{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:14:59Z","timestamp":1771488899741,"version":"3.50.1"},"reference-count":28,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T00:00:00Z","timestamp":1622246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Spinal deformity corrections in paediatric patients are long-lasting procedures involving damage to many tissues and long pain exposure; therefore, effective pain management after surgical treatment is an important issue. In this study, the effect of inclusion of local infiltration analgesia, as an integral part of the scheme in postoperative pain control, in children and adolescents, subjected to the spinal deformity correction procedure, was assessed. Thirty patients, aged 8 to 17 years, undergoing spinal deformity correction were divided into a study group, receiving a 0.25% bupivacaine solution before wound closure, and a control group (no local analgesic agent). Morphine, at the doses of 0.10 mg\/kg of body weight, was administered to the patients when pain occurred. Pain scores, morphine administration, and bleeding were observed during 48 postoperative hours. The pain scores were slightly lower in a 0\u20134 h period in patients who received bupivacaine compared with those in the control group. However, no differences were observed in a longer period of time and in the total opioid consumption. Moreover, increasing bleeding was observed in the bupivacaine-treated patients (study group) vs. the control. Bupivacaine only modestly affects analgesia and, due to the increased bleeding observed, it should not to be part of pain control management in young patients after spinal deformity correction.<\/jats:p>","DOI":"10.3390\/jcm10112407","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:22:15Z","timestamp":1622420535000},"page":"2407","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Subcutaneous Bupivacaine Infiltration Is Not Effective to Support Control of Postoperative Pain in Paediatric Patients Undergoing Spinal Surgery"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0884-7498","authenticated-orcid":false,"given":"Anna","family":"Danielewicz","sequence":"first","affiliation":[{"name":"Department of Paediatric Orthopaedics, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Fatyga","sequence":"additional","affiliation":[{"name":"Childrens\u2019 Ortopeadic Department, Childrens\u2019 University Hospital in Lublin, 20-093 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz","family":"Starobrat","sequence":"additional","affiliation":[{"name":"Childrens\u2019 Ortopeadic Department, Childrens\u2019 University Hospital in Lublin, 20-093 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6108-1607","authenticated-orcid":false,"given":"Monika","family":"R\u00f3\u017ca\u0144ska-Boczula","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics and Computer Science, University of Life Sciences in Lublin, 20-033 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0466-1343","authenticated-orcid":false,"given":"Magdalena","family":"W\u00f3jciak","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9346-6325","authenticated-orcid":false,"given":"Ireneusz","family":"Sowa","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4413-3748","authenticated-orcid":false,"given":"S\u0142awomir","family":"Dresler","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7919-0294","authenticated-orcid":false,"given":"Micha\u0142","family":"Latalski","sequence":"additional","affiliation":[{"name":"Department of Paediatric Orthopaedics, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2174\/1874325001610010143","article-title":"Adolescent Idiopathic Scoliosis","volume":"10","author":"Choudhry","year":"2016","journal-title":"Open Orthop. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1097\/BPO.0000000000001350","article-title":"The Natural History of Adolescent Idiopathic Scoliosis","volume":"39","author":"Weinstein","year":"2019","journal-title":"J. Pediatr. Orthop."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1007\/s00586-012-2370-4","article-title":"Risk factors for major peri-operative complications in adult spinal deformity surgery: A multi-center review of 953 consecutive patients","volume":"21","author":"Schwab","year":"2012","journal-title":"Eur. Spine J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"E594","DOI":"10.1097\/BRS.0000000000003846","article-title":"Comparison of Different Surgical Systems for Treatment of Early-onset Scoliosis in the Context of Release of Titanium Ions","volume":"46","author":"Danielewicz","year":"2021","journal-title":"Spine"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.anclin.2011.04.005","article-title":"Local Infiltration Analgesia","volume":"29","author":"Ganapathy","year":"2011","journal-title":"Anesthesiol. Clin."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2147\/JPR.S4554","article-title":"Acute pain management in children","volume":"3","author":"Verghese","year":"2010","journal-title":"J. Pain Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/BPO.0000000000001639","article-title":"Pain control and medication use in children following closed reduction and percutaneous pinning of supracondylar humerus fractures: Are we still overprescribing opioids?","volume":"40","author":"Stillwagon","year":"2020","journal-title":"J. Pediatr. Orthop."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"131628","DOI":"10.1016\/j.tet.2020.131628","article-title":"A brief history behind the most used local anesthetics","volume":"76","author":"Bezerra","year":"2020","journal-title":"Tetrahedron"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1213\/ane.0b013e3181aff25e","article-title":"The Effect of a Peripheral Block on Inflammation-Induced Prostaglandin E2 and Cyclooxygenase Expression in Rats","volume":"109","author":"Beloeil","year":"2009","journal-title":"Anesth. Analg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1302\/0301-620X.94B9.28611","article-title":"The local infiltration of analgesia following total knee replacement: A review of current literature","volume":"94","author":"Gibbs","year":"2012","journal-title":"J. Bone Jt. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"959","DOI":"10.2106\/JBJS.E.00344","article-title":"Efficacy of periarticular multimodal drug injection in total knee arthroplasty. A randomized trial","volume":"88","author":"Busch","year":"2006","journal-title":"J. Bone Jt. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3109\/17453674.2014.961399","article-title":"Single periarticular local infiltration analgesia reduces opiate consumption until 48 hours after total knee arthroplasty","volume":"85","author":"Kalliovalkama","year":"2014","journal-title":"Acta Orthop."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Sun, Q.B., Liu, S.D., Meng, Q.J., Qu, H.Z., and Zhang, Z. (2015). Single administration of intra-articular bupivacaine in arthroscopic knee surgery: A system-atic review and meta-analysis. BMC Musculoskelet. Disord., 16.","DOI":"10.1186\/s12891-015-0477-6"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3109\/17453674.2010.487241","article-title":"Reduced morphine consumption and pain intensity with local infiltration analgesia (LIA) following total knee arthroplasty","volume":"81","author":"Essving","year":"2010","journal-title":"Acta Orthop."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e2833","DOI":"10.1097\/GOX.0000000000002833","article-title":"Basics and best practices of multimodal pain management for the plastic surgeon","volume":"8","author":"Barker","year":"2020","journal-title":"Plast. Reconstr. Surg. Glob. Open."},{"key":"ref_16","first-page":"756","article-title":"Effect of wound infiltration with bupivacaine on pulmonary function after elective lower abdominal operations","volume":"13","author":"Ige","year":"2013","journal-title":"Afr. Heal. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/00000658-199901000-00015","article-title":"Effect of topical local anesthetic application to skin harvest sites for pain manage-ment in burn patients undergoing skin-grafting procedures","volume":"229","author":"Jellish","year":"1999","journal-title":"Ann. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1093\/bja\/aeq093","article-title":"Clinically relevant doses of lidocaine and bupivacaine do not impair cutaneous wound healing in mice","volume":"104","author":"Waite","year":"2010","journal-title":"Br. J. Anaesth."},{"key":"ref_19","first-page":"301","article-title":"Intraperitoneal Bupivacaine Does Not Attenuate Pain Following Laparoscopic Cholecystectomy","volume":"4","author":"Zmora","year":"2000","journal-title":"JSLS J. Soc. Laparoendosc. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3889\/oamjms.2016.023","article-title":"Evaluation of anesthesia profile in pediatric patients after in-guinal hernia repair with caudal block or local wound infiltration","volume":"4","author":"Kuzmanovska","year":"2016","journal-title":"Maced. J. Med. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.urology.2016.04.064","article-title":"Port site local anesthetic infiltration vs single-dose intrathecal opioid in-jection to control perioperative pain in children undergoing minimal invasive surgery: A comparative analysis","volume":"97","author":"Srinivasan","year":"2016","journal-title":"Urology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3109\/17453674.2015.1113375","article-title":"Epidural analgesia is superior to local infiltration analgesia in children with cerebral palsy undergoing unilateral hip reconstruction","volume":"87","author":"Pedersen","year":"2015","journal-title":"Acta Orthop."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/pan.12919","article-title":"The effect of continuous wound infusion of ropivacaine on postoperative pain after median sternotomy and mediastinal drain in children","volume":"26","author":"Mattila","year":"2016","journal-title":"Pediatr. Anesth."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1007\/s00586-016-4428-1","article-title":"Does continuous wound infiltration enhance baseline intravenous multimodal analgesia after posterior spinal fusion surgery? A randomized, double-blinded, placebo-controlled study","volume":"26","author":"Greze","year":"2017","journal-title":"Eur. Spine J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.spinee.2016.06.013","article-title":"Liposomal bupivacaine incisional injection in single-level lumbar spine surgery","volume":"16","author":"Puffer","year":"2016","journal-title":"Spine J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"E533","DOI":"10.1097\/BSD.0000000000000996","article-title":"Liposomal Bupivacaine Is Both Safe and Effective in Controlling Postoperative Pain After Spinal Surgery in Children","volume":"33","author":"Chughtai","year":"2020","journal-title":"Clin. Spine Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1308\/003588403766275105","article-title":"Use of adrenaline and bupivacaine to reduce bleeding and pain following harvesting of bone graft","volume":"85","author":"Cheeseman","year":"2003","journal-title":"Ann. R. Coll. Surg. Engl."},{"key":"ref_28","first-page":"209","article-title":"The Effect of Local Injection of Epinephrine and Bupivacaine on Post-Tonsillectomy Pain and Bleeding","volume":"25","author":"Bameshki","year":"2013","journal-title":"Iran. J. Otorhinolaryngol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/11\/2407\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:10:24Z","timestamp":1760163024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/11\/2407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,29]]},"references-count":28,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["jcm10112407"],"URL":"https:\/\/doi.org\/10.3390\/jcm10112407","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,29]]}}}