{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:23:36Z","timestamp":1788200616526,"version":"build-2803163510"},"reference-count":60,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T00:00:00Z","timestamp":1617408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016266","name":"Magyar T\u00fcd\u0151gy\u00f3gy\u00e1sz T\u00e1rsas\u00e1g","doi-asserted-by":"publisher","award":["to Andras Bikov, Martina Meszaros and David Laszlo Tarnoki"],"award-info":[{"award-number":["to Andras Bikov, Martina Meszaros and David Laszlo Tarnoki"]}],"id":[{"id":"10.13039\/501100016266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Intermittent hypoxia in obstructive sleep apnoea (OSA) is related to inflammation and metabolic abnormalities. Soluble low-density lipoprotein receptor-related protein-1 (sLRP-1) is involved in anti-inflammatory and metabolic processes. However, its ligand, calreticulin (CALR) promotes pro-inflammatory responses and apoptosis. Our aim was to analyse the levels of these biomarkers in OSA. We recruited 46 patients with OSA and 30 control subjects. Inpatient sleep study was performed and fasting plasma samples were collected. Triglyceride glucose index (TyG) and atherogenic index of plasma (AIP) were calculated. Plasma sLRP-1 levels were significantly lower in the OSA group compared to the controls (1.67 (0.90\u20132.11) mg\/L vs. 1.99 (1.53\u20133.51) mg\/L; p = 0.04) after adjustment for age, gender, BMI and lipid profile. Plasma sLRP-1 concentrations were inversely related to age (r = \u22120.29), BMI (r = \u22120.35), cigarette pack years (r = \u22120.31), LDL-C (r = \u22120.34) and triglyceride levels (r = \u22120.27), TyG (r = \u22120.37) and AIP (r = \u22120.27) as well as to the oxygen desaturation index (ODI, r = \u22120.24; all p &lt; 0.05). BMI (p = 0.01) and ODI (p = 0.04) were independent predictors for low sLRP-1 levels. CALR did not differ significantly between the two groups (0.23 (0.17\u20130.34) ng\/mL vs. 0.24 (0.20\u20130.36) ng\/mL p = 0.76). We detected lower sLRP-1 levels in subjects with OSA which could contribute to metabolic abnormalities associated with this disease.<\/jats:p>","DOI":"10.3390\/jcm10071494","type":"journal-article","created":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T22:03:36Z","timestamp":1617487416000},"page":"1494","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Role of Soluble Low-Density Lipoprotein Receptor-Related Protein-1 in Obstructive Sleep Apnoea"],"prefix":"10.3390","volume":"10","author":[{"given":"Martina","family":"Meszaros","sequence":"first","affiliation":[{"name":"Department of Pulmonology, Semmelweis University, 1083 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laszlo","family":"Kunos","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Semmelweis University, 1083 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5909-3780","authenticated-orcid":false,"given":"Adam Domonkos","family":"Tarnoki","sequence":"additional","affiliation":[{"name":"Medical Imaging Centre, Semmelweis University, 1082 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7001-7647","authenticated-orcid":false,"given":"David Laszlo","family":"Tarnoki","sequence":"additional","affiliation":[{"name":"Medical Imaging Centre, Semmelweis University, 1082 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2444-9040","authenticated-orcid":false,"given":"Zsofia","family":"Lazar","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Semmelweis University, 1083 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8983-740X","authenticated-orcid":false,"given":"Andras","family":"Bikov","sequence":"additional","affiliation":[{"name":"North West Lung Centre, Manchester University NHS Foundation Trust, Manchester M13 9WL, UK"},{"name":"Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester M13 9NT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1378\/chest.12-1652","article-title":"Independent association between nocturnal intermittent hypoxemia and metabolic dyslipidemia","volume":"143","author":"Trzepizur","year":"2013","journal-title":"Chest"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"15015","DOI":"10.1038\/nrdp.2015.15","article-title":"Obstructive sleep apnoea syndrome","volume":"1","author":"Kohler","year":"2015","journal-title":"Nat. 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