{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:04:00Z","timestamp":1771661040016,"version":"3.50.1"},"reference-count":47,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to 5% to 16% hospitalization in intensive care units (ICU) and is associated with 23% to 75% of kidney impairments, including acute kidney injury (AKI). The current work aims to precisely characterize the renal impairment associated to SARS-CoV-2 in ICU patients. Forty-two patients consecutively admitted to the ICU of a French university hospital who tested positive for SARS-CoV-2 between 25 March 2020, and 29 April 2020, were included and classified in categories according to their renal function. Complete renal profiles and evolution during ICU stay were fully characterized in 34 patients. Univariate analyses were performed to determine risk factors associated with AKI. In a second step, we conducted a logistic regression model with inverse probability of treatment weighting (IPTW) analyses to assess major comorbidities as predictors of AKI. Thirty-two patients (94.1%) met diagnostic criteria for intrinsic renal injury with a mixed pattern of tubular and glomerular injuries within the first week of ICU admission, which lasted upon discharge. During their ICU stay, 24 patients (57.1%) presented AKI which was associated with increased mortality (p = 0.007), hemodynamic failure (p = 0.022), and more altered clearance at hospital discharge (p = 0.001). AKI occurrence was associated with lower pH (p = 0.024), higher PaCO2 (CO2 partial pressure in the arterial blood) (p = 0.027), PEEP (positive end-expiratory pressure) (p = 0.027), procalcitonin (p = 0.015), and CRP (C-reactive protein) (p = 0.045) on ICU admission. AKI was found to be independently associated with chronic kidney disease (adjusted OR (odd ratio) 5.97 (2.1\u201319.69), p = 0.00149). Critical SARS-CoV-2 infection is associated with persistent intrinsic renal injury and AKI, which is a risk factor of mortality. Mechanical ventilation settings seem to be a critical factor of kidney impairment.<\/jats:p>","DOI":"10.3390\/jcm10081571","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T11:58:45Z","timestamp":1617883125000},"page":"1571","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["SARS-CoV-2 Renal Impairment in Critical Care: An Observational Study of 42 Cases (Kidney COVID)"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7753-7143","authenticated-orcid":false,"given":"Antoine-Marie","family":"Molina Barragan","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, H\u00f4pital Saint-Antoine, Assistance Publique-H\u00f4pitaux de Paris, 75012 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6326-3834","authenticated-orcid":false,"given":"Emmanuel","family":"Pardo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, H\u00f4pital Saint-Antoine, Assistance Publique-H\u00f4pitaux de Paris, 75012 Paris, France"},{"name":"Sorbonne University, GRC 29, DMU DREAM, Assistance Publique-H\u00f4pitaux de Paris, 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2771-1596","authenticated-orcid":false,"given":"Pierre","family":"Galichon","sequence":"additional","affiliation":[{"name":"Sorbonne University, GRC 29, DMU DREAM, Assistance Publique-H\u00f4pitaux de Paris, 75013 Paris, France"},{"name":"Transplantation and Nephrology Department, H\u00f4pital Piti\u00e9-Salp\u00e9tri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Hantala","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, H\u00f4pital Saint-Antoine, Assistance Publique-H\u00f4pitaux de Paris, 75012 Paris, France"},{"name":"Sorbonne University, GRC 29, DMU DREAM, Assistance Publique-H\u00f4pitaux de Paris, 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Charlotte","family":"Gianinazzi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, H\u00f4pital Saint-Antoine, Assistance Publique-H\u00f4pitaux de Paris, 75012 Paris, France"},{"name":"Sorbonne University, GRC 29, DMU DREAM, Assistance Publique-H\u00f4pitaux de Paris, 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6638-8437","authenticated-orcid":false,"given":"Lucie","family":"Darrivere","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, H\u00f4pital Saint-Antoine, Assistance Publique-H\u00f4pitaux de Paris, 75012 Paris, France"},{"name":"Sorbonne University, GRC 29, DMU DREAM, Assistance Publique-H\u00f4pitaux de Paris, 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen S.","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Garnier","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, H\u00f4pital Saint-Antoine, Assistance Publique-H\u00f4pitaux