{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T14:22:25Z","timestamp":1769610145698,"version":"3.49.0"},"reference-count":41,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015051","name":"Fundaci\u00f3n Dexeus Mujer","doi-asserted-by":"publisher","award":["\"Medicina Materno-Fetal 2019\""],"award-info":[{"award-number":["\"Medicina Materno-Fetal 2019\""]}],"id":[{"id":"10.13039\/501100015051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003176","name":"Ministerio de Educaci\u00f3n, Cultura y Deporte","doi-asserted-by":"publisher","award":["FPU15\/03548"],"award-info":[{"award-number":["FPU15\/03548"]}],"id":[{"id":"10.13039\/501100003176","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["Centro de Excelencia Severo Ochoa 2019-2023, CEX2018-000806-S"],"award-info":[{"award-number":["Centro de Excelencia Severo Ochoa 2019-2023, CEX2018-000806-S"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["CERCA Program"],"award-info":[{"award-number":["CERCA Program"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Sub-Saharan Africa concentrates the burden of HIV and the highest adolescent fertility rates. However, there is limited information about the impact of the interaction between adolescence and HIV infection on maternal health in the region. Data collected prospectively from three clinical trials conducted between 2003 and 2014 were analysed to evaluate the association between age, HIV infection, and their interaction, with the risk of maternal morbidity and adverse pregnancy and perinatal outcomes in women from southern Mozambique. Logistic regression and negative binomial models were used. A total of 2352 women were included in the analyses; 31% were adolescents (\u226419 years) and 29% HIV-infected women. The effect of age on maternal morbidity and pregnancy and perinatal adverse outcomes was not modified by HIV status. Adolescence was associated with an increased incidence of hospital admissions (IRR 0.55, 95%CI 0.37\u20130.80 for women 20\u201324 years; IRR 0.60, 95%CI 0.42\u20130.85 for women &gt;25 years compared to adolescents; p-value &lt; 0.01) and outpatient visits (IRR 0.86, 95%CI 0.71\u20131.04; IRR 0.76, 95%CI 0.63\u20130.92; p-value = 0.02), and an increased likelihood of having a small-for-gestational age newborn (OR 0.50, 95%CI 0.38\u20130.65; OR 0.43, 95%CI 0.34\u20130.56; p-value &lt; 0.001), a low birthweight (OR 0.40, 95%CI 0.27\u20130.59; OR 0.37, 95%CI 0.26\u20130.53; p-value &lt;0.001) and a premature birth (OR 0.42, 95%CI 0.24\u20130.72; OR 0.51, 95%CI 0.32\u20130.82; p-value &lt; 0.01). Adolescence was associated with an increased risk of poor morbidity, pregnancy and perinatal outcomes, irrespective of HIV infection. In addition to provision of a specific maternity care package for this vulnerable group interventions are imperative to prevent adolescent pregnancy.<\/jats:p>","DOI":"10.3390\/jcm10081564","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T11:58:45Z","timestamp":1617883125000},"page":"1564","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Adolescent, Pregnant, and HIV-Infected: Risk of Adverse Pregnancy and Perinatal Outcomes in Young Women from Southern Mozambique"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9840-7559","authenticated-orcid":false,"given":"Clara","family":"Pons-Duran","sequence":"first","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic-Universitat de Barcelona, 08036 Barcelona, Spain"},{"name":"Consorcio de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aina","family":"Casellas","sequence":"additional","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic-Universitat de Barcelona, 08036 Barcelona, Spain"},{"name":"Departament de Fonaments Cl\u00ednics, Facultat de Medicina, Universitat de Barcelona (UB), Casanova 143, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azucena","family":"Bardaj\u00ed","sequence":"additional","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic-Universitat de Barcelona, 08036 Barcelona, Spain"},{"name":"Consorcio de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), 28029 Madrid, Spain"},{"name":"Manhi\u00e7a Health Research Center (CISM), Manhi\u00e7a 1929, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anifa","family":"Val\u00e1","sequence":"additional","affiliation":[{"name":"Manhi\u00e7a Health Research Center (CISM), Manhi\u00e7a 1929, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9025-4052","authenticated-orcid":false,"given":"Esperan\u00e7a","family":"Sevene","sequence":"additional","affiliation":[{"name":"Manhi\u00e7a