{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:14:10Z","timestamp":1790723650931,"version":"4.1.0"},"reference-count":140,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Sciatica is a condition often accompanied by neuropathic pain (NP). Acupuncture and dry needling are common treatments for pain, and the current literature supports acupuncture as an effective treatment for sciatica. However, it is unknown if the mechanisms of NP are considered in the delivery of needling interventions for sciatica. Our objective was to assess the efficacy and the effectiveness of needling therapies, to identify common needling practices and to investigate if NP mechanisms are considered in the treatment of sciatica. A scoping review of the literature on needling interventions for sciatica and a review of the literature on mechanisms related to NP and needling interventions were performed. Electronic literature searches were conducted on PubMed, MEDLINE, CINAHL and Cochrane Database of Systematic Reviews from inception to August, 2020 to identify relevant papers. Reference lists of included papers were also manually screened and a related-articles search through PubMed was performed on all included articles. Mapping of the results included description of included studies, summary of results, and identification of gaps in the existing literature. Ten articles were included. All studies used acupuncture for the treatment of sciatica, no studies on dry needling were identified. Current evidence supports the efficacy and effectiveness of acupuncture for sciatica, however, no studies considered underlying NP mechanisms in the acupuncture approach for sciatica and the rationale for using acupuncture was inconsistent among trials. This review reveals that neuropathic pain mechanisms are not routinely considered in needling approaches for patients with sciatica. Studies showed acupuncture to be an effective treatment for sciatic pain, however, further research is warranted to explore if needling interventions for sciatica and NP would be more effective if NP mechanisms are considered.<\/jats:p>","DOI":"10.3390\/jcm10102189","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T12:58:07Z","timestamp":1621429087000},"page":"2189","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Needling Interventions for Sciatica: Choosing Methods Based on Neuropathic Pain Mechanisms\u2014A Scoping Review"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0325-2652","authenticated-orcid":false,"given":"Thomas","family":"Perreault","sequence":"first","affiliation":[{"name":"Northern New England Spine Center, Department of Physical Therapy, Wentworth Douglass Hospital, Dover, NH 03820, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3772-9690","authenticated-orcid":false,"given":"C\u00e9sar","family":"Fern\u00e1ndez-de-las-Pe\u00f1as","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Universidad Rey Juan Carlos, 28922 Alcorc\u00f3n, Madrid, Spain"},{"name":"C\u00e1tedra Institucional en Docencia, Cl\u00ednica e Investigaci\u00f3n en Fisioterapia: Terapia Manual, Punci\u00f3n Seca y Ejercicio Terap\u00e9utico, Universidad Rey Juan Carlos, 28922 Alcorc\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2224-8835","authenticated-orcid":false,"given":"Mike","family":"Cummings","sequence":"additional","affiliation":[{"name":"British Medical Acupuncture Society, London WC1N 3HR, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry C.","family":"Gendron","sequence":"additional","affiliation":[{"name":"Northern New England Spine Center, Department of Physical Medicine and Rehabilitation, Musculoskeletal Health and Rehabilitation, Wentworth Douglass Hospital, Dover, NH 03820, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/j.1532-2149.2013.00384.x","article-title":"How is radiating leg pain defined in randomized controlled trials of conservative treatments in primary care? A systematic review","volume":"18","author":"Lin","year":"2014","journal-title":"Eur. J. Pain"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/bja\/aem238","article-title":"Sciatica: A review of history, epidemiology, pathogenesis, and the role of epidural steroid injection in management","volume":"99","author":"Stafford","year":"2007","journal-title":"Br. J. Anaesth."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1056\/NEJMra1410151","article-title":"Sciatica","volume":"372","author":"Ropper","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_4","first-page":"149","article-title":"Therapeutic approach of acupuncture for sciatica: A brief review","volume":"7","author":"Liu","year":"2017","journal-title":"Neuropsychiatry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1097\/BRS.0b013e318183a4a2","article-title":"Sciatica: Review of epidemiological studies and prevalence estimates","volume":"33","author":"Konstantinou","year":"2008","journal-title":"Spine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"l6273","DOI":"10.1136\/bmj.l6273","article-title":"Diagnosis and treatment of sciatica","volume":"367","author":"Jensen","year":"2019","journal-title":"BMJ"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1097\/BRS.0000000000001956","article-title":"Epidemiological Differences Between Localized and Nonlocalized Low Back