de Paris, 75012 Paris, France"},{"name":"Sorbonne University, GRC 29, DMU DREAM, Assistance Publique-H\u00f4pitaux de Paris, 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, H\u00f4pital Saint-Antoine, Assistance Publique-H\u00f4pitaux de Paris, 75012 Paris, France"},{"name":"Sorbonne University, GRC 29, DMU DREAM, Assistance Publique-H\u00f4pitaux de Paris, 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5448-8150","authenticated-orcid":false,"given":"Fabienne","family":"Fieux","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, H\u00f4pital Saint-Antoine, Assistance Publique-H\u00f4pitaux de Paris, 75012 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7061-5594","authenticated-orcid":false,"given":"Franck","family":"Verdonk","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, H\u00f4pital Saint-Antoine, Assistance Publique-H\u00f4pitaux de Paris, 75012 Paris, France"},{"name":"Sorbonne University, GRC 29, DMU DREAM, Assistance Publique-H\u00f4pitaux de Paris, 75013 Paris, France"},{"name":"Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1001\/jama.2020.2648","article-title":"Characteristics of and important lessons from the coronavirus disease 2019(COVID-19) outbreak in China","volume":"323","author":"Wu","year":"2020","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S2213-2600(20)30161-2","article-title":"Intensive care management of coronavirus disease 2019 (COVID-19): Challenges and recommendations","volume":"8","author":"Phua","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1056\/NEJMoa2004500","article-title":"Covid-19 in Critically Ill Patients in the Seattle Region\u2014Case Series","volume":"382","author":"Bhatraju","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1001\/jama.2020.2648","article-title":"Characteristics of and Important Lessons from the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72314 Cases from the Chinese Center for Disease Control and Prevention","volume":"323","author":"Wu","year":"2020","journal-title":"JAMA-J. Am. Med. Assoc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1001\/jama.2020.4326","article-title":"Characteristics and Outcomes of 21 Critically Ill Patients with COVID-19 in Washington State","volume":"323","author":"Arentz","year":"2020","journal-title":"JAMA-J. Am. Med. Assoc."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Thakur, V., Ratho, R.K., Kumar, P., Bhatia, S.K., Bora, I., Mohi, G.K., Saxena, S.K., Devi, M., Yadav, D., and Mehariya, S. (2021). Multi-Organ Involvement in COVID-19: Beyond Pulmonary Manifestations. J. Clin. Med., 10.","DOI":"10.3390\/jcm10030446"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1007\/s10072-020-04487-2","article-title":"Brainstem involvement and respiratory failure in COVID-19","volume":"41","author":"Manganelli","year":"2020","journal-title":"Neurol. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1007\/s00134-020-06153-9","article-title":"Acute kidney injury in critically ill patients with COVID-19","volume":"46","author":"Gabarre","year":"2020","journal-title":"Intensive Care Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.jinf.2020.05.009","article-title":"Acute kidney injury in hospitalized patients with coronavirus disease 2019 (COVID-19): A meta-analysis","volume":"81","author":"Ng","year":"2020","journal-title":"J. Infect."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1681\/ASN.2020030276","article-title":"Renal Involvement and Early Prognosis in Patients with COVID-19 Pneumonia","volume":"31","author":"Pei","year":"2020","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Nasr, S.H., and Kopp, J.B. (2020). COVID-19\u2013Associated Collapsing Glomerulopathy: An Emerging Entity. Kidney Int. Rep., 102\u2013104.","DOI":"10.1016\/j.ekir.2020.04.030"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Pan, X.W., Xu, D., Zhang, H., Zhou, W., Wang, L.-H., and Cui, X.G. (2020). gang Identification of a potential mechanism of acute kidney injury during the COVID-19 outbreak: A study based on single-cell transcriptome analysis. Intensive Care Med., 2\u20134.","DOI":"10.1007\/s00134-020-06026-1"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Su, H., Yang, M., Wan, C., Yi, L.X., Tang, F., Zhu, H.Y., Yi, F., Yang, H.C., Fogo, A.B., and Nie, X. (2020). Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney Int.","DOI":"10.1016\/j.kint.2020.04.003"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1159\/000508381","article-title":"Acute Kidney Injury in COVID-19 Pandemic","volume":"144","author":"Capuano","year":"2020","journal-title":"Nephron"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.2215\/CJN.08300813","article-title":"Acute respiratory distress syndrome and risk of AKI among critically ill patients","volume":"9","author":"Darmon","year":"2014","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1097\/CCM.0000000000003832","article-title":"Impact of Early Acute Kidney Injury on Management and Outcome in Patients with Acute Respiratory Distress Syndrome: A Secondary Analysis of a Multicenter Observational Study","volume":"47","author":"McNicholas","year":"2020","journal-title":"Crit. Care Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S2213-2600(20)30079-5","article-title":"Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: A single-centered, retrospective, observational study","volume":"8","author":"Yang","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"ref_19","first-page":"2526","article-title":"Acute respiratory distress syndrome: The Berlin definition","volume":"307","author":"Ranieri","year":"2012","journal-title":"JAMA-J. Am. Med. Assoc."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"(2012). Summary of Recommendation Statements. Kidney Int. Suppl., 2, 8\u201312.","DOI":"10.1038\/kisup.2012.7"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.kint.2020.03.005","article-title":"Kidney disease is associated with in-hospital death of patients with COVID-19","volume":"97","author":"Cheng","year":"2020","journal-title":"Kidney Int."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Mahmoud, S.H., and Shen, C. (2017). Augmented renal clearance in critical illness: An important consideration in drug dosing. Pharmaceutics, 9.","DOI":"10.3390\/pharmaceutics9030036"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1097\/00001648-200009000-00011","article-title":"Marginal structural models and causal inference in epidemiology","volume":"11","author":"Robins","year":"2000","journal-title":"Epidemiology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.accpm.2018.10.013","article-title":"French legal approach to clinical research","volume":"37","author":"Toulouse","year":"2018","journal-title":"Anaesth. Crit. Care Pain Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1007\/s00330-020-06865-y","article-title":"COVID-19 patients and the radiology department\u2013advice from the European Society of Radiology (ESR) and the European Society of Thoracic Imaging (ESTI)","volume":"30","author":"Revel","year":"2020","journal-title":"Eur. Radiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1001\/jama.2020.5394","article-title":"Baseline Characteristics and Outcomes of 1591 Patients Infected with SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy","volume":"323","author":"Grasselli","year":"2020","journal-title":"JAMA-J. Am. Med. Assoc."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1001\/jama.2020.6775","article-title":"Presenting Characteristics, Comorbidities, and Outcomes among 5700 Patients Hospitalized with COVID-19 in the New York City Area","volume":"323","author":"Richardson","year":"2020","journal-title":"JAMA-J. Am. Med. Assoc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1007\/s00134-018-5209-6","article-title":"Management and outcomes of acute respiratory distress syndrome patients with and without comorbid conditions","volume":"44","author":"Azoulay","year":"2018","journal-title":"Intensive Care Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1164\/rccm.201211-1983OC","article-title":"Mechanisms of cardiac and renal dysfunction in patients dying of sepsis","volume":"187","author":"Takasu","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/MCC.0000000000000153","article-title":"Sepsis-induced acute kidney injury revisited: Pathophysiology, prevention and future therapies","volume":"20","author":"Zarbock","year":"2014","journal-title":"Curr. Opin. Crit. Care"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Michard, F., and Vieillard-Baron, A. (2020). Critically ill patients with COVID-19: Are they hemodynamically unstable and do we know why?. Intensive Care Med.","DOI":"10.1007\/s00134-020-06238-5"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"R231","DOI":"10.1186\/cc13054","article-title":"Risk of developing severe sepsis after acute kidney injury: A population-based cohort study","volume":"17","author":"Lai","year":"2013","journal-title":"Crit. Care"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13613-017-0260-y","article-title":"Acute kidney injury in the ICU: From injury to recovery: Reports from the 5th Paris International Conference","volume":"7","author":"Bellomo","year":"2017","journal-title":"Ann. Intensive