Health Research Center (CISM), Manhi\u00e7a 1929, Mozambique"},{"name":"Department of Physiological Science, Clinical Pharmacology, Faculty of Medicine, Eduardo Mondlane University, Maputo 3453, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9992-6951","authenticated-orcid":false,"given":"Lloren\u00e7","family":"Quint\u00f3","sequence":"additional","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic-Universitat de Barcelona, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eusebio","family":"Macete","sequence":"additional","affiliation":[{"name":"Manhi\u00e7a Health Research Center (CISM), Manhi\u00e7a 1929, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Men\u00e9ndez","sequence":"additional","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic-Universitat de Barcelona, 08036 Barcelona, Spain"},{"name":"Consorcio de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), 28029 Madrid, Spain"},{"name":"Manhi\u00e7a Health Research Center (CISM), Manhi\u00e7a 1929, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic-Universitat de Barcelona, 08036 Barcelona, Spain"},{"name":"Consorcio de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), 28029 Madrid, Spain"},{"name":"Manhi\u00e7a Health Research Center (CISM), Manhi\u00e7a 1929, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,8]]},"reference":[{"key":"ref_1","unstructured":"Darroch, J.E., Woog, V., Bankoleand, A., and Ashford, L.S. (2020, December 24). Adding It Up: Costs and Benefits of Meeting the Contraceptive Needs of Adolescents. Available online: https:\/\/www.guttmacher.org\/report\/adding-it-meeting-contraceptive-needs-of-adolescents."},{"key":"ref_2","unstructured":"World Health Organization (2021, February 04). Adolescents: Health Risks and Solutions. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/adolescents-health-risks-and-solutions."},{"key":"ref_3","unstructured":"United Nations (2020, December 24). The Global Strategy for Women\u2019s, Children\u2019s and Adolescents\u2019 Health (2016\u20132030). Available online: https:\/\/www.who.int\/life-course\/partners\/global-strategy\/globalstrategyreport2016-2030-lowres.pdf."},{"key":"ref_4","unstructured":"WHO (2020, December 24). Core Competencies in Adolescent Health and Development for Primary Care Providers: Including a Tool to Assess the Adolescent Health And Development Component in Pre-Service Education of Health-Care Providers. Available online: https:\/\/www.who.int\/maternal_child_adolescent\/documents\/core_competencies\/en\/."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/1471-0528.12630","article-title":"Pregnancy and childbirth outcomes among adolescent mothers: A World Health Organization multicountry study","volume":"121","author":"Ganchimeg","year":"2014","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1111\/1471-0528.12391","article-title":"Maternal and perinatal outcomes among nulliparous adolescents in low- and mid-dle-income countries: A multi-country study","volume":"120","author":"Ganchimeg","year":"2013","journal-title":"BJOG"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Kozuki, N., Lee, A.C.C., Silveira, M.F., Sania, A., Vogel, J.P., Adair, L., Barros, F., Caulfield, L.E., Christian, P., and Fawzi, W. (2013). The associations of parity and maternal age with small-for-gestational-age, preterm, and neonatal and infant mortality: A meta-analysis. BMC Public Health, 13.","DOI":"10.1186\/1471-2458-13-S3-S2"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e011783","DOI":"10.1136\/bmjopen-2016-011783","article-title":"Young adolescent girls are at high risk for adverse pregnancy outcomes in sub-Saharan Africa: An observational multicountry study","volume":"6","author":"Mackanga","year":"2016","journal-title":"BMJ Open"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Gr\u00f8nvik, T., and Sand\u00f8y, I.F. (2018). Complications associated with adolescent childbearing in Sub-Saharan Africa: A systematic literature review and meta-analysis. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0204327"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/ije\/dyl284","article-title":"Teenage pregnancy and adverse birth outcomes: A large population based retro-spective cohort study","volume":"36","author":"Chen","year":"2007","journal-title":"Int. J. Epidemiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1056\/NEJM199504273321701","article-title":"Association of Young Maternal Age with Adverse Reproductive Outcomes","volume":"332","author":"Fraser","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"ref_12","unstructured":"UNAIDS (2020, December 24). AIDSinfo. Available online: https:\/\/aidsinfo.unaids.org\/."