{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:17Z","timestamp":1787028617003,"version":"build-2736575974"},"reference-count":20,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Home-use light-emitting diodes (LEDs) are attracting growing attention regarding their anti-aging effects. Although most previous studies on the use of LED devices as a form of low-level laser therapy reported no significant adverse events, questions regarding the safety of using a light source on secretory tissues have been raised. This study aimed to assess the safety and efficacy of a home-use LED device for neck skin rejuvenation, particularly regarding its effect on thyroid gland morphology and function. Thyroid function tests and ultrasonographic analyses showed no significant changes after 16 weeks of LED use. Evaluation using the Lemperle wrinkle scale and global improvement scales by both investigators and subjects showed significant improvement after 16 weeks of daily application, as well as 8 weeks after discontinuation. Biophysical parameters, such as hydration, elasticity, and density, also showed significant improvements. Hence, the long-term use of the LED device was safe and effective for neck rejuvenation, and showed no significant side effects on the adjacent thyroid and parathyroid glands.<\/jats:p>","DOI":"10.3390\/jcm10081774","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T11:21:38Z","timestamp":1618831298000},"page":"1774","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Use of a Light-Emitting Diode Device for Neck Rejuvenation and Its Safety on Thyroid Glands"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6831-7379","authenticated-orcid":false,"given":"Young In","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, College of Medicine, Yonsei University, Seoul 03722, Korea"},{"name":"Scar Laser and Plastic Surgery Center, Yonsei Cancer Hospital, College of Medicine, Yonsei University, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunjung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Computational Science and Engineering, Yonsei University, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee-Hyun","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Surgery, Severance Hospital, Cutaneous Biology Research Institute, College of Medicine, Yonsei University, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1048-7978","authenticated-orcid":false,"given":"Dong Yeob","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Severance Hospital, College of Medicine, Yonsei University, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, College of Medicine, Yonsei University, Seoul 03722, Korea"},{"name":"Scar Laser and Plastic Surgery Center, Yonsei Cancer Hospital, College of Medicine, Yonsei University, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jangmi","family":"Suk","sequence":"additional","affiliation":[{"name":"Global Medical Research Center, Seoul 06035, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Young","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, College of Medicine, Yonsei University, Seoul 03722, Korea"},{"name":"Scar Laser and Plastic Surgery Center, Yonsei Cancer Hospital, College of Medicine, Yonsei University, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.36849\/JDD.2020.4711","article-title":"Light emitting diode phototherapy for skin aging","volume":"19","author":"Huang","year":"2020","journal-title":"J. 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