{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:54:54Z","timestamp":1779368094226,"version":"3.53.0"},"reference-count":28,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Finnish Governmental VTR-funding","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Patients with rheumatoid arthritis (RA) have increased risk of developing cardiovascular disease and events. Little is, however, known about the influence of RA to the outcomes after surgical aortic valve replacement (SAVR). Methods: In a retrospective, nationwide, multicenter cohort study, RA patients (n = 109) were compared to patients without RA (n = 1090) treated with isolated SAVR for aortic valve stenosis. Propensity score-matching adjustment for baseline features was used to study the outcome differences in a median follow-up of 5.6 years. Results: Patients with RA had higher all-cause mortality (HR 1.76; CI 1.21\u20132.57; p = 0.003), higher incidence of major adverse cardiovascular events (HR 1.63; CI 1.06\u20132.49; p = 0.025), and they needed more often coronary artery revascularization for coronary artery disease (HR 3.96; CI 1.21\u201312.90; p = 0.027) in long-term follow-up after SAVR. As well, cardiovascular mortality rate was higher in patients with RA (35.7% vs. 23.4%, p = 0.023). There was no difference in 30-day mortality (2.8% vs. 1.8%, p = 0.518) or in the need for aortic valve reoperations (3.7% vs. 4.0%, p = 0.532). Conclusions: Patients with rheumatoid arthritis had impaired long-term results and increased cardiovascular mortality after SAVR for aortic valve stenosis. Special attention is needed to improve outcomes of aortic valve stenosis patients with RA after SAVR.<\/jats:p>","DOI":"10.3390\/jcm10112492","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T11:12:13Z","timestamp":1622805133000},"page":"2492","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Long-Term Outcomes of Surgical Aortic Valve Replacement in Patients with Rheumatoid Arthritis"],"prefix":"10.3390","volume":"10","author":[{"given":"Markus","family":"Malmberg","sequence":"first","affiliation":[{"name":"Heart Center, Turku University Hospital and University of Turku, 20520 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8835-8116","authenticated-orcid":false,"given":"Antti","family":"Palom\u00e4ki","sequence":"additional","affiliation":[{"name":"Centre of Rheumatology and Clinical Immunology, Division of Medicine, Turku University Hospital, 20520 Turku, Finland"},{"name":"Department of Medicine, University of Turku, 20520 Turku, Finland"},{"name":"Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, 00290 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0183-9054","authenticated-orcid":false,"given":"Jussi O. T.","family":"Sipil\u00e4","sequence":"additional","affiliation":[{"name":"Department of Neurology, North Karelia Central Hospital, Siun Sote, 80210 Joensuu, Finland"},{"name":"Clinical Neurosciences, University of Turku, 20520 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4ivi","family":"Rautava","sequence":"additional","affiliation":[{"name":"Department of Public Health, University of Turku, 20520 Turku, Finland"},{"name":"Turku Clinical Research Centre, Turku University Hospital, 20520 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarmo","family":"Gunn","sequence":"additional","affiliation":[{"name":"Heart Center, Turku University Hospital and University of Turku, 20520 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4521-1093","authenticated-orcid":false,"given":"Ville","family":"Kyt\u00f6","sequence":"additional","affiliation":[{"name":"Heart Center, Turku University Hospital and University of Turku, 20520 Turku, Finland"},{"name":"Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520 Turku, Finland"},{"name":"Center for Population Health Research, Turku University Hospital and University of Turku, 20520 Turku, Finland"},{"name":"Administrative Center, Hospital District of Southwest Finland, 20520 Turku, Finland"},{"name":"Department of Public Health, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.autrev.2017.12.001","article-title":"Cardiovascular involvement in systemic rheumatic diseases: An integrated view for the treating physicians","volume":"17","author":"Lee","year":"2018","journal-title":"Autoimmun. 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