{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T03:15:58Z","timestamp":1774322158659,"version":"3.50.1"},"reference-count":44,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T00:00:00Z","timestamp":1617926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010809","name":"Jascha Fonden","doi-asserted-by":"publisher","award":["Grant Number: 5240A"],"award-info":[{"award-number":["Grant Number: 5240A"]}],"id":[{"id":"10.13039\/100010809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Psychiatric Research Foundation of The Region of Southern Denmark","award":["Grant numbers A3385 and A2721 1.r.18"],"award-info":[{"award-number":["Grant numbers A3385 and A2721 1.r.18"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>A better understanding of explanatory factors for disease-specific health-related quality of life (HRQoL) in anorexia nervosa (AN) could help direct treatment providers to aspects of the most relevance for patient wellbeing and recovery. We aimed to investigate whether factors associated with HRQoL are the same for women with AN and normal-weight controls. The participants in this study were women with AN recruited from specialized eating disorder centers in Denmark and healthy, normal-weight controls invited via online social media. Participants completed online questionnaires on medical history, disease-specific HRQoL (Eating Disorders Quality of Life Scale, EDQLS) and generic HRQoL (SF-36), eating disorder symptomatology, depression, psychological wellbeing, and work and social adjustment. Questionnaires were fully completed by 211 women with AN (median age 21.7 years) and 199 controls (median age 23.9 years). Women with AN had poorer scores on all measures, i.e., worse HRQoL, psychological health, and work\/social functioning. Eating disorder symptomatology affected EDQLS score in both groups, but poorer HRQoL in women with AN was also significantly associated with worse scores on bulimia, maturity fears, depression, vitality, and with older age. The factors investigated together explained 79% of the variance in EDQLS score. Management of disordered self-assessment and thought processes may be of particular importance to women with AN. Greater emphasis on these aspects alongside weight gain could enhance patient\u2013clinician alliance and contribute to better treatment outcomes.<\/jats:p>","DOI":"10.3390\/jcm10081592","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T10:05:21Z","timestamp":1617962721000},"page":"1592","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Explanatory Factors for Disease-Specific Health-Related Quality of Life in Women with Anorexia Nervosa"],"prefix":"10.3390","volume":"10","author":[{"given":"Laura Al-Dakhiel","family":"Winkler","sequence":"first","affiliation":[{"name":"Center for Eating Disorders, Research Unit for Medical Endocrinology, Odense University Hospital, Mental Health Services in the Region of Southern Denmark, DK-5000 Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Gudex","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, University of Southern Denmark, DK-5000 Odense, Denmark"},{"name":"OPEN\u2014Open Patient Data Explorative Network, Odense University Hospital, DK-5000 Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia Beck","family":"Lichtenstein","sequence":"additional","affiliation":[{"name":"Centre for Telepsychiatry, Region of Southern Denmark, Department of Clinical Research, University of Southern Denmark, DK-5000 Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Ejnar","family":"R\u00f8der","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Odense, Odense University Hospital, DK-5000 Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol E.","family":"Adair","sequence":"additional","affiliation":[{"name":"Departments of Community Health Sciences and Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2060-1914","authenticated-orcid":false,"given":"Jan Magnus","family":"Sj\u00f6gren","sequence":"additional","affiliation":[{"name":"Center for Eating Disorders, Ballerup Psychiatric Center, DK-2750 Ballerup, Denmark"},{"name":"Institute for Clinical Medicine, University of Copenhagen, DK-2200 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4255-5544","authenticated-orcid":false,"given":"Ren\u00e9 Klinkby","family":"St\u00f8ving","sequence":"additional","affiliation":[{"name":"Center for Eating Disorders, Research Unit for Medical Endocrinology, Odense University Hospital, Mental Health Services in the Region of Southern Denmark, DK-5000 Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.eurpsy.2017.07.012","article-title":"Naturalistic follow-up of subjects affected with anorexia nervosa 8 years after multimodal treatment: Personality and psychopathology changes and predictors of outcome","volume":"45","author":"Amianto","year":"2017","journal-title":"Eur. 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