{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:59:30Z","timestamp":1789826370510,"version":"4.0.1"},"reference-count":30,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Left bundle branch block is not a benign pathology, and its presence requires the identification of a pathological substrate, such as ischemic heart disease. Left bundle branch block appears to be more commonly associated with normal coronary arteries, especially in women. The objectives of our study were to describe the particularities of left bundle branch block in women compared to men with ischemic heart disease. Result: We included seventy patients with left bundle branch block and ischemic heart disease, with a mean age of 67.01 \u00b1 8.89 years. There were no differences in the profile of risk factors, except for smoking and uric acid. The ventricular depolarization (QRS) duration was longer in men than women (136.86 \u00b1 8.32 vs. 132.57 \u00b1 9.19 msec; p = 0.018) and also men were observed to have larger left ventricular diameters. Left bundle branch block duration was directly associated with ventricular diameters and indirectly associated with left ventricular ejection fraction value, especially in women (R = \u22120.52, p = 0.0012 vs. R = \u22120.50, p = 0.002). In angiography, 80% of women had normal epicardial arteries compared with 65.7% of men; all these patients presented with microvascular dysfunction. Conclusion: The differences between the sexes were not so obvious in terms of the presence of risk factors; instead, there were differences in electrocardiographic, echocardiographic, and angiographic aspects. Left bundle branch block appears to be a marker of microvascular angina and systolic dysfunction, especially in women.<\/jats:p>","DOI":"10.3390\/jcm10112284","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T13:14:21Z","timestamp":1621948461000},"page":"2284","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Major Left Bundle Branch Block and Coronary Heart Disease\u2014Are There Any Differences between the Sexes?"],"prefix":"10.3390","volume":"10","author":[{"given":"Diana","family":"Gurz\u0103u","sequence":"first","affiliation":[{"name":"\u201cIuliu Ha\u021bieganu\u201d, University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"D\u0103d\u00e2rlat-Pop","sequence":"additional","affiliation":[{"name":"\u201cIuliu Ha\u021bieganu\u201d, University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Caloian","sequence":"additional","affiliation":[{"name":"\u201cIuliu Ha\u021bieganu\u201d, University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7352-9584","authenticated-orcid":false,"given":"Gabriel","family":"Cismaru","sequence":"additional","affiliation":[{"name":"\u201cIuliu Ha\u021bieganu\u201d, University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hora\u0163iu","family":"Com\u015fa","sequence":"additional","affiliation":[{"name":"\u201cIuliu Ha\u021bieganu\u201d, University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1944-4088","authenticated-orcid":false,"given":"Raluca","family":"Tomoaia","sequence":"additional","affiliation":[{"name":"\u201cIuliu Ha\u021bieganu\u201d, University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dumitru","family":"Zdrenghea","sequence":"additional","affiliation":[{"name":"\u201cIuliu Ha\u021bieganu\u201d, University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Pop","sequence":"additional","affiliation":[{"name":"\u201cIuliu Ha\u021bieganu\u201d, University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1161\/01.CIR.51.3.477","article-title":"A clinical and follow-up study of right and left bundle branch block","volume":"51","author":"Rotman","year":"1975","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/ehjci\/jev202","article-title":"Association of left bundle branch block with obstructive coronary artery disease on coronary CT angiography: A case\u2013control study","volume":"17","author":"Clerc","year":"2015","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.gheart.2012.08.001","article-title":"Third Universal Definition of Myocardial Infarction","volume":"7","author":"Thygesen","year":"2012","journal-title":"Glob. Heart"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1161\/CIRCULATIONAHA.116.024534","article-title":"Ischemia and No Obstructive Coronary Artery Disease (INOCA) Developing Evidence-Based Therapies and Research Agenda for the Next Decade","volume":"135","author":"Pepine","year":"2017","journal-title":"Circulation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1001\/jama.293.4.477","article-title":"Angina with \u201cNormal\u201d Coronary Arteries A Changing Philosophy","volume":"293","author":"Bugiardini","year":"2005","journal-title":"JAMA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4236\/wjcd.2014.42010","article-title":"Prognostic implication of the coronary microvascular dysfunction in patients with isolated left bundle branch block","volume":"04","author":"Rodrigo","year":"2014","journal-title":"World J. Cardiovasc. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/eurheartj\/ehz425","article-title":"2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes","volume":"41","author":"Knuuti","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/eurheartj\/ehaa575","article-title":"2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation","volume":"42","author":"Collet","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_9","first-page":"39","article-title":"LBBB: State-of-the-Art Criteria","volume":"7","author":"Nikoo","year":"2013","journal-title":"Int. Cardivasc. Res. J."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Gepner, A.D., Piper, M.E., Leal, M.A., Asthana, A., Fiore, M.C., Baker, T.B., and Stein, J.H. (2013). Electrocardiographic Changes Associated with Smoking and Smoking Cessation: Outcomes from a Randomized Controlled Trial. