{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:30:58Z","timestamp":1792099858232,"version":"4.4.0"},"reference-count":36,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T00:00:00Z","timestamp":1620432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"POR Campania FESR 2014\/2020","award":["project SENSORMIRCIRCOLAR and by FSN 2014-2015-2016 Linea 5\/11."],"award-info":[{"award-number":["project SENSORMIRCIRCOLAR and by FSN 2014-2015-2016 Linea 5\/11."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Laryngeal neuroendocrine carcinomas (LNECs) are rare and highly heterogeneous malignancies presenting a wide range of pathological and clinical manifestations. Herein, we retrospectively characterize ten patients diagnosticated with LNEC, five of which were defined as well-moderately differentiated neuroendocrine carcinomas, and five that were defined as poorly differentiated neuroendocrine carcinomas, according to the latest WHO classification. Clinical features were analyzed and compared between the two subgroups together with a microRNA study which evidenced a peculiar signature likely related to poorly differentiated larynx neuroendocrine carcinomas. These findings may offer new useful insights for clinicians to improve diagnosis efficiency, therapy response, and patients\u2019 outcome for this aggressive neoplasm.<\/jats:p>","DOI":"10.3390\/jcm10092019","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T21:32:46Z","timestamp":1620595966000},"page":"2019","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Poorly Differentiated Neuroendocrine Larynx Carcinoma: Clinical Features and miRNAs Signature\u2014A New Goal for Early Diagnosis and Therapy?"],"prefix":"10.3390","volume":"10","author":[{"given":"Filippo","family":"Ricciardiello","sequence":"first","affiliation":[{"name":"U.O.C. Otolaryngology, AORN \u201cAntonio Cardarelli\u201d, 80131 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Falco","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Tortoriello","sequence":"additional","affiliation":[{"name":"U.O.C. Otolaryngology, ASL-NA1 Ospedale del Mare, 80147 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando","family":"Riccardi","sequence":"additional","affiliation":[{"name":"U.O.C. Oncology, AORN \u201cAntonio Cardarelli\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Pellini","sequence":"additional","affiliation":[{"name":"U.O.C. Otolaryngology-Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3749-1133","authenticated-orcid":false,"given":"Brigida","family":"Iorio","sequence":"additional","affiliation":[{"name":"U.O.C. Otolaryngology, San Paolo Hospital, ASL Napoli 1, 80145 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Russo","sequence":"additional","affiliation":[{"name":"U.O.C. General Direction, AORN \u201cAntonio Cardarelli\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Longo","sequence":"additional","affiliation":[{"name":"U.O.C. Healthcare Direction, AORN \u201cAntonio Cardarelli\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro","family":"Coppola","sequence":"additional","affiliation":[{"name":"U.O.C. General Direction, AORN \u201cAntonio Cardarelli\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"},{"name":"Molecular Diagnostics Division, Wakunaga Pharmaceutical Co., Ltd., Hiroshima 739-1195, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Grimaldi","sequence":"additional","affiliation":[{"name":"U.P. Diagnostics Cytometric and Mutational, Vanvitelli Hospital, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Abate","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Scrima","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Precision Oncology, Biogem Institute of Molecular Biology and Genetics, 83031 Ariano Irpino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2646-1254","authenticated-orcid":false,"given":"Alessia Maria","family":"Cossu","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"},{"name":"Laboratory of Molecular and Precision Oncology, Biogem Institute of Molecular Biology and Genetics, 83031 Ariano Irpino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9197-8060","authenticated-orcid":false,"given":"Raffaele","family":"Addeo","sequence":"additional","affiliation":[{"name":"U.O.C Oncology, Day Hospital, San Giovanni di Dio Hospital, ASL Naples 2 Nord, 80020 Frattamaggiore, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2901-3855","authenticated-orcid":false,"given":"Alessandro","family":"Ottaiano","sequence":"additional","affiliation":[{"name":"S.S.D. Innovative Therapies for Abdominal Metastases, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Scarpa","sequence":"additional","affiliation":[{"name":"U.O.C Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amedeo","family":"Boscaino","sequence":"additional","affiliation":[{"name":"U.O.C Pathologic Anatomy, AORN \u201cAntonio Cardarelli\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Motta","sequence":"additional","affiliation":[{"name":"U.O.C. Otolaryngology, AORN \u201cAntonio Cardarelli\u201d, 80131 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2408-6091","authenticated-orcid":false,"given":"Michele","family":"Caraglia","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"},{"name":"Laboratory of Molecular and Precision Oncology, Biogem Institute of Molecular Biology and Genetics, 83031 Ariano Irpino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2143-6669","authenticated-orcid":false,"given":"Marco","family":"Bocchetti","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"},{"name":"Laboratory of Molecular and Precision Oncology, Biogem Institute of Molecular Biology and Genetics, 83031 Ariano Irpino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Misso","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1097\/MLG.0b013e3181671b3d","article-title":"Staging and Survival Analysis for Nonsquamous Cell Carcinomas of the Larynx","volume":"118","author":"Lin","year":"2008","journal-title":"Laryngoscope"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1002\/hed.21162","article-title":"Neuroendocrine neoplasms of the larynx: An overview","volume":"31","author":"Ferlito","year":"2009","journal-title":"Head Neck"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1093\/ajcp\/aqz106","article-title":"Update on Neuroendocrine Carcinomas of the Larynx","volume":"152","author":"Strosberg","year":"2019","journal-title":"Am. 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