{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:31:40Z","timestamp":1765233100868,"version":"build-2065373602"},"reference-count":45,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>A single-center retrospective cohort study examined the association between molar malocclusion status at ICU admission and loss of activities of daily living (ADL) at hospital discharge among acutely ill patients. Patients were assigned to the bilateral occlusion group or malocclusion group (N = 227 and 93, respectively). The following data were collected from electronic medical records: age, sex, Clinical Frailty Scale (CFS) on admission, Acute Physiology and Chronic Health Evaluation (APACHE) \u2161 score, confirmed diagnosis (neurological disorders or others), CFS at hospital discharge, and occlusion condition. Patients who were frail at admission (CFS &gt; 5) were excluded from analysis, and ADL loss was defined as CFS &gt; 5 at hospital discharge. Multivariate analysis showed malocclusion was independently associated with ADL loss [OR, 2.03; 95% CI, 1.13\u20133.64; p = 0.02]. For those aged 65 and older, malocclusion was significantly associated with both ADL loss [OR, 3.25; 95% CI, 1.44\u20137.32; p &lt; 0.01] and the incidence of delirium [OR, 2.61; 95% CI, 1.14\u20135.95; p = 0.02]. Malocclusion on ICU admission was associated with ADL loss in critically ill patients, and was associated with ADL loss and the incidence of delirium in the elderly. Poor oral health was a poor prognostic factor among critically ill patients.<\/jats:p>","DOI":"10.3390\/jcm10102157","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T04:25:07Z","timestamp":1621225507000},"page":"2157","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Malocclusion of Molar Teeth Is Associated with Activities of Daily Living Loss and Delirium in Elderly Critically Ill Older Patients"],"prefix":"10.3390","volume":"10","author":[{"given":"Yoshihisa","family":"Fujinami","sequence":"first","affiliation":[{"name":"Department of Disaster and Emergency and Critical Care Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Hifumi","sequence":"additional","affiliation":[{"name":"Department of Disaster and Emergency and Critical Care Medicine, Kagawa University Graduate School of Medicine, Kagawa 761-0701, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5953-3042","authenticated-orcid":false,"given":"Yuko","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Disaster and Emergency and Critical Care Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Disaster and Emergency and Critical Care Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0540-8772","authenticated-orcid":false,"given":"Tomoya","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Disaster and Emergency and Critical Care Medicine, Kagawa University Graduate School of Medicine, Kagawa 761-0701, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsuyo","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Department of Disaster and Emergency and Critical Care Medicine, Kagawa University Graduate School of Medicine, Kagawa 761-0701, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Department of Disaster and Emergency and Critical Care Medicine, Kagawa University Graduate School of Medicine, Kagawa 761-0701, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misa","family":"Kunikata","sequence":"additional","affiliation":[{"name":"Department of Disaster and Emergency and Critical Care Medicine, Kagawa University Graduate School of Medicine, Kagawa 761-0701, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3907-8537","authenticated-orcid":false,"given":"Shigeaki","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Disaster and Emergency and Critical Care Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joji","family":"Kotani","sequence":"additional","affiliation":[{"name":"Department of Disaster and Emergency and Critical Care Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Disaster and Emergency and Critical Care Medicine, Kagawa University Graduate School of Medicine, Kagawa 761-0701, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/01.CCM.0000194535.82812.BA","article-title":"The effect of age on the development and outcome of adult sepsis","volume":"34","author":"Martin","year":"2006","journal-title":"Crit. Care Med."},{"key":"ref_2","first-page":"52","article-title":"The very elderly admitted to ICU: A quality finish?","volume":"4313","author":"Heyland","year":"2015","journal-title":"Crit. Care Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0140-6736(12)62167-9","article-title":"Frailty in elderly people","volume":"381","author":"Clegg","year":"2013","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in Older Adults: Evidence for a Phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s00134-017-4867-0","article-title":"The impact of frailty on intensive care unit outcomes: A systematic review and meta-analysis","volume":"43","author":"Muscedere","year":"2017","journal-title":"Intensiv. Care Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1007\/s00134-001-1132-2","article-title":"The impact of delirium in the intensive care unit on hospital length of stay","volume":"27","author":"Ely","year":"2001","journal-title":"Intensiv. Care Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1111\/jgs.13826","article-title":"Frailty, Frailty