{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T06:02:25Z","timestamp":1781935345014,"version":"3.54.5"},"reference-count":30,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T00:00:00Z","timestamp":1620864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Cardiac rehabilitation (CR) improves symptoms and survival in patients with acute myocardial infarction (AMI). We studied the change of diastolic function and its prognostic impact after CR. After reviewing all consecutive AMI patients from January 2012 to October 2015, we analyzed 405 patients (mean, 63.7 \u00b1 11.7 years; 300 males) with baseline and follow-up echocardiographic examinations. We divided them into three groups according to their CR sessions: No-CR group (n = 225), insufficient-CR group (CR &lt; 6 sessions, n = 117) and CR group (CR \u2265 6 sessions, n = 63). We compared echocardiographic parameters of diastolic dysfunction including E\/e\u2019 ratio &gt; 14, septal e\u2019 velocity &lt; 7 cm\/s, left atrial volume index (LAVI) &gt; 34 mL\/m2, and maximal TR velocity &gt; 2.8 m\/s. At baseline, there were no significant differences in all echocardiographic parameters among the three groups. At follow-up echocardiographic examination, mitral annular e\u2019 and a\u2019 velocities were higher in the CR group (p = 0.024, and p = 0.009, respectively), and mitral E\/e\u2019 ratio was significantly lower (p = 0.009) in the CR group. The total number of echocardiographic parameters of diastolic dysfunction at the baseline echocardiography was similar (1.29 vs. 1.41 vs. 1.52, p = 0.358). However, the CR group showed the lowest number of diastolic parameters at the follow-up echocardiography (1.05 vs. 1.32 vs. 1.50, p = 0.017). There was a significant difference between the No-CR group and CR group (p = 0.021). The presence of CR was a significant determinant of major adverse cardiovascular events in the univariate analysis (HR = 0.606, p = 0.049). However, the significance disappeared in the multivariate analysis (HR = 0.738, p = 0.249). In conclusion, the CR was significantly associated with favorable diastolic function, with the highest mitral e\u2019 and a\u2019 velocity, and the lowest mitral E\/e\u2019 ratio and total number of echocardiographic parameters of diastolic dysfunction at the follow-up echocardiographic examinations in AMI patients.<\/jats:p>","DOI":"10.3390\/jcm10102088","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T11:10:06Z","timestamp":1620904206000},"page":"2088","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effect of Cardiac Rehabilitation on Left Ventricular Diastolic Function in Patients with Acute Myocardial Infarction"],"prefix":"10.3390","volume":"10","author":[{"given":"Jae-Hwan","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Cardiology in Internal Medicine, Chungnam National University Sejong Hospital, Chungnam National University School of Medicine, Sejong 30099, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungai","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology in Internal Medicine, Chungnam National University Sejong Hospital, Chungnam National University School of Medicine, Sejong 30099, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Joo","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology in Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon 35015, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Ju","family":"Jee","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon 35015, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7035-286X","authenticated-orcid":false,"given":"Jae-Hyeong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Cardiology in Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon 35015, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.36628\/ijhf.2019.0014","article-title":"Management of Acute Heart Failure during an Early Phase","volume":"2","author":"Takagi","year":"2020","journal-title":"Int. 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