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062311"},{"key":"ref_11","first-page":"247","article-title":"Hyperuricemia on admission predicts short-term mortality due to myocardial infarction in a population with high prevalence of cardiovascular risk factors","volume":"69","author":"Bojalil","year":"2017","journal-title":"Rev. Investig. Clin."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s40292-020-00368-z","article-title":"Hyperuricemia and Risk of Cardiovascular Outcomes: The Experience of the URRAH (Uric Acid Right for Heart Health) Project","volume":"27","author":"Maloberti","year":"2020","journal-title":"High Blood Press. Cardiovasc. Prev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e13048","DOI":"10.1111\/ijcp.13048","article-title":"Uric acid and cardiovascular risk: What genes can say","volume":"72","author":"Kei","year":"2017","journal-title":"Int. J. Clin. Pract."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.7326\/0003-4819-134-3-200102060-00007","article-title":"Sex Differences in 2-Year Mortality after Hospital Discharge for Myocardial Infarction","volume":"134","author":"Vaccarino","year":"2001","journal-title":"Ann. Intern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ijcard.2017.10.055","article-title":"Gender differences in electro-mechanical characteristics of left bundle branch block: Potential implications for selection and response of cardiac resynchronization therapy","volume":"257","author":"Kamoen","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1089\/jwh.2014.4980","article-title":"Sex Differences in Device Therapy for Heart Failure: Utilization, Outcomes, and Adverse Events","volume":"24","author":"Herz","year":"2015","journal-title":"J. Women Health"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e002013","DOI":"10.1161\/JAHA.115.002013","article-title":"Sex Differences in Long-Term Outcomes with Cardiac Resynchronization Therapy in Mild Heart Failure Patients with Left Bundle Branch Block","volume":"4","author":"Biton","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/j.amjcard.2014.02.026","article-title":"Comparison of the Relation Between Left Ventricular Anatomy and QRS Duration in Patients with Cardiomyopathy with Versus without Left Bundle Branch Block","volume":"113","author":"Chan","year":"2014","journal-title":"Am. J. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1161\/CIRCIMAGING.110.961417","article-title":"Mechanisms of Abnormal Systolic Motion of the Interventricular Septum During Left Bundle-Branch Block","volume":"4","author":"Gjesdal","year":"2011","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1161\/01.CIR.65.7.1486","article-title":"Mechanism of abnormal inter-ventricular septal motion during delayed left-ventricular activation","volume":"65","author":"Little","year":"1982","journal-title":"Circulation"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3329\/uhj.v12i2.36389","article-title":"Coronary Angiographic Findings among the Left Bundle Branch Block Patients","volume":"12","author":"Iqbal","year":"2018","journal-title":"Univ. Heart J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.amjcard.2004.02.048","article-title":"Presence and extent of angiographic coronary narrowing in patients with left bundle branch block","volume":"93","author":"Nguyen","year":"2004","journal-title":"Am. J. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1177\/0003319707308893","article-title":"Is There an Association Between Left Bundle Branch Block and Coronary Slow Flow in Patients with Normal Coronary Arteries?","volume":"58","author":"Biceroglu","year":"2007","journal-title":"Angiology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.amjcard.2006.06.021","article-title":"Predictors of Coronary Artery Disease in Patients with Left Bundle Branch Block Undergoing Coronary Angiography","volume":"98","author":"Abrol","year":"2006","journal-title":"Am. J. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/ejhf.162","article-title":"Age, prognostic impact of QRS prolongation and left bundle branch block, and utilization of cardiac resynchronization therapy: Findings from 14713 patients in the Swedish Heart Failure Registry","volume":"16","author":"Lund","year":"2014","journal-title":"Eur. J. Heart Fail."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1093\/oxfordjournals.eurheartj.a060084","article-title":"Exercise dependent complete left bundle branch block","volume":"13","author":"Hertzeanu","year":"1992","journal-title":"Eur. Heart J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S0300-8932(02)76638-4","article-title":"Exercise-Induced Left Bundle-Branch Block in Patients with Coronary Artery Disease versus Patients with Normal Coronary Arteries","volume":"55","author":"Riera","year":"2002","journal-title":"Rev. Esp. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/0002-9149(84)90276-5","article-title":"Exercise-induced left bundle branch block and chest discomfort without myocardial ischemia","volume":"54","author":"Kafka","year":"1984","journal-title":"Am. J. Cardiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1161\/01.CIR.79.4.845","article-title":"Functional abnormalities in isolated left bundle branch block. The effect of interventricular asynchrony","volume":"79","author":"Grines","year":"1989","journal-title":"Circulation"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0735-1097(87)80162-6","article-title":"Bundle branch block in patients with chronic coronary artery disease: Angiographic correlates and prognostic significance","volume":"10","author":"Freedman","year":"1987","journal-title":"J. Am. Coll. Cardiol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/11\/2284\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:07:15Z","timestamp":1760162835000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/11\/2284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,25]]},"references-count":30,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["jcm10112284"],"URL":"https:\/\/doi.org\/10.3390\/jcm10112284","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,25]]}}}