Components, and Oral Health: A Systematic Review","volume":"63","author":"Tellez","year":"2015","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/jgs.14355","article-title":"Relationship between Frailty and Oral Function in Community-Dwelling Elderly Adults","volume":"65","author":"Watanabe","year":"2017","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/ije\/dyh375","article-title":"Tooth loss is associated with increased risk of total death and death from upper gastrointestinal cancer, heart disease, and stroke in a Chinese population-based cohort","volume":"34","author":"Abnet","year":"2005","journal-title":"Int. J. Epidemiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2147\/COPD.S194991","article-title":"The relationship between oral health and COPD exacerbations","volume":"ume 14","author":"Baldomero","year":"2019","journal-title":"Int. J. Chronic Obs. Pulm. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/MAJ.0b013e31828bdedf","article-title":"Oral Health and Type 2 Diabetes","volume":"345","author":"Leite","year":"2013","journal-title":"Am. J. Med. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/ger.12397","article-title":"Frailty, oral health and nutrition in geriatrics inpatients: A cross-sectional study","volume":"36","author":"Shwe","year":"2019","journal-title":"Gerodontology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/sj.bdj.2017.992","article-title":"Evidence summary: The relationship between oral health and dementia","volume":"223","author":"Daly","year":"2017","journal-title":"Br. Dent. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e240","DOI":"10.17269\/CJPH.108.5929","article-title":"Inequalities in oral health: Understanding the contributions of education and income","volume":"108","author":"Farmer","year":"2017","journal-title":"Can. J. Public Health"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1136\/hrt.2006.097410","article-title":"Associations between tooth loss and mortality patterns in the Glasgow Alumni Cohort","volume":"93","author":"Tu","year":"2007","journal-title":"Heart"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1752-7325.2009.00132.x","article-title":"Complete Edentulism Prior to the Age of 65 Years is Associated with All-Cause Mortality","volume":"69","author":"Brown","year":"2009","journal-title":"J. Public Health Dent."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Ansai, T., Takata, Y., Soh, I., Awano, S., Yoshida, A., Sonoki, K., Hamasaki, T., Torisu, T., Sogame, A., and Shimada, N. (2010). Relationship between tooth loss and mortality in 80-year-old Japanese community-dwelling subjects. BMC Public Health, 10.","DOI":"10.1186\/1471-2458-10-386"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jpor.2014.07.001","article-title":"Influence of occlusal loading force on occlusal contacts in natural dentition","volume":"59","author":"Imamura","year":"2015","journal-title":"J. Prosthodont. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.archoralbio.2011.03.019","article-title":"Association of masticatory performance with age, gender, number of teeth, occlusal force and salivary flow in Japanese older adults: Is ageing a risk factor for masticatory dysfunction?","volume":"56","author":"Ikebe","year":"2011","journal-title":"Arch. Oral Biol."},{"key":"ref_20","first-page":"521","article-title":"Validation of the Eichner index in relation to occlusal force and masticatory performance","volume":"23","author":"Ikebe","year":"2011","journal-title":"Int. J. Prosthodont."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1503\/cmaj.050051","article-title":"A global clinical measure of fitness and frailty in elderly people","volume":"173","author":"Rockwood","year":"2005","journal-title":"Can. Med. Assoc. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.jamcollsurg.2017.08.008","article-title":"Canadian Study of Health and Aging Clinical Frailty Scale: Does It Predict Adverse Outcomes among Geriatric Trauma Patients?","volume":"225","author":"Cheung","year":"2017","journal-title":"J. Am. Coll. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1001\/jama.291.14.1753","article-title":"Delirium as a Predictor of Mortality in Mechanically Ventilated Patients in the Intensive Care Unit","volume":"291","author":"Ely","year":"2004","journal-title":"JAMA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.aucc.2016.07.002","article-title":"The impact of oral care on oral health status and prevention of ventilator-associated pneumonia in critically ill patients","volume":"30","author":"Haghighi","year":"2017","journal-title":"Aust. Crit. Care"},{"key":"ref_25","first-page":"141","article-title":"Is the social status a new prognostic factor in the Fournier\u2019s gangrene?","volume":"40","author":"Capasso","year":"2019","journal-title":"G. Chir."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Giannico, O.V., Ambrosino, I., Patano, F., Germinario, C., Quarto, M., and Moretti, A.M. (2019). Educational level, marital status and sex as social gender discharge determinants in chronic obstructive pulmonary disease exacerbations: A time-to-event analysis. Monaldi Arch. Chest Dis., 89.","DOI":"10.4081\/monaldi.2019.1017"},{"key":"ref_27","first-page":"1661","article-title":"Oral Frailty as a Risk Factor for Physical Frailty and Mortality in Community-Dwelling Elderly","volume":"73","author":"Tanaka","year":"2018","journal-title":"J. Gerontol. Ser. A Boil. Sci. Med. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1177\/00220345990780060301","article-title":"Occlusal disharmonies modulate central catechola-minergic activity in the rat","volume":"78","author":"Areso","year":"1999","journal-title":"J. Dent. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/cdoe.12000","article-title":"Interrelationship of oral health status, swallowing function, nutritional status, and cognitive ability with activities of daily living in Japanese elderly people receiving home care services due to physical disabilities","volume":"41","author":"Furuta","year":"2012","journal-title":"Community Dent. Oral Epidemiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e420","DOI":"10.1136\/bmj.e420","article-title":"Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for intensive care patients: Observational multicentre study","volume":"344","author":"Pickkers","year":"2012","journal-title":"BMJ"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1159\/000499707","article-title":"Associations between Frailty and Delirium among Older Patients Admitted to an Emergency Department","volume":"9","author":"Verloo","year":"2019","journal-title":"Dement. Geriatr. Cogn. Dis. Extra"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/gerona\/63.5.495","article-title":"Cognitive function and oral health among community-dwelling older adults","volume":"63","author":"Wu","year":"2008","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/jgs.13190","article-title":"Tooth Loss Associated with Physical and Cognitive Decline in Older Adults","volume":"63","author":"Tsakos","year":"2015","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/MEJ.0000000000000587","article-title":"CAM-ICU may not be the optimal screening tool for early delirium screening in older emergency department patients: A prospective cohort study","volume":"26","author":"Lucke","year":"2019","journal-title":"Eur. J. Emerg. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/CCM.0b013e318232da75","article-title":"Improving long-term outcomes after discharge from intensive care unit: Report from a stakeholders\u2019 conference","volume":"40","author":"Needham","year":"2012","journal-title":"Crit. Care Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1097\/01.CCM.0000119429.16055.92","article-title":"Costs associated with delirium in mechanically ventilated patients","volume":"32","author":"Milbrandt","year":"2004","journal-title":"Crit. Care Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1097\/CCM.0b013e3181e47be1","article-title":"Delirium as a predictor of long-term cognitive impairment in survivors of critical illness","volume":"38","author":"Girard","year":"2010","journal-title":"Crit. Care Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1902\/jop.2014.140340","article-title":"Is Periodontitis a Risk Factor for Cognitive Impairment and Dementia? A Case-Control Study","volume":"86","author":"Fornieles","year":"2015","journal-title":"J. Periodontol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/jgs.13781","article-title":"Periodontitis Is Associated with Cognitive Impairment in Elderly Koreans: Results from the Yangpyeong Cohort Study","volume":"64","author":"Shin","year":"2016","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1042\/BST0390898","article-title":"Systemic inflammation and Alzheimer\u2019s disease","volume":"39","author":"Holmes","year":"2011","journal-title":"Biochem. Soc. Trans."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"865","DOI":"10.2147\/NDT.S3610","article-title":"Inflammation as a potential mediator for the association between periodontal disease and Alzheimer\u2019s disease","volume":"4","author":"Watts","year":"2008","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3233\/JAD-2012-111853","article-title":"A critical review of vitamin C for the prevention of age-related cognitive decline and Alzheimer\u2019s disease","volume":"29","author":"Harrison","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"ref_43","first-page":"150","article-title":"Nutritional factors and risk of incident dementia in the PAQUID longitudinal cohort","volume":"8","author":"Larrieu","year":"2004","journal-title":"J. Nutr. Health Aging"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1177\/0810743","article-title":"Mapping brain region activity during chewing: A functional magnetic resonance imaging study","volume":"81","author":"Onozuka","year":"2002","journal-title":"J. Dent. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0003-9969(96)00081-7","article-title":"Effect of mastication on regional cerebral blood flow in humans examined by pos-itron-emission tomography with 15O-labelled water and magnetic resonance imaging","volume":"42","author":"Momose","year":"1997","journal-title":"Arch. Oral. Biol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/10\/2157\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:02:24Z","timestamp":1760162544000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/10\/2157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,17]]},"references-count":45,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,5]]}},"alternative-id":["jcm10102157"],"URL":"https:\/\/doi.org\/10.3390\/jcm10102157","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2021,5,17]]}}}