{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T15:49:07Z","timestamp":1783784947983,"version":"3.55.0"},"reference-count":79,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Survivors of childhood cancer are at high risk of developing metabolic diseases in adulthood. Recently, several patients developing partial lipodystrophy following hematopoietic stem cell transplantation (HSCT) have been described. In this review, we summarize the cases described so far and discuss potential underlying mechanisms of the disease. The findings suggest that HSCT-associated lipodystrophies may be seen as a novel form of acquired lipodystrophy.<\/jats:p>","DOI":"10.3390\/jcm10081559","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T11:58:45Z","timestamp":1617883125000},"page":"1559","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Lipodystrophy as a Late Effect after Stem Cell Transplantation"],"prefix":"10.3390","volume":"10","author":[{"given":"Daniel","family":"Tews","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, 89075 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, 89075 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Denzer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, 89075 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"von Schnurbein","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, 89075 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0701-642X","authenticated-orcid":false,"given":"Giovanni","family":"Ceccarini","sequence":"additional","affiliation":[{"name":"Obesity and Lipodystrophy Center at the Endocrine Unit, University Hospital of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus-Michael","family":"Debatin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, 89075 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6795-8430","authenticated-orcid":false,"given":"Martin","family":"Wabitsch","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, 89075 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nrendo.2016.45","article-title":"Late endocrine effects of childhood cancer","volume":"12","author":"Rose","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_2","first-page":"65","article-title":"Endocrine late effects of childhood cancer therapy: A report from the children\u2019s oncology group","volume":"69","author":"Nandagopal","year":"2008","journal-title":"Horm. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1053\/j.seminhematol.2011.10.010","article-title":"Endocrine complications in long-term survivors after allogeneic stem cell transplant","volume":"49","author":"Gunasekaran","year":"2012","journal-title":"Semin. Hematol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Orio, F., Muscogiuri, G., Palomba, S., Serio, B., Sessa, M., Giudice, V., Ferrara, I., Tauchmanov\u00e0, L., Colao, A., and Selleri, C. (2014). Endocrinopathies after allogeneic and autologous transplantation of hematopoietic stem cells. Sci. World J., 2014.","DOI":"10.1155\/2014\/282147"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0140-6736(00)02717-3","article-title":"Impaired glucose tolerance and dyslipidaemia as late effects after bone-marrow transplantation in childhood","volume":"356","author":"Taskinen","year":"2000","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/bmt.2010.144","article-title":"High incidence of fatty liver and insulin resistance in long-term adult survivors of childhood SCT","volume":"46","author":"Tomita","year":"2011","journal-title":"Bone Marrow Transplant."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4158\/EP12115.OR","article-title":"Severe Insulin Resistance and Hypertriglyceridemia after Childhood Total Body Irradiation","volume":"19","author":"Mayson","year":"2013","journal-title":"Endocr. Pract."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1182\/blood-2006-05-022335","article-title":"Diabetes, hypertension, and cardiovascular events in survivors of hematopoietic cell transplantation: A report from the bone marrow transplantation survivor study","volume":"109","author":"Baker","year":"2007","journal-title":"Blood"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/dme.12234","article-title":"Late effects of childhood cancer treatment: Severe hypertriglyceridaemia, central obesity, non alcoholic fatty liver disease and diabetes as complications of childhood total body irradiation","volume":"30","author":"Rajendran","year":"2013","journal-title":"Diabet. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1001\/archinternmed.2009.209","article-title":"Diabetes mellitus in long-term survivors of childhood cancer - Increased risk associated with radiation therapy: A report for the childhood cancer survivor study","volume":"169","author":"Meacham","year":"2009","journal-title":"Arch. Intern. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1210\/jc.2006-0128","article-title":"Hyperinsulinemia, impaired glucose tolerance, and diabetes mellitus in survivors of childhood cancer: Prevalence and risk factors","volume":"91","author":"Neville","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1002\/1873-3468.13430","article-title":"A new mouse model for noninvasive fluorescence-based monitoring of mitochondrial UCP 1 expression","volume":"593","author":"Kawarasaki","year":"2019","journal-title":"FEBS Lett."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1002\/pbc.25601","article-title":"Reduced insulin sensitivity in childhood survivors of haematopoietic stem cell transplantation is associated with lipodystropic and sarcopenic phenotypes","volume":"62","author":"Wei","year":"2015","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1210\/jc.2016-2466","article-title":"The Diagnosis and Management of Lipodystrophy Syndromes: A Multi-Society Practice Guideline","volume":"101","author":"Brown","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/emmm.200900037","article-title":"Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC","volume":"1","author":"Puri","year":"2009","journal-title":"EMBO Mol. Med."