Pain","volume":"42","author":"Coggon","year":"2017","journal-title":"Spine"},{"key":"ref_8","first-page":"1253","article-title":"Relationship between severity of lumbar disc disease and disability scores in sciatica patients","volume":"50","author":"Porchet","year":"2002","journal-title":"Neurosurgery"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/j.pain.0000000000000753","article-title":"Peripheral neuropathic pain: A mechanism-related organizing principle based on sensory profiles","volume":"158","author":"Baron","year":"2017","journal-title":"Pain"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ejp.1475","article-title":"New insight to the characteristics and clinical course of clusters of patients with imaging confirmed disc-related sciatica","volume":"24","author":"Stynes","year":"2020","journal-title":"Eur. J. Pain"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/j.pain.0000000000001365","article-title":"The IASP classification of chronic pain for ICD-11: Chronic neuropathic pain","volume":"160","author":"Scholz","year":"2019","journal-title":"Pain"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1097\/AJP.0000000000000879","article-title":"Prevalence, Characteristics, and Clinical Course of Neuropathic Pain in Primary Care Patients Consulting with Low Back-related Leg Pain","volume":"36","author":"Harrisson","year":"2020","journal-title":"Clin. J. Pain"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.2147\/JPR.S139324","article-title":"Application of the chronic constriction injury of the partial sciatic nerve model to assess acupuncture analgesia","volume":"10","author":"Zhi","year":"2017","journal-title":"J. Pain Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1113\/jphysiol.2002.036186","article-title":"Peripheral nerve injury alters excitatory synaptic transmission in lamina II of the rat dorsal horn","volume":"548","author":"Kohno","year":"2003","journal-title":"J. Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1093\/brain\/awt334","article-title":"Enhancing K-Cl co-transport restores normal spinothalamic sensory coding in a neuropathic pain model","volume":"137","author":"Lavertu","year":"2014","journal-title":"Brain"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1152\/jn.00087.2006","article-title":"Sciatic chronic constriction injury produces cell-type-specific changes in the electrophysiological properties of rat substantia gelatinosa neurons","volume":"96","author":"Balasubramanyan","year":"2006","journal-title":"J. Neurophysiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nn.2562","article-title":"Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture","volume":"13","author":"Goldman","year":"2010","journal-title":"Nat. Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"235491","DOI":"10.1155\/2015\/235491","article-title":"Strong Manual Acupuncture Stimulation of \u201cHuantiao\u201d (GB 30) Reduces Pain-Induced Anxiety and p-ERK in the Anterior Cingulate Cortex in a Rat Model of Neuropathic Pain","volume":"2015","author":"Shao","year":"2015","journal-title":"Evid. Based Complementary Altern. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jams.2018.05.006","article-title":"Analgesic Effects Elicited by Neuroactive Mediators Injected into the ST 36 Acupuncture Point on Inflammatory and Neuropathic Pain in Mice","volume":"11","author":"Vieira","year":"2018","journal-title":"J. Acupunct. Meridian Stud."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3349\/ymj.2006.47.3.359","article-title":"Antiallodynic effects of acupuncture in neuropathic rats","volume":"47","author":"Cha","year":"2006","journal-title":"Yonsei Med. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.neuroscience.2011.07.076","article-title":"Manual acupuncture inhibits mechanical hypersensitivity induced by spinal nerve ligation in rats","volume":"193","author":"More","year":"2011","journal-title":"Neuroscience"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.2147\/JPR.S210672","article-title":"Therapeutic Efficacy and the Impact of the \u201cDose\u201d Effect of Acupuncture to Treat Sciatica: A Randomized Controlled Pilot Study","volume":"12","author":"Liu","year":"2019","journal-title":"J. Pain Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.neuroscience.2010.07.031","article-title":"Electroacupuncture versus celecoxib for neuropathic pain in rat SNL model","volume":"170","author":"Lau","year":"2010","journal-title":"Neuroscience"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.spinee.2013.08.049","article-title":"Comparative clinical effectiveness of management strategies for sciatica: Systematic review and network meta-analyses","volume":"15","author":"Lewis","year":"2015","journal-title":"Spine J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3389\/fnins.2019.00110","article-title":"Peripheral Sensory Nerve Tissue but Not Connective Tissue Is Involved in the Action of Acupuncture","volume":"13","author":"Chang","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3524279","DOI":"10.1155\/2018\/3524279","article-title":"Mast Cells and Nerve Signal Conduction in Acupuncture","volume":"2018","author":"Yin","year":"2018","journal-title":"Evid. Based Complementary Alternat. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1136\/acupmed-2015-011026","article-title":"Acupuncture at distant myofascial trigger spots enhances endogenous opioids in rabbits: A possible mechanism for managing myofascial pain","volume":"34","author":"Hsieh","year":"2016","journal-title":"Acupunct. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1136\/acupmed-2015-010911","article-title":"Dry needling versus acupuncture: The ongoing debate","volume":"33","author":"Zhou","year":"2015","journal-title":"Acupunct. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"705327","DOI":"10.1155\/2012\/705327","article-title":"Probable mechanisms of needling therapies for myofascial pain control","volume":"2012","author":"Chou","year":"2012","journal-title":"Evid. Based Complementary Alternat. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ctim.2016.02.013","article-title":"Traditional Chinese Medicine acupuncture and myofascial trigger needling: The same stimulation points?","volume":"26","author":"Liu","year":"2016","journal-title":"Complementary Ther. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1097\/j.pain.0000000000000283","article-title":"Acupuncture-induced changes of pressure pain threshold are mediated by segmental inhibition-a randomized controlled trial","volume":"156","author":"Baeumler","year":"2015","journal-title":"Pain"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2340\/16501977-0535","article-title":"Dry needle stimulation of myofascial trigger points evokes segmental anti-nociceptive effects","volume":"42","author":"Srbely","year":"2010","journal-title":"J. Rehabil. Med."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Baeumler, P.I., Fleckenstein, J., Takayama, S., Simang, M., Seki, T., and Irnich, D. (2014). Effects of acupuncture on sensory perception: A systematic review and meta-analysis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0113731"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Leitner, J., Westerholz, S., Heinke, B., Forsthuber, L., Wunderbaldinger, G., J\u00e4ger, T., Gruber-Schoffnegger, D., Braun, K., and Sandk\u00fchler, J. (2013). Impaired excitatory drive to spinal GABAergic neurons of neuropathic mice. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0073370"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pain.2005.05.035","article-title":"Peripheral axonal injury results in reduced mu opioid receptor pre- and post-synaptic action in the spinal cord","volume":"117","author":"Kohno","year":"2005","journal-title":"Pain"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1744-8069-3-27","article-title":"Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain","volume":"3","author":"Keller","year":"2007","journal-title":"Mol. Pain"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA extension for scoping reviews (PRISMA-ScR): Checklist and explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Int. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"9502718","DOI":"10.1155\/2017\/9502718","article-title":"A Randomized Clinical Trial Comparing the Effectiveness of Electroacupuncture versus Medium-Frequency Electrotherapy for Discogenic Sciatica","volume":"2017","author":"Zhang","year":"2017","journal-title":"Evid. Based Complementary Alternat. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"677","DOI":"10.2147\/JPR.S234761","article-title":"Acupotomy versus Manual Acupuncture for the Treatment of Back and\/or Leg Pain in Patients with Lumbar Disc Herniation: A Multicenter, Randomized, Controlled, Assessor-Blinded Clinical Trial","volume":"13","author":"Jeong","year":"2020","journal-title":"J. Pain Res."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Huang, J.-F., Zheng, X.-Q., Chen, D., Lin, J.-L., Zhou, W.-X., Wang, H., Qin, Z., and Wu, A.-M. (2020). Can Acupuncture Improve Chronic Spinal Pain? A Systematic Review and Meta-Analysis. Glob. Spine J., 2192568220962440.","DOI":"10.1177\/2192568220962440"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1093\/pm\/pnz167","article-title":"Efficacy and Safety of Acupuncture for Chronic Discogenic Sciatica, a Randomized Controlled Sham Acupuncture Trial","volume":"20","author":"Huang","year":"2019","journal-title":"Pain Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta15390","article-title":"The clinical effectiveness and cost-effectiveness of management strategies for sciatica: Systematic review and economic model","volume":"15","author":"Lewis","year":"2011","journal-title":"Health Technol. Assess."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s00586-007-0367-1","article-title":"Effectiveness of conservative treatments for the lumbosacral radicular syndrome: A systematic review","volume":"16","author":"Luijsterburg","year":"2007","journal-title":"Eur. Spine J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"192808","DOI":"10.1155\/2015\/192808","article-title":"The Efficacy of Acupuncture for the Treatment of Sciatica: A Systematic Review and Meta-Analysis","volume":"2015","author":"Ji","year":"2015","journal-title":"Evid. Based Complementary Alternat. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"425108","DOI":"10.1155\/2015\/425108","article-title":"Effectiveness of Acupuncture for Treating Sciatica: A Systematic Review and Meta-Analysis","volume":"2015","author":"Qin","year":"2015","journal-title":"Evid. Based Complementary Alternat. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jpain.2017.11.005","article-title":"Acupuncture for Chronic Pain: Update of an Individual Patient Data Meta-Analysis","volume":"19","author":"Vickers","year":"2018","journal-title":"J. Pain"},{"key":"ref_47","first-page":"3109","article-title":"Acupuncture and sciatica in the acute phase. Double-blind study of 30 cases","volume":"59","author":"Duplan","year":"1983","journal-title":"Sem. Hop."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"MacPherson, H., Maschino, A.C., Lewith, G., Foster, N.E., Witt, C.M., Vickers, A.J., and Acupuncture Trialists, C. (2013). Characteristics of acupuncture treatment associated with outcome: An individual patient meta-analysis of 17,922 patients with chronic pain in randomised controlled trials. PLoS ONE, 8.","DOI":"10.1371\/annotation\/23629d97-3b72-474b-9d89-c7198ba43d60"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e11951","DOI":"10.1097\/MD.0000000000011951","article-title":"Effectiveness and safety of acupotomy for treating back and\/or leg pain in patients with lumbar disc herniation: A study protocol for a multicenter, randomized, controlled, clinical trial","volume":"97","author":"Jeong","year":"2018","journal-title":"Medicine"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2147\/JPR.S280404","article-title":"The Management of Sciatica by Acupuncture: An Expert Consensus Using the Improved Delphi Survey","volume":"14","author":"Zhang","year":"2021","journal-title":"J. Pain Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1136\/aim.2009.000455","article-title":"Neuroanatomical basis of acupuncture treatment for some common illnesses","volume":"27","author":"Cheng","year":"2009","journal-title":"Acupunct. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"0964528419889636","DOI":"10.1177\/0964528419889636","article-title":"The selection of dermatomes for sham (placebo) acupuncture points is relevant for the outcome of acupuncture studies: A systematic review of sham (placebo)-controlled randomized acupuncture trials","volume":"38","author":"Ots","year":"2020","journal-title":"Acupunct. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2170\/physiolsci.SC002706","article-title":"The analgesic effects of automatically controlled rotating acupuncture in rats: Mediation by endogenous opioid system","volume":"56","author":"Kim","year":"2006","journal-title":"J. Physiol. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"9171","DOI":"10.1523\/JNEUROSCI.23-27-09171.2003","article-title":"Dorsal Horn Neurons Firing at High Frequency, But Not Primary Afferents, Release Opioid Peptides that Produce \u03bc-Opioid Receptor Internalization in the Rat Spinal Cord","volume":"23","author":"Song","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/acupmed-2013-010372","article-title":"Analysis of interspike interval of dorsal horn neurons evoked by different needle manipulations at ST36","volume":"32","author":"Zhou","year":"2014","journal-title":"Acupunct. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2170\/jjphysiol.R2120","article-title":"Manual acupuncture needle stimulation of the rat hindlimb activates groups I, II, III and IV single afferent nerve fibers in the dorsal spinal roots","volume":"55","author":"Kagitani","year":"2005","journal-title":"Jpn. J. Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.autneu.2010.03.004","article-title":"Afferent nerve fibers and acupuncture","volume":"157","author":"Kagitani","year":"2010","journal-title":"Auton. Neurosci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.brainres.2007.12.040","article-title":"Noxious mechanical stimulation evokes the segmental release of opioid peptides that induce \u03bc-opioid receptor internalization in the presence of peptidase inhibitors","volume":"1197","author":"Lao","year":"2008","journal-title":"Brain Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.3748\/wjg.v11.i7.1011","article-title":"Acupuncture inhibition on neuronal activity of spinal dorsal horn induced by noxious colorectal distention in rat","volume":"11","author":"Rong","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"675437","DOI":"10.1155\/2015\/675437","article-title":"Strong Manual Acupuncture Manipulation Could Better Inhibit Spike Frequency of the Dorsal Horn Neurons in Rats with Acute Visceral Nociception","volume":"2015","author":"Hong","year":"2015","journal-title":"Evid. Based Complementary Alternat. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neuroscience.2014.02.023","article-title":"mu-Opioid receptor inhibition of substance P release from primary afferents disappears in neuropathic pain but not inflammatory pain","volume":"267","author":"Chen","year":"2014","journal-title":"Neuroscience"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.ejpain.2010.11.018","article-title":"Dynamic temporal and spatial regulation of mu opioid receptor expression in primary afferent neurons following spinal nerve injury","volume":"15","author":"Lee","year":"2011","journal-title":"Eur. J. Pain"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"8578","DOI":"10.1523\/JNEUROSCI.20-23-08578.2000","article-title":"Postsynaptic signaling via the [mu]-opioid receptor: Responses of dorsal horn neurons to exogenous opioids and noxious stimulation","volume":"20","author":"Trafton","year":"2000","journal-title":"J. Neurosci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00702-019-02090-0","article-title":"Reviewing the case for compromised spinal inhibition in neuropathic pain","volume":"127","author":"Gradwell","year":"2020","journal-title":"J. Neural Transm."