{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:38:05Z","timestamp":1787495885018,"version":"build-2736575974"},"reference-count":42,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Atherosclerosis is associated with a worse prognosis in many diseases such as ischemic cardiomyopathy, but its impact in non-ischemic dilated cardiomyopathy (dCMP) is lesser known. Our aim was to study the prognostic impact of coronary atherosclerotic burden (CAB) in patients with dCMP. Methods: Consecutive patients with dCMP and left ventricular (LV) dysfunction diagnosed by concomitant analysis of invasive coronary angiography (ICA) and CMR imaging were identified from registry-database. CAB was measured by Gensini score. The primary composite endpoint was the occurrence of major adverse cardiovascular events (MACE) defined as cardiovascular (CV) mortality, non-fatal MI and unplanned myocardial revascularization. The results of 139 patients constituting the prospective study population (mean age 59.4 \u00b1 14.7 years old, 74% male), average LV ejection fraction was 31.1 \u00b1 11.02%, median Gensini score was 0 (0\u20133), and mid-wall late gadolinium enhancement (LGE) was the most frequent LGE pattern (42%). Over a median follow-up of 2.8 years, 9% of patients presented MACE. Patients with MACE had significantly higher CAB compared to those who were free of events (0 (0\u20133) vs. 3.75 (2\u201315), p &lt; 0.0001). CAB remained the significant predictor of MACE on multivariate logistic analysis (OR: 1.12, CI: 1.01\u20131.23, p = 0.02). Conclusion: High CAB may be a new prognostic factor in dCMP patients.<\/jats:p>","DOI":"10.3390\/jcm10102183","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T12:17:16Z","timestamp":1621340236000},"page":"2183","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prognosis of Coronary Atherosclerotic Burden in Non-Ischemic Dilated Cardiomyopathies"],"prefix":"10.3390","volume":"10","author":[{"given":"Marjorie","family":"Canu","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Hospital, 38000 Grenoble Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a","family":"Margerit","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, 38000 Grenoble Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Mekhdoul","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, 38000 Grenoble Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4265-8463","authenticated-orcid":false,"given":"Alexis","family":"Broisat","sequence":"additional","affiliation":[{"name":"INSERM, U1039, Radiopharmaceutiques Biocliniques, Grenoble Alpes University, 38000 Grenoble Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Riou","sequence":"additional","affiliation":[{"name":"INSERM, U1039, Radiopharmaceutiques Biocliniques, Grenoble Alpes University, 38000 Grenoble Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Djaileb","sequence":"additional","affiliation":[{"name":"INSERM, U1039, Radiopharmaceutiques Biocliniques, Grenoble Alpes University, 38000 Grenoble Alpes, France"},{"name":"Department of Nuclear Medicine, University Hospital, 38000 Grenoble Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mence","family":"Charlon","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, 38000 Grenoble Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Jankowski","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital, 38000 Grenoble Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2058-6865","authenticated-orcid":false,"given":"Michele","family":"Magnesa","sequence":"additional","affiliation":[{"name":"Department of Medical &amp; Surgical Sciences, University of Foggia, 71121 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Augier","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, 38000 Grenoble Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Marli\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, 38000 Grenoble Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Salvat","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, 38000 Grenoble Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Casset","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, 38000 Grenoble Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4156-3208","authenticated-orcid":false,"given":"Marion","family":"Maurin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, 38000 Grenoble Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Saunier","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, 38000 Grenoble Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Fagret","sequence":"additional","affiliation":[{"name":"INSERM, U1039, Radiopharmaceutiques Biocliniques, Grenoble Alpes University, 38000 Grenoble Alpes, France"},{"name":"Department of Nuclear Medicine, University Hospital, 38000 Grenoble Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Ghezzi","sequence":"additional","affiliation":[{"name":"INSERM, U1039, Radiopharmaceutiques Biocliniques, Grenoble Alpes University, 38000 Grenoble Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Vanzetto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, 38000 Grenoble Alpes, France"},{"name":"INSERM, U1039, Radiopharmaceutiques Biocliniques, Grenoble Alpes University, 38000 Grenoble Alpes, France"},{"name":"French Alliance Clinical Trial, French Clinical Research Infrastructure Network, 31059 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1146-0542","authenticated-orcid":false,"given":"Gilles","family":"Barone-Rochette","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, 38000 Grenoble Alpes, France"},{"name":"INSERM, U1039, Radiopharmaceutiques Biocliniques, Grenoble Alpes University, 38000 Grenoble Alpes, France"},{"name":"French Alliance Clinical Trial, French Clinical Research Infrastructure Network, 31059 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/eurheartj\/ehm342","article-title":"Classification of the cardiomyopathies: A position statement from the European Society Of Cardiology Working Group on Myocardial and Pericardial Diseases","volume":"29","author":"Elliott","year":"2008","journal-title":"Eur. 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