{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:12:48Z","timestamp":1787785968558,"version":"build-2784847793"},"reference-count":46,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>While the diagnosis of adult-onset Still\u2019s disease (AOSD) involves the exclusion of differential diagnoses, the characteristics and value of 18F-Fluorodeoxyglucose (18F-FDG) Positron Emission Tomography coupled with CT (PET\/CT) in the management of AOSD remain poorly known. Our retrospective study included patients from four centers, fulfilling Yamaguchi or Fautrel criteria, who underwent a PET\/CT during an active AOSD. Thirty-five patients were included. At the time of PET\/CT, the Yamaguchi criteria were met in 23 of 29 evaluable cases. PET\/CT showed bone marrow (74.3%), lymph node (74.3%), and splenic (48.6%) FDG uptake. Despite arthralgia or arthritis in most patients, joints were rarely the sites of 18F-FDG accumulation. The spatial distribution of 18F-FDG uptake was nonspecific, and its intensity could be similar to malignant disease. Lymph node or bone marrow biopsy was performed after PET\/CT in 20 patients (57.1%). The intensity of bone marrow; splenic and lymph node hypermetabolism appeared to be correlated with disease activity. Abnormal PET\/CT in the cervical lymph nodes and age \u2265 60 years seemed to be predictive factors for monocyclic evolution. The clinical value of PET\/CT is not in direct diagnosis; but as an aid in excluding differential diagnoses by searching for their scintigraphic features and guiding biopsy.<\/jats:p>","DOI":"10.3390\/jcm10112489","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T11:12:13Z","timestamp":1622805133000},"page":"2489","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Characteristics and Clinical Value of 18F-FDG PET\/CT in the Management of Adult-Onset Still\u2019s Disease: 35 Cases"],"prefix":"10.3390","volume":"10","author":[{"given":"Josselin","family":"Brisset","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Interne, CHU Dupuytren, 87000 Limoges, France"},{"name":"Service de Maladies Infectieuses et Tropicales, CHU Dupuytren, 87000 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5249-3650","authenticated-orcid":false,"given":"Yvan","family":"Jamilloux","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4pital de la Croix-Rousse, 69004 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Dumonteil","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, CHU Dupuytren, 87000 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Lades","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Nucl\u00e9aire, CHU Dupuytren, 87000 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7115-3248","authenticated-orcid":false,"given":"Martin","family":"Killian","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, CHU Saint-Etienne, 42055 Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4245-8039","authenticated-orcid":false,"given":"Mathieu","family":"Gerfaud-Valentin","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4pital de la Croix-Rousse, 69004 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Lemaire","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, Centre Hospitalier Alpes-L\u00e9man, 74130 Contamine-sur-Arve, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Chroboczek","sequence":"additional","affiliation":[{"name":"Service de Maladies Infectieuses, Centre Hospitalier Alpes-L\u00e9man, 74130 Contamine-sur-Arve, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Liozon","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, CHU Dupuytren, 87000 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Gondran","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, CHU Dupuytren, 87000 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3070-3842","authenticated-orcid":false,"given":"Pascal","family":"S\u00e8ve","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4pital de la Croix-Rousse, 69004 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Monteil","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Nucl\u00e9aire, CHU Dupuytren, 87000 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure","family":"Fauchais","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, CHU Dupuytren, 87000 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim Heang","family":"Ly","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, CHU Dupuytren, 87000 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.autrev.2014.01.058","article-title":"Adult-Onset Still\u2019s Disease","volume":"13","author":"Jamilloux","year":"2014","journal-title":"Autoimmun. 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