{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T01:55:51Z","timestamp":1789869351165,"version":"4.0.1"},"reference-count":19,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T00:00:00Z","timestamp":1623283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Patients in end-stage heart failure can experiment cardiogenic shock and may not be weanable from dobutamine. The fate of these patients is a challenge for doctors, patients, family, and the institution. Dobutamine use at home can be a solution. The aim of the present study was to assess the outcome, biological predictors, and safety of dobutamine use at home in dobutamine-dependent patients. All consecutive dobutamine-dependent patients discharged with continuous home intravenous dobutamine, from a single tertiary center between February 2014 and November 2019, were retrospectively analyzed. A total of 19 patients (age 65 \u00b1 10 years) were followed for one year. At one-year, the survival rate was 32%, (6\/19). Five (26%) patients had an adverse event related to the intravenous catheter. In a multivariate logistic regression analysis, the combination of a glomerular filtration rate &gt;60 mL\/min and a brain natriuretic peptide level &lt;1000 ng\/L, were highly predictive of one-year survival (HR = 10.87, IC95% (5.78\u201336.44), p &lt; 0.001). Management of dobutamine-unweanable patients after cardiogenic shock may involve dobutamine at home to permit a home return. This strategy allows a significant survival and few readmissions, and, if eligible, access to surgical strategies, such as heart transplantation. Simple biological markers at discharge can identify severe patients to refer to palliative care and good responders.<\/jats:p>","DOI":"10.3390\/jcm10122571","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T13:31:39Z","timestamp":1623331899000},"page":"2571","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Outcome Predictors and Safety of Home Dobutamine Intravenous Infusion in End Stage Heart Failure Patients"],"prefix":"10.3390","volume":"10","author":[{"given":"Antoine","family":"Jobb\u00e9-Duval","sequence":"first","affiliation":[{"name":"Heart Failure and Transplant Department, Hospices Civils de Lyon, \u201cLouis Pradel\u201d Cardiologic Hospital, 69002 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5889-7506","authenticated-orcid":false,"given":"Thomas","family":"Bochaton","sequence":"additional","affiliation":[{"name":"Cardiac Intensive Care Unit, Hospices Civils de Lyon, \u201cLouis Pradel\u201d Cardiologic Hospital, 69002 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9200-2729","authenticated-orcid":false,"given":"Guillaume","family":"Baudry","sequence":"additional","affiliation":[{"name":"Heart Failure and Transplant Department, Hospices Civils de Lyon, \u201cLouis Pradel\u201d Cardiologic Hospital, 69002 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bonnefoy-Cudraz","sequence":"additional","affiliation":[{"name":"Cardiac Intensive Care Unit, Hospices Civils de Lyon, \u201cLouis Pradel\u201d Cardiologic Hospital, 69002 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Hugon-Vallet","sequence":"additional","affiliation":[{"name":"Heart Failure and Transplant Department, Hospices Civils de Lyon, \u201cLouis Pradel\u201d Cardiologic Hospital, 69002 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Pozzi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Hospices Civils de Lyon, \u201cLouis Pradel\u201d Cardiologic Hospital, 69002 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1644-9542","authenticated-orcid":false,"given":"Jean-Francois","family":"Obadia","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Hospices Civils de Lyon, \u201cLouis Pradel\u201d Cardiologic Hospital, 69002 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danka","family":"Tomasevic","sequence":"additional","affiliation":[{"name":"Cardiac Intensive Care Unit, Hospices Civils de Lyon, \u201cLouis Pradel\u201d Cardiologic Hospital, 69002 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4811-3859","authenticated-orcid":false,"given":"Camille","family":"Amaz","sequence":"additional","affiliation":[{"name":"Clinical Investigation Center, Hospices Civils de Lyon, \u201cLouis Pradel\u201d Cardiologic Hospital, 69002 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4526-8129","authenticated-orcid":false,"given":"Nathan","family":"Mewton","sequence":"additional","affiliation":[{"name":"Heart Failure and Transplant Department, Hospices Civils de Lyon, \u201cLouis Pradel\u201d Cardiologic Hospital, 69002 Lyon, France"},{"name":"Clinical Investigation Center, Hospices Civils de Lyon, \u201cLouis Pradel\u201d Cardiologic Hospital, 69002 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Sebbag","sequence":"additional","affiliation":[{"name":"Heart Failure and Transplant Department, Hospices Civils de Lyon, \u201cLouis Pradel\u201d Cardiologic Hospital, 69002 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.cardfail.2015.04.013","article-title":"Advanced (Stage D) Heart Failure: A Statement From the Heart Failure Society of America Guidelines Committee","volume":"21","author":"Fang","year":"2015","journal-title":"J. Card. Fail."