{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:56:38Z","timestamp":1788220598457,"version":"build-2803163510"},"reference-count":31,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Multiple sclerosis (MS) is a chronic disease marked by progressive disability and decreased mobility over time. We studied whether individuals with MS of higher disability levels will be more overweight\/obese as a result of their immobility and\/or recurrent steroid treatments. In a prospective study, 130 individuals with MS and significant disability were classified according to the Expanded Disability Status Scale (EDSS) score as belonging to four groups: EDSS 3.0\u20134.0 (n = 31, 24%), EDSS 4.5\u20135.5 (n = 24, 18%), EDSS = 6.0 (n = 44, 34%) and EDSS \u2265 6.5 (n = 31, 24%). Medical history, body mass index (BMI), waist circumference and the level of engagement in physical activity were obtained. The mean \u00b1 standard error age was 55.8 \u00b1 0.5 years, disease duration 18.2 \u00b1 1.0 years and EDSS score 5.5 \u00b1 0.1. Disease duration, the number of steroid courses per disease duration, weight, BMI and physical activity did not differ according to the four disability groups. The mean waist circumference increased significantly with increased severity of EDSS, p = 0.03. Increased disability in individuals with MS was not correlated with disease duration, lifestyle habits or overweight\/obesity. However, increased disability was associated with central obesity.<\/jats:p>","DOI":"10.3390\/jcm10102083","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T10:59:12Z","timestamp":1620817152000},"page":"2083","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Bodyweight Measures and Lifestyle Habits in Individuals with Multiple Sclerosis and Moderate to Severe Disability"],"prefix":"10.3390","volume":"10","author":[{"given":"Moran","family":"Livne-Margolin","sequence":"first","affiliation":[{"name":"Sackler School of Medicine, Tel-Aviv University, Ramat Aviv 69978, Israel"},{"name":"Gastroenterology Department, Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itay","family":"Tokatly Latzer","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel-Aviv University, Ramat Aviv 69978, Israel"},{"name":"Pediatric Neurology Institute, Dana-Dwek Children\u2019s Hospital, Tel Aviv Medical Center, Tel Aviv 60198, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orit","family":"Pinhas-Hamiel","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel-Aviv University, Ramat Aviv 69978, Israel"},{"name":"Pediatric Endocrinology and Diabetes Unit, Edmond and Lily Safra Children\u2019s Hospital, Sheba Medical Center, Tel-Hashomer, Ramat Gan 52621, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Harari","sequence":"additional","affiliation":[{"name":"School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa 3498838, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2020-3126","authenticated-orcid":false,"given":"Anat","family":"Achiron","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel-Aviv University, Ramat Aviv 69978, Israel"},{"name":"Multiple Sclerosis Center, Sheba Medical Center, Tel-Hashomer, Ramat Gan 52621, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"key":"ref_1","first-page":"527","article-title":"Progressive multiple sclerosis: From pathogenic mechanisms to treatment","volume":"140","author":"Correale","year":"2016","journal-title":"Brain"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ctim.2019.02.006","article-title":"Weight control and physical exercise in people with multiple sclerosis: Current knowledge and future perspectives","volume":"43","author":"Mokhtarzade","year":"2019","journal-title":"Complement. 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