{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T04:55:48Z","timestamp":1768971348117,"version":"3.49.0"},"reference-count":29,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T00:00:00Z","timestamp":1620518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Computed tomography-guided needle biopsy (CT-GNB) has a high diagnostic yield for lung cancer but higher complication rates compared to those of other biopsy modalities. We sought to clarify in which thoracic lesions we could achieve a quick pathological diagnosis using CT-GNB, considering the risks and benefits. We retrospectively enrolled 110 patients who underwent CT-GNB and 547 patients who underwent transbronchial biopsy (TBB) for parenchymal lung lesions in clinical practice. The diagnostic rates of CT-GNB and TBB were 87.3% and 75.3%. After failed diagnosis with other biopsy modalities, 92.3% of patients were finally diagnosed using CT-GNB and 65.8% using TBB. In cases with a negative bronchial sign, there was a statistically higher diagnostic rate with CT-GNB than with TBB (p &lt; 0.001: 89.4% vs. 0%). Complication rates were higher with CT-GNB (50.9%) than with TBB (16.3%). However, there were lower rates of complications in cases with inhomogeneous tumors, subpleural lesions, and when more than 15 mm of the punctured needle length was within the target. We conclude that CT-GNB is an effective biopsy modality with a high diagnostic rate that is especially recommended when the bronchus sign is negative. It can be safely performed if risk factors for complications are taken into account.<\/jats:p>","DOI":"10.3390\/jcm10092031","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T21:32:46Z","timestamp":1620595966000},"page":"2031","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["CT Guided Needle Biopsy of Peripheral Lesions\u2013Lesion Characteristics That May Increase the Diagnostic Yield and Reduce the Complication Rate"],"prefix":"10.3390","volume":"10","author":[{"given":"Manabu","family":"Tajima","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine, Juntendo University Faculty of Medicine &amp; Graduate School of Medicine, 3-1-3, Hongo, Bunkyo-ku, Tokyo 113-8431, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsaku","family":"Togo","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Juntendo University Faculty of Medicine &amp; Graduate School of Medicine, 3-1-3, Hongo, Bunkyo-ku, Tokyo 113-8431, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Ko","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Juntendo University Faculty of Medicine &amp; Graduate School of Medicine, 3-1-3, Hongo, Bunkyo-ku, Tokyo 113-8431, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshika","family":"Koinuma","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Juntendo University Faculty of Medicine &amp; Graduate School of Medicine, 3-1-3, Hongo, Bunkyo-ku, Tokyo 113-8431, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Issei","family":"Sumiyoshi","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Juntendo University Faculty of Medicine &amp; Graduate School of Medicine, 3-1-3, Hongo, Bunkyo-ku, Tokyo 113-8431, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Torasawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Juntendo University Urayasu Hospital, 2-1-1, Tomioka, Urayasu, Chiba 273-0021, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nao","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Juntendo University Urayasu Hospital, 2-1-1, Tomioka, Urayasu, Chiba 273-0021, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Juntendo University Faculty of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Juntendo University Urayasu Hospital, 2-1-1, Tomioka, Urayasu, Chiba 273-0021, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Kyogoku","sequence":"additional","affiliation":[{"name":"Department of Radiology, Juntendo University Urayasu Hospital, 2-1-1, Tomioka, Urayasu, Chiba 273-0021, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryohei","family":"Kuwatsuru","sequence":"additional","affiliation":[{"name":"Department of Radiology, Juntendo University Faculty of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhisa","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Juntendo University Faculty of Medicine &amp; Graduate School of Medicine, 3-1-3, Hongo, Bunkyo-ku, Tokyo 113-8431, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/crj.13275","article-title":"Endobronchial ultrasound-guided versus computed tomography-guided biopsy for peripheral pulmonary lesions: A meta-analysis","volume":"15","author":"Fu","year":"2021","journal-title":"Clin. Respir. J."},{"key":"ref_2","first-page":"596","article-title":"Endobronchial ultrasound with a guide sheath for small malignant pulmonary nodules: A retrospective comparison between central and peripheral locations","volume":"7","author":"Chavez","year":"2015","journal-title":"J. Thorac. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e142S","DOI":"10.1378\/chest.12-2353","article-title":"Establishing the diagnosis of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"143","author":"Rivera","year":"2013","journal-title":"Chest"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1183\/09031936.04.00138603","article-title":"Endobronchial ultrasonography with guide-sheath for peripheral pulmonary lesions","volume":"24","author":"Kikuchi","year":"2004","journal-title":"Eur. Respir. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.athoracsur.2016.09.001","article-title":"Usefulness of endobronchial ultrasonography with a guide sheath and virtual bronchoscopic navigation for ground-glass opacity lesions","volume":"103","author":"Ikezawa","year":"2017","journal-title":"Ann. Thorac. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000362885","article-title":"Endobronchial ultrasonography with a guide sheath for pure or mixed ground-glass opacity lesions","volume":"88","author":"Ikezawa","year":"2014","journal-title":"Respiration"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Minezawa, T., Okamura, T., Yatsuya, H., Yamamoto, N., Morikawa, S., Yamaguchi, T., Morishita, M., Niwa, Y., Takeyama, T., and Mieno, Y. (2015). Bronchus sign on thin-section computed tomography is a powerful predictive factor for successful transbronchial biopsy using endobronchial ultrasound with a guide sheath for small peripheral lung lesions: A retrospective observational study. BMC Med. Imaging, 15.","DOI":"10.1186\/s12880-015-0060-5"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.jvir.2010.01.011","article-title":"Quality improvement guidelines for percutaneous needle biopsy","volume":"21","author":"Gupta","year":"2010","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.2214\/ajr.180.6.1801665","article-title":"CT-guided transthoracic needle aspiration biopsy of small (<or = 20 mm) solitary pulmonary nodules","volume":"180","author":"Ohno","year":"2003","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/JTO.0b013e318233d7dd","article-title":"Percutaneous computed tomography-guided coaxial core biopsy for small pulmonary lesions with ground-glass attenuation","volume":"7","author":"Lu","year":"2012","journal-title":"J. Thorac. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"20120447","DOI":"10.1259\/bjr.20120447","article-title":"Diagnostic performance of percutaneous lung biopsy using automated biopsy needles under CT-fluoroscopic guidance for ground-glass opacity lesions","volume":"86","author":"Yamagami","year":"2013","journal-title":"Br. J. Radiol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Zhang, L., Shi, L., Xiao, Z., Qiu, H., Peng, P., and Zhang, M. (2018). Coaxial technique-promoted diagnostic accuracy of CT-guided percutaneous cutting needle biopsy for small and deep lung lesions. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0192920"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"W678","DOI":"10.2214\/AJR.10.4659","article-title":"Complications of CT-guided percutaneous needle biopsy of the chest: Prevention and management","volume":"196","author":"Wu","year":"2011","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S1051-0443(98)70279-9","article-title":"Percutaneous transthoracic needle biopsy of the lung: Review of 612 lesions","volume":"9","author":"Swischuk","year":"1998","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1148\/radiol.2291020499","article-title":"CT-guided transthoracic needle aspiration biopsy of pulmonary nodules: Needle size and pneumothorax rate","volume":"229","author":"Geraghty","year":"2003","journal-title":"Radiology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1007\/s00330-008-0893-1","article-title":"Variables affecting the risk of pneumothorax and intrapulmonal hemorrhage in CT-guided transthoracic biopsy","volume":"18","author":"Khan","year":"2008","journal-title":"Eur. Radiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1378\/chest.126.3.748","article-title":"Risk factors of pneumothorax and bleeding: Multivariate analysis of 660 CT-guided coaxial cutting needle lung biopsies","volume":"126","author":"Yeow","year":"2004","journal-title":"Chest"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1136\/thx.2010.145490","article-title":"Virtual Navigation in Japan (V-NINJA) Trial Group. Virtual bronchoscopic navigation combined with endobronchial ultrasound to diagnose small peripheral pulmonary lesions: A randomised trial","volume":"66","author":"Ishida","year":"2011","journal-title":"Thorax"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4103\/2303-9027.151332","article-title":"Endoscopic ultrasound and\/or endobronchial ultrasound-guided needle biopsy of central intraparenchymal lung lesions not adjacent to airways or esophagus","volume":"4","author":"Dincer","year":"2015","journal-title":"Endosc. Ultrasound"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/LBR.0000000000000020","article-title":"The usefulness of endobronchial ultrasonography-guided transbronchial needle aspiration at the lobar, segmental, or subsegmental bronchus smaller than a convex-type bronchoscope","volume":"21","author":"Kurimoto","year":"2014","journal-title":"J. Bronchol. Interv. Pulmonol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2217\/fon-2019-0076","article-title":"CT-guided transthoracic needle biopsy: Advantages in histopathological and molecular tests","volume":"16","author":"Porrello","year":"2020","journal-title":"Future Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.21037\/qims-19-1024","article-title":"Risk factors associated with pulmonary hemorrhage and hemoptysis following percutaneous CT-guided transthoracic lung core needle biopsy: A retrospective study of 1,090 cases","volume":"10","author":"Zhu","year":"2020","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.5152\/dir.2014.140140","article-title":"CT-guided transthoracic biopsy: Histopathologic results and complication rates","volume":"21","author":"Kayan","year":"2015","journal-title":"Diagn. Interv. Radiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s40644-019-0240-6","article-title":"Accuracy and complications of CT-guided pulmonary core biopsy in small nodules: A single-center experience","volume":"19","author":"Huang","year":"2019","journal-title":"Cancer Imaging"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.ejrad.2014.06.023","article-title":"Risk factor analysis of pulmonary hemorrhage complicating CT-guided lung biopsy in coaxial and non-coaxial core biopsy techniques in 650 patients","volume":"83","author":"Alsubhi","year":"2014","journal-title":"Eur. J. Radiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00270-015-1167-3","article-title":"Pneumothorax complicating coaxial and non-coaxial CT-Guided lung biopsy: Comparative analysis of determining risk factors and management of pneumothorax in a retrospective review of 650 patients","volume":"39","author":"Alsubhi","year":"2016","journal-title":"Cardiovasc. Interv. Radiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1148\/radiol.2322031201","article-title":"Pleomorphic carcinoma of lung: Comparison of CT features and pathologic findings","volume":"232","author":"Kim","year":"2004","journal-title":"Radiology"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Kim, H., Kwon, D., Yoon, S.H., Park, C.M., Goo, J.M., Jeon, Y.K., and Ahn, S.Y. (2018). Bronchovascular injury associated with clinically significant hemoptysis after CT-guided core biopsy of the lung: Radiologic and histopathologic analysis. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0204064"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.3348\/kjr.2019.0014","article-title":"Non-diagnostic CT-Guided percutaneous needle biopsy of the lung: Predictive factors and final diagnoses","volume":"20","author":"Tongbai","year":"2019","journal-title":"Korean J. Radiol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/9\/2031\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:58:31Z","timestamp":1760162311000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/9\/2031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,9]]},"references-count":29,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,5]]}},"alternative-id":["jcm10092031"],"URL":"https:\/\/doi.org\/10.3390\/jcm10092031","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,9]]}}}