Care"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S1473-3099(20)30482-5","article-title":"Clinical characteristics of COVID-19 in 104 people with SARS-CoV-2 infection on the Diamond Princess cruise ship: A retrospective analysis","volume":"20","author":"Tabata","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41586-020-2521-4","article-title":"Factors associated with COVID-19-related death using OpenSAFELY","volume":"584","author":"Williamson","year":"2020","journal-title":"Nature"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1136\/heartjnl-2018-314158","article-title":"Change in renal function associated with drug treatment in heart failure: National guidance","volume":"105","author":"Clark","year":"2019","journal-title":"Heart"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Griffiths, M.J.D., McAuley, D.F., Perkins, G.D., Barrett, N., Blackwood, B., Boyle, A., Chee, N., Connolly, B., Dark, P., and Finney, S. (2019). Guidelines on the management of acute respiratory distress syndrome. BMJ Open Respir. Res., 6.","DOI":"10.1136\/bmjresp-2019-000420"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s00134-020-06059-6","article-title":"Facing COVID-19 in the ICU: Vascular dysfunction, thrombosis, and dysregulated inflammation","volume":"46","author":"Leisman","year":"2020","journal-title":"Intensive Care Med."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Hirsch, J.S., Ng, J.H., Ross, D.W., Sharma, P., Shah, H.H., Barnett, R.L., Hazzan, A.D., Fishbane, S., and Jhaveri, K.D. (2020). Acute Kidney Injury in Patients Hospitalized with Covid-19. Kidney Int.","DOI":"10.1016\/j.kint.2020.05.006"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1007\/s00134-019-05869-7","article-title":"Lung\u2013kidney interactions in critically ill patients: Consensus report of the Acute Disease Quality Initiative (ADQI) 21 Workgroup","volume":"46","author":"Joannidis","year":"2020","journal-title":"Intensive Care Med."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Panitchote, A., Mehkri, O., Hasting, A., Hanane, T., Demirjian, S., Torbic, H., Mireles-Cabodevila, E., Krishnan, S., and Duggal, A. (2019). Factors associated with acute kidney injury in acute respiratory distress syndrome. Ann. Intensive Care, 9.","DOI":"10.1186\/s13613-019-0552-5"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s13054-015-0920-y","article-title":"Evolution of chronic renal impairment and long-term mortality after de novo acute kidney injury in the critically ill; a Swedish multi-centre cohort study","volume":"19","author":"Frumento","year":"2015","journal-title":"Crit. Care"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s40262-018-0636-7","article-title":"Augmented Renal Clearance in Critically Ill Patients: A Systematic Review","volume":"57","author":"Barrasa","year":"2018","journal-title":"Clin. Pharmacokinet."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.ijantimicag.2016.12.022","article-title":"Association between augmented renal clearance and clinical outcomes in patients receiving \u03b2-lactam antibiotic therapy by continuous or intermittent infusion: A nested cohort study of the BLING-II randomised, placebo-controlled, clinical trial","volume":"49","author":"Udy","year":"2017","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/CCM.0b013e31826ab4c4","article-title":"Optimal doripenem dosing simulations in critically ill nosocomial pneumonia patients with obesity, augmented renal clearance, and decreased bacterial susceptibility","volume":"41","author":"Roberts","year":"2013","journal-title":"Crit. Care Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jcrc.2011.02.012","article-title":"Acute kidney injury in critically ill patients with pandemic influenza A pneumonia 2009 in Korea: A multicenter study","volume":"26","author":"Jung","year":"2011","journal-title":"J. Crit. Care"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1177\/0009922818779222","article-title":"Acute Kidney Injury in Children with Acute Respiratory Failure","volume":"57","author":"Medar","year":"2018","journal-title":"Clin. Pediatr. (Phila)."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/8\/1571\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T14:12:06Z","timestamp":1760364726000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/8\/1571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,8]]},"references-count":47,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,4]]}},"alternative-id":["jcm10081571"],"URL":"https:\/\/doi.org\/10.3390\/jcm10081571","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,8]]}}}