},{"key":"ref_16","first-page":"1","article-title":"European lipodystrophy registry: Background and structure","volume":"15","author":"Adams","year":"2020","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/cen.13311","article-title":"Spectrum of disease associated with partial lipodystrophy: Lessons from a trial cohort","volume":"86","author":"Ajluni","year":"2017","journal-title":"Clin. Endocrinol. (Oxf)."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1297\/cpe.22.53","article-title":"Abnormal adipose tissue distribution with unfavorable metabolic profile in five children following hematopoietic stem cell transplantation: A new etiology for acquired partial lipodystrophy","volume":"22","author":"Adachi","year":"2013","journal-title":"Clin. Pediatr. Endocrinol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1297\/cpe.26.99","article-title":"Partial lipodystrophy in patients who have undergone hematopoietic stem cell transplantation during childhood: An institutional cross-sectional survey","volume":"26","author":"Adachi","year":"2017","journal-title":"Clin. Pediatr. Endocrinol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1007\/s40618-017-0731-x","article-title":"Acquired partial lipodystrophy after bone marrow transplant during childhood: A novel syndrome to be added to the disease classification list","volume":"40","author":"Ceccarini","year":"2017","journal-title":"J. Endocrinol. Invest."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/j.1464-5491.2006.01855.x","article-title":"Diabetes with partial lipodystrophy following sclerodermatous chronic graft vs. host disease","volume":"23","author":"Rooney","year":"2006","journal-title":"Diabet. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/pbc.26427","article-title":"Temporary resolution of insulin requirement in acquired partial lipodystrophy associated with chronic graft-versus-host disease","volume":"64","author":"Kimura","year":"2017","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1515\/jpem-2018-0356","article-title":"Acquired partial lipodystrophy with metabolic disease in children following hematopoietic stem cell transplantation: A report of two cases and a review of the literature","volume":"32","author":"Hosokawa","year":"2019","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13256-018-1901-y","article-title":"Acquired partial lipoatrophy as graft-versus-host disease and treatment with metreleptin: Two case reports","volume":"12","author":"Shibata","year":"2018","journal-title":"J. Med. Case Rep."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Adachi, M., Muroya, K., Hanakawa, J., and Asakura, Y. (2020). Metreleptin worked in a diabetic woman with a history of hematopoietic stem cell transplantation (HSCT) during infancy: Further support for the concept of \u2018HSCT-associated lipodystrophy\u2019. Endocr. J.","DOI":"10.1507\/endocrj.EJ20-0325"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1007\/s11764-020-00871-1","article-title":"Body composition after allogeneic haematopoietic cell transplantation\/total body irradiation in children and young people: A restricted systematic review","volume":"14","author":"Lorenc","year":"2020","journal-title":"J. Cancer Surviv."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1210\/jcem.87.5.8624","article-title":"Serum Adiponectin and Leptin Levels in Patients with Lipodystrophies","volume":"87","author":"Haque","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1007\/s00125-005-0038-x","article-title":"Adipokines and the insulin resistance syndrome in familial partial lipodystrophy caused by a mutation in lamin A\/C","volume":"48","author":"Wong","year":"2005","journal-title":"Diabetologia"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1210\/er.2018-00092","article-title":"Long-Term Endocrine and Metabolic Consequences of Cancer Treatment: A Systematic Review","volume":"40","author":"Gebauer","year":"2018","journal-title":"Endocr. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/0026-0495(95)90004-7","article-title":"Growth hormone-deficient adults are insulin-resistant","volume":"44","author":"Johansson","year":"1995","journal-title":"Metabolism"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e387","DOI":"10.1542\/peds.2007-0575","article-title":"Monitoring for cardiovascular disease in survivors of childhood cancer: Report from the cardiovascular disease task force of the children\u2019s oncology group","volume":"121","author":"Shankar","year":"2008","journal-title":"Pediatrics"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/annonc\/mdq200","article-title":"Cardiotoxicity of chemotherapeutic agents and radiotherapy-related heart disease: ESMO clinical practice guidelines","volume":"21","author":"Bovelli","year":"2010","journal-title":"Ann. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1136\/archdischild-2013-305452","article-title":"Long-term follow-up of survivors of childhood cancer (SIGN Clinical Guideline 132)","volume":"99","author":"Gan","year":"2014","journal-title":"Arch. Dis. Child. - Educ. Pract. Ed."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/bmt.2016.203","article-title":"Metabolic syndrome and cardiovascular disease following hematopoietic cell transplantation: Screening and preventive practice recommendations from CIBMTR and EBMT","volume":"52","author":"DeFilipp","year":"2017","journal-title":"Bone Marrow Transplant."