\/1393\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T14:10:43Z","timestamp":1760364643000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/7\/1393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,31]]},"references-count":13,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,4]]}},"alternative-id":["jcm10071393"],"URL":"https:\/\/doi.org\/10.3390\/jcm10071393","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,31]]}}}