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.healun.2009.02.015","article-title":"INTERMACS Profiles of Advanced Heart Failure: The Current Picture","volume":"28","author":"Stevenson","year":"2009","journal-title":"J. Heart Lung Transplant."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/ehf2.12248","article-title":"Effects of intravenous home dobutamine in palliative end-stage heart failure on quality of life, heart failure hospitalization, and cost expenditure","volume":"5","author":"Martens","year":"2018","journal-title":"ESC Heart Fail."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S1053-2498(02)00570-3","article-title":"Morbidity and mortality of UNOS status 1B cardiac transplant candidates at home","volume":"22","author":"Lang","year":"2003","journal-title":"J. Heart Lung Transplant."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1054\/jcaf.2003.24","article-title":"Care processes and clinical outcomes of continuous outpatient support with inotropes (COSI) in patients with refractory endstage heart failure","volume":"9","author":"Hershberger","year":"2003","journal-title":"J. Card. Fail."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1161\/CIRCHEARTFAILURE.114.001778","article-title":"Clinical Characteristics and Outcomes of Intravenous Inotropic Therapy in Advanced Heart Failure","volume":"8","author":"Hashim","year":"2015","journal-title":"Circ. Heart Fail."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1161\/CIRCHEARTFAILURE.108.839076","article-title":"Prognosis on Chronic Dobutamine or Milrinone Infusions for Stage D Heart Failure","volume":"2","author":"Gorodeski","year":"2009","journal-title":"Circ. Heart Fail."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1056\/NEJMoa012175","article-title":"Long-Term Use of a Left Ventricular Assist Device for End-Stage Heart Failure","volume":"345","author":"Rose","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.cardfail.2008.08.004","article-title":"The Use of Continuous Milrinone Therapy as Bridge to Transplant Is Safe in Patients with Short Waiting Times","volume":"14","author":"Chen","year":"2008","journal-title":"J. Card. Fail."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/j.jacc.2012.12.044","article-title":"B-Type Natriuretic Peptide and Prognosis in Heart Failure Patients With Preserved and Reduced Ejection Fraction","volume":"61","author":"Linssen","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1586\/14779072.2015.1071664","article-title":"The potential role of natriuretic peptides and other biomarkers in heart failure diagnosis, prognosis and management","volume":"13","author":"Ibrahim","year":"2015","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1136\/bmj.330.7492.625","article-title":"How well does B-type natriuretic peptide predict death and cardiac events in patients with heart failure: Systematic review","volume":"330","author":"Pietrzak","year":"2005","journal-title":"BMJ"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.healun.2018.09.021","article-title":"Outcomes with ambulatory advanced heart failure from the Medical Arm of Mechanically Assisted Circulatory Support (MedaMACS) Registry","volume":"38","author":"Ambardekar","year":"2019","journal-title":"J. Heart Lung Transplant."},{"key":"ref_14","first-page":"1507","article-title":"Optimization of heart allocation: The transplant risk score","volume":"19","author":"Jasseron","year":"2019","journal-title":"Arab. Archaeol. Epigr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1536\/ihj.54.146","article-title":"Characteristics of Patients with Advanced Heart Failure Having Eosinophilic Infiltration of the Myocardium in the Recent Era","volume":"54","author":"Yoshizawa","year":"2013","journal-title":"Int. Heart J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/MAT.0000000000000175","article-title":"Dobutamine Induced Eosinophilic Myocarditis and Right Heart Failure Requiring Emergent Biventricular Assist Device Implantation","volume":"61","author":"Raje","year":"2015","journal-title":"ASAIO J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s10557-018-6838-2","article-title":"Levosimendan in Acute and Advanced Heart Failure: An Expert Perspective on Posology and Therapeutic Application","volume":"32","author":"Bouchez","year":"2018","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/ejhf.118","article-title":"Efficacy and safety of the pulsed infusions of levosimendan in outpatients with advanced heart failure (LevoRep) study: A multicentre randomized trial","volume":"16","author":"Altenberger","year":"2014","journal-title":"Eur. J. Heart Fail."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-019-2674-4","article-title":"Levosimendan in the light of the results of the recent randomized controlled trials: An expert opinion paper","volume":"23","author":"Cholley","year":"2019","journal-title":"Crit. 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