},{"key":"ref_13","unstructured":"UNAIDS (2020, December 24). Start Free Stay Free AIDS Free. Available online: https:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/20190722_UNAIDS_SFSFAF_2019_en.pdf."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"21858","DOI":"10.7448\/IAS.20.1.21858","article-title":"Pregnant adolescents living with HIV: What we know, what we need to know, where we need to go","volume":"20","author":"Callahan","year":"2017","journal-title":"J. Int. AIDS Soc."},{"key":"ref_15","unstructured":"WHO (2016). Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection: Rec-Ommendations for a Public Health Approach, WHO."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1093\/abm\/kaaa005","article-title":"PMTCT Adherence in Pregnant South African Women: The Role of Depression, Social Support, Stigma, and Structural Barriers to Care","volume":"54","author":"Psaros","year":"2020","journal-title":"Ann. Behav. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.11604\/pamj.2020.35.49.20078","article-title":"Adherence to antiretroviral therapy among HIV infected pregnant women in public health sectors: A pilot of Chilenje level one Hospital Lusaka, Zambia","volume":"35","author":"Mukosha","year":"2020","journal-title":"Pan Afr. Med. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"874","DOI":"10.7196\/SAMJ.8207","article-title":"Adolescent and young pregnant women at increased risk of mother-to-child transmission of HIV and poorer maternal and infant health outcomes: A cohort study at public facilities in the Nelson Mandela Bay Metropolitan district, Eastern Cape, South Africa","volume":"104","author":"Fatti","year":"2014","journal-title":"S. Afr. Med. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/QAI.0000000000001176","article-title":"Gaps in Adolescent Engagement in Antenatal Care and Prevention of Moth-er-to-Child HIV Transmission Services in Kenya","volume":"74","author":"Ronen","year":"2017","journal-title":"J. Acquir. Immune Defic. Synd."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jadohealth.2017.10.007","article-title":"Adolescent Access to Care and Risk of Early Mother-to-Child HIV Transmission","volume":"62","author":"Ramraj","year":"2018","journal-title":"J. Adolesc. Health"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e25155","DOI":"10.1002\/jia2.25155","article-title":"Addressing the unique needs of adolescent mothers in the fight against HIV","volume":"21","author":"Groves","year":"2018","journal-title":"J. Int. AIDS Soc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1080\/17441692.2020.1775867","article-title":"Adolescent mothers affected by HIV and their children: A scoping review of evidence and experiences from sub-Saharan Africa","volume":"15","author":"Toska","year":"2020","journal-title":"Glob. Public Health"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Men\u00e9ndez, C., Bardaj\u00ed, A., Sigauque, B., Romagosa, C., Sanz, S., Serra-Casas, E., Macete, E., Berenguera, A., David, C., and Doba\u00f1o, C. (2008). A Randomized Placebo-Controlled Trial of Intermittent Preventive Treatment in Pregnant Women in the Context of Insecticide Treated Nets Delivered through the Antenatal Clinic. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0001934"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez, R., Mombo-Ngoma, G., Ouedraogo, S., Kakolwa, M.A., Abdulla, S., Accrombessi, M., Aponte, J.J., Akerey-Diop, D., Basra, A., and Briand, V. (2014). Intermittent Preventive Treatment of Malaria in Pregnancy with Mefloquine in HIV-Negative Women: A Multicentre Randomized Controlled Trial. PLoS Med., 11.","DOI":"10.1371\/journal.pmed.1001733"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez, R., Desai, M., Macete, E., Ouma, P., Kakolwa, M.A., Abdulla, S., Aponte, J.J., Bulo, H., Kabanywanyi, A.M., and Katana, A. (2014). Intermittent Preventive Treatment of Malaria in Pregnancy with Mefloquine in HIV-Infected Women Receiving Cotrimoxazole Prophylaxis: A Multicenter Randomized Placebo-Controlled Trial. PLoS Med., 11.","DOI":"10.1371\/journal.pmed.1001735"},{"key":"ref_26","unstructured":"WHO (2021, February 04). Adolescent Pregnancy. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/adolescent-pregnancy."