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.bbmt.2016.01.023","article-title":"Late Effects Surveillance Recommendations among Survivors of Childhood Hematopoietic Cell Transplantation: A Children\u2019s Oncology Group Report","volume":"22","author":"Chow","year":"2016","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/pbc.28687","article-title":"Combined resistance and aerobic exercise intervention improves fitness, insulin resistance and quality of life in survivors of childhood haemopoietic stem cell transplantation with total body irradiation","volume":"67","author":"Davis","year":"2020","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s40265-013-0074-7","article-title":"Metreleptin: First global approval","volume":"73","author":"Chou","year":"2013","journal-title":"Drugs"},{"key":"ref_38","unstructured":"(2021, February 01). Myalepta | European Medicines Agency. Available online: https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/myalepta."},{"key":"ref_39","unstructured":"(2021, February 01). NICE Metreleptin for treating lipodystrophy. Available online: https:\/\/www.nice.org.uk\/guidance\/hst14."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.stem.2008.07.003","article-title":"A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs","volume":"3","author":"Crisan","year":"2008","journal-title":"Cell Stem Cell"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nature06902","article-title":"Dynamics of fat cell turnover in humans","volume":"453","author":"Spalding","year":"2008","journal-title":"Nature"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Shreder, K., Rapp, F., Tsoukala, I., Rzeznik, V., Wabitsch, M., Fischer-Posovszky, P., and Fournier, C. (2018). Impact of x-ray exposure on the proliferation and differentiation of human pre-adipocytes. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092717"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2353\/ajpath.2009.080505","article-title":"Adipose tissue sensitivity to radiation exposure","volume":"174","author":"Poglio","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1038\/oby.2007.170","article-title":"Reduced adiposity in ob\/ob mice following total body irradiation and bone marrow transplantation","volume":"15","author":"Ablamunits","year":"2007","journal-title":"Obesity"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1056\/NEJMra1609337","article-title":"Acute Graft-versus-Host Disease\u2014Biologic Process, Prevention, and Therapy","volume":"377","author":"Zeiser","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1038\/s41409-018-0204-7","article-title":"EBMT\u2212NIH\u2212CIBMTR Task Force position statement on standardized terminology & guidance for graft-versus-host disease assessment","volume":"53","author":"Schoemans","year":"2018","journal-title":"Bone Marrow Transplant."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/rheumatology\/keg025","article-title":"Polymyositis as a manifestation of chronic graft-versus-host disease","volume":"42","author":"Stevens","year":"2003","journal-title":"Rheumatology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4919","DOI":"10.1182\/blood-2008-10-161638","article-title":"The role of B cells in the pathogenesis of graft-versus-host disease","volume":"114","author":"Hallek","year":"2009","journal-title":"Blood"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/01.md.0000111061.69212.59","article-title":"Clinical Features and Metabolic and Autoimmune Derangements in Acquired Partial Lipodystrophy: Report of 35 Cases and Review of the Literature","volume":"83","author":"Misra","year":"2004","journal-title":"Medicine (Baltimore)"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/DAD.0000000000000721","article-title":"Lipophagic Panniculitis of Childhood: A Case Report and Comprehensive Review of the Literature","volume":"39","author":"Levy","year":"2017","journal-title":"Am. J. Dermatopathol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2018.02142","article-title":"Autoantibodies against perilipin 1 as a cause of acquired generalized lipodystrophy","volume":"9","author":"Corvillo","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13023-019-1292-1","article-title":"Immunological features of patients affected by Barraquer-Simons syndrome","volume":"15","author":"Corvillo","year":"2020","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1210\/jc.2005-0737","article-title":"Role of {CD}95-mediated adipocyte loss in autoimmune lipodystrophy","volume":"91","author":"Hebestreit","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1002\/pbc.24960","article-title":"Predictors of being overweight or obese in survivors of pediatric acute lymphoblastic leukemia (ALL)","volume":"61","author":"Zhang","year":"2014","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/386413","article-title":"Increased Body Mass Index during Therapy for Childhood Acute Lymphoblastic Leukemia: A Significant and Underestimated Complication","volume":"2015","author":"Atkinson","year":"2015","journal-title":"Int. J. Pediatr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1002\/pbc.25519","article-title":"Growth patterns during and after treatment in patients with pediatric ALL: A meta-analysis","volume":"62","author":"Zhang","year":"2015","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/pbc.25316","article-title":"Weight change during childhood acute lymphoblastic leukemia induction therapy predicts obesity: A report from the children\u2019s oncology group","volume":"62","author":"Withycombe","year":"2015","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1210\/jcem.86.8.7764","article-title":"Effect of Glucocorticoid Therapy on Energy Intake in Children Treated for Acute Lymphoblastic Leukemia","volume":"86","author":"Reilly","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e704","DOI":"10.1542\/peds.2013-3332","article-title":"Obesity in pediatric ALL survivors: A meta-analysis","volume":"133","author":"Zhang","year":"2014","journal-title":"Pediatrics"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1002\/cncr.29153","article-title":"Genetic and clinical factors associated with obesity among adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort","volume":"121","author":"Wilson","year":"2015","journal-title":"Cancer"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"139","DOI":"10.32527\/2018\/101373","article-title":"Glucocorticoid Receptor and Adipocyte Biology","volume":"5","author":"Lee","year":"2018","journal-title":"Nucl. Recept. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1172\/JCI114345","article-title":"Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium","volume":"84","author":"Hauner","year":"1989","journal-title":"J. Clin. Invest."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1210\/en.2018-00118","article-title":"Glucocorticoid Receptor Signaling Is Not Required for in Vivo Adipogenesis","volume":"159","author":"Bauerle","year":"2018","journal-title":"Endocrinology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.cmet.2015.06.011","article-title":"Transplanted bone marrow-derived cells contribute to human adipogenesis","volume":"22","author":"Uzunel","year":"2015","journal-title":"Cell Metab."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1096\/fj.15-278994","article-title":"De novo generation of adipocytes from circulating progenitor cells in mouse and human adipose tissue","volume":"30","author":"Gavin","year":"2016","journal-title":"FASEB J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/bs.pmbts.2015.06.016","article-title":"Exercise and the Regulation of Adipose Tissue Metabolism","volume":"135","author":"Tsiloulis","year":"2015","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cmet.2013.10.003","article-title":"Weighing in on adipocyte precursors","volume":"19","author":"Berry","year":"2014","journal-title":"Cell Metab."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.celrep.2019.04.010","article-title":"Identification of Metabolically Distinct Adipocyte Progenitor Cells in Human Adipose Tissues","volume":"27","author":"Raajendiran","year":"2019","journal-title":"Cell Rep."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/ncb3122","article-title":"Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity","volume":"17","author":"Jeffery","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.celrep.2014.09.049","article-title":"Independent stem cell lineages regulate adipose organogenesis and adipose homeostasis","volume":"9","author":"Jiang","year":"2014","journal-title":"Cell Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/734731","article-title":"Stem Cells and Regenerative Medicine: Myth or Reality of the 21th Century","volume":"2015","author":"Stoltz","year":"2015","journal-title":"Stem Cells Int."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0002-9440(10)63203-8","article-title":"Epithelial Tissue Chimerism after Human Hematopoietic Cell Transplantation Is a Real Phenomenon","volume":"164","author":"Spyridonidis","year":"2004","journal-title":"Am. J. Pathol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/S0140-6736(03)12894-2","article-title":"Differentiation of human bone marrow-derived cells into buccal epithelial cells in vivo: A molecular analytical study","volume":"361","author":"Tran","year":"2003","journal-title":"Lancet"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4161\/chim.15276","article-title":"DNA chimerism and its consequences after allogeneic hematopoietic cell transplantation","volume":"2","author":"Themeli","year":"2011","journal-title":"Chimerism"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1096\/fj.04-2604rev","article-title":"Hematopoietic stem cell trafficking in liver injury","volume":"19","author":"Dalakas","year":"2005","journal-title":"FASEB J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1111\/jcmm.12227","article-title":"The peripheral chimerism of bone marrow-derived stem cells after transplantation: Regeneration of gastrointestinal tissues in lethally irradiated mice","volume":"18","author":"Filip","year":"2014","journal-title":"J. Cell. Mol. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.1172\/JCI28510","article-title":"Rosiglitazone promotes development of a novel adipocyte population from bone marrow\u2013derived circulating progenitor cells","volume":"116","author":"Crossno","year":"2006","journal-title":"J. Clin. Invest."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"14781","DOI":"10.1073\/pnas.1003512107","article-title":"De novo generation of white adipocytes from the myeloid lineage via mesenchymal intermediates is age, adipose depot, and gender specific","volume":"107","author":"Majka","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1634\/stemcells.2007-0567","article-title":"Characterization of transplanted GFP+ bone marrow cells into adipose tissue","volume":"26","author":"Tomiyama","year":"2008","journal-title":"Stem Cells"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/8\/1559\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:58:50Z","timestamp":1760363930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/8\/1559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,8]]},"references-count":79,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,4]]}},"alternative-id":["jcm10081559"],"URL":"https:\/\/doi.org\/10.3390\/jcm10081559","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,8]]}}}