{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:07:45Z","timestamp":1790485665809,"version":"4.1.0"},"reference-count":64,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003386","name":"Soci\u00e9t\u00e9 de N\u00e9phrologie","doi-asserted-by":"publisher","award":["DEQ20170336759"],"award-info":[{"award-number":["DEQ20170336759"]}],"id":[{"id":"10.13039\/501100003386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Lupus nephritis (LN) is a severe manifestation of Systemic Lupus Erythematosus (SLE). The therapeutic strategy relies on kidney biopsy (KB) results. We tested whether urinary peptidome analysis could non-invasively differentiate active from non-active LN. Design: Urinary samples were collected from 93 patients (55 with active LN and 38 with non-active LN), forming a discovery (n = 42) and an independent validation (n = 51) cohort. Clinical characteristics were collected at inclusion and prospectively for 24 months. The urinary peptidome was analyzed by capillary-electrophoresis coupled to mass-spectrometry, comparing active LN to non-active LN, and assessing chronic lesions and response to therapy. The value of previously validated prognostic (CKD273) and differential diagnostic (LN172) signatures was evaluated. Results: Urinary peptides could not discriminate between active and non-active LN or predict early response to therapy. Tubulo-interstitial fibrosis was correlated to the CKD273. The LN172 score identified 92.5% of samples as LN. Few patients developed new-onset CKD. Conclusions: We validated the CKD273 and LN172 classifiers but did not identify a robust signature that could predict active LN and replace KB. The value of urinary peptidome to predict long-term CKD, or renal flares in SLE, remains to be evaluated.<\/jats:p>","DOI":"10.3390\/jcm10081690","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T23:35:12Z","timestamp":1618443312000},"page":"1690","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Urinary Peptides as Potential Non-Invasive Biomarkers for Lupus Nephritis: Results of the Peptidu-LUP Study"],"prefix":"10.3390","volume":"10","author":[{"given":"Maxence","family":"Tailliar","sequence":"first","affiliation":[{"name":"AP-HM, Centre de N\u00e9phrologie et Transplantation R\u00e9nale, H\u00f4pital de la Conception, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"Schanstra","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1297, Institut of Metabolic and Cardiovascular Disease (I2MC), 31432 Toulouse, France"},{"name":"Universit\u00e9 Toulouse III Paul-Sabatier, 31062 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1969-7974","authenticated-orcid":false,"given":"Tim","family":"Dierckx","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Breuil","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1297, Institut of Metabolic and Cardiovascular Disease (I2MC), 31432 Toulouse, France"},{"name":"Universit\u00e9 Toulouse III Paul-Sabatier, 31062 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Hanouna","sequence":"additional","affiliation":[{"name":"AP-HP, Service de N\u00e9phrologie, H\u00f4pital Bichat, DMU VICTOIRE, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5416-5834","authenticated-orcid":false,"given":"Nicolas","family":"Charles","sequence":"additional","affiliation":[{"name":"Centre de Recherche sur l\u2019Inflammation, Universit\u00e9 de Paris, INSERM UMRS1149, CNRS ERL8252, Labex INFLAMEX, DHU FIRE, 75890 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1667-5913","authenticated-orcid":false,"given":"Jean-Loup","family":"Bascands","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1188-Universit\u00e9 de La R\u00e9union, 97490 Saint-Denis, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Dussol","sequence":"additional","affiliation":[{"name":"AP-HM, Centre de N\u00e9phrologie et Transplantation R\u00e9nale, H\u00f4pital de la Conception, 13005 Marseille, France"},{"name":"Centre d\u2019Investigation Clinique, CHU Conception, AP-HM, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Vazi","sequence":"additional","affiliation":[{"name":"Centre d\u2019Investigation Clinique, CHU Conception, AP-HM, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Chiche","sequence":"additional","affiliation":[{"name":"M\u00e9decine Interne, H\u00f4pital Europ\u00e9en, 13003 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1407-2534","authenticated-orcid":false,"given":"Justyna","family":"Siwy","sequence":"additional","affiliation":[{"name":"Mosaiques Diagnostics GmbH, 30659 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislas","family":"Faguer","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1297, Institut of Metabolic and Cardiovascular Disease (I2MC), 31432 Toulouse, France"},{"name":"Universit\u00e9 Toulouse III Paul-Sabatier, 31062 Toulouse, France"},{"name":"CHU de Toulouse, Service de N\u00e9phrologie, 31300 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Daniel","sequence":"additional","affiliation":[{"name":"AP-HM, Laboratoire d\u2019Ananatomie Pathologique, H\u00f4pital de la Timone, 13005 Marseille, France"},{"name":"Center for CardioVascular and Nutrition Research (C2VN), Aix-Marseille University, INSERM, INRAE, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Daugas","sequence":"additional","affiliation":[{"name":"AP-HP, Service de N\u00e9phrologie, H\u00f4pital Bichat, DMU VICTOIRE, 75018 Paris, France"},{"name":"Centre de Recherche sur l\u2019Inflammation, Universit\u00e9 de Paris, INSERM UMRS1149, CNRS ERL8252, Labex INFLAMEX, DHU FIRE, 75890 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9315-1577","authenticated-orcid":false,"given":"No\u00e9mie","family":"Jourde-Chiche","sequence":"additional","affiliation":[{"name":"AP-HM, Centre de N\u00e9phrologie et Transplantation R\u00e9nale, H\u00f4pital de la Conception, 13005 Marseille, France"},{"name":"Center for CardioVascular and Nutrition Research (C2VN), Aix-Marseille University, INSERM, INRAE, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Groupe Coop\u00e9ratif sur le Lupus R\u00e9nal (GCLR)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.autrev.2005.06.004","article-title":"Systemic lupus erythematosus in Europe at the change of the millennium: Lessons from the \u201cEuro-Lupus Project\u201d","volume":"5","author":"Cervera","year":"2006","journal-title":"Autoimmun. 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