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1093\/ije\/dyt148","article-title":"Profile: Manhica Health Research Centre (Manhica HDSS)","volume":"42","author":"Sacoor","year":"2012","journal-title":"Int. J. Epidemiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/j.1468-1293.2012.01018.x","article-title":"High HIV prevalence in a southern semi-rural area of Mozambique: A community-based survey","volume":"13","author":"Munguambe","year":"2012","journal-title":"HIV Med."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez, R., Augusto, O.J., Munguambe, K., Pierrat, C., Pedro, E.N., Sacoor, C., De Lazzari, E., Aponte, J.J., Macete, E., and Alonso, P.L. (2015). HIV Incidence and Spatial Clustering in a Rural Area of Southern Mozambique. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0132053"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/biomet\/80.1.27","article-title":"Bias reduction of maximum likelihood estimates","volume":"80","author":"Firth","year":"1993","journal-title":"Biometrika"},{"key":"ref_31","unstructured":"StataCorp (2019). Stata Statistical Software: Release 16, StataCorp LLC."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/j.1468-1293.2008.00626.x","article-title":"Mother-to-child transmission of HIV-1: Association with malaria prevention, anaemia and placental malaria","volume":"9","author":"Naniche","year":"2008","journal-title":"HIV Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/QAI.0b013e31802ea4b0","article-title":"Pregnancy Outcomes in HIV-Infected and Uninfected Women in Rural and Urban South Africa","volume":"44","author":"Rollins","year":"2007","journal-title":"JAIDS J. Acquir. Immune Defic. Syndr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1097\/QAD.0000000000002222","article-title":"Perinatal outcomes associated with maternal HIV and an-tiretroviral therapy in pregnancies with accurate gestational age in South Africa","volume":"33","author":"Santosa","year":"2019","journal-title":"AIDS"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Xiao, P.-L., Zhou, Y.-B., Chen, Y., Yang, M.-X., Song, X.-X., Shi, Y., and Jiang, Q.-W. (2015). Association between maternal HIV infection and low birth weight and prematurity: A meta-analysis of cohort studies. BMC Pregnancy Childbirth, 15.","DOI":"10.1186\/s12884-015-0684-z"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez, R., Rup\u00e9rez, M., Sevene, E., Vala, A., Maculuve, S., Bulo, H., Nhacolo, A., Mayor, A., Aponte, J.J., and Macete, E. (2017). Effects of HIV infection on maternal and neonatal health in southern Mozambique: A prospective cohort study after a decade of antiretroviral drugs roll out. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0178134"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1097\/QAI.0000000000000019","article-title":"Impact of HIV exposure on health outcomes in HIV-negative infants born to HIV-positive mothers in Sub-Saharan Africa","volume":"65","author":"Moraleda","year":"2014","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_38","first-page":"502","article-title":"A retrospective cohort study comparing pregnancy outcomes and neonatal char-acteristics between HIV-infected and HIV-non-infected mothers","volume":"110","author":"Goldman","year":"2020","journal-title":"S. Afr. Med. J."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Twabi, H.S., Manda, S.O., and Small, D.S. (2020). Assessing the effects of maternal HIV infection on pregnancy outcomes using cross-sectional data in Malawi. BMC Public Health, 20.","DOI":"10.1186\/s12889-020-09046-0"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Theron, G., Brummel, S., Fairlie, L., Pinilla, M., McCarthy, K., Owor, M., Chinula, L., Makanani, B., Violari, A., and Moodley, D. (2020). Pregnancy Outcomes of Women Conceiving on Antiretroviral Therapy (ART) Compared to Those Commenced on ART During Pregnancy. Clin. Infect. Dis.","DOI":"10.1093\/cid\/ciaa805"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1097\/QAD.0000000000002593","article-title":"Adverse perinatal outcomes associated with antiretroviral therapy regimens: Systematic review and network meta-analysis","volume":"34","author":"Honeyman","year":"2020","journal-title":"AIDS"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/8\/1564\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:26:35Z","timestamp":1760361995000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/8\/1564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,8]]},"references-count":41,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,4]]}},"alternative-id":["jcm10081564"],"URL":"https:\/\/doi.org\/10.3390\/jcm10081564","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,8]]}}}