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1212\/WNL.0000000000002478","article-title":"Dorsal horn circuitry: Complexity and implications for mechanisms of neuropathic pain","volume":"86","author":"Benarroch","year":"2016","journal-title":"Neurology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/nature01868","article-title":"Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain","volume":"424","author":"Coull","year":"2003","journal-title":"Nature"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1744-8069-2-32","article-title":"Reduction of anion reversal potential subverts the inhibitory control of firing rate in spinal lamina I neurons: Towards a biophysical basis for neuropathic pain","volume":"2","author":"Prescott","year":"2006","journal-title":"Mol. Pain"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0006-8993(98)01291-8","article-title":"Myelinated afferents sprout into lamina II of L3\u20135 dorsal horn following chronic constriction nerve injury in rats","volume":"818","author":"Nakamura","year":"1999","journal-title":"Brain Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/355075a0","article-title":"Peripheral nerve injury triggers central sprouting of myelinated afferents","volume":"355","author":"Woolf","year":"1992","journal-title":"Nature"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1090-3801(97)90107-5","article-title":"Sprouting of A-fibre primary afferents into lamina II in two rat models of neuropathic pain","volume":"1","author":"Shortland","year":"1997","journal-title":"Eur J. Pain"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s11916-009-0035-8","article-title":"Spinal inhibitory neurotransmission in neuropathic pain","volume":"13","author":"Taylor","year":"2009","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1172\/JCI70026","article-title":"A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia","volume":"123","author":"Lu","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2813437","DOI":"10.1155\/2017\/2813437","article-title":"Role of Acupoint Area Collagen Fibers in Anti-Inflammation of Acupuncture Lifting and Thrusting Manipulation","volume":"2017","author":"Wang","year":"2017","journal-title":"Evid. Based Complementary Alternat. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1080\/03008200802471856","article-title":"Role of collagen fibers in acupuncture analgesia therapy on rats","volume":"50","author":"Yu","year":"2009","journal-title":"Connect. Tissue Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1096\/fj.01-0015hyp","article-title":"Mechanical signaling through connective tissue: A mechanism for the therapeutic effect of acupuncture","volume":"15","author":"Langevin","year":"2001","journal-title":"FASEB J."},{"key":"ref_76","first-page":"9","article-title":"Mechanisms and Dose Parameters of Manual Needle Stimulation: Clinical Considerations\u2014Part 2","volume":"31","author":"Perreault","year":"2019","journal-title":"Acupunct. Physiother."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Kwon, S., Lee, Y., Park, H.J., and Hahm, D.H. (2017). Coarse needle surface potentiates analgesic effect elicited by acupuncture with twirling manipulation in rats with nociceptive pain. BMC Complementary Altern. Med., 17.","DOI":"10.1186\/s12906-016-1505-2"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"652","DOI":"10.3389\/fnins.2019.00652","article-title":"Augmented Mechanical Forces of the Surface-Modified Nanoporous Acupuncture Needles Elicit Enhanced Analgesic Effects","volume":"13","author":"Bae","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1159\/000493627","article-title":"TRPV1 is a Responding Channel for Acupuncture Manipulation in Mice Peripheral and Central Nerve System","volume":"49","author":"Chen","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s12264-020-00509-3","article-title":"Responses of Primary Afferent Fibers to Acupuncture-Like Peripheral Stimulation at Different Frequencies: Characterization by Single-Unit Recording in Rats","volume":"36","author":"Huo","year":"2020","journal-title":"Neurosci. Bull."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.explore.2008.02.002","article-title":"Role of mast cells in acupuncture effect: A pilot study","volume":"4","author":"Zhang","year":"2008","journal-title":"Explore"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"483","DOI":"10.2147\/JPR.S152015","article-title":"Mast cell deficiency attenuates acupuncture analgesia for mechanical pain using c-kit gene mutant rats","volume":"11","author":"Cui","year":"2018","journal-title":"J. Pain Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00249-009-0542-x","article-title":"Single-channel properties of a stretch-sensitive chloride channel in the human mast cell line HMC-1","volume":"39","author":"Wang","year":"2010","journal-title":"Eur. Biophys. J."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"113","DOI":"10.33549\/physiolres.932053","article-title":"Mast-cell degranulation induced by physical stimuli involves the activation of transient-receptor-potential channel TRPV2","volume":"61","author":"Zhang","year":"2012","journal-title":"Physiol. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"6523","DOI":"10.1038\/s41598-018-24654-y","article-title":"Critical roles of TRPV2 channels, histamine H1 and adenosine A1 receptors in the initiation of acupoint signals for acupuncture analgesia","volume":"8","author":"Huang","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"850","DOI":"10.4208\/cicp.101214.240515s","article-title":"Modeling and simulation of the interstitial medium deformation induced by the needle manipulation during acupuncture","volume":"18","author":"Deleuze","year":"2015","journal-title":"Commun. Comput. Physics"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"831","DOI":"10.4208\/cicp.121214.250515s","article-title":"A biological model of acupuncture and its derived mathematical modeling and simulations","volume":"18","author":"Thiriet","year":"2015","journal-title":"Commun. Comput. Physics"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"91","DOI":"10.15547\/bjvm.2066","article-title":"Mast cell distribution around the needle tract following acupuncture in zusanli (st36) acupoint in rats","volume":"22","author":"Dimitrov","year":"2019","journal-title":"Bulg. J. Vet. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.7150\/ijbs.26738","article-title":"An investigation of the distribution and location of mast cells affected by the stiffness of substrates as a mechanical niche","volume":"14","author":"Yang","year":"2018","journal-title":"Int J. Biol. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.jpain.2012.09.012","article-title":"Traditional acupuncture triggers a local increase in adenosine in human subjects","volume":"13","author":"Takano","year":"2012","journal-title":"J. Pain"},{"key":"ref_91","first-page":"350949","article-title":"ATP release from mast cells by physical stimulation: A putative early step in activation of acupuncture points","volume":"2013","author":"Wang","year":"2013","journal-title":"Evid. Based Complementary Alternat. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1002\/jcp.29148","article-title":"Acupuncture induces adenosine in fibroblasts through energy metabolism and promotes proliferation by activating MAPK signaling pathway via adenosine3 receptor","volume":"235","author":"Qu","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Wu, S.Y., Chen, W.H., Hsieh, C.L., and Lin, Y.W. (2014). Abundant expression and functional participation of TRPV1 at Zusanli acupoint (ST36) in mice: Mechanosensitive TRPV1 as an \u201cacupuncture-responding channel\u201d. BMC Complementary Alternat. Med., 14.","DOI":"10.1186\/1472-6882-14-96"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/exd.14093","article-title":"P2Y13 and P2X7 receptors modulate mechanically induced adenosine triphosphate release from mast cells","volume":"29","author":"Shen","year":"2020","journal-title":"Exp. Dermatol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1523\/JNEUROSCI.5324-09.2010","article-title":"Ecto-5\u2032-nucleotidase (CD73) inhibits nociception by hydrolyzing AMP to adenosine in nociceptive circuits","volume":"30","author":"Sowa","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1744-8069-6-20","article-title":"Recombinant ecto-5\u2032-nucleotidase (CD73) has long lasting antinociceptive effects that are dependent on adenosine A1 receptor activation","volume":"6","author":"Sowa","year":"2010","journal-title":"Mol. Pain"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0306-4522(03)00480-9","article-title":"Distribution of antinociceptive adenosine A1 receptors in the spinal cord dorsal horn, and relationship to primary afferents and neuronal subpopulations","volume":"121","author":"Schulte","year":"2003","journal-title":"Neuroscience"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1152\/jn.1994.72.4.1611","article-title":"Adenosine inhibition of synaptic transmission in the substantia gelatinosa","volume":"72","author":"Li","year":"1994","journal-title":"J. Neurophysiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1152\/jn.00291.2004","article-title":"Adenosine inhibits GABAergic and glycinergic transmission in adult rat substantia gelatinosa neurons","volume":"92","author":"Yang","year":"2004","journal-title":"J. Neurophysiol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/978-3-540-33823-9_11","article-title":"Adenosine and ATP receptors","volume":"Volume 177","author":"Stein","year":"2006","journal-title":"Analgesia. Handbook of Experimental Pharmacology"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1469-7793.2000.t01-1-00471.x","article-title":"ATP facilitates spontaneous glycinergic IPSC frequency at dissociated rat dorsal horn interneuron synapses","volume":"524","author":"Rhee","year":"2000","journal-title":"J. Physiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1097\/j.pain.0000000000001246","article-title":"Downregulation of adenosine and adenosine A1 receptor contributes to neuropathic pain in resiniferatoxin neuropathy","volume":"159","author":"Kan","year":"2018","journal-title":"Pain"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jneumeth.2011.04.002","article-title":"Simultaneous identification of unmyelinated and myelinated primary somatic afferents by co-injection of isolectin B4 and Cholera toxin subunit B into the sciatic nerve of the rat","volume":"198","author":"Shehab","year":"2011","journal-title":"J. Neurosci. Methods"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-40967-y","article-title":"Central expression of synaptophysin and synaptoporin in nociceptive afferent subtypes in the dorsal horn","volume":"9","author":"Chung","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/26975","article-title":"Local control of information flow in segmental and ascending collaterals of single afferents","volume":"395","author":"Lomeli","year":"1998","journal-title":"Nature"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/cne.902940110","article-title":"Correlation of monosynaptic field potentials evoked by single action potentials in single primary afferent axons and their bouton distributions in the dorsal horn","volume":"294","author":"Koerber","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"4165","DOI":"10.1113\/jphysiol.2008.154898","article-title":"Monosynaptic convergence of C-and A\u03b4-afferent fibres from different segmental dorsal roots on to single substantia gelatinosa neurones in the rat spinal cord","volume":"586","author":"Pinto","year":"2008","journal-title":"J. Physiol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1523\/JNEUROSCI.3445-09.2010","article-title":"Multisegmental A\u03b4-and C-fiber input to neurons in lamina I and the lateral spinal nucleus","volume":"30","author":"Pinto","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"101786","DOI":"10.1016\/j.pneurobio.2020.101786","article-title":"Primary afferent-driven presynaptic inhibition of C-fiber inputs to spinal lamina I neurons","volume":"188","author":"Fernandes","year":"2020","journal-title":"Prog. Neurobiol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s002210050933","article-title":"Presynaptic inhibition in the vertebrate spinal cord revisited","volume":"129","author":"Rudomin","year":"1999","journal-title":"Exp. Brain Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1097\/j.pain.0000000000000394","article-title":"Diverse firing properties and A\u03b2-, A\u03b4-, and C-afferent inputs of small local circuit neurons in spinal lamina I","volume":"157","author":"Fernandes","year":"2016","journal-title":"Pain"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ejpain.2004.06.004","article-title":"GABAB receptors on central terminals of C-afferents mediate intersegmental A\u03b4-afferent evoked hypoalgesia","volume":"9","author":"Jones","year":"2005","journal-title":"Eur. J. Pain"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.neuroscience.2011.07.033","article-title":"Blockade of GABAB receptors facilitates evoked neurotransmitter release at spinal dorsal horn synapse","volume":"193","author":"Yang","year":"2011","journal-title":"Neuroscience"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0361-9230(01)00546-9","article-title":"Distribution and depression of the GABAB receptor in the spinal dorsal horn of adult rat","volume":"55","author":"Yang","year":"2001","journal-title":"Brain Res. Bull."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jams.2013.06.013","article-title":"Cord dorsum potentials evoked by electroacupuncture applied to the hind limbs of rats","volume":"7","year":"2014","journal-title":"J. Acupunct. Meridian Stud."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1113\/jphysiol.2011.223271","article-title":"Changes in correlation between spontaneous activity of dorsal horn neurones lead to differential recruitment of inhibitory pathways in the cat spinal cord","volume":"590","author":"Chavez","year":"2012","journal-title":"J. Physiol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0929-6646(10)60075-7","article-title":"Norepinephrine can act via \u03b12-adrenoceptors to reduce the hyper-excitability of spinal dorsal horn neurons following chronic nerve injury","volume":"109","author":"Jiang","year":"2010","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/BF03177488","article-title":"A delta afferent fiber stimulation activates descending noradrenergic system from the locus coeruleus","volume":"23","author":"Hitoto","year":"1998","journal-title":"Neurochem. Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s00221-020-05805-y","article-title":"Activation of \u03b1-adrenoceptors depresses synaptic transmission of myelinated afferents and inhibits pathways mediating primary afferent depolarization (PAD) in the in vitro mouse spinal cord","volume":"238","author":"Calvo","year":"2020","journal-title":"Exp. Brain Res."},{"key":"ref_120","first-page":"436913","article-title":"Mechanisms of electroacupuncture-induced analgesia on neuropathic pain in animal model","volume":"2013","author":"Kim","year":"2013","journal-title":"Evid. Based Complementary Alternat Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.pain.2009.06.021","article-title":"Direct excitation of spinal GABAergic interneurons by noradrenaline","volume":"145","author":"Gassner","year":"2009","journal-title":"Pain"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.2147\/JPR.S181210","article-title":"Noradrenaline modulates mechanically evoked responses in the rat spinal dorsal horn: An in vivo patch-clamp study","volume":"12","author":"Sonohata","year":"2019","journal-title":"J. Pain Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.npep.2015.06.002","article-title":"The role of arginine vasopressin in electroacupuncture treatment of primary sciatica in human","volume":"52","author":"Zhao","year":"2015","journal-title":"Neuropeptides"},{"key":"ref_124","first-page":"11","article-title":"The roles of vasopressin in acupuncture analgesia","volume":"3","author":"Deng","year":"2015","journal-title":"J. Pharm. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3109\/00207450802333649","article-title":"Norepinephrine plays an important role in antinociceptive modulation of hypothalamic paraventricular nucleus in the rat","volume":"120","author":"Zhou","year":"2010","journal-title":"Int. J. Neurosci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1113\/JP274103","article-title":"Noradrenergic inhibition of presynaptic TRPV1 channels: A new pathway of pain control","volume":"595","author":"Carbone","year":"2017","journal-title":"J. Physiol."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Wang, J.Y., Gao, Y.H., Qiao, L.N., Zhang, J.L., Duan-Mu, C.L., Yan, Y.X., Chen, S.P., and Liu, J.L. (2018). Repeated electroacupuncture treatment attenuated hyperalgesia through suppression of spinal glial activation in chronic neuropathic pain rats. BMC Complementary Alternat. Med., 18.","DOI":"10.1186\/s12906-018-2134-8"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1136\/acupmed-2015-010773","article-title":"Inhibition of spinal microglia and astrocytes contributes to the anti-allodynic effect of electroacupuncture in neuropathic pain induced by spinal nerve ligation","volume":"34","author":"Liang","year":"2016","journal-title":"Acupunct. Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/nature04223","article-title":"BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain","volume":"438","author":"Coull","year":"2005","journal-title":"Nature"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neuint.2019.04.003","article-title":"Role of the BDNF-TrkB pathway in KCC2 regulation and rehabilitation following neuronal injury: A mini review","volume":"128","author":"Uchiyama","year":"2019","journal-title":"Neurochem. Int."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"e49753","DOI":"10.7554\/eLife.49753","article-title":"Excitatory neurons are more disinhibited than inhibitory neurons by chloride dysregulation in the spinal dorsal horn","volume":"8","author":"Lee","year":"2019","journal-title":"Elife"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1083\/jcb.200209011","article-title":"BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion","volume":"159","author":"Rivera","year":"2002","journal-title":"J. Cell Biol."},{"key":"ref_133","first-page":"3307","article-title":"Effect of electro-acupuncture on the BDNF-TrkB pathway in the spinal cord of CCI rats","volume":"41","author":"Tu","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Xue, M., Sun, Y.L., Xia, Y.Y., Huang, Z.H., Huang, C., and Xing, G.G. (2020). Electroacupuncture Modulates Spinal BDNF\/TrkappaB Signaling Pathway and Ameliorates the Sensitization of Dorsal Horn WDR Neurons in Spared Nerve Injury Rats. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186524"},{"key":"ref_135","first-page":"6961","article-title":"KCC2-GABAA pathway correlates with the analgesic effect of electro-acupuncture in CCI rats","volume":"17","author":"Li","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_136","first-page":"17","article-title":"Mechanisms and dose parameters of electric needle stimulation: Clinical considerations\u2014Part 1","volume":"30","author":"Perreault","year":"2018","journal-title":"Acupunct. Physiother."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1089\/acm.2014.0186","article-title":"Manual and electrical needle stimulation in acupuncture research: Pitfalls and challenges of heterogeneity","volume":"21","author":"Langevin","year":"2015","journal-title":"J. Alternat. Complementary Med."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.nbd.2010.04.003","article-title":"Acupuncture-mediated inhibition of inflammation facilitates significant functional recovery after spinal cord injury","volume":"39","author":"Choi","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.expneurol.2012.05.014","article-title":"Inhibition of ROS-induced p38MAPK and ERK activation in microglia by acupuncture relieves neuropathic pain after spinal cord injury in rats","volume":"236","author":"Choi","year":"2012","journal-title":"Exp. Neurol."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Lee, J.Y., Choi, D.C., Oh, T.H., and Yune, T.Y. (2013). Analgesic effect of acupuncture is mediated via inhibition of JNK activation in astrocytes after spinal cord injury. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0073948"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/10\/2189\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:03:45Z","timestamp":1760162625000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/10\/2189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,19]]},"references-count":140,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,5]]}},"alternative-id":["jcm10102189"],"URL":"https:\/\/doi.org\/10.3390\/jcm